BRCT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AM31_LEIMU

TriTrypDb:

LmxM.08_29.0480partial

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AM31

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM31

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	30	34	PF00656	0.443
CLV_C14_Caspase3-7	77	81	PF00656	0.461
CLV_NRD_NRD_1	118	120	PF00675	0.459
CLV_NRD_NRD_1	137	139	PF00675	0.526
CLV_NRD_NRD_1	14	16	PF00675	0.478
CLV_NRD_NRD_1	206	208	PF00675	0.596
CLV_NRD_NRD_1	221	223	PF00675	0.534
CLV_NRD_NRD_1	237	239	PF00675	0.601
CLV_PCSK_FUR_1	235	239	PF00082	0.510
CLV_PCSK_KEX2_1	118	120	PF00082	0.448
CLV_PCSK_KEX2_1	136	138	PF00082	0.518
CLV_PCSK_KEX2_1	14	16	PF00082	0.478
CLV_PCSK_KEX2_1	206	208	PF00082	0.548
CLV_PCSK_KEX2_1	221	223	PF00082	0.421
CLV_PCSK_KEX2_1	237	239	PF00082	0.507
CLV_PCSK_PC7_1	132	138	PF00082	0.478
CLV_PCSK_SKI1_1	173	177	PF00082	0.547
DOC_CKS1_1	99	104	PF01111	0.414
DOC_MAPK_gen_1	219	226	PF00069	0.560
DOC_MAPK_MEF2A_6	137	146	PF00069	0.609
DOC_PP2B_LxvP_1	155	158	PF13499	0.579
DOC_PP2B_LxvP_1	32	35	PF13499	0.620
DOC_USP7_MATH_1	81	85	PF00917	0.517
DOC_USP7_MATH_2	74	80	PF00917	0.441
DOC_WW_Pin1_4	106	111	PF00397	0.527
DOC_WW_Pin1_4	237	242	PF00397	0.516
DOC_WW_Pin1_4	49	54	PF00397	0.546
DOC_WW_Pin1_4	98	103	PF00397	0.432
LIG_14-3-3_CanoR_1	29	33	PF00244	0.607
LIG_BIR_II_1	1	4	PF00653	0.479
LIG_BRCT_BRCA1_1	83	87	PF00533	0.365
LIG_eIF4E_1	161	167	PF01652	0.484
LIG_FHA_1	225	231	PF00498	0.389
LIG_FHA_1	46	52	PF00498	0.630
LIG_FHA_1	68	74	PF00498	0.597
LIG_FHA_1	99	105	PF00498	0.416
LIG_FHA_2	107	113	PF00498	0.533
LIG_LIR_Gen_1	141	151	PF02991	0.593
LIG_LIR_Gen_1	84	93	PF02991	0.340
LIG_LIR_LC3C_4	152	157	PF02991	0.465
LIG_LIR_Nem_3	141	146	PF02991	0.599
LIG_LIR_Nem_3	84	90	PF02991	0.360
LIG_MLH1_MIPbox_1	83	87	PF16413	0.365
LIG_MYND_1	57	61	PF01753	0.476
LIG_SH2_PTP2	143	146	PF00017	0.593
LIG_SH2_STAT3	121	124	PF00017	0.556
LIG_SH2_STAT5	143	146	PF00017	0.605
LIG_SH2_STAT5	161	164	PF00017	0.668
LIG_SH2_STAT5	215	218	PF00017	0.602
LIG_SH2_STAT5	37	40	PF00017	0.511
LIG_SH2_STAT5	86	89	PF00017	0.349
LIG_SH3_3	55	61	PF00018	0.539
MOD_CDC14_SPxK_1	240	243	PF00782	0.458
MOD_CDK_SPxK_1	237	243	PF00069	0.455
MOD_CK1_1	28	34	PF00069	0.674
MOD_CK1_1	36	42	PF00069	0.600
MOD_CK1_1	79	85	PF00069	0.417
MOD_CK2_1	106	112	PF00069	0.685
MOD_Cter_Amidation	12	15	PF01082	0.491
MOD_GlcNHglycan	70	73	PF01048	0.491
MOD_GSK3_1	33	40	PF00069	0.548
MOD_GSK3_1	45	52	PF00069	0.583
MOD_NEK2_1	27	32	PF00069	0.618
MOD_NEK2_1	3	8	PF00069	0.648
MOD_NEK2_2	81	86	PF00069	0.486
MOD_PIKK_1	37	43	PF00454	0.519
MOD_PKA_2	224	230	PF00069	0.385
MOD_PKA_2	28	34	PF00069	0.562
MOD_Plk_1	130	136	PF00069	0.509
MOD_Plk_4	33	39	PF00069	0.494
MOD_ProDKin_1	106	112	PF00069	0.523
MOD_ProDKin_1	237	243	PF00069	0.521
MOD_ProDKin_1	49	55	PF00069	0.548
MOD_ProDKin_1	98	104	PF00069	0.433
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.552
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.642
TRG_ENDOCYTIC_2	143	146	PF00928	0.605
TRG_ER_diArg_1	135	138	PF00400	0.530
TRG_ER_diArg_1	14	16	PF00400	0.478
TRG_ER_diArg_1	235	238	PF00400	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Y3	Leptomonas seymouri	55%	79%
A0A1X0NZJ3	Trypanosomatidae	41%	100%
A0A3S7X240	Leishmania donovani	86%	78%
A0A422NUJ3	Trypanosoma rangeli	40%	100%
A4HH49	Leishmania braziliensis	71%	100%
A4I4A0	Leishmania infantum	86%	78%
E9ADP9	Leishmania major	85%	100%