Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AM27_LEIMU

TriTrypDb:

LmxM.08_29.0520

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AM27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM27

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	74	78	PF00656	0.610
CLV_NRD_NRD_1	184	186	PF00675	0.627
CLV_NRD_NRD_1	62	64	PF00675	0.663
CLV_NRD_NRD_1	66	68	PF00675	0.728
CLV_PCSK_KEX2_1	184	186	PF00082	0.751
CLV_PCSK_KEX2_1	62	64	PF00082	0.663
CLV_PCSK_SKI1_1	226	230	PF00082	0.612
DEG_Nend_UBRbox_3	1	3	PF02207	0.690
DEG_SPOP_SBC_1	129	133	PF00917	0.587
DEG_SPOP_SBC_1	217	221	PF00917	0.626
DOC_CDC14_PxL_1	137	145	PF14671	0.627
DOC_CDC14_PxL_1	30	38	PF14671	0.653
DOC_CYCLIN_RxL_1	223	232	PF00134	0.608
DOC_CYCLIN_yCln2_LP_2	111	117	PF00134	0.617
DOC_PP2B_LxvP_1	111	114	PF13499	0.623
DOC_USP7_MATH_1	167	171	PF00917	0.677
DOC_USP7_MATH_1	18	22	PF00917	0.633
DOC_USP7_MATH_1	212	216	PF00917	0.637
DOC_USP7_MATH_1	217	221	PF00917	0.589
DOC_WW_Pin1_4	199	204	PF00397	0.625
DOC_WW_Pin1_4	22	27	PF00397	0.495
LIG_BRCT_BRCA1_1	220	224	PF00533	0.602
LIG_Clathr_ClatBox_1	116	120	PF01394	0.637
LIG_eIF4E_1	145	151	PF01652	0.610
LIG_EVH1_1	208	212	PF00568	0.578
LIG_EVH1_2	34	38	PF00568	0.780
LIG_FHA_1	177	183	PF00498	0.656
LIG_FHA_1	220	226	PF00498	0.620
LIG_FHA_1	67	73	PF00498	0.552
LIG_FHA_1	92	98	PF00498	0.695
LIG_GSK3_LRP6_1	199	204	PF00069	0.515
LIG_LIR_Gen_1	15	22	PF02991	0.609
LIG_LIR_Gen_1	202	213	PF02991	0.578
LIG_LIR_Nem_3	15	20	PF02991	0.612
LIG_LIR_Nem_3	202	208	PF02991	0.583
LIG_LIR_Nem_3	32	36	PF02991	0.654
LIG_LYPXL_yS_3	33	36	PF13949	0.654
LIG_SH2_NCK_1	145	149	PF00017	0.497
LIG_SH2_SRC	155	158	PF00017	0.565
LIG_SH2_STAT5	155	158	PF00017	0.575
LIG_SH2_STAT5	163	166	PF00017	0.495
LIG_SH3_3	161	167	PF00018	0.597
LIG_SH3_3	188	194	PF00018	0.793
LIG_SH3_3	197	203	PF00018	0.686
LIG_SH3_3	206	212	PF00018	0.749
LIG_SH3_3	28	34	PF00018	0.623
LIG_SUMO_SIM_par_1	39	48	PF11976	0.493
LIG_TYR_ITIM	31	36	PF00017	0.654
MOD_CK1_1	12	18	PF00069	0.580
MOD_CK1_1	131	137	PF00069	0.513
MOD_CK1_1	219	225	PF00069	0.618
MOD_CK1_1	43	49	PF00069	0.697
MOD_CK2_1	171	177	PF00069	0.810
MOD_Cter_Amidation	60	63	PF01082	0.686
MOD_Cter_Amidation	65	68	PF01082	0.690
MOD_GlcNHglycan	146	149	PF01048	0.514
MOD_GlcNHglycan	158	161	PF01048	0.723
MOD_GlcNHglycan	174	177	PF01048	0.675
MOD_GlcNHglycan	77	81	PF01048	0.604
MOD_GSK3_1	167	174	PF00069	0.750
MOD_GSK3_1	18	25	PF00069	0.523
MOD_GSK3_1	212	219	PF00069	0.599
MOD_GSK3_1	39	46	PF00069	0.738
MOD_GSK3_1	6	13	PF00069	0.598
MOD_GSK3_1	66	73	PF00069	0.813
MOD_LATS_1	142	148	PF00433	0.475
MOD_NEK2_1	10	15	PF00069	0.478
MOD_NEK2_1	128	133	PF00069	0.520
MOD_NEK2_1	218	223	PF00069	0.613
MOD_PIKK_1	66	72	PF00454	0.697
MOD_PKA_2	66	72	PF00069	0.647
MOD_Plk_1	18	24	PF00069	0.636
MOD_Plk_1	39	45	PF00069	0.600
MOD_Plk_1	90	96	PF00069	0.611
MOD_Plk_4	12	18	PF00069	0.654
MOD_Plk_4	40	46	PF00069	0.491
MOD_ProDKin_1	199	205	PF00069	0.626
MOD_ProDKin_1	22	28	PF00069	0.497
MOD_SUMO_for_1	88	91	PF00179	0.566
TRG_DiLeu_BaEn_1	146	151	PF01217	0.578
TRG_DiLeu_BaEn_2	123	129	PF01217	0.510
TRG_DiLeu_BaEn_3	39	45	PF01217	0.489
TRG_DiLeu_BaEn_4	90	96	PF01217	0.523
TRG_DiLeu_BaLyEn_6	111	116	PF01217	0.664
TRG_ENDOCYTIC_2	33	36	PF00928	0.654
TRG_ER_diArg_1	183	185	PF00400	0.641

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IR44	Leishmania donovani	87%	100%
A4HH53	Leishmania braziliensis	63%	95%
A4I4A4	Leishmania infantum	87%	100%
E9ADQ3	Leishmania major	82%	97%