Exonuclease domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exonuclease, putative

Species:

Leishmania mexicana

UniProt:

E9AM25_LEIMU

TriTrypDb:

LmxM.08_29.0540

Length:

502

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AM25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM25

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9
GO:0003824	catalytic activity	1	3
GO:0004518	nuclease activity	4	3
GO:0004527	exonuclease activity	5	3
GO:0016787	hydrolase activity	2	3
GO:0016788	hydrolase activity, acting on ester bonds	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.816
CLV_C14_Caspase3-7	135	139	PF00656	0.744
CLV_C14_Caspase3-7	341	345	PF00656	0.573
CLV_NRD_NRD_1	147	149	PF00675	0.638
CLV_NRD_NRD_1	335	337	PF00675	0.364
CLV_NRD_NRD_1	367	369	PF00675	0.301
CLV_NRD_NRD_1	421	423	PF00675	0.325
CLV_NRD_NRD_1	45	47	PF00675	0.695
CLV_PCSK_KEX2_1	213	215	PF00082	0.525
CLV_PCSK_KEX2_1	335	337	PF00082	0.339
CLV_PCSK_KEX2_1	367	369	PF00082	0.339
CLV_PCSK_KEX2_1	421	423	PF00082	0.329
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.525
CLV_PCSK_PC7_1	209	215	PF00082	0.615
CLV_PCSK_SKI1_1	117	121	PF00082	0.563
CLV_PCSK_SKI1_1	148	152	PF00082	0.711
CLV_PCSK_SKI1_1	213	217	PF00082	0.510
CLV_PCSK_SKI1_1	40	44	PF00082	0.689
CLV_PCSK_SKI1_1	403	407	PF00082	0.314
CLV_PCSK_SKI1_1	497	501	PF00082	0.692
DEG_APCC_DBOX_1	116	124	PF00400	0.657
DEG_SPOP_SBC_1	78	82	PF00917	0.745
DEG_SPOP_SBC_1	83	87	PF00917	0.735
DOC_CYCLIN_yCln2_LP_2	216	222	PF00134	0.466
DOC_MAPK_gen_1	412	418	PF00069	0.482
DOC_PP4_FxxP_1	99	102	PF00568	0.618
DOC_SPAK_OSR1_1	127	131	PF12202	0.645
DOC_USP7_MATH_1	153	157	PF00917	0.692
DOC_USP7_MATH_1	178	182	PF00917	0.816
DOC_USP7_MATH_1	233	237	PF00917	0.502
DOC_USP7_MATH_1	28	32	PF00917	0.775
DOC_USP7_MATH_1	348	352	PF00917	0.564
DOC_USP7_MATH_1	38	42	PF00917	0.706
DOC_USP7_MATH_1	51	55	PF00917	0.730
DOC_USP7_MATH_1	67	71	PF00917	0.815
DOC_USP7_MATH_1	83	87	PF00917	0.723
DOC_WW_Pin1_4	102	107	PF00397	0.611
DOC_WW_Pin1_4	19	24	PF00397	0.679
DOC_WW_Pin1_4	53	58	PF00397	0.728
DOC_WW_Pin1_4	79	84	PF00397	0.809
LIG_14-3-3_CanoR_1	180	184	PF00244	0.544
LIG_14-3-3_CanoR_1	27	35	PF00244	0.723
LIG_14-3-3_CanoR_1	3	8	PF00244	0.646
LIG_14-3-3_CanoR_1	393	397	PF00244	0.499
LIG_14-3-3_CanoR_1	40	48	PF00244	0.681
LIG_Actin_WH2_2	243	259	PF00022	0.539
LIG_Actin_WH2_2	363	379	PF00022	0.564
LIG_APCC_ABBAyCdc20_2	335	341	PF00400	0.539
LIG_BRCT_BRCA1_1	396	400	PF00533	0.602
LIG_BRCT_BRCA1_1	414	418	PF00533	0.382
LIG_deltaCOP1_diTrp_1	361	369	PF00928	0.499
LIG_FHA_1	251	257	PF00498	0.499
LIG_FHA_1	406	412	PF00498	0.499
LIG_FHA_1	427	433	PF00498	0.539
LIG_FHA_1	73	79	PF00498	0.566
LIG_FHA_2	348	354	PF00498	0.516
LIG_FHA_2	69	75	PF00498	0.742
LIG_HP1_1	247	251	PF01393	0.539
LIG_Integrin_RGD_1	175	177	PF01839	0.619
LIG_Integrin_RGD_1	457	459	PF01839	0.627
LIG_LIR_Apic_2	96	102	PF02991	0.616
LIG_LIR_Gen_1	126	132	PF02991	0.645
LIG_LIR_Nem_3	126	131	PF02991	0.643
LIG_LIR_Nem_3	245	249	PF02991	0.484
LIG_LIR_Nem_3	261	265	PF02991	0.484
LIG_MYND_1	102	106	PF01753	0.525
LIG_PCNA_yPIPBox_3	401	411	PF02747	0.539
LIG_Pex14_1	317	321	PF04695	0.539
LIG_SH2_CRK	387	391	PF00017	0.539
LIG_SH2_GRB2like	389	392	PF00017	0.539
LIG_SH2_PTP2	265	268	PF00017	0.474
LIG_SH2_PTP2	389	392	PF00017	0.539
LIG_SH2_SRC	339	342	PF00017	0.517
LIG_SH2_SRC	389	392	PF00017	0.539
LIG_SH2_STAP1	396	400	PF00017	0.539
LIG_SH2_STAT5	265	268	PF00017	0.474
LIG_SH2_STAT5	389	392	PF00017	0.539
LIG_SH3_3	193	199	PF00018	0.721
LIG_SH3_3	20	26	PF00018	0.689
LIG_SH3_3	204	210	PF00018	0.738
LIG_SH3_3	234	240	PF00018	0.499
LIG_SH3_3	288	294	PF00018	0.489
LIG_SH3_3	377	383	PF00018	0.564
LIG_SUMO_SIM_par_1	245	253	PF11976	0.509
LIG_SUMO_SIM_par_1	287	293	PF11976	0.556
LIG_SxIP_EBH_1	199	213	PF03271	0.648
LIG_TRAF2_1	168	171	PF00917	0.704
LIG_TRAF2_1	467	470	PF00917	0.639
LIG_TRAF2_2	172	177	PF00917	0.512
LIG_TYR_ITIM	385	390	PF00017	0.484
LIG_WW_3	24	28	PF00397	0.685
MOD_CDK_SPK_2	53	58	PF00069	0.744
MOD_CDK_SPxxK_3	102	109	PF00069	0.522
MOD_CK1_1	105	111	PF00069	0.644
MOD_CK1_1	41	47	PF00069	0.790
MOD_CK1_1	52	58	PF00069	0.800
MOD_CK1_1	82	88	PF00069	0.693
MOD_CK2_1	179	185	PF00069	0.741
MOD_CK2_1	27	33	PF00069	0.511
MOD_CK2_1	347	353	PF00069	0.568
MOD_CK2_1	68	74	PF00069	0.697
MOD_Cter_Amidation	419	422	PF01082	0.339
MOD_GlcNHglycan	155	158	PF01048	0.782
MOD_GlcNHglycan	203	206	PF01048	0.695
MOD_GlcNHglycan	233	236	PF01048	0.274
MOD_GlcNHglycan	350	353	PF01048	0.364
MOD_GlcNHglycan	40	43	PF01048	0.716
MOD_GlcNHglycan	423	426	PF01048	0.287
MOD_GlcNHglycan	64	67	PF01048	0.779
MOD_GlcNHglycan	96	99	PF01048	0.784
MOD_GSK3_1	119	126	PF00069	0.684
MOD_GSK3_1	148	155	PF00069	0.624
MOD_GSK3_1	201	208	PF00069	0.686
MOD_GSK3_1	272	279	PF00069	0.474
MOD_GSK3_1	38	45	PF00069	0.716
MOD_GSK3_1	47	54	PF00069	0.747
MOD_GSK3_1	68	75	PF00069	0.754
MOD_GSK3_1	78	85	PF00069	0.678
MOD_N-GLC_1	348	353	PF02516	0.381
MOD_NEK2_1	123	128	PF00069	0.664
MOD_NEK2_1	132	137	PF00069	0.623
MOD_NEK2_1	200	205	PF00069	0.725
MOD_NEK2_1	228	233	PF00069	0.539
MOD_NEK2_2	233	238	PF00069	0.539
MOD_OFUCOSY	226	232	PF10250	0.299
MOD_PIKK_1	142	148	PF00454	0.747
MOD_PIKK_1	166	172	PF00454	0.776
MOD_PIKK_1	282	288	PF00454	0.485
MOD_PKA_1	148	154	PF00069	0.744
MOD_PKA_1	412	418	PF00069	0.488
MOD_PKA_1	421	427	PF00069	0.479
MOD_PKA_2	179	185	PF00069	0.547
MOD_PKA_2	201	207	PF00069	0.482
MOD_PKA_2	324	330	PF00069	0.525
MOD_PKA_2	392	398	PF00069	0.493
MOD_PKA_2	421	427	PF00069	0.501
MOD_Plk_1	178	184	PF00069	0.660
MOD_Plk_1	371	377	PF00069	0.477
MOD_Plk_2-3	179	185	PF00069	0.687
MOD_Plk_4	179	185	PF00069	0.770
MOD_Plk_4	294	300	PF00069	0.517
MOD_Plk_4	371	377	PF00069	0.499
MOD_ProDKin_1	102	108	PF00069	0.609
MOD_ProDKin_1	19	25	PF00069	0.681
MOD_ProDKin_1	53	59	PF00069	0.726
MOD_ProDKin_1	79	85	PF00069	0.809
MOD_SUMO_for_1	306	309	PF00179	0.517
MOD_SUMO_for_1	330	333	PF00179	0.539
TRG_DiLeu_BaEn_1	179	184	PF01217	0.689
TRG_DiLeu_BaEn_2	332	338	PF01217	0.539
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.593
TRG_ENDOCYTIC_2	387	390	PF00928	0.484
TRG_ER_diArg_1	2	5	PF00400	0.623
TRG_ER_diArg_1	335	337	PF00400	0.564
TRG_ER_diArg_1	366	368	PF00400	0.539
TRG_Pf-PMV_PEXEL_1	12	17	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	434	438	PF00026	0.299
TRG_Pf-PMV_PEXEL_1	5	10	PF00026	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7G3	Leptomonas seymouri	60%	95%
A0A0S4JDV1	Bodo saltans	36%	100%
A0A3R7M512	Trypanosoma rangeli	50%	100%
A0A3S7X262	Leishmania donovani	94%	100%
A4HH55	Leishmania braziliensis	79%	100%
A4I4A6	Leishmania infantum	93%	100%
E9ADQ5	Leishmania major	92%	100%