LeishMANIAdb
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Exonuclease domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Exonuclease domain-containing protein
Gene product:
exonuclease, putative
Species:
Leishmania mexicana
UniProt:
E9AM24_LEIMU
TriTrypDb:
LmxM.08_29.0550
Length:
879

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AM24
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM24

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 7
GO:0005488 binding 1 7
GO:0097159 organic cyclic compound binding 2 7
GO:1901363 heterocyclic compound binding 2 7
GO:0003824 catalytic activity 1 1
GO:0004518 nuclease activity 4 1
GO:0004527 exonuclease activity 5 1
GO:0016787 hydrolase activity 2 1
GO:0016788 hydrolase activity, acting on ester bonds 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 696 700 PF00656 0.414
CLV_NRD_NRD_1 551 553 PF00675 0.665
CLV_PCSK_FUR_1 678 682 PF00082 0.415
CLV_PCSK_KEX2_1 550 552 PF00082 0.664
CLV_PCSK_KEX2_1 680 682 PF00082 0.415
CLV_PCSK_PC1ET2_1 680 682 PF00082 0.415
CLV_PCSK_PC7_1 676 682 PF00082 0.415
CLV_PCSK_SKI1_1 566 570 PF00082 0.567
CLV_PCSK_SKI1_1 688 692 PF00082 0.308
CLV_PCSK_SKI1_1 724 728 PF00082 0.308
CLV_PCSK_SKI1_1 777 781 PF00082 0.408
CLV_Separin_Metazoa 268 272 PF03568 0.695
CLV_Separin_Metazoa 547 551 PF03568 0.658
CLV_Separin_Metazoa 706 710 PF03568 0.418
DEG_COP1_1 360 370 PF00400 0.698
DEG_SCF_FBW7_1 356 362 PF00400 0.587
DEG_SCF_FBW7_1 384 389 PF00400 0.668
DEG_SCF_FBW7_1 855 862 PF00400 0.529
DEG_SCF_FBW7_2 505 511 PF00400 0.697
DEG_SPOP_SBC_1 373 377 PF00917 0.810
DEG_SPOP_SBC_1 378 382 PF00917 0.742
DEG_SPOP_SBC_1 388 392 PF00917 0.581
DOC_ANK_TNKS_1 87 94 PF00023 0.831
DOC_CKS1_1 29 34 PF01111 0.683
DOC_CKS1_1 295 300 PF01111 0.706
DOC_CKS1_1 353 358 PF01111 0.719
DOC_CKS1_1 505 510 PF01111 0.697
DOC_CKS1_1 92 97 PF01111 0.820
DOC_CYCLIN_RxL_1 149 160 PF00134 0.819
DOC_CYCLIN_RxL_1 266 279 PF00134 0.613
DOC_CYCLIN_yClb1_LxF_4 820 825 PF00134 0.493
DOC_CYCLIN_yCln2_LP_2 624 630 PF00134 0.600
DOC_CYCLIN_yCln2_LP_2 843 846 PF00134 0.714
DOC_MAPK_gen_1 775 782 PF00069 0.501
DOC_MAPK_MEF2A_6 799 808 PF00069 0.545
DOC_PP2B_LxvP_1 27 30 PF13499 0.557
DOC_PP2B_LxvP_1 783 786 PF13499 0.536
DOC_PP2B_LxvP_1 842 845 PF13499 0.696
DOC_PP4_FxxP_1 674 677 PF00568 0.545
DOC_USP7_MATH_1 146 150 PF00917 0.809
DOC_USP7_MATH_1 246 250 PF00917 0.742
DOC_USP7_MATH_1 316 320 PF00917 0.821
DOC_USP7_MATH_1 339 343 PF00917 0.810
DOC_USP7_MATH_1 357 361 PF00917 0.522
DOC_USP7_MATH_1 373 377 PF00917 0.662
DOC_USP7_MATH_1 378 382 PF00917 0.707
DOC_USP7_MATH_1 457 461 PF00917 0.788
DOC_USP7_MATH_1 518 522 PF00917 0.842
DOC_USP7_MATH_1 561 565 PF00917 0.790
DOC_USP7_MATH_1 613 617 PF00917 0.691
DOC_USP7_MATH_1 700 704 PF00917 0.418
DOC_USP7_MATH_1 850 854 PF00917 0.789
DOC_USP7_UBL2_3 139 143 PF12436 0.611
DOC_WW_Pin1_4 115 120 PF00397 0.769
DOC_WW_Pin1_4 128 133 PF00397 0.629
DOC_WW_Pin1_4 22 27 PF00397 0.695
DOC_WW_Pin1_4 28 33 PF00397 0.737
DOC_WW_Pin1_4 294 299 PF00397 0.775
DOC_WW_Pin1_4 312 317 PF00397 0.478
DOC_WW_Pin1_4 352 357 PF00397 0.721
DOC_WW_Pin1_4 382 387 PF00397 0.714
DOC_WW_Pin1_4 423 428 PF00397 0.612
DOC_WW_Pin1_4 445 450 PF00397 0.745
DOC_WW_Pin1_4 469 474 PF00397 0.719
DOC_WW_Pin1_4 483 488 PF00397 0.738
DOC_WW_Pin1_4 504 509 PF00397 0.704
DOC_WW_Pin1_4 523 528 PF00397 0.737
DOC_WW_Pin1_4 535 540 PF00397 0.724
DOC_WW_Pin1_4 578 583 PF00397 0.698
DOC_WW_Pin1_4 609 614 PF00397 0.786
DOC_WW_Pin1_4 616 621 PF00397 0.651
DOC_WW_Pin1_4 681 686 PF00397 0.516
DOC_WW_Pin1_4 837 842 PF00397 0.558
DOC_WW_Pin1_4 855 860 PF00397 0.688
DOC_WW_Pin1_4 91 96 PF00397 0.731
LIG_14-3-3_CanoR_1 293 298 PF00244 0.759
LIG_14-3-3_CanoR_1 434 439 PF00244 0.807
LIG_14-3-3_CanoR_1 550 559 PF00244 0.678
LIG_14-3-3_CanoR_1 566 575 PF00244 0.616
LIG_14-3-3_CanoR_1 713 721 PF00244 0.615
LIG_14-3-3_CanoR_1 770 776 PF00244 0.559
LIG_14-3-3_CanoR_1 83 92 PF00244 0.747
LIG_APCC_ABBAyCdc20_2 49 55 PF00400 0.562
LIG_BIR_II_1 1 5 PF00653 0.835
LIG_BIR_III_2 199 203 PF00653 0.731
LIG_BRCT_BRCA1_1 190 194 PF00533 0.714
LIG_BRCT_BRCA1_1 434 438 PF00533 0.823
LIG_BRCT_BRCA1_1 536 540 PF00533 0.737
LIG_Clathr_ClatBox_1 631 635 PF01394 0.508
LIG_CtBP_PxDLS_1 153 157 PF00389 0.582
LIG_CtBP_PxDLS_1 732 736 PF00389 0.545
LIG_deltaCOP1_diTrp_1 258 267 PF00928 0.665
LIG_EVH1_1 29 33 PF00568 0.556
LIG_FHA_1 104 110 PF00498 0.492
LIG_FHA_1 159 165 PF00498 0.644
LIG_FHA_1 214 220 PF00498 0.600
LIG_FHA_1 279 285 PF00498 0.671
LIG_FHA_1 398 404 PF00498 0.772
LIG_FHA_1 567 573 PF00498 0.690
LIG_FHA_1 57 63 PF00498 0.775
LIG_FHA_1 838 844 PF00498 0.563
LIG_FHA_1 85 91 PF00498 0.830
LIG_FHA_2 161 167 PF00498 0.533
LIG_FHA_2 253 259 PF00498 0.642
LIG_FHA_2 301 307 PF00498 0.810
LIG_FHA_2 491 497 PF00498 0.816
LIG_FHA_2 542 548 PF00498 0.775
LIG_FHA_2 637 643 PF00498 0.503
LIG_FHA_2 95 101 PF00498 0.541
LIG_Integrin_isoDGR_2 81 83 PF01839 0.795
LIG_LIR_Apic_2 615 620 PF02991 0.655
LIG_LIR_Gen_1 258 267 PF02991 0.595
LIG_LIR_Gen_1 629 638 PF02991 0.351
LIG_LIR_Gen_1 670 679 PF02991 0.545
LIG_LIR_Gen_1 753 761 PF02991 0.583
LIG_LIR_Gen_1 764 769 PF02991 0.559
LIG_LIR_Gen_1 814 823 PF02991 0.490
LIG_LIR_Gen_1 867 876 PF02991 0.525
LIG_LIR_Nem_3 258 263 PF02991 0.608
LIG_LIR_Nem_3 291 295 PF02991 0.656
LIG_LIR_Nem_3 629 633 PF02991 0.352
LIG_LIR_Nem_3 654 658 PF02991 0.503
LIG_LIR_Nem_3 670 674 PF02991 0.503
LIG_LIR_Nem_3 737 741 PF02991 0.539
LIG_LIR_Nem_3 753 759 PF02991 0.609
LIG_LIR_Nem_3 764 768 PF02991 0.559
LIG_LIR_Nem_3 814 818 PF02991 0.493
LIG_LIR_Nem_3 867 872 PF02991 0.741
LIG_MYND_1 841 845 PF01753 0.715
LIG_NRP_CendR_1 877 879 PF00754 0.533
LIG_PCNA_yPIPBox_3 770 780 PF02747 0.561
LIG_Pex14_2 71 75 PF04695 0.647
LIG_Pex14_2 751 755 PF04695 0.503
LIG_Pex14_2 765 769 PF04695 0.503
LIG_PTAP_UEV_1 147 152 PF05743 0.755
LIG_REV1ctd_RIR_1 766 774 PF16727 0.561
LIG_SH2_CRK 560 564 PF00017 0.678
LIG_SH2_CRK 617 621 PF00017 0.620
LIG_SH2_CRK 628 632 PF00017 0.341
LIG_SH2_CRK 741 745 PF00017 0.533
LIG_SH2_NCK_1 560 564 PF00017 0.678
LIG_SH2_NCK_1 650 654 PF00017 0.530
LIG_SH2_SRC 304 307 PF00017 0.710
LIG_SH2_SRC 516 519 PF00017 0.820
LIG_SH2_SRC 650 653 PF00017 0.530
LIG_SH2_STAP1 628 632 PF00017 0.382
LIG_SH2_STAT5 630 633 PF00017 0.355
LIG_SH2_STAT5 648 651 PF00017 0.503
LIG_SH3_1 607 613 PF00018 0.667
LIG_SH3_3 145 151 PF00018 0.756
LIG_SH3_3 208 214 PF00018 0.528
LIG_SH3_3 27 33 PF00018 0.606
LIG_SH3_3 292 298 PF00018 0.663
LIG_SH3_3 341 347 PF00018 0.717
LIG_SH3_3 350 356 PF00018 0.720
LIG_SH3_3 45 51 PF00018 0.774
LIG_SH3_3 499 505 PF00018 0.733
LIG_SH3_3 512 518 PF00018 0.700
LIG_SH3_3 569 575 PF00018 0.679
LIG_SH3_3 589 595 PF00018 0.696
LIG_SH3_3 607 613 PF00018 0.516
LIG_SH3_3 89 95 PF00018 0.729
LIG_SUMO_SIM_anti_2 166 173 PF11976 0.426
LIG_SUMO_SIM_anti_2 629 635 PF11976 0.351
LIG_SUMO_SIM_par_1 105 110 PF11976 0.691
LIG_SUMO_SIM_par_1 25 31 PF11976 0.749
LIG_SUMO_SIM_par_1 629 635 PF11976 0.351
LIG_SUMO_SIM_par_1 654 661 PF11976 0.551
LIG_TRAF2_1 544 547 PF00917 0.671
LIG_TRAF2_1 639 642 PF00917 0.503
LIG_TRAF2_1 703 706 PF00917 0.545
LIG_TYR_ITIM 754 759 PF00017 0.503
LIG_WRC_WIRS_1 866 871 PF05994 0.690
LIG_WW_1 645 648 PF00397 0.530
MOD_CDK_SPxxK_3 681 688 PF00069 0.418
MOD_CK1_1 103 109 PF00069 0.814
MOD_CK1_1 177 183 PF00069 0.668
MOD_CK1_1 225 231 PF00069 0.720
MOD_CK1_1 382 388 PF00069 0.718
MOD_CK1_1 392 398 PF00069 0.683
MOD_CK1_1 421 427 PF00069 0.625
MOD_CK1_1 465 471 PF00069 0.814
MOD_CK1_1 535 541 PF00069 0.612
MOD_CK1_1 57 63 PF00069 0.766
MOD_CK1_1 577 583 PF00069 0.707
MOD_CK1_1 612 618 PF00069 0.669
MOD_CK1_1 853 859 PF00069 0.793
MOD_CK2_1 160 166 PF00069 0.544
MOD_CK2_1 252 258 PF00069 0.649
MOD_CK2_1 300 306 PF00069 0.732
MOD_CK2_1 541 547 PF00069 0.687
MOD_CK2_1 636 642 PF00069 0.503
MOD_CK2_1 700 706 PF00069 0.545
MOD_CK2_1 71 77 PF00069 0.696
MOD_CK2_1 811 817 PF00069 0.493
MOD_CK2_1 868 874 PF00069 0.691
MOD_CK2_1 94 100 PF00069 0.544
MOD_DYRK1A_RPxSP_1 128 132 PF00069 0.681
MOD_GlcNHglycan 1 4 PF01048 0.838
MOD_GlcNHglycan 102 105 PF01048 0.728
MOD_GlcNHglycan 109 112 PF01048 0.834
MOD_GlcNHglycan 128 131 PF01048 0.538
MOD_GlcNHglycan 144 147 PF01048 0.639
MOD_GlcNHglycan 148 151 PF01048 0.560
MOD_GlcNHglycan 190 193 PF01048 0.662
MOD_GlcNHglycan 211 214 PF01048 0.791
MOD_GlcNHglycan 224 227 PF01048 0.675
MOD_GlcNHglycan 228 231 PF01048 0.620
MOD_GlcNHglycan 235 238 PF01048 0.725
MOD_GlcNHglycan 318 321 PF01048 0.730
MOD_GlcNHglycan 361 364 PF01048 0.675
MOD_GlcNHglycan 367 370 PF01048 0.795
MOD_GlcNHglycan 381 384 PF01048 0.711
MOD_GlcNHglycan 406 409 PF01048 0.812
MOD_GlcNHglycan 434 437 PF01048 0.637
MOD_GlcNHglycan 438 441 PF01048 0.734
MOD_GlcNHglycan 518 521 PF01048 0.823
MOD_GlcNHglycan 530 533 PF01048 0.625
MOD_GlcNHglycan 55 59 PF01048 0.731
MOD_GlcNHglycan 552 555 PF01048 0.575
MOD_GlcNHglycan 576 579 PF01048 0.774
MOD_GlcNHglycan 792 795 PF01048 0.303
MOD_GSK3_1 103 110 PF00069 0.691
MOD_GSK3_1 111 118 PF00069 0.700
MOD_GSK3_1 138 145 PF00069 0.766
MOD_GSK3_1 156 163 PF00069 0.483
MOD_GSK3_1 209 216 PF00069 0.679
MOD_GSK3_1 222 229 PF00069 0.730
MOD_GSK3_1 238 245 PF00069 0.703
MOD_GSK3_1 312 319 PF00069 0.713
MOD_GSK3_1 355 362 PF00069 0.725
MOD_GSK3_1 373 380 PF00069 0.702
MOD_GSK3_1 382 389 PF00069 0.825
MOD_GSK3_1 390 397 PF00069 0.628
MOD_GSK3_1 432 439 PF00069 0.711
MOD_GSK3_1 445 452 PF00069 0.717
MOD_GSK3_1 453 460 PF00069 0.728
MOD_GSK3_1 462 469 PF00069 0.774
MOD_GSK3_1 503 510 PF00069 0.703
MOD_GSK3_1 518 525 PF00069 0.735
MOD_GSK3_1 528 535 PF00069 0.680
MOD_GSK3_1 56 63 PF00069 0.713
MOD_GSK3_1 574 581 PF00069 0.621
MOD_GSK3_1 605 612 PF00069 0.683
MOD_GSK3_1 67 74 PF00069 0.742
MOD_GSK3_1 828 835 PF00069 0.671
MOD_GSK3_1 855 862 PF00069 0.816
MOD_GSK3_1 864 871 PF00069 0.779
MOD_GSK3_1 94 101 PF00069 0.767
MOD_N-GLC_1 312 317 PF02516 0.528
MOD_N-GLC_1 397 402 PF02516 0.821
MOD_N-GLC_1 523 528 PF02516 0.750
MOD_N-GLC_1 535 540 PF02516 0.597
MOD_NEK2_1 387 392 PF00069 0.551
MOD_NEK2_1 464 469 PF00069 0.702
MOD_NEK2_1 522 527 PF00069 0.834
MOD_NEK2_1 534 539 PF00069 0.621
MOD_NEK2_1 559 564 PF00069 0.699
MOD_NEK2_1 585 590 PF00069 0.740
MOD_NEK2_1 71 76 PF00069 0.698
MOD_NEK2_1 715 720 PF00069 0.545
MOD_NEK2_1 769 774 PF00069 0.545
MOD_NEK2_1 828 833 PF00069 0.753
MOD_NEK2_2 42 47 PF00069 0.773
MOD_NEK2_2 457 462 PF00069 0.830
MOD_NEK2_2 865 870 PF00069 0.535
MOD_PIKK_1 471 477 PF00454 0.720
MOD_PIKK_1 490 496 PF00454 0.745
MOD_PIKK_1 566 572 PF00454 0.523
MOD_PIKK_1 769 775 PF00454 0.615
MOD_PKA_1 550 556 PF00069 0.670
MOD_PKA_1 688 694 PF00069 0.508
MOD_PKA_2 17 23 PF00069 0.681
MOD_PKA_2 195 201 PF00069 0.705
MOD_PKA_2 373 379 PF00069 0.813
MOD_PKA_2 482 488 PF00069 0.760
MOD_PKA_2 550 556 PF00069 0.651
MOD_PKA_2 769 775 PF00069 0.559
MOD_Plk_1 497 503 PF00069 0.560
MOD_Plk_2-3 160 166 PF00069 0.544
MOD_Plk_4 166 172 PF00069 0.627
MOD_Plk_4 190 196 PF00069 0.718
MOD_Plk_4 497 503 PF00069 0.560
MOD_Plk_4 518 524 PF00069 0.838
MOD_Plk_4 581 587 PF00069 0.682
MOD_Plk_4 71 77 PF00069 0.717
MOD_Plk_4 750 756 PF00069 0.530
MOD_Plk_4 800 806 PF00069 0.545
MOD_ProDKin_1 115 121 PF00069 0.773
MOD_ProDKin_1 128 134 PF00069 0.629
MOD_ProDKin_1 22 28 PF00069 0.699
MOD_ProDKin_1 294 300 PF00069 0.775
MOD_ProDKin_1 312 318 PF00069 0.482
MOD_ProDKin_1 352 358 PF00069 0.723
MOD_ProDKin_1 382 388 PF00069 0.713
MOD_ProDKin_1 423 429 PF00069 0.614
MOD_ProDKin_1 445 451 PF00069 0.741
MOD_ProDKin_1 469 475 PF00069 0.719
MOD_ProDKin_1 483 489 PF00069 0.736
MOD_ProDKin_1 504 510 PF00069 0.700
MOD_ProDKin_1 523 529 PF00069 0.738
MOD_ProDKin_1 535 541 PF00069 0.723
MOD_ProDKin_1 578 584 PF00069 0.700
MOD_ProDKin_1 609 615 PF00069 0.679
MOD_ProDKin_1 616 622 PF00069 0.648
MOD_ProDKin_1 681 687 PF00069 0.516
MOD_ProDKin_1 837 843 PF00069 0.560
MOD_ProDKin_1 855 861 PF00069 0.685
MOD_ProDKin_1 91 97 PF00069 0.732
TRG_DiLeu_BaEn_2 669 675 PF01217 0.545
TRG_DiLeu_BaLyEn_6 838 843 PF01217 0.801
TRG_ENDOCYTIC_2 560 563 PF00928 0.700
TRG_ENDOCYTIC_2 628 631 PF00928 0.386
TRG_ENDOCYTIC_2 650 653 PF00928 0.530
TRG_ENDOCYTIC_2 741 744 PF00928 0.523
TRG_ENDOCYTIC_2 756 759 PF00928 0.477
TRG_ER_diArg_1 46 49 PF00400 0.564
TRG_ER_diArg_1 549 552 PF00400 0.662
TRG_ER_diArg_1 675 678 PF00400 0.545
TRG_NES_CRM1_1 279 291 PF08389 0.624
TRG_NES_CRM1_1 651 665 PF08389 0.487
TRG_Pf-PMV_PEXEL_1 282 286 PF00026 0.692
TRG_Pf-PMV_PEXEL_1 462 466 PF00026 0.724

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7U4 Leptomonas seymouri 50% 77%
A0A3S7X257 Leishmania donovani 87% 100%
A4HH56 Leishmania braziliensis 73% 100%
A4I4A7 Leishmania infantum 87% 100%
E9ADQ6 Leishmania major 85% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS