Exonuclease domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exonuclease, putative

Species:

Leishmania mexicana

UniProt:

E9AM22_LEIMU

TriTrypDb:

LmxM.08_29.0560

Length:

405

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AM22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM22

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004527	exonuclease activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.521
CLV_NRD_NRD_1	227	229	PF00675	0.296
CLV_NRD_NRD_1	285	287	PF00675	0.367
CLV_NRD_NRD_1	342	344	PF00675	0.451
CLV_NRD_NRD_1	351	353	PF00675	0.405
CLV_PCSK_KEX2_1	285	287	PF00082	0.367
CLV_PCSK_KEX2_1	341	343	PF00082	0.460
CLV_PCSK_KEX2_1	350	352	PF00082	0.416
CLV_PCSK_KEX2_1	6	8	PF00082	0.461
CLV_PCSK_PC1ET2_1	341	343	PF00082	0.474
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.461
CLV_PCSK_PC7_1	346	352	PF00082	0.395
CLV_PCSK_SKI1_1	167	171	PF00082	0.259
DEG_SCF_FBW7_1	127	134	PF00400	0.544
DOC_MAPK_gen_1	228	234	PF00069	0.484
DOC_MAPK_gen_1	350	360	PF00069	0.542
DOC_MAPK_MEF2A_6	214	223	PF00069	0.460
DOC_MAPK_MEF2A_6	354	362	PF00069	0.473
DOC_PP4_FxxP_1	120	123	PF00568	0.479
DOC_USP7_MATH_1	146	150	PF00917	0.572
DOC_USP7_MATH_1	399	403	PF00917	0.348
DOC_WW_Pin1_4	127	132	PF00397	0.509
LIG_14-3-3_CanoR_1	113	118	PF00244	0.467
LIG_14-3-3_CanoR_1	208	212	PF00244	0.466
LIG_14-3-3_CanoR_1	357	361	PF00244	0.384
LIG_14-3-3_CanoR_1	393	398	PF00244	0.457
LIG_BIR_II_1	1	5	PF00653	0.725
LIG_BIR_III_2	145	149	PF00653	0.545
LIG_Clathr_ClatBox_1	366	370	PF01394	0.261
LIG_deltaCOP1_diTrp_1	176	184	PF00928	0.466
LIG_FHA_1	106	112	PF00498	0.554
LIG_FHA_1	138	144	PF00498	0.479
LIG_FHA_1	149	155	PF00498	0.505
LIG_FHA_1	384	390	PF00498	0.405
LIG_FHA_1	393	399	PF00498	0.508
LIG_FHA_1	63	69	PF00498	0.621
LIG_FHA_2	59	65	PF00498	0.672
LIG_LIR_Apic_2	119	123	PF02991	0.453
LIG_LIR_Gen_1	116	123	PF02991	0.508
LIG_LIR_Gen_1	199	207	PF02991	0.472
LIG_LIR_Gen_1	74	83	PF02991	0.453
LIG_LIR_Nem_3	116	120	PF02991	0.475
LIG_LIR_Nem_3	180	184	PF02991	0.475
LIG_LIR_Nem_3	196	200	PF02991	0.481
LIG_LIR_Nem_3	203	207	PF02991	0.488
LIG_LIR_Nem_3	309	313	PF02991	0.496
LIG_LIR_Nem_3	74	78	PF02991	0.475
LIG_MYND_1	127	131	PF01753	0.483
LIG_NRBOX	362	368	PF00104	0.317
LIG_Pex14_2	120	124	PF04695	0.479
LIG_Pex14_2	197	201	PF04695	0.466
LIG_SH2_PTP2	75	78	PF00017	0.503
LIG_SH2_SRC	204	207	PF00017	0.524
LIG_SH2_SRC	75	78	PF00017	0.522
LIG_SH2_STAT3	373	376	PF00017	0.383
LIG_SH2_STAT5	204	207	PF00017	0.466
LIG_SH2_STAT5	310	313	PF00017	0.510
LIG_SH2_STAT5	373	376	PF00017	0.392
LIG_SH2_STAT5	397	400	PF00017	0.300
LIG_SH2_STAT5	46	49	PF00017	0.732
LIG_SH2_STAT5	75	78	PF00017	0.486
LIG_SH3_3	192	198	PF00018	0.480
LIG_Sin3_3	365	372	PF02671	0.366
LIG_SUMO_SIM_anti_2	74	80	PF11976	0.453
LIG_SUMO_SIM_par_1	102	108	PF11976	0.500
LIG_SUMO_SIM_par_1	365	370	PF11976	0.396
LIG_SUMO_SIM_par_1	74	80	PF11976	0.453
LIG_TYR_ITIM	200	205	PF00017	0.466
LIG_WRC_WIRS_1	117	122	PF05994	0.479
MOD_CK1_1	116	122	PF00069	0.453
MOD_CK1_1	196	202	PF00069	0.394
MOD_CK1_1	45	51	PF00069	0.808
MOD_CK2_1	146	152	PF00069	0.496
MOD_CK2_1	24	30	PF00069	0.633
MOD_GlcNHglycan	287	292	PF01048	0.394
MOD_GlcNHglycan	399	402	PF01048	0.547
MOD_GSK3_1	127	134	PF00069	0.554
MOD_GSK3_1	31	38	PF00069	0.771
MOD_GSK3_1	384	391	PF00069	0.456
MOD_GSK3_1	393	400	PF00069	0.364
MOD_GSK3_1	42	49	PF00069	0.721
MOD_GSK3_1	58	65	PF00069	0.680
MOD_LATS_1	23	29	PF00433	0.704
MOD_LATS_1	328	334	PF00433	0.633
MOD_NEK2_2	168	173	PF00069	0.517
MOD_PIKK_1	131	137	PF00454	0.492
MOD_PIKK_1	399	405	PF00454	0.414
MOD_PKA_2	161	167	PF00069	0.463
MOD_PKA_2	207	213	PF00069	0.466
MOD_PKA_2	24	30	PF00069	0.736
MOD_PKA_2	356	362	PF00069	0.512
MOD_PKA_2	392	398	PF00069	0.397
MOD_Plk_4	116	122	PF00069	0.546
MOD_Plk_4	168	174	PF00069	0.583
MOD_Plk_4	196	202	PF00069	0.486
MOD_Plk_4	356	362	PF00069	0.563
MOD_Plk_4	384	390	PF00069	0.277
MOD_Plk_4	393	399	PF00069	0.319
MOD_Plk_4	42	48	PF00069	0.744
MOD_ProDKin_1	127	133	PF00069	0.509
MOD_SUMO_rev_2	176	184	PF00179	0.453
TRG_ENDOCYTIC_2	202	205	PF00928	0.477
TRG_ENDOCYTIC_2	310	313	PF00928	0.534
TRG_ENDOCYTIC_2	75	78	PF00928	0.516
TRG_ER_diArg_1	284	286	PF00400	0.525
TRG_ER_diArg_1	350	352	PF00400	0.526
TRG_NES_CRM1_1	135	145	PF08389	0.373
TRG_NES_CRM1_1	70	82	PF08389	0.484
TRG_NLS_MonoExtN_4	3	10	PF00514	0.748

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILS5	Leptomonas seymouri	75%	99%
A0A1X0P115	Trypanosomatidae	58%	100%
A0A3R7MWK6	Trypanosoma rangeli	58%	100%
A0A3S7X264	Leishmania donovani	94%	100%
A4HH55	Leishmania braziliensis	30%	80%
A4HH64	Leishmania braziliensis	86%	100%
A4I4A8	Leishmania infantum	94%	100%
C9ZKL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	90%
E9ADQ8	Leishmania major	92%	100%
V5BUL7	Trypanosoma cruzi	58%	100%