ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies), putative

Species:

Leishmania mexicana

UniProt:

E9AM21_LEIMU

TriTrypDb:

LmxM.08_29.0570

Length:

843

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AM21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.767
CLV_C14_Caspase3-7	563	567	PF00656	0.596
CLV_NRD_NRD_1	251	253	PF00675	0.504
CLV_NRD_NRD_1	445	447	PF00675	0.468
CLV_NRD_NRD_1	448	450	PF00675	0.548
CLV_NRD_NRD_1	489	491	PF00675	0.608
CLV_NRD_NRD_1	5	7	PF00675	0.619
CLV_PCSK_FUR_1	446	450	PF00082	0.387
CLV_PCSK_KEX2_1	251	253	PF00082	0.504
CLV_PCSK_KEX2_1	445	447	PF00082	0.452
CLV_PCSK_KEX2_1	448	450	PF00082	0.534
CLV_PCSK_KEX2_1	468	470	PF00082	0.711
CLV_PCSK_KEX2_1	5	7	PF00082	0.619
CLV_PCSK_KEX2_1	789	791	PF00082	0.527
CLV_PCSK_PC1ET2_1	468	470	PF00082	0.684
CLV_PCSK_PC1ET2_1	789	791	PF00082	0.483
CLV_PCSK_SKI1_1	132	136	PF00082	0.545
CLV_PCSK_SKI1_1	251	255	PF00082	0.579
CLV_PCSK_SKI1_1	46	50	PF00082	0.500
CLV_PCSK_SKI1_1	605	609	PF00082	0.447
CLV_PCSK_SKI1_1	61	65	PF00082	0.498
CLV_PCSK_SKI1_1	683	687	PF00082	0.362
CLV_PCSK_SKI1_1	719	723	PF00082	0.318
DEG_APCC_DBOX_1	489	497	PF00400	0.609
DEG_APCC_DBOX_1	73	81	PF00400	0.508
DEG_APCC_DBOX_1	822	830	PF00400	0.508
DEG_SPOP_SBC_1	474	478	PF00917	0.568
DOC_CYCLIN_RxL_1	680	687	PF00134	0.439
DOC_CYCLIN_yClb5_NLxxxL_5	390	399	PF00134	0.576
DOC_CYCLIN_yCln2_LP_2	406	412	PF00134	0.520
DOC_PP4_FxxP_1	531	534	PF00568	0.409
DOC_SPAK_OSR1_1	766	770	PF12202	0.293
DOC_USP7_MATH_1	187	191	PF00917	0.630
DOC_USP7_MATH_1	192	196	PF00917	0.693
DOC_USP7_MATH_1	210	214	PF00917	0.433
DOC_USP7_MATH_1	237	241	PF00917	0.607
DOC_USP7_MATH_1	243	247	PF00917	0.757
DOC_USP7_MATH_1	360	364	PF00917	0.382
DOC_USP7_MATH_1	418	422	PF00917	0.480
DOC_USP7_MATH_1	474	478	PF00917	0.641
DOC_USP7_MATH_1	489	493	PF00917	0.709
DOC_USP7_MATH_1	494	498	PF00917	0.457
DOC_USP7_MATH_1	572	576	PF00917	0.733
DOC_USP7_MATH_1	623	627	PF00917	0.521
DOC_USP7_MATH_1	735	739	PF00917	0.484
DOC_USP7_UBL2_3	753	757	PF12436	0.465
DOC_WW_Pin1_4	206	211	PF00397	0.645
DOC_WW_Pin1_4	228	233	PF00397	0.657
DOC_WW_Pin1_4	478	483	PF00397	0.743
DOC_WW_Pin1_4	53	58	PF00397	0.358
DOC_WW_Pin1_4	568	573	PF00397	0.649
DOC_WW_Pin1_4	574	579	PF00397	0.684
DOC_WW_Pin1_4	629	634	PF00397	0.372
DOC_WW_Pin1_4	692	697	PF00397	0.402
DOC_WW_Pin1_4	86	91	PF00397	0.549
LIG_14-3-3_CanoR_1	251	258	PF00244	0.688
LIG_14-3-3_CanoR_1	338	348	PF00244	0.528
LIG_14-3-3_CanoR_1	472	482	PF00244	0.726
LIG_14-3-3_CanoR_1	490	494	PF00244	0.547
LIG_14-3-3_CanoR_1	602	608	PF00244	0.420
LIG_14-3-3_CanoR_1	719	724	PF00244	0.260
LIG_14-3-3_CanoR_1	772	776	PF00244	0.501
LIG_Actin_WH2_2	105	122	PF00022	0.483
LIG_Actin_WH2_2	429	447	PF00022	0.512
LIG_Actin_WH2_2	716	733	PF00022	0.473
LIG_BIR_III_4	827	831	PF00653	0.539
LIG_BRCT_BRCA1_1	406	410	PF00533	0.507
LIG_BRCT_BRCA1_1	625	629	PF00533	0.511
LIG_CtBP_PxDLS_1	10	14	PF00389	0.549
LIG_CtBP_PxDLS_1	645	649	PF00389	0.489
LIG_eIF4E_1	376	382	PF01652	0.397
LIG_eIF4E_1	697	703	PF01652	0.444
LIG_FAT_LD_1	147	155	PF03623	0.365
LIG_FHA_1	122	128	PF00498	0.464
LIG_FHA_1	253	259	PF00498	0.760
LIG_FHA_1	431	437	PF00498	0.479
LIG_FHA_1	47	53	PF00498	0.518
LIG_FHA_1	539	545	PF00498	0.478
LIG_FHA_1	630	636	PF00498	0.379
LIG_FHA_1	679	685	PF00498	0.424
LIG_FHA_1	696	702	PF00498	0.345
LIG_FHA_1	724	730	PF00498	0.477
LIG_FHA_1	79	85	PF00498	0.593
LIG_FHA_2	171	177	PF00498	0.564
LIG_FHA_2	261	267	PF00498	0.711
LIG_FHA_2	317	323	PF00498	0.624
LIG_FHA_2	340	346	PF00498	0.508
LIG_FHA_2	746	752	PF00498	0.520
LIG_FHA_2	779	785	PF00498	0.449
LIG_LIR_Apic_2	529	534	PF02991	0.410
LIG_LIR_Apic_2	694	700	PF02991	0.450
LIG_LIR_Gen_1	295	305	PF02991	0.462
LIG_LIR_Gen_1	407	418	PF02991	0.506
LIG_LIR_Gen_1	515	525	PF02991	0.477
LIG_LIR_Nem_3	113	119	PF02991	0.312
LIG_LIR_Nem_3	25	31	PF02991	0.611
LIG_LIR_Nem_3	295	301	PF02991	0.458
LIG_LIR_Nem_3	343	349	PF02991	0.493
LIG_LIR_Nem_3	407	413	PF02991	0.517
LIG_LIR_Nem_3	515	520	PF02991	0.485
LIG_LIR_Nem_3	540	545	PF02991	0.616
LIG_LIR_Nem_3	60	66	PF02991	0.456
LIG_LIR_Nem_3	628	634	PF02991	0.561
LIG_LIR_Nem_3	668	674	PF02991	0.339
LIG_MYND_1	29	33	PF01753	0.611
LIG_NRBOX	377	383	PF00104	0.397
LIG_Pex14_2	349	353	PF04695	0.464
LIG_Pex14_2	527	531	PF04695	0.415
LIG_SH2_CRK	542	546	PF00017	0.503
LIG_SH2_CRK	697	701	PF00017	0.449
LIG_SH2_NCK_1	672	676	PF00017	0.388
LIG_SH2_NCK_1	780	784	PF00017	0.498
LIG_SH2_PTP2	304	307	PF00017	0.438
LIG_SH2_SRC	672	675	PF00017	0.374
LIG_SH2_STAP1	736	740	PF00017	0.475
LIG_SH2_STAP1	814	818	PF00017	0.477
LIG_SH2_STAT3	376	379	PF00017	0.551
LIG_SH2_STAT3	814	817	PF00017	0.496
LIG_SH2_STAT5	125	128	PF00017	0.429
LIG_SH2_STAT5	304	307	PF00017	0.431
LIG_SH2_STAT5	314	317	PF00017	0.475
LIG_SH2_STAT5	412	415	PF00017	0.505
LIG_SH2_STAT5	428	431	PF00017	0.320
LIG_SH2_STAT5	498	501	PF00017	0.495
LIG_SH2_STAT5	603	606	PF00017	0.413
LIG_SH2_STAT5	697	700	PF00017	0.449
LIG_SH2_STAT5	780	783	PF00017	0.454
LIG_SH3_1	229	235	PF00018	0.575
LIG_SH3_1	543	549	PF00018	0.482
LIG_SH3_3	229	235	PF00018	0.575
LIG_SH3_3	29	35	PF00018	0.543
LIG_SH3_3	345	351	PF00018	0.539
LIG_SH3_3	381	387	PF00018	0.488
LIG_SH3_3	483	489	PF00018	0.660
LIG_SH3_3	542	548	PF00018	0.687
LIG_SH3_3	553	559	PF00018	0.661
LIG_SH3_3	566	572	PF00018	0.653
LIG_SUMO_SIM_anti_2	222	227	PF11976	0.636
LIG_SUMO_SIM_anti_2	643	650	PF11976	0.473
LIG_SUMO_SIM_anti_2	737	744	PF11976	0.488
LIG_SUMO_SIM_anti_2	93	98	PF11976	0.469
LIG_SUMO_SIM_par_1	124	131	PF11976	0.503
LIG_SUMO_SIM_par_1	371	377	PF11976	0.421
LIG_SUMO_SIM_par_1	741	748	PF11976	0.448
LIG_TRAF2_1	342	345	PF00917	0.548
LIG_TRAF2_1	513	516	PF00917	0.567
LIG_TRAF2_1	69	72	PF00917	0.505
LIG_TRAF2_2	482	487	PF00917	0.493
LIG_UBA3_1	150	156	PF00899	0.265
MOD_CDC14_SPxK_1	209	212	PF00782	0.496
MOD_CDK_SPK_2	228	233	PF00069	0.657
MOD_CDK_SPxK_1	206	212	PF00069	0.521
MOD_CDK_SPxK_1	574	580	PF00069	0.535
MOD_CK1_1	374	380	PF00069	0.402
MOD_CK1_1	464	470	PF00069	0.788
MOD_CK1_1	492	498	PF00069	0.554
MOD_CK1_1	501	507	PF00069	0.575
MOD_CK1_1	519	525	PF00069	0.512
MOD_CK1_1	695	701	PF00069	0.357
MOD_CK1_1	760	766	PF00069	0.509
MOD_CK2_1	197	203	PF00069	0.680
MOD_CK2_1	316	322	PF00069	0.549
MOD_CK2_1	339	345	PF00069	0.552
MOD_CK2_1	56	62	PF00069	0.463
MOD_CK2_1	745	751	PF00069	0.449
MOD_CK2_1	759	765	PF00069	0.518
MOD_CK2_1	778	784	PF00069	0.447
MOD_CMANNOS	822	825	PF00535	0.502
MOD_GlcNHglycan	194	197	PF01048	0.758
MOD_GlcNHglycan	235	238	PF01048	0.723
MOD_GlcNHglycan	273	276	PF01048	0.569
MOD_GlcNHglycan	400	403	PF01048	0.368
MOD_GlcNHglycan	42	45	PF01048	0.646
MOD_GlcNHglycan	521	524	PF01048	0.330
MOD_GlcNHglycan	589	592	PF01048	0.465
MOD_GlcNHglycan	754	757	PF01048	0.515
MOD_GlcNHglycan	762	765	PF01048	0.467
MOD_GlcNHglycan	773	776	PF01048	0.302
MOD_GlcNHglycan	781	784	PF01048	0.426
MOD_GlcNHglycan	86	89	PF01048	0.533
MOD_GSK3_1	170	177	PF00069	0.579
MOD_GSK3_1	18	25	PF00069	0.569
MOD_GSK3_1	187	194	PF00069	0.579
MOD_GSK3_1	206	213	PF00069	0.522
MOD_GSK3_1	224	231	PF00069	0.713
MOD_GSK3_1	233	240	PF00069	0.605
MOD_GSK3_1	430	437	PF00069	0.341
MOD_GSK3_1	463	470	PF00069	0.741
MOD_GSK3_1	474	481	PF00069	0.699
MOD_GSK3_1	492	499	PF00069	0.483
MOD_GSK3_1	53	60	PF00069	0.353
MOD_GSK3_1	564	571	PF00069	0.665
MOD_GSK3_1	625	632	PF00069	0.572
MOD_GSK3_1	688	695	PF00069	0.440
MOD_GSK3_1	719	726	PF00069	0.255
MOD_GSK3_1	741	748	PF00069	0.235
MOD_GSK3_1	836	843	PF00069	0.598
MOD_N-GLC_1	587	592	PF02516	0.455
MOD_NEK2_1	108	113	PF00069	0.454
MOD_NEK2_1	413	418	PF00069	0.494
MOD_NEK2_1	573	578	PF00069	0.666
MOD_NEK2_1	745	750	PF00069	0.442
MOD_NEK2_2	210	215	PF00069	0.469
MOD_NEK2_2	371	376	PF00069	0.420
MOD_PIKK_1	170	176	PF00454	0.555
MOD_PIKK_1	197	203	PF00454	0.461
MOD_PIKK_1	243	249	PF00454	0.619
MOD_PIKK_1	793	799	PF00454	0.444
MOD_PK_1	757	763	PF00069	0.488
MOD_PKA_1	251	257	PF00069	0.501
MOD_PKA_2	174	180	PF00069	0.659
MOD_PKA_2	251	257	PF00069	0.777
MOD_PKA_2	489	495	PF00069	0.437
MOD_PKA_2	771	777	PF00069	0.559
MOD_Plk_1	587	593	PF00069	0.445
MOD_Plk_1	665	671	PF00069	0.426
MOD_Plk_1	679	685	PF00069	0.483
MOD_Plk_1	736	742	PF00069	0.477
MOD_Plk_1	757	763	PF00069	0.501
MOD_Plk_4	121	127	PF00069	0.528
MOD_Plk_4	237	243	PF00069	0.522
MOD_Plk_4	360	366	PF00069	0.404
MOD_Plk_4	564	570	PF00069	0.594
MOD_Plk_4	611	617	PF00069	0.480
MOD_Plk_4	719	725	PF00069	0.338
MOD_Plk_4	745	751	PF00069	0.534
MOD_ProDKin_1	206	212	PF00069	0.638
MOD_ProDKin_1	228	234	PF00069	0.657
MOD_ProDKin_1	478	484	PF00069	0.742
MOD_ProDKin_1	53	59	PF00069	0.353
MOD_ProDKin_1	568	574	PF00069	0.648
MOD_ProDKin_1	629	635	PF00069	0.367
MOD_ProDKin_1	692	698	PF00069	0.399
MOD_ProDKin_1	86	92	PF00069	0.538
MOD_SUMO_for_1	579	582	PF00179	0.481
MOD_SUMO_rev_2	59	66	PF00179	0.507
MOD_SUMO_rev_2	747	755	PF00179	0.468
TRG_DiLeu_BaEn_3	344	350	PF01217	0.479
TRG_DiLeu_BaLyEn_6	377	382	PF01217	0.358
TRG_DiLeu_BaLyEn_6	553	558	PF01217	0.529
TRG_DiLeu_BaLyEn_6	630	635	PF01217	0.358
TRG_DiLeu_BaLyEn_6	697	702	PF01217	0.389
TRG_ENDOCYTIC_2	155	158	PF00928	0.325
TRG_ENDOCYTIC_2	304	307	PF00928	0.380
TRG_ENDOCYTIC_2	412	415	PF00928	0.505
TRG_ENDOCYTIC_2	542	545	PF00928	0.505
TRG_ENDOCYTIC_2	671	674	PF00928	0.340
TRG_ER_diArg_1	444	446	PF00400	0.449
TRG_ER_diArg_1	800	803	PF00400	0.457
TRG_Pf-PMV_PEXEL_1	683	687	PF00026	0.387
TRG_Pf-PMV_PEXEL_1	766	771	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7G5	Leptomonas seymouri	56%	94%
A0A3Q8IF85	Leishmania donovani	88%	100%
A4HH65	Leishmania braziliensis	73%	99%
A4I4A9	Leishmania infantum	88%	100%
C9ZKL8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ADQ9	Leishmania major	87%	100%
V5BKD9	Trypanosoma cruzi	37%	100%