Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AM20_LEIMU

TriTrypDb:

LmxM.08_29.0580

Length:

482

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AM20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.588
CLV_NRD_NRD_1	127	129	PF00675	0.522
CLV_NRD_NRD_1	131	133	PF00675	0.520
CLV_NRD_NRD_1	146	148	PF00675	0.592
CLV_NRD_NRD_1	184	186	PF00675	0.762
CLV_NRD_NRD_1	187	189	PF00675	0.718
CLV_NRD_NRD_1	255	257	PF00675	0.643
CLV_NRD_NRD_1	368	370	PF00675	0.686
CLV_NRD_NRD_1	399	401	PF00675	0.821
CLV_NRD_NRD_1	432	434	PF00675	0.661
CLV_PCSK_FUR_1	125	129	PF00082	0.532
CLV_PCSK_FUR_1	185	189	PF00082	0.516
CLV_PCSK_KEX2_1	125	127	PF00082	0.544
CLV_PCSK_KEX2_1	130	132	PF00082	0.543
CLV_PCSK_KEX2_1	145	147	PF00082	0.313
CLV_PCSK_KEX2_1	184	186	PF00082	0.762
CLV_PCSK_KEX2_1	187	189	PF00082	0.718
CLV_PCSK_KEX2_1	368	370	PF00082	0.686
CLV_PCSK_KEX2_1	399	401	PF00082	0.755
CLV_PCSK_KEX2_1	432	434	PF00082	0.661
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.643
CLV_PCSK_PC7_1	126	132	PF00082	0.630
CLV_PCSK_SKI1_1	117	121	PF00082	0.430
CLV_PCSK_SKI1_1	226	230	PF00082	0.719
CLV_PCSK_SKI1_1	328	332	PF00082	0.694
CLV_PCSK_SKI1_1	390	394	PF00082	0.589
DEG_SPOP_SBC_1	392	396	PF00917	0.789
DEG_SPOP_SBC_1	453	457	PF00917	0.701
DOC_MAPK_DCC_7	185	195	PF00069	0.698
DOC_MAPK_gen_1	184	195	PF00069	0.625
DOC_MAPK_gen_1	445	454	PF00069	0.672
DOC_MAPK_GRA24_9	181	195	PF00069	0.690
DOC_MAPK_RevD_3	419	433	PF00069	0.630
DOC_USP7_MATH_1	2	6	PF00917	0.700
DOC_USP7_MATH_1	279	283	PF00917	0.647
DOC_USP7_MATH_1	295	299	PF00917	0.542
DOC_USP7_MATH_1	300	304	PF00917	0.556
DOC_USP7_MATH_1	309	313	PF00917	0.565
DOC_USP7_MATH_1	35	39	PF00917	0.729
DOC_USP7_MATH_1	370	374	PF00917	0.668
DOC_USP7_MATH_1	392	396	PF00917	0.791
DOC_USP7_MATH_1	453	457	PF00917	0.790
DOC_USP7_MATH_1	87	91	PF00917	0.672
DOC_WW_Pin1_4	205	210	PF00397	0.732
DOC_WW_Pin1_4	263	268	PF00397	0.814
DOC_WW_Pin1_4	5	10	PF00397	0.796
DOC_WW_Pin1_4	80	85	PF00397	0.559
LIG_14-3-3_CanoR_1	276	286	PF00244	0.523
LIG_14-3-3_CanoR_1	328	333	PF00244	0.681
LIG_14-3-3_CanoR_1	369	375	PF00244	0.737
LIG_14-3-3_CanoR_1	390	398	PF00244	0.749
LIG_14-3-3_CanoR_1	474	481	PF00244	0.609
LIG_BIR_III_4	249	253	PF00653	0.602
LIG_deltaCOP1_diTrp_1	415	418	PF00928	0.460
LIG_eIF4E_1	171	177	PF01652	0.612
LIG_FHA_1	167	173	PF00498	0.723
LIG_FHA_1	377	383	PF00498	0.529
LIG_FHA_1	456	462	PF00498	0.807
LIG_FHA_1	87	93	PF00498	0.483
LIG_FHA_2	118	124	PF00498	0.425
LIG_FHA_2	233	239	PF00498	0.636
LIG_FHA_2	244	250	PF00498	0.528
LIG_FHA_2	309	315	PF00498	0.640
LIG_FHA_2	329	335	PF00498	0.640
LIG_FHA_2	438	444	PF00498	0.625
LIG_FHA_2	47	53	PF00498	0.514
LIG_Integrin_RGD_1	468	470	PF01839	0.736
LIG_LIR_Apic_2	323	329	PF02991	0.706
LIG_LIR_Gen_1	342	350	PF02991	0.605
LIG_LIR_Gen_1	415	425	PF02991	0.682
LIG_LIR_Gen_1	51	61	PF02991	0.588
LIG_LIR_Gen_1	62	71	PF02991	0.499
LIG_LIR_Nem_3	342	348	PF02991	0.623
LIG_LIR_Nem_3	415	421	PF02991	0.612
LIG_LIR_Nem_3	51	57	PF02991	0.599
LIG_LIR_Nem_3	62	67	PF02991	0.506
LIG_MYND_1	12	16	PF01753	0.679
LIG_SH2_CRK	345	349	PF00017	0.601
LIG_SH2_SRC	171	174	PF00017	0.611
LIG_SH2_STAP1	50	54	PF00017	0.759
LIG_SH2_STAP1	94	98	PF00017	0.585
LIG_SH2_STAT5	171	174	PF00017	0.611
LIG_SH2_STAT5	63	66	PF00017	0.590
LIG_SH3_2	271	276	PF14604	0.533
LIG_SH3_3	191	197	PF00018	0.682
LIG_SH3_3	206	212	PF00018	0.707
LIG_SH3_3	268	274	PF00018	0.563
LIG_SH3_3	6	12	PF00018	0.719
LIG_TRAF2_1	39	42	PF00917	0.761
LIG_TRAF2_1	70	73	PF00917	0.502
LIG_UBA3_1	67	74	PF00899	0.601
MOD_CK1_1	232	238	PF00069	0.733
MOD_CK1_1	272	278	PF00069	0.826
MOD_CK1_1	303	309	PF00069	0.519
MOD_CK1_1	36	42	PF00069	0.705
MOD_CK1_1	456	462	PF00069	0.810
MOD_CK1_1	476	482	PF00069	0.461
MOD_CK1_1	5	11	PF00069	0.798
MOD_CK1_1	59	65	PF00069	0.643
MOD_CK1_1	79	85	PF00069	0.439
MOD_CK1_1	90	96	PF00069	0.568
MOD_CK2_1	117	123	PF00069	0.428
MOD_CK2_1	196	202	PF00069	0.642
MOD_CK2_1	232	238	PF00069	0.661
MOD_CK2_1	317	323	PF00069	0.632
MOD_CK2_1	328	334	PF00069	0.679
MOD_CK2_1	35	41	PF00069	0.814
MOD_CK2_1	409	415	PF00069	0.473
MOD_CK2_1	437	443	PF00069	0.630
MOD_CK2_1	46	52	PF00069	0.556
MOD_CK2_1	67	73	PF00069	0.500
MOD_Cter_Amidation	185	188	PF01082	0.504
MOD_GlcNHglycan	17	20	PF01048	0.723
MOD_GlcNHglycan	198	201	PF01048	0.713
MOD_GlcNHglycan	232	235	PF01048	0.614
MOD_GlcNHglycan	297	300	PF01048	0.770
MOD_GlcNHglycan	302	305	PF01048	0.808
MOD_GlcNHglycan	311	314	PF01048	0.588
MOD_GlcNHglycan	35	38	PF01048	0.737
MOD_GlcNHglycan	355	358	PF01048	0.534
MOD_GlcNHglycan	4	7	PF01048	0.795
MOD_GlcNHglycan	78	81	PF01048	0.678
MOD_GlcNHglycan	89	92	PF01048	0.526
MOD_GSK3_1	1	8	PF00069	0.802
MOD_GSK3_1	229	236	PF00069	0.717
MOD_GSK3_1	261	268	PF00069	0.801
MOD_GSK3_1	36	43	PF00069	0.712
MOD_GSK3_1	388	395	PF00069	0.709
MOD_GSK3_1	452	459	PF00069	0.704
MOD_GSK3_1	76	83	PF00069	0.612
MOD_GSK3_1	86	93	PF00069	0.585
MOD_NEK2_1	92	97	PF00069	0.505
MOD_PIKK_1	166	172	PF00454	0.693
MOD_PIKK_1	243	249	PF00454	0.613
MOD_PIKK_1	265	271	PF00454	0.756
MOD_PK_1	409	415	PF00069	0.686
MOD_PKA_1	126	132	PF00069	0.576
MOD_PKA_2	126	132	PF00069	0.576
MOD_PKA_2	473	479	PF00069	0.683
MOD_PKB_1	115	123	PF00069	0.531
MOD_Plk_1	437	443	PF00069	0.732
MOD_Plk_1	476	482	PF00069	0.550
MOD_Plk_1	59	65	PF00069	0.428
MOD_Plk_2-3	317	323	PF00069	0.514
MOD_Plk_2-3	437	443	PF00069	0.732
MOD_Plk_4	117	123	PF00069	0.428
MOD_Plk_4	393	399	PF00069	0.529
MOD_ProDKin_1	205	211	PF00069	0.734
MOD_ProDKin_1	263	269	PF00069	0.814
MOD_ProDKin_1	5	11	PF00069	0.798
MOD_ProDKin_1	80	86	PF00069	0.558
TRG_DiLeu_BaEn_4	72	78	PF01217	0.535
TRG_DiLeu_BaLyEn_6	6	11	PF01217	0.720
TRG_ENDOCYTIC_2	345	348	PF00928	0.599
TRG_ER_diArg_1	125	128	PF00400	0.510
TRG_ER_diArg_1	130	132	PF00400	0.492
TRG_ER_diArg_1	146	148	PF00400	0.465
TRG_ER_diArg_1	184	187	PF00400	0.651
TRG_ER_diArg_1	367	369	PF00400	0.728
TRG_ER_diArg_1	398	400	PF00400	0.528
TRG_ER_diArg_1	432	434	PF00400	0.661
TRG_ER_diArg_1	462	465	PF00400	0.676
TRG_NLS_Bipartite_1	127	149	PF00514	0.626
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.641
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.699
TRG_Pf-PMV_PEXEL_1	432	436	PF00026	0.656

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCW8	Leptomonas seymouri	41%	97%
A0A3Q8IF08	Leishmania donovani	85%	100%
A4HH66	Leishmania braziliensis	63%	99%
A4I4B0	Leishmania infantum	85%	100%
E9ADR0	Leishmania major	85%	100%