C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AM17_LEIMU

TriTrypDb:

LmxM.08_29.0610

Length:

635

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AM17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM17

Function

Biological processes
Term	Name	Level	Count
GO:0000491	small nucleolar ribonucleoprotein complex assembly	7	1
GO:0000492	box C/D snoRNP assembly	8	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	431	435	PF00656	0.491
CLV_NRD_NRD_1	114	116	PF00675	0.610
CLV_NRD_NRD_1	154	156	PF00675	0.484
CLV_NRD_NRD_1	187	189	PF00675	0.492
CLV_NRD_NRD_1	220	222	PF00675	0.466
CLV_NRD_NRD_1	230	232	PF00675	0.523
CLV_NRD_NRD_1	268	270	PF00675	0.626
CLV_NRD_NRD_1	280	282	PF00675	0.660
CLV_NRD_NRD_1	37	39	PF00675	0.519
CLV_NRD_NRD_1	587	589	PF00675	0.621
CLV_NRD_NRD_1	592	594	PF00675	0.576
CLV_PCSK_FUR_1	278	282	PF00082	0.669
CLV_PCSK_KEX2_1	219	221	PF00082	0.472
CLV_PCSK_KEX2_1	232	234	PF00082	0.528
CLV_PCSK_KEX2_1	268	270	PF00082	0.626
CLV_PCSK_KEX2_1	280	282	PF00082	0.660
CLV_PCSK_KEX2_1	37	39	PF00082	0.519
CLV_PCSK_KEX2_1	587	589	PF00082	0.621
CLV_PCSK_KEX2_1	592	594	PF00082	0.576
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.538
CLV_PCSK_PC7_1	588	594	PF00082	0.591
CLV_PCSK_SKI1_1	453	457	PF00082	0.655
CLV_PCSK_SKI1_1	568	572	PF00082	0.642
CLV_PCSK_SKI1_1	626	630	PF00082	0.475
CLV_PCSK_SKI1_1	72	76	PF00082	0.576
DEG_ODPH_VHL_1	49	61	PF01847	0.517
DOC_CKS1_1	336	341	PF01111	0.530
DOC_CYCLIN_RxL_1	69	80	PF00134	0.645
DOC_CYCLIN_yCln2_LP_2	55	61	PF00134	0.616
DOC_MAPK_gen_1	158	168	PF00069	0.523
DOC_MAPK_gen_1	231	242	PF00069	0.705
DOC_MAPK_MEF2A_6	20	29	PF00069	0.527
DOC_PP1_RVXF_1	437	444	PF00149	0.554
DOC_PP2B_LxvP_1	74	77	PF13499	0.646
DOC_PP4_FxxP_1	309	312	PF00568	0.616
DOC_SPAK_OSR1_1	621	625	PF12202	0.525
DOC_USP7_MATH_1	247	251	PF00917	0.618
DOC_USP7_MATH_1	261	265	PF00917	0.769
DOC_USP7_MATH_1	298	302	PF00917	0.623
DOC_USP7_MATH_1	365	369	PF00917	0.648
DOC_USP7_MATH_1	488	492	PF00917	0.706
DOC_USP7_MATH_1	509	513	PF00917	0.681
DOC_USP7_MATH_1	519	523	PF00917	0.593
DOC_USP7_MATH_1	533	537	PF00917	0.660
DOC_USP7_MATH_1	77	81	PF00917	0.572
DOC_USP7_MATH_1	8	12	PF00917	0.562
DOC_WW_Pin1_4	249	254	PF00397	0.606
DOC_WW_Pin1_4	294	299	PF00397	0.567
DOC_WW_Pin1_4	331	336	PF00397	0.672
DOC_WW_Pin1_4	359	364	PF00397	0.628
DOC_WW_Pin1_4	388	393	PF00397	0.494
DOC_WW_Pin1_4	507	512	PF00397	0.527
DOC_WW_Pin1_4	528	533	PF00397	0.720
DOC_WW_Pin1_4	54	59	PF00397	0.734
LIG_14-3-3_CanoR_1	151	159	PF00244	0.500
LIG_14-3-3_CanoR_1	233	242	PF00244	0.556
LIG_14-3-3_CanoR_1	278	287	PF00244	0.642
LIG_14-3-3_CanoR_1	603	610	PF00244	0.495
LIG_14-3-3_CanoR_1	72	77	PF00244	0.655
LIG_BIR_III_2	332	336	PF00653	0.534
LIG_BIR_III_4	346	350	PF00653	0.650
LIG_FHA_1	343	349	PF00498	0.682
LIG_FHA_1	350	356	PF00498	0.588
LIG_FHA_1	377	383	PF00498	0.595
LIG_FHA_2	29	35	PF00498	0.602
LIG_FHA_2	40	46	PF00498	0.451
LIG_FHA_2	429	435	PF00498	0.465
LIG_FHA_2	519	525	PF00498	0.534
LIG_FHA_2	597	603	PF00498	0.518
LIG_LIR_Apic_2	317	321	PF02991	0.545
LIG_LIR_Gen_1	141	152	PF02991	0.406
LIG_LIR_Gen_1	45	54	PF02991	0.553
LIG_LIR_Gen_1	599	608	PF02991	0.506
LIG_LIR_Nem_3	141	147	PF02991	0.478
LIG_LIR_Nem_3	45	49	PF02991	0.532
LIG_LIR_Nem_3	599	604	PF02991	0.518
LIG_Pex14_1	36	40	PF04695	0.525
LIG_REV1ctd_RIR_1	620	630	PF16727	0.458
LIG_SH2_CRK	144	148	PF00017	0.490
LIG_SH2_CRK	22	26	PF00017	0.576
LIG_SH2_CRK	40	44	PF00017	0.446
LIG_SH2_NCK_1	110	114	PF00017	0.443
LIG_SH2_SRC	110	113	PF00017	0.447
LIG_SH2_SRC	318	321	PF00017	0.658
LIG_SH2_STAP1	135	139	PF00017	0.407
LIG_SH2_STAP1	22	26	PF00017	0.644
LIG_SH2_STAP1	437	441	PF00017	0.649
LIG_SH2_STAT3	184	187	PF00017	0.473
LIG_SH2_STAT5	121	124	PF00017	0.598
LIG_SH2_STAT5	144	147	PF00017	0.441
LIG_SH2_STAT5	184	187	PF00017	0.473
LIG_SH2_STAT5	413	416	PF00017	0.315
LIG_SH3_1	288	294	PF00018	0.575
LIG_SH3_1	380	386	PF00018	0.536
LIG_SH3_1	592	598	PF00018	0.552
LIG_SH3_3	170	176	PF00018	0.474
LIG_SH3_3	210	216	PF00018	0.440
LIG_SH3_3	284	290	PF00018	0.675
LIG_SH3_3	310	316	PF00018	0.631
LIG_SH3_3	380	386	PF00018	0.679
LIG_SH3_3	4	10	PF00018	0.601
LIG_SH3_3	503	509	PF00018	0.705
LIG_SH3_3	551	557	PF00018	0.622
LIG_SH3_3	591	597	PF00018	0.583
LIG_TRAF2_1	130	133	PF00917	0.520
LIG_TRAF2_1	478	481	PF00917	0.648
LIG_TRAF2_1	521	524	PF00917	0.675
LIG_TRAF2_2	327	332	PF00917	0.561
LIG_WW_3	1	5	PF00397	0.656
MOD_CDK_SPK_2	388	393	PF00069	0.494
MOD_CDK_SPxxK_3	388	395	PF00069	0.488
MOD_CK1_1	252	258	PF00069	0.651
MOD_CK1_1	260	266	PF00069	0.645
MOD_CK1_1	267	273	PF00069	0.615
MOD_CK1_1	297	303	PF00069	0.686
MOD_CK1_1	314	320	PF00069	0.589
MOD_CK1_1	331	337	PF00069	0.568
MOD_CK1_1	361	367	PF00069	0.637
MOD_CK1_1	454	460	PF00069	0.529
MOD_CK1_1	504	510	PF00069	0.529
MOD_CK1_1	536	542	PF00069	0.588
MOD_CK2_1	270	276	PF00069	0.716
MOD_CK2_1	28	34	PF00069	0.401
MOD_CK2_1	297	303	PF00069	0.623
MOD_CK2_1	39	45	PF00069	0.454
MOD_CK2_1	446	452	PF00069	0.673
MOD_CK2_1	454	460	PF00069	0.608
MOD_CK2_1	507	513	PF00069	0.563
MOD_CK2_1	518	524	PF00069	0.519
MOD_CK2_1	596	602	PF00069	0.522
MOD_CK2_1	8	14	PF00069	0.631
MOD_GlcNHglycan	180	184	PF01048	0.467
MOD_GlcNHglycan	257	260	PF01048	0.644
MOD_GlcNHglycan	300	303	PF01048	0.549
MOD_GlcNHglycan	367	370	PF01048	0.721
MOD_GlcNHglycan	452	456	PF01048	0.647
MOD_GlcNHglycan	490	493	PF01048	0.647
MOD_GlcNHglycan	503	506	PF01048	0.633
MOD_GlcNHglycan	524	529	PF01048	0.681
MOD_GlcNHglycan	558	561	PF01048	0.656
MOD_GlcNHglycan	81	84	PF01048	0.721
MOD_GSK3_1	187	194	PF00069	0.369
MOD_GSK3_1	247	254	PF00069	0.600
MOD_GSK3_1	257	264	PF00069	0.622
MOD_GSK3_1	267	274	PF00069	0.618
MOD_GSK3_1	294	301	PF00069	0.608
MOD_GSK3_1	331	338	PF00069	0.670
MOD_GSK3_1	361	368	PF00069	0.633
MOD_GSK3_1	424	431	PF00069	0.458
MOD_GSK3_1	447	454	PF00069	0.502
MOD_GSK3_1	482	489	PF00069	0.667
MOD_GSK3_1	509	516	PF00069	0.593
MOD_GSK3_1	524	531	PF00069	0.664
MOD_GSK3_1	68	75	PF00069	0.635
MOD_N-GLC_1	386	391	PF02516	0.505
MOD_N-GLC_1	466	471	PF02516	0.660
MOD_N-GLC_1	528	533	PF02516	0.692
MOD_NEK2_1	143	148	PF00069	0.438
MOD_NEK2_1	178	183	PF00069	0.447
MOD_NEK2_2	150	155	PF00069	0.434
MOD_NEK2_2	39	44	PF00069	0.572
MOD_PIKK_1	128	134	PF00454	0.462
MOD_PIKK_1	191	197	PF00454	0.469
MOD_PIKK_1	519	525	PF00454	0.534
MOD_PKA_1	268	274	PF00069	0.623
MOD_PKA_1	280	286	PF00069	0.622
MOD_PKA_2	150	156	PF00069	0.483
MOD_PKA_2	187	193	PF00069	0.372
MOD_PKA_2	264	270	PF00069	0.647
MOD_PKA_2	271	277	PF00069	0.620
MOD_PKA_2	279	285	PF00069	0.608
MOD_PKA_2	602	608	PF00069	0.499
MOD_PKA_2	8	14	PF00069	0.506
MOD_PKB_1	231	239	PF00069	0.611
MOD_PKB_1	278	286	PF00069	0.609
MOD_PKB_1	70	78	PF00069	0.571
MOD_Plk_1	179	185	PF00069	0.425
MOD_Plk_1	236	242	PF00069	0.543
MOD_Plk_1	433	439	PF00069	0.629
MOD_Plk_1	568	574	PF00069	0.611
MOD_Plk_2-3	602	608	PF00069	0.499
MOD_Plk_4	236	242	PF00069	0.548
MOD_Plk_4	350	356	PF00069	0.507
MOD_Plk_4	596	602	PF00069	0.539
MOD_ProDKin_1	249	255	PF00069	0.607
MOD_ProDKin_1	294	300	PF00069	0.567
MOD_ProDKin_1	331	337	PF00069	0.672
MOD_ProDKin_1	359	365	PF00069	0.625
MOD_ProDKin_1	388	394	PF00069	0.487
MOD_ProDKin_1	507	513	PF00069	0.529
MOD_ProDKin_1	528	534	PF00069	0.720
MOD_ProDKin_1	54	60	PF00069	0.739
MOD_SUMO_for_1	200	203	PF00179	0.508
TRG_DiLeu_BaEn_1	164	169	PF01217	0.538
TRG_DiLeu_BaEn_1	612	617	PF01217	0.453
TRG_DiLeu_BaLyEn_6	50	55	PF01217	0.619
TRG_ENDOCYTIC_2	144	147	PF00928	0.405
TRG_ENDOCYTIC_2	22	25	PF00928	0.749
TRG_ENDOCYTIC_2	40	43	PF00928	0.393
TRG_ENDOCYTIC_2	601	604	PF00928	0.519
TRG_ER_diArg_1	219	221	PF00400	0.450
TRG_ER_diArg_1	230	233	PF00400	0.533
TRG_ER_diArg_1	278	281	PF00400	0.738
TRG_ER_diArg_1	3	6	PF00400	0.650
TRG_ER_diArg_1	36	38	PF00400	0.525
TRG_ER_diArg_1	392	395	PF00400	0.494
TRG_ER_diArg_1	592	594	PF00400	0.580
TRG_NLS_Bipartite_1	219	236	PF00514	0.474
TRG_NLS_MonoCore_2	231	236	PF00514	0.604
TRG_NLS_MonoExtC_3	154	159	PF00514	0.503
TRG_NLS_MonoExtC_3	230	235	PF00514	0.551
TRG_NLS_MonoExtN_4	231	236	PF00514	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Y7	Leptomonas seymouri	47%	100%
A0A3Q8IDJ2	Leishmania donovani	86%	100%
A4I4B3	Leishmania infantum	86%	100%
E9ADR3	Leishmania major	87%	100%
E9AIT5	Leishmania braziliensis	73%	99%