zf-C2HE domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Scavenger mRNA decapping enzyme C-term binding, putative

Species:

Leishmania mexicana

UniProt:

E9AM14_LEIMU

TriTrypDb:

LmxM.08_29.0640

Length:

264

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AM14

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM14

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	11
GO:0006281	DNA repair	5	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0006950	response to stress	2	11
GO:0006974	DNA damage response	4	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0033554	cellular response to stress	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0050896	response to stimulus	1	11
GO:0051716	cellular response to stimulus	2	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0004518	nuclease activity	4	11
GO:0004527	exonuclease activity	5	11
GO:0004529	DNA exonuclease activity	5	11
GO:0004536	DNA nuclease activity	4	11
GO:0005488	binding	1	11
GO:0008409	5'-3' exonuclease activity	6	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	11
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	6	11
GO:0033699	DNA 5'-adenosine monophosphate hydrolase activity	8	11
GO:0035312	5'-3' DNA exonuclease activity	7	11
GO:0097159	organic cyclic compound binding	2	11
GO:0140097	catalytic activity, acting on DNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.416
CLV_NRD_NRD_1	13	15	PF00675	0.593
CLV_NRD_NRD_1	156	158	PF00675	0.305
CLV_NRD_NRD_1	38	40	PF00675	0.279
CLV_PCSK_KEX2_1	13	15	PF00082	0.640
CLV_PCSK_KEX2_1	156	158	PF00082	0.305
CLV_PCSK_KEX2_1	36	38	PF00082	0.263
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.331
DEG_APCC_DBOX_1	24	32	PF00400	0.389
DEG_Nend_UBRbox_3	1	3	PF02207	0.647
DOC_CDC14_PxL_1	162	170	PF14671	0.401
DOC_CDC14_PxL_1	68	76	PF14671	0.408
DOC_CYCLIN_yCln2_LP_2	109	115	PF00134	0.426
DOC_MAPK_gen_1	25	34	PF00069	0.464
DOC_PP2B_LxvP_1	109	112	PF13499	0.401
DOC_USP7_MATH_1	16	20	PF00917	0.484
DOC_USP7_MATH_1	164	168	PF00917	0.443
DOC_USP7_MATH_1	246	250	PF00917	0.400
DOC_USP7_MATH_1	38	42	PF00917	0.517
DOC_USP7_MATH_1	51	55	PF00917	0.567
DOC_USP7_MATH_1	82	86	PF00917	0.293
DOC_USP7_UBL2_3	258	262	PF12436	0.470
DOC_USP7_UBL2_3	36	40	PF12436	0.483
DOC_WW_Pin1_4	1	6	PF00397	0.532
DOC_WW_Pin1_4	179	184	PF00397	0.427
DOC_WW_Pin1_4	46	51	PF00397	0.592
DOC_WW_Pin1_4	72	77	PF00397	0.494
LIG_14-3-3_CanoR_1	13	20	PF00244	0.505
LIG_14-3-3_CanoR_1	214	218	PF00244	0.306
LIG_14-3-3_CanoR_1	37	45	PF00244	0.324
LIG_Actin_WH2_2	130	148	PF00022	0.505
LIG_BIR_III_2	99	103	PF00653	0.401
LIG_CtBP_PxDLS_1	112	116	PF00389	0.426
LIG_DLG_GKlike_1	116	123	PF00625	0.505
LIG_FHA_1	47	53	PF00498	0.678
LIG_FHA_2	122	128	PF00498	0.474
LIG_FHA_2	176	182	PF00498	0.416
LIG_LIR_Gen_1	193	200	PF02991	0.382
LIG_LIR_Nem_3	139	144	PF02991	0.426
LIG_LIR_Nem_3	193	197	PF02991	0.361
LIG_LIR_Nem_3	66	71	PF02991	0.314
LIG_LYPXL_yS_3	71	74	PF13949	0.392
LIG_MYND_1	72	76	PF01753	0.488
LIG_Pex14_2	158	162	PF04695	0.412
LIG_Pex14_2	194	198	PF04695	0.237
LIG_PTB_Apo_2	95	102	PF02174	0.401
LIG_SH2_STAT5	141	144	PF00017	0.398
LIG_SH3_3	163	169	PF00018	0.401
LIG_SH3_3	239	245	PF00018	0.350
LIG_SH3_3	47	53	PF00018	0.566
LIG_WRC_WIRS_1	191	196	PF05994	0.257
LIG_WRPW_2	68	71	PF00400	0.425
MOD_CDK_SPxxK_3	179	186	PF00069	0.427
MOD_CK1_1	19	25	PF00069	0.441
MOD_CK1_1	193	199	PF00069	0.252
MOD_CK1_1	41	47	PF00069	0.457
MOD_CK1_1	54	60	PF00069	0.559
MOD_CK2_1	54	60	PF00069	0.647
MOD_CK2_1	72	78	PF00069	0.495
MOD_GlcNHglycan	40	43	PF01048	0.460
MOD_GSK3_1	12	19	PF00069	0.559
MOD_GSK3_1	175	182	PF00069	0.549
MOD_GSK3_1	246	253	PF00069	0.267
MOD_GSK3_1	41	48	PF00069	0.454
MOD_GSK3_1	51	58	PF00069	0.558
MOD_GSK3_1	72	79	PF00069	0.347
MOD_PKA_2	12	18	PF00069	0.577
MOD_PKA_2	213	219	PF00069	0.306
MOD_PKA_2	38	44	PF00069	0.523
MOD_Plk_4	101	107	PF00069	0.401
MOD_Plk_4	193	199	PF00069	0.349
MOD_Plk_4	83	89	PF00069	0.355
MOD_ProDKin_1	1	7	PF00069	0.533
MOD_ProDKin_1	179	185	PF00069	0.427
MOD_ProDKin_1	46	52	PF00069	0.591
MOD_ProDKin_1	72	78	PF00069	0.491
MOD_SUMO_rev_2	228	235	PF00179	0.257
MOD_SUMO_rev_2	75	82	PF00179	0.438
TRG_DiLeu_BaLyEn_6	126	131	PF01217	0.444
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.488
TRG_ENDOCYTIC_2	191	194	PF00928	0.250
TRG_ENDOCYTIC_2	71	74	PF00928	0.402
TRG_ER_diArg_1	12	14	PF00400	0.630
TRG_ER_diArg_1	156	158	PF00400	0.505
TRG_NLS_MonoExtC_3	35	40	PF00514	0.228
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.306

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IB39	Leptomonas seymouri	71%	100%
A0A0S4IR98	Bodo saltans	40%	100%
A0A0S4JC46	Bodo saltans	29%	84%
A0A0S4JGA0	Bodo saltans	39%	100%
A0A1X0NZZ4	Trypanosomatidae	51%	100%
A0A3S7X266	Leishmania donovani	91%	100%
A4HH71	Leishmania braziliensis	83%	100%
A4I4B7	Leishmania infantum	92%	100%
C9ZL51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
O74859	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
P61797	Canis lupus familiaris	33%	77%
P61798	Gallus gallus	35%	84%
P61801	Xenopus tropicalis	34%	76%
Q08702	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
Q7Z2E3	Homo sapiens	34%	74%
Q8K4H4	Rattus norvegicus	34%	80%
V5BUM6	Trypanosoma cruzi	51%	100%