Phosphate transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphate transporter, putative

Species:

Leishmania mexicana

UniProt:

E9AM13_LEIMU

TriTrypDb:

LmxM.08_29.0650

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AM13

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM13

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0006811	monoatomic ion transport	4	7
GO:0006817	phosphate ion transport	7	7
GO:0006820	monoatomic anion transport	5	7
GO:0015698	inorganic anion transport	6	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0009987	cellular process	1	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0035435	phosphate ion transmembrane transport	6	1
GO:0055085	transmembrane transport	2	1
GO:0098656	monoatomic anion transmembrane transport	4	1
GO:0098660	inorganic ion transmembrane transport	4	1
GO:0098661	inorganic anion transmembrane transport	5	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	7
GO:0005315	inorganic phosphate transmembrane transporter activity	4	7
GO:0015291	secondary active transmembrane transporter activity	4	7
GO:0015293	symporter activity	5	7
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	7
GO:0022804	active transmembrane transporter activity	3	7
GO:0022857	transmembrane transporter activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.437
CLV_C14_Caspase3-7	228	232	PF00656	0.482
CLV_NRD_NRD_1	2	4	PF00675	0.402
CLV_NRD_NRD_1	235	237	PF00675	0.220
CLV_PCSK_KEX2_1	2	4	PF00082	0.412
CLV_PCSK_SKI1_1	3	7	PF00082	0.387
CLV_PCSK_SKI1_1	312	316	PF00082	0.313
DEG_MDM2_SWIB_1	65	73	PF02201	0.191
DEG_Nend_UBRbox_1	1	4	PF02207	0.535
DOC_CKS1_1	210	215	PF01111	0.384
DOC_CYCLIN_yCln2_LP_2	360	366	PF00134	0.468
DOC_MAPK_gen_1	236	243	PF00069	0.449
DOC_MAPK_gen_1	9	17	PF00069	0.483
DOC_MAPK_MEF2A_6	11	19	PF00069	0.451
DOC_MAPK_MEF2A_6	46	55	PF00069	0.211
DOC_MAPK_MEF2A_6	72	81	PF00069	0.191
DOC_PP1_RVXF_1	111	118	PF00149	0.482
DOC_PP2B_LxvP_1	163	166	PF13499	0.482
DOC_USP7_MATH_1	205	209	PF00917	0.482
DOC_USP7_MATH_1	229	233	PF00917	0.551
DOC_USP7_MATH_1	296	300	PF00917	0.414
DOC_USP7_MATH_1	41	45	PF00917	0.286
DOC_USP7_MATH_1	82	86	PF00917	0.482
DOC_WW_Pin1_4	209	214	PF00397	0.543
DOC_WW_Pin1_4	249	254	PF00397	0.425
DOC_WW_Pin1_4	327	332	PF00397	0.458
DOC_WW_Pin1_4	449	454	PF00397	0.445
LIG_14-3-3_CanoR_1	198	205	PF00244	0.551
LIG_Actin_WH2_2	220	238	PF00022	0.384
LIG_APCC_ABBA_1	332	337	PF00400	0.384
LIG_BRCT_BRCA1_1	43	47	PF00533	0.184
LIG_CaM_NSCaTE_8	457	464	PF13499	0.329
LIG_FHA_1	125	131	PF00498	0.592
LIG_FHA_1	14	20	PF00498	0.488
LIG_FHA_1	148	154	PF00498	0.542
LIG_FHA_1	262	268	PF00498	0.391
LIG_FHA_2	405	411	PF00498	0.286
LIG_Integrin_RGD_1	121	123	PF01839	0.282
LIG_LIR_Gen_1	31	42	PF02991	0.277
LIG_LIR_Gen_1	396	406	PF02991	0.245
LIG_LIR_Gen_1	417	427	PF02991	0.245
LIG_LIR_Gen_1	463	470	PF02991	0.191
LIG_LIR_Nem_3	31	37	PF02991	0.277
LIG_LIR_Nem_3	369	375	PF02991	0.445
LIG_LIR_Nem_3	396	402	PF02991	0.245
LIG_LIR_Nem_3	417	423	PF02991	0.245
LIG_NRBOX	24	30	PF00104	0.329
LIG_Pex14_2	65	69	PF04695	0.293
LIG_REV1ctd_RIR_1	115	125	PF16727	0.486
LIG_SH2_CRK	57	61	PF00017	0.283
LIG_SH2_STAP1	57	61	PF00017	0.254
LIG_SH2_STAT5	370	373	PF00017	0.486
LIG_SH3_2	350	355	PF14604	0.445
LIG_SH3_3	133	139	PF00018	0.532
LIG_SH3_3	152	158	PF00018	0.403
LIG_SH3_3	163	169	PF00018	0.475
LIG_SH3_3	207	213	PF00018	0.438
LIG_SH3_3	347	353	PF00018	0.445
LIG_SH3_3	360	366	PF00018	0.445
LIG_SUMO_SIM_anti_2	16	21	PF11976	0.191
LIG_SUMO_SIM_par_1	170	177	PF11976	0.384
LIG_SUMO_SIM_par_1	330	339	PF11976	0.384
LIG_SUMO_SIM_par_1	447	452	PF11976	0.445
LIG_TYR_ITIM	55	60	PF00017	0.277
LIG_WRC_WIRS_1	382	387	PF05994	0.277
LIG_WW_3	135	139	PF00397	0.598
MOD_CDK_SPxK_1	449	455	PF00069	0.445
MOD_CK1_1	196	202	PF00069	0.506
MOD_CK1_1	225	231	PF00069	0.541
MOD_CK1_1	261	267	PF00069	0.513
MOD_CK1_1	307	313	PF00069	0.454
MOD_CK1_1	381	387	PF00069	0.277
MOD_CK1_1	418	424	PF00069	0.286
MOD_CK1_1	85	91	PF00069	0.482
MOD_CK2_1	315	321	PF00069	0.438
MOD_CK2_1	333	339	PF00069	0.461
MOD_CK2_1	404	410	PF00069	0.286
MOD_DYRK1A_RPxSP_1	209	213	PF00069	0.429
MOD_GlcNHglycan	123	127	PF01048	0.297
MOD_GlcNHglycan	130	133	PF01048	0.297
MOD_GlcNHglycan	227	230	PF01048	0.372
MOD_GlcNHglycan	298	301	PF01048	0.316
MOD_GlcNHglycan	396	399	PF01048	0.482
MOD_GlcNHglycan	84	87	PF01048	0.348
MOD_GSK3_1	113	120	PF00069	0.529
MOD_GSK3_1	124	131	PF00069	0.485
MOD_GSK3_1	173	180	PF00069	0.488
MOD_GSK3_1	192	199	PF00069	0.459
MOD_GSK3_1	205	212	PF00069	0.462
MOD_GSK3_1	218	225	PF00069	0.443
MOD_GSK3_1	245	252	PF00069	0.480
MOD_GSK3_1	254	261	PF00069	0.445
MOD_GSK3_1	296	303	PF00069	0.504
MOD_GSK3_1	304	311	PF00069	0.425
MOD_GSK3_1	414	421	PF00069	0.304
MOD_GSK3_1	436	443	PF00069	0.335
MOD_GSK3_1	460	467	PF00069	0.280
MOD_GSK3_1	9	16	PF00069	0.384
MOD_N-GLC_1	218	223	PF02516	0.334
MOD_N-GLC_1	393	398	PF02516	0.445
MOD_N-GLC_2	187	189	PF02516	0.184
MOD_NEK2_1	117	122	PF00069	0.520
MOD_NEK2_1	13	18	PF00069	0.384
MOD_NEK2_1	174	179	PF00069	0.483
MOD_NEK2_1	222	227	PF00069	0.555
MOD_NEK2_1	24	29	PF00069	0.303
MOD_NEK2_1	315	320	PF00069	0.395
MOD_NEK2_1	436	441	PF00069	0.335
MOD_NEK2_2	229	234	PF00069	0.384
MOD_PIKK_1	254	260	PF00454	0.384
MOD_PIKK_1	41	47	PF00454	0.286
MOD_PIKK_1	415	421	PF00454	0.286
MOD_PKA_2	197	203	PF00069	0.551
MOD_Plk_1	113	119	PF00069	0.470
MOD_Plk_1	13	19	PF00069	0.488
MOD_Plk_1	218	224	PF00069	0.470
MOD_Plk_4	113	119	PF00069	0.486
MOD_Plk_4	149	155	PF00069	0.384
MOD_Plk_4	218	224	PF00069	0.456
MOD_Plk_4	24	30	PF00069	0.367
MOD_Plk_4	381	387	PF00069	0.277
MOD_Plk_4	436	442	PF00069	0.335
MOD_Plk_4	461	467	PF00069	0.277
MOD_ProDKin_1	209	215	PF00069	0.543
MOD_ProDKin_1	249	255	PF00069	0.425
MOD_ProDKin_1	327	333	PF00069	0.458
MOD_ProDKin_1	449	455	PF00069	0.445
TRG_ENDOCYTIC_2	403	406	PF00928	0.245
TRG_ENDOCYTIC_2	57	60	PF00928	0.292
TRG_ER_diArg_1	1	3	PF00400	0.603
TRG_ER_diArg_1	246	249	PF00400	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8C5	Leptomonas seymouri	53%	68%
A0A1X0P0T2	Trypanosomatidae	41%	71%
A0A3S7X2A5	Leishmania donovani	84%	66%
A4I4B8	Leishmania infantum	84%	66%
E9ADR7	Leishmania major	84%	66%