Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AM11_LEIMU

TriTrypDb:

LmxM.08_29.0670

Length:

137

Annotations

LeishMANIAdb annotations

1TM protein with a basic N-terminus that might be a mitochondrial transit signal.. Though conservative, not found outside Kinetoplastida

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9AM11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.446
CLV_NRD_NRD_1	19	21	PF00675	0.384
CLV_PCSK_KEX2_1	19	21	PF00082	0.398
CLV_Separin_Metazoa	11	15	PF03568	0.678
DOC_CYCLIN_yClb5_NLxxxL_5	116	122	PF00134	0.461
DOC_CYCLIN_yCln2_LP_2	118	124	PF00134	0.441
DOC_MAPK_gen_1	22	32	PF00069	0.627
DOC_MAPK_gen_1	36	44	PF00069	0.704
DOC_MAPK_MEF2A_6	25	32	PF00069	0.632
DOC_PP4_FxxP_1	48	51	PF00568	0.408
DOC_PP4_FxxP_1	6	9	PF00568	0.602
DOC_USP7_MATH_1	61	65	PF00917	0.480
DOC_WW_Pin1_4	110	115	PF00397	0.446
LIG_14-3-3_CanoR_1	19	25	PF00244	0.610
LIG_BRCT_BRCA1_1	98	102	PF00533	0.512
LIG_FHA_1	60	66	PF00498	0.339
LIG_LIR_Apic_2	108	114	PF02991	0.435
LIG_LIR_Apic_2	5	9	PF02991	0.534
LIG_LIR_Gen_1	127	134	PF02991	0.473
LIG_LIR_Gen_1	99	110	PF02991	0.545
LIG_LIR_Nem_3	127	131	PF02991	0.499
LIG_LIR_Nem_3	21	27	PF02991	0.618
LIG_LIR_Nem_3	99	105	PF02991	0.549
LIG_SH2_STAP1	81	85	PF00017	0.406
LIG_SH2_STAP1	87	91	PF00017	0.426
LIG_SH2_STAT5	67	70	PF00017	0.449
LIG_SH3_1	10	16	PF00018	0.680
LIG_SH3_2	121	126	PF14604	0.460
LIG_SH3_3	10	16	PF00018	0.680
LIG_SH3_3	118	124	PF00018	0.434
MOD_CDC14_SPxK_1	113	116	PF00782	0.446
MOD_CDK_SPxK_1	110	116	PF00069	0.449
MOD_GSK3_1	70	77	PF00069	0.457
MOD_GSK3_1	92	99	PF00069	0.519
MOD_N-GLC_1	32	37	PF02516	0.435
MOD_NEK2_1	32	37	PF00069	0.635
MOD_NEK2_1	59	64	PF00069	0.350
MOD_NEK2_1	74	79	PF00069	0.359
MOD_NEK2_2	61	66	PF00069	0.480
MOD_PIKK_1	96	102	PF00454	0.554
MOD_PKA_2	18	24	PF00069	0.620
MOD_Plk_4	61	67	PF00069	0.388
MOD_Plk_4	70	76	PF00069	0.382
MOD_ProDKin_1	110	116	PF00069	0.448
MOD_SUMO_rev_2	127	137	PF00179	0.462
TRG_ENDOCYTIC_2	66	69	PF00928	0.443
TRG_ER_diArg_1	18	20	PF00400	0.590
TRG_Pf-PMV_PEXEL_1	25	29	PF00026	0.431

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9D3	Leptomonas seymouri	77%	100%
A0A0S4JF31	Bodo saltans	58%	84%
A0A1X0NZT9	Trypanosomatidae	73%	100%
A0A3Q8IH51	Leishmania donovani	98%	99%
A0A3S5IRQ2	Trypanosoma rangeli	65%	100%
A4HH74	Leishmania braziliensis	90%	100%
A4I4C0	Leishmania infantum	98%	99%
C9ZL48	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9ADR9	Leishmania major	96%	100%