Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Triple RNA binding domain protein 3

Species:

Leishmania mexicana

UniProt:

E9AM10_LEIMU

TriTrypDb:

LmxM.08_29.0680

Length:

772

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9AM10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM10

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	405	409	PF00656	0.547
CLV_C14_Caspase3-7	681	685	PF00656	0.738
CLV_NRD_NRD_1	102	104	PF00675	0.645
CLV_NRD_NRD_1	310	312	PF00675	0.479
CLV_NRD_NRD_1	346	348	PF00675	0.317
CLV_NRD_NRD_1	387	389	PF00675	0.507
CLV_NRD_NRD_1	415	417	PF00675	0.499
CLV_NRD_NRD_1	488	490	PF00675	0.717
CLV_NRD_NRD_1	548	550	PF00675	0.341
CLV_NRD_NRD_1	632	634	PF00675	0.684
CLV_NRD_NRD_1	759	761	PF00675	0.600
CLV_PCSK_KEX2_1	102	104	PF00082	0.703
CLV_PCSK_KEX2_1	346	348	PF00082	0.317
CLV_PCSK_KEX2_1	415	417	PF00082	0.499
CLV_PCSK_KEX2_1	488	490	PF00082	0.717
CLV_PCSK_KEX2_1	632	634	PF00082	0.694
CLV_PCSK_KEX2_1	679	681	PF00082	0.753
CLV_PCSK_KEX2_1	697	699	PF00082	0.492
CLV_PCSK_KEX2_1	758	760	PF00082	0.637
CLV_PCSK_PC1ET2_1	632	634	PF00082	0.694
CLV_PCSK_PC1ET2_1	679	681	PF00082	0.753
CLV_PCSK_PC1ET2_1	697	699	PF00082	0.492
CLV_PCSK_PC1ET2_1	758	760	PF00082	0.637
CLV_PCSK_SKI1_1	281	285	PF00082	0.479
CLV_PCSK_SKI1_1	311	315	PF00082	0.501
CLV_PCSK_SKI1_1	347	351	PF00082	0.432
CLV_PCSK_SKI1_1	364	368	PF00082	0.466
CLV_PCSK_SKI1_1	388	392	PF00082	0.441
CLV_PCSK_SKI1_1	634	638	PF00082	0.644
CLV_PCSK_SKI1_1	749	753	PF00082	0.651
CLV_PCSK_SKI1_1	767	771	PF00082	0.767
CLV_Separin_Metazoa	365	369	PF03568	0.464
DEG_APCC_DBOX_1	363	371	PF00400	0.463
DEG_SCF_FBW7_1	400	405	PF00400	0.506
DEG_SPOP_SBC_1	61	65	PF00917	0.617
DOC_MAPK_gen_1	239	247	PF00069	0.546
DOC_MAPK_gen_1	388	394	PF00069	0.447
DOC_MAPK_gen_1	549	555	PF00069	0.560
DOC_MAPK_gen_1	587	595	PF00069	0.560
DOC_MAPK_gen_1	707	714	PF00069	0.507
DOC_MAPK_MEF2A_6	707	714	PF00069	0.507
DOC_MAPK_RevD_3	402	416	PF00069	0.538
DOC_PP2B_PxIxI_1	709	715	PF00149	0.505
DOC_PP4_FxxP_1	116	119	PF00568	0.762
DOC_PP4_FxxP_1	570	573	PF00568	0.501
DOC_USP7_MATH_1	166	170	PF00917	0.729
DOC_USP7_MATH_1	173	177	PF00917	0.706
DOC_USP7_MATH_1	217	221	PF00917	0.543
DOC_USP7_MATH_1	33	37	PF00917	0.734
DOC_USP7_MATH_1	445	449	PF00917	0.726
DOC_USP7_MATH_1	496	500	PF00917	0.749
DOC_USP7_MATH_1	50	54	PF00917	0.688
DOC_USP7_MATH_1	61	65	PF00917	0.750
DOC_USP7_MATH_1	739	743	PF00917	0.748
DOC_USP7_MATH_1	80	84	PF00917	0.618
DOC_USP7_UBL2_3	240	244	PF12436	0.573
DOC_USP7_UBL2_3	326	330	PF12436	0.626
DOC_USP7_UBL2_3	338	342	PF12436	0.600
DOC_USP7_UBL2_3	630	634	PF12436	0.594
DOC_USP7_UBL2_3	675	679	PF12436	0.751
DOC_USP7_UBL2_3	749	753	PF12436	0.676
DOC_USP7_UBL2_3	763	767	PF12436	0.749
DOC_WW_Pin1_4	181	186	PF00397	0.804
DOC_WW_Pin1_4	294	299	PF00397	0.476
DOC_WW_Pin1_4	398	403	PF00397	0.511
DOC_WW_Pin1_4	450	455	PF00397	0.788
LIG_14-3-3_CanoR_1	165	174	PF00244	0.800
LIG_14-3-3_CanoR_1	40	50	PF00244	0.730
LIG_14-3-3_CanoR_1	436	444	PF00244	0.536
LIG_AP2alpha_1	406	410	PF02296	0.487
LIG_APCC_ABBA_1	553	558	PF00400	0.560
LIG_BIR_III_2	93	97	PF00653	0.737
LIG_BRCT_BRCA1_1	112	116	PF00533	0.841
LIG_FHA_1	222	228	PF00498	0.667
LIG_FHA_1	315	321	PF00498	0.583
LIG_FHA_1	399	405	PF00498	0.513
LIG_FHA_1	447	453	PF00498	0.495
LIG_FHA_1	731	737	PF00498	0.733
LIG_FHA_2	260	266	PF00498	0.603
LIG_FHA_2	394	400	PF00498	0.490
LIG_FHA_2	403	409	PF00498	0.423
LIG_FHA_2	84	90	PF00498	0.757
LIG_Integrin_isoDGR_2	309	311	PF01839	0.488
LIG_Integrin_RGD_1	139	141	PF01839	0.678
LIG_Integrin_RGD_1	682	684	PF01839	0.609
LIG_LIR_Apic_2	113	119	PF02991	0.741
LIG_LIR_Apic_2	569	573	PF02991	0.528
LIG_LIR_Gen_1	408	417	PF02991	0.488
LIG_LIR_Gen_1	511	521	PF02991	0.554
LIG_LIR_Nem_3	408	413	PF02991	0.479
LIG_LIR_Nem_3	511	517	PF02991	0.553
LIG_NRP_CendR_1	770	772	PF00754	0.807
LIG_Pex14_2	270	274	PF04695	0.460
LIG_Pex14_2	406	410	PF04695	0.487
LIG_RPA_C_Fungi	411	423	PF08784	0.495
LIG_SH2_STAP1	252	256	PF00017	0.630
LIG_SH2_STAP1	575	579	PF00017	0.357
LIG_SH2_STAP1	618	622	PF00017	0.656
LIG_SH2_STAT5	252	255	PF00017	0.601
LIG_SH2_STAT5	525	528	PF00017	0.391
LIG_SH2_STAT5	635	638	PF00017	0.593
LIG_SH3_2	185	190	PF14604	0.642
LIG_SH3_3	182	188	PF00018	0.639
LIG_SH3_3	255	261	PF00018	0.664
LIG_SH3_3	273	279	PF00018	0.532
LIG_SH3_3	317	323	PF00018	0.495
LIG_SH3_3	354	360	PF00018	0.492
LIG_SH3_3	44	50	PF00018	0.742
LIG_SH3_3	55	61	PF00018	0.763
LIG_SUMO_SIM_anti_2	465	474	PF11976	0.728
LIG_SUMO_SIM_par_1	95	100	PF11976	0.737
LIG_TRAF2_1	108	111	PF00917	0.752
LIG_TRAF2_1	207	210	PF00917	0.815
LIG_TRAF2_1	262	265	PF00917	0.597
LIG_TRAF2_1	610	613	PF00917	0.676
LIG_UBA3_1	350	356	PF00899	0.419
LIG_WRC_WIRS_1	391	396	PF05994	0.490
LIG_WW_3	117	121	PF00397	0.521
MOD_CDC14_SPxK_1	187	190	PF00782	0.745
MOD_CDK_SPxK_1	184	190	PF00069	0.741
MOD_CK1_1	167	173	PF00069	0.803
MOD_CK1_1	184	190	PF00069	0.762
MOD_CK1_1	195	201	PF00069	0.701
MOD_CK1_1	297	303	PF00069	0.446
MOD_CK1_1	484	490	PF00069	0.641
MOD_CK1_1	505	511	PF00069	0.581
MOD_CK1_1	743	749	PF00069	0.792
MOD_CK1_1	83	89	PF00069	0.542
MOD_CK1_1	9	15	PF00069	0.819
MOD_CK2_1	104	110	PF00069	0.631
MOD_CK2_1	204	210	PF00069	0.771
MOD_CK2_1	230	236	PF00069	0.586
MOD_CK2_1	259	265	PF00069	0.619
MOD_CK2_1	393	399	PF00069	0.542
MOD_CK2_1	656	662	PF00069	0.815
MOD_Cter_Amidation	309	312	PF01082	0.496
MOD_Cter_Amidation	413	416	PF01082	0.504
MOD_Cter_Amidation	677	680	PF01082	0.766
MOD_GlcNHglycan	106	109	PF01048	0.766
MOD_GlcNHglycan	110	115	PF01048	0.767
MOD_GlcNHglycan	166	169	PF01048	0.750
MOD_GlcNHglycan	171	174	PF01048	0.751
MOD_GlcNHglycan	194	198	PF01048	0.775
MOD_GlcNHglycan	219	222	PF01048	0.690
MOD_GlcNHglycan	232	235	PF01048	0.645
MOD_GlcNHglycan	271	274	PF01048	0.623
MOD_GlcNHglycan	35	38	PF01048	0.760
MOD_GlcNHglycan	417	420	PF01048	0.446
MOD_GlcNHglycan	43	46	PF01048	0.770
MOD_GlcNHglycan	483	486	PF01048	0.714
MOD_GlcNHglycan	496	499	PF01048	0.700
MOD_GlcNHglycan	601	604	PF01048	0.611
MOD_GlcNHglycan	64	67	PF01048	0.772
MOD_GlcNHglycan	745	748	PF01048	0.667
MOD_GlcNHglycan	760	763	PF01048	0.548
MOD_GlcNHglycan	99	102	PF01048	0.829
MOD_GSK3_1	169	176	PF00069	0.664
MOD_GSK3_1	217	224	PF00069	0.668
MOD_GSK3_1	226	233	PF00069	0.635
MOD_GSK3_1	398	405	PF00069	0.568
MOD_GSK3_1	424	431	PF00069	0.579
MOD_GSK3_1	446	453	PF00069	0.709
MOD_GSK3_1	494	501	PF00069	0.769
MOD_GSK3_1	739	746	PF00069	0.821
MOD_GSK3_1	9	16	PF00069	0.802
MOD_N-GLC_1	494	499	PF02516	0.724
MOD_N-GLC_1	505	510	PF02516	0.560
MOD_N-GLC_1	670	675	PF02516	0.801
MOD_NEK2_1	314	319	PF00069	0.545
MOD_NEK2_1	636	641	PF00069	0.583
MOD_NEK2_1	71	76	PF00069	0.627
MOD_NEK2_2	341	346	PF00069	0.368
MOD_NEK2_2	747	752	PF00069	0.673
MOD_PIKK_1	118	124	PF00454	0.638
MOD_PIKK_1	382	388	PF00454	0.603
MOD_PK_1	637	643	PF00069	0.589
MOD_PKA_1	415	421	PF00069	0.499
MOD_PKA_1	758	764	PF00069	0.530
MOD_PKA_2	164	170	PF00069	0.515
MOD_PKA_2	39	45	PF00069	0.682
MOD_PKA_2	415	421	PF00069	0.499
MOD_PKA_2	435	441	PF00069	0.448
MOD_PKA_2	6	12	PF00069	0.815
MOD_PKA_2	743	749	PF00069	0.589
MOD_PKA_2	758	764	PF00069	0.497
MOD_PKA_2	83	89	PF00069	0.771
MOD_Plk_1	468	474	PF00069	0.706
MOD_Plk_2-3	204	210	PF00069	0.702
MOD_Plk_2-3	656	662	PF00069	0.723
MOD_Plk_4	468	474	PF00069	0.706
MOD_ProDKin_1	181	187	PF00069	0.803
MOD_ProDKin_1	294	300	PF00069	0.470
MOD_ProDKin_1	398	404	PF00069	0.510
MOD_ProDKin_1	450	456	PF00069	0.791
MOD_SUMO_rev_2	321	325	PF00179	0.615
MOD_SUMO_rev_2	369	378	PF00179	0.517
MOD_SUMO_rev_2	681	688	PF00179	0.740
TRG_DiLeu_BaEn_1	512	517	PF01217	0.556
TRG_DiLeu_BaEn_3	111	117	PF01217	0.749
TRG_DiLeu_BaLyEn_6	278	283	PF01217	0.519
TRG_ENDOCYTIC_2	514	517	PF00928	0.549
TRG_ER_diArg_1	162	165	PF00400	0.745
TRG_ER_diArg_1	345	347	PF00400	0.333
TRG_ER_diArg_1	415	417	PF00400	0.499
TRG_ER_diLys_1	768	772	PF00400	0.777
TRG_NES_CRM1_1	236	248	PF08389	0.563
TRG_NLS_Bipartite_1	679	701	PF00514	0.818
TRG_NLS_Bipartite_1	752	771	PF00514	0.757
TRG_NLS_MonoExtC_3	696	702	PF00514	0.743
TRG_NLS_MonoExtC_3	766	771	PF00514	0.770
TRG_Pf-PMV_PEXEL_1	316	321	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	73	78	PF00026	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8C3	Leptomonas seymouri	61%	100%
A0A0S4JB85	Bodo saltans	47%	100%
A0A3S7X2A3	Leishmania donovani	87%	100%
A4HH75	Leishmania braziliensis	75%	95%
A4I4C1	Leishmania infantum	87%	100%
C9ZL47	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9ADS0	Leishmania major	88%	100%