Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH-ubiquinone oxidoreductase complex I subunit, putative

Species:

Leishmania mexicana

UniProt:

E9AM09_LEIMU

TriTrypDb:

LmxM.08_29.0690

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0005747	mitochondrial respiratory chain complex I	4	1
GO:0020023	kinetoplast	2	1
GO:0030964	NADH dehydrogenase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0045271	respiratory chain complex I	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:0098803	respiratory chain complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1902495	transmembrane transporter complex	3	1
GO:1990204	oxidoreductase complex	3	1
GO:1990351	transporter complex	2	1

Expansion

Sequence features

E9AM09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM09

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	217	221	PF00656	0.251
CLV_NRD_NRD_1	230	232	PF00675	0.431
CLV_PCSK_KEX2_1	230	232	PF00082	0.410
CLV_PCSK_SKI1_1	149	153	PF00082	0.519
CLV_PCSK_SKI1_1	191	195	PF00082	0.564
CLV_PCSK_SKI1_1	242	246	PF00082	0.400
DEG_MDM2_SWIB_1	38	46	PF02201	0.676
DEG_Nend_Nbox_1	1	3	PF02207	0.640
DOC_CDC14_PxL_1	219	227	PF14671	0.397
DOC_CKS1_1	157	162	PF01111	0.553
DOC_MAPK_gen_1	230	237	PF00069	0.411
DOC_USP7_MATH_1	174	178	PF00917	0.356
DOC_USP7_MATH_1	5	9	PF00917	0.728
DOC_USP7_MATH_1	75	79	PF00917	0.623
DOC_USP7_MATH_1	87	91	PF00917	0.508
DOC_USP7_UBL2_3	187	191	PF12436	0.359
DOC_WW_Pin1_4	156	161	PF00397	0.528
DOC_WW_Pin1_4	257	262	PF00397	0.570
DOC_WW_Pin1_4	97	102	PF00397	0.659
LIG_14-3-3_CanoR_1	111	121	PF00244	0.557
LIG_14-3-3_CanoR_1	4	11	PF00244	0.696
LIG_BIR_III_2	220	224	PF00653	0.502
LIG_BRCT_BRCA1_1	189	193	PF00533	0.565
LIG_BRCT_BRCA1_1	90	94	PF00533	0.631
LIG_deltaCOP1_diTrp_1	143	154	PF00928	0.522
LIG_FHA_1	113	119	PF00498	0.527
LIG_FHA_1	257	263	PF00498	0.547
LIG_FHA_2	224	230	PF00498	0.580
LIG_FHA_2	245	251	PF00498	0.447
LIG_GBD_Chelix_1	211	219	PF00786	0.273
LIG_LIR_Gen_1	144	155	PF02991	0.513
LIG_LIR_Gen_1	167	176	PF02991	0.432
LIG_LIR_Nem_3	105	110	PF02991	0.540
LIG_LIR_Nem_3	144	150	PF02991	0.419
LIG_LIR_Nem_3	167	172	PF02991	0.393
LIG_LIR_Nem_3	28	32	PF02991	0.525
LIG_LIR_Nem_3	97	102	PF02991	0.566
LIG_Pex14_1	169	173	PF04695	0.493
LIG_Pex14_2	165	169	PF04695	0.409
LIG_Pex14_2	38	42	PF04695	0.671
LIG_PTB_Apo_2	61	68	PF02174	0.746
LIG_SH2_CRK	107	111	PF00017	0.610
LIG_SH2_NCK_1	173	177	PF00017	0.526
LIG_SH2_SRC	173	176	PF00017	0.355
LIG_SH2_STAP1	205	209	PF00017	0.516
LIG_SH2_STAT5	202	205	PF00017	0.509
LIG_SH3_1	117	123	PF00018	0.515
LIG_SH3_3	117	123	PF00018	0.515
LIG_SUMO_SIM_anti_2	128	133	PF11976	0.466
LIG_TRAF2_1	254	257	PF00917	0.701
LIG_TYR_ITIM	203	208	PF00017	0.530
LIG_UBA3_1	121	127	PF00899	0.281
LIG_WRC_WIRS_1	26	31	PF05994	0.422
MOD_CDK_SPxxK_3	97	104	PF00069	0.658
MOD_CK1_1	156	162	PF00069	0.588
MOD_CK1_1	17	23	PF00069	0.607
MOD_CK1_1	44	50	PF00069	0.594
MOD_CK1_1	6	12	PF00069	0.696
MOD_CK2_1	164	170	PF00069	0.493
MOD_CK2_1	223	229	PF00069	0.586
MOD_CK2_1	97	103	PF00069	0.566
MOD_GlcNHglycan	166	169	PF01048	0.489
MOD_GlcNHglycan	175	179	PF01048	0.439
MOD_GlcNHglycan	19	22	PF01048	0.582
MOD_GlcNHglycan	43	46	PF01048	0.638
MOD_GlcNHglycan	5	8	PF01048	0.704
MOD_GlcNHglycan	73	76	PF01048	0.604
MOD_GlcNHglycan	83	86	PF01048	0.564
MOD_GSK3_1	106	113	PF00069	0.729
MOD_GSK3_1	17	24	PF00069	0.590
MOD_GSK3_1	3	10	PF00069	0.707
MOD_GSK3_1	71	78	PF00069	0.604
MOD_LATS_1	12	18	PF00433	0.444
MOD_N-GLC_1	134	139	PF02516	0.444
MOD_N-GLC_1	81	86	PF02516	0.643
MOD_N-GLC_1	88	93	PF02516	0.671
MOD_NEK2_1	110	115	PF00069	0.705
MOD_NEK2_1	244	249	PF00069	0.525
MOD_NEK2_1	3	8	PF00069	0.686
MOD_NEK2_2	223	228	PF00069	0.519
MOD_NEK2_2	7	12	PF00069	0.733
MOD_PIKK_1	47	53	PF00454	0.589
MOD_PKA_2	110	116	PF00069	0.694
MOD_PKA_2	238	244	PF00069	0.394
MOD_PKA_2	3	9	PF00069	0.707
MOD_Plk_1	223	229	PF00069	0.381
MOD_Plk_4	223	229	PF00069	0.573
MOD_ProDKin_1	156	162	PF00069	0.527
MOD_ProDKin_1	257	263	PF00069	0.573
MOD_ProDKin_1	97	103	PF00069	0.657
TRG_DiLeu_BaLyEn_6	117	122	PF01217	0.324
TRG_ENDOCYTIC_2	107	110	PF00928	0.605
TRG_ENDOCYTIC_2	145	148	PF00928	0.238
TRG_ENDOCYTIC_2	205	208	PF00928	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2P4	Leptomonas seymouri	66%	100%
A0A0S4JHC6	Bodo saltans	37%	100%
A0A1X0P070	Trypanosomatidae	58%	100%
A0A3S7X260	Leishmania donovani	91%	100%
A4HH76	Leishmania braziliensis	84%	100%
A4I4C2	Leishmania infantum	92%	100%
C9ZL46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9ADS1	Leishmania major	90%	100%
V5BQ11	Trypanosoma cruzi	58%	100%