Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AM08_LEIMU

TriTrypDb:

LmxM.08_29.0700

Length:

718

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AM08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM08

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	339	343	PF00656	0.630
CLV_NRD_NRD_1	133	135	PF00675	0.649
CLV_NRD_NRD_1	262	264	PF00675	0.657
CLV_NRD_NRD_1	377	379	PF00675	0.515
CLV_NRD_NRD_1	534	536	PF00675	0.574
CLV_NRD_NRD_1	715	717	PF00675	0.709
CLV_NRD_NRD_1	97	99	PF00675	0.768
CLV_PCSK_FUR_1	260	264	PF00082	0.478
CLV_PCSK_FUR_1	95	99	PF00082	0.762
CLV_PCSK_KEX2_1	262	264	PF00082	0.623
CLV_PCSK_KEX2_1	377	379	PF00082	0.564
CLV_PCSK_KEX2_1	463	465	PF00082	0.558
CLV_PCSK_KEX2_1	534	536	PF00082	0.541
CLV_PCSK_KEX2_1	647	649	PF00082	0.489
CLV_PCSK_KEX2_1	97	99	PF00082	0.762
CLV_PCSK_PC1ET2_1	463	465	PF00082	0.509
CLV_PCSK_PC1ET2_1	647	649	PF00082	0.503
CLV_PCSK_SKI1_1	262	266	PF00082	0.478
CLV_PCSK_SKI1_1	435	439	PF00082	0.555
CLV_PCSK_SKI1_1	440	444	PF00082	0.511
CLV_PCSK_SKI1_1	567	571	PF00082	0.588
CLV_PCSK_SKI1_1	73	77	PF00082	0.609
DEG_SPOP_SBC_1	46	50	PF00917	0.595
DOC_CYCLIN_RxL_1	538	551	PF00134	0.500
DOC_CYCLIN_yCln2_LP_2	206	212	PF00134	0.646
DOC_CYCLIN_yCln2_LP_2	494	500	PF00134	0.723
DOC_MAPK_DCC_7	204	214	PF00069	0.559
DOC_MAPK_gen_1	377	384	PF00069	0.463
DOC_MAPK_gen_1	463	470	PF00069	0.569
DOC_MAPK_gen_1	538	548	PF00069	0.323
DOC_MAPK_gen_1	593	602	PF00069	0.569
DOC_MAPK_MEF2A_6	377	386	PF00069	0.543
DOC_PP1_RVXF_1	202	209	PF00149	0.504
DOC_PP1_RVXF_1	542	549	PF00149	0.608
DOC_PP2B_LxvP_1	469	472	PF13499	0.588
DOC_PP4_FxxP_1	443	446	PF00568	0.511
DOC_PP4_FxxP_1	618	621	PF00568	0.471
DOC_USP7_MATH_1	160	164	PF00917	0.781
DOC_USP7_MATH_1	18	22	PF00917	0.553
DOC_USP7_MATH_1	26	30	PF00917	0.505
DOC_USP7_MATH_1	51	55	PF00917	0.680
DOC_USP7_MATH_1	585	589	PF00917	0.478
DOC_USP7_MATH_1	6	10	PF00917	0.426
DOC_USP7_MATH_1	654	658	PF00917	0.695
DOC_USP7_MATH_1	668	672	PF00917	0.673
DOC_USP7_MATH_1	704	708	PF00917	0.765
DOC_WW_Pin1_4	13	18	PF00397	0.614
DOC_WW_Pin1_4	174	179	PF00397	0.634
DOC_WW_Pin1_4	662	667	PF00397	0.537
DOC_WW_Pin1_4	702	707	PF00397	0.493
LIG_14-3-3_CanoR_1	138	145	PF00244	0.786
LIG_14-3-3_CanoR_1	147	151	PF00244	0.633
LIG_14-3-3_CanoR_1	252	256	PF00244	0.650
LIG_14-3-3_CanoR_1	262	267	PF00244	0.729
LIG_14-3-3_CanoR_1	294	302	PF00244	0.574
LIG_14-3-3_CanoR_1	32	41	PF00244	0.484
LIG_14-3-3_CanoR_1	352	360	PF00244	0.448
LIG_14-3-3_CanoR_1	440	446	PF00244	0.550
LIG_14-3-3_CanoR_1	457	466	PF00244	0.459
LIG_14-3-3_CanoR_1	648	656	PF00244	0.580
LIG_14-3-3_CanoR_1	78	84	PF00244	0.674
LIG_Actin_WH2_2	281	296	PF00022	0.673
LIG_Actin_WH2_2	426	442	PF00022	0.589
LIG_BIR_III_4	342	346	PF00653	0.663
LIG_deltaCOP1_diTrp_1	300	308	PF00928	0.381
LIG_FHA_1	101	107	PF00498	0.723
LIG_FHA_1	159	165	PF00498	0.709
LIG_FHA_1	175	181	PF00498	0.703
LIG_FHA_1	211	217	PF00498	0.482
LIG_FHA_1	272	278	PF00498	0.657
LIG_FHA_1	317	323	PF00498	0.498
LIG_FHA_1	33	39	PF00498	0.259
LIG_FHA_1	352	358	PF00498	0.424
LIG_FHA_1	368	374	PF00498	0.560
LIG_FHA_1	381	387	PF00498	0.434
LIG_FHA_1	454	460	PF00498	0.506
LIG_FHA_1	677	683	PF00498	0.628
LIG_FHA_1	74	80	PF00498	0.643
LIG_FHA_2	105	111	PF00498	0.660
LIG_FHA_2	273	279	PF00498	0.764
LIG_FHA_2	295	301	PF00498	0.471
LIG_FHA_2	442	448	PF00498	0.522
LIG_FHA_2	69	75	PF00498	0.621
LIG_LIR_Apic_2	549	555	PF02991	0.491
LIG_LIR_Nem_3	19	25	PF02991	0.545
LIG_LIR_Nem_3	253	258	PF02991	0.689
LIG_LYPXL_yS_3	255	258	PF13949	0.753
LIG_MYND_1	662	666	PF01753	0.583
LIG_NRBOX	323	329	PF00104	0.431
LIG_PCNA_yPIPBox_3	294	302	PF02747	0.530
LIG_Pex14_2	548	552	PF04695	0.491
LIG_SH2_CRK	379	383	PF00017	0.632
LIG_SH2_NCK_1	23	27	PF00017	0.540
LIG_SH2_SRC	379	382	PF00017	0.553
LIG_SH2_SRC	514	517	PF00017	0.687
LIG_SH2_STAP1	23	27	PF00017	0.560
LIG_SH2_STAT5	27	30	PF00017	0.429
LIG_SH2_STAT5	454	457	PF00017	0.502
LIG_SH2_STAT5	514	517	PF00017	0.667
LIG_SH3_3	261	267	PF00018	0.667
LIG_SH3_3	35	41	PF00018	0.275
LIG_SH3_3	383	389	PF00018	0.507
LIG_SH3_3	476	482	PF00018	0.754
LIG_SH3_3	510	516	PF00018	0.706
LIG_SH3_3	618	624	PF00018	0.523
LIG_SH3_3	660	666	PF00018	0.711
LIG_Sin3_3	8	15	PF02671	0.526
LIG_SUMO_SIM_anti_2	193	199	PF11976	0.462
LIG_SUMO_SIM_anti_2	325	331	PF11976	0.443
LIG_SUMO_SIM_par_1	101	107	PF11976	0.713
LIG_TRAF2_1	560	563	PF00917	0.559
LIG_TRAF2_2	242	247	PF00917	0.562
LIG_UBA3_1	83	92	PF00899	0.564
LIG_WW_1	511	514	PF00397	0.427
MOD_CK1_1	130	136	PF00069	0.688
MOD_CK1_1	137	143	PF00069	0.660
MOD_CK1_1	158	164	PF00069	0.557
MOD_CK1_1	21	27	PF00069	0.534
MOD_CK1_1	251	257	PF00069	0.615
MOD_CK1_1	271	277	PF00069	0.447
MOD_CK1_1	4	10	PF00069	0.589
MOD_CK1_1	45	51	PF00069	0.581
MOD_CK1_1	458	464	PF00069	0.576
MOD_CK1_1	707	713	PF00069	0.795
MOD_CK2_1	146	152	PF00069	0.742
MOD_CK2_1	160	166	PF00069	0.711
MOD_CK2_1	272	278	PF00069	0.775
MOD_CK2_1	294	300	PF00069	0.511
MOD_CK2_1	441	447	PF00069	0.482
MOD_CK2_1	616	622	PF00069	0.734
MOD_CK2_1	68	74	PF00069	0.491
MOD_Cter_Amidation	260	263	PF01082	0.480
MOD_Cter_Amidation	714	717	PF01082	0.659
MOD_GlcNHglycan	100	103	PF01048	0.731
MOD_GlcNHglycan	114	117	PF01048	0.549
MOD_GlcNHglycan	129	132	PF01048	0.738
MOD_GlcNHglycan	140	143	PF01048	0.770
MOD_GlcNHglycan	157	160	PF01048	0.587
MOD_GlcNHglycan	166	170	PF01048	0.701
MOD_GlcNHglycan	191	195	PF01048	0.441
MOD_GlcNHglycan	270	273	PF01048	0.710
MOD_GlcNHglycan	28	31	PF01048	0.532
MOD_GlcNHglycan	280	283	PF01048	0.624
MOD_GlcNHglycan	483	486	PF01048	0.574
MOD_GlcNHglycan	618	621	PF01048	0.532
MOD_GlcNHglycan	656	659	PF01048	0.576
MOD_GlcNHglycan	706	709	PF01048	0.800
MOD_GlcNHglycan	8	11	PF01048	0.533
MOD_GSK3_1	100	107	PF00069	0.696
MOD_GSK3_1	130	137	PF00069	0.657
MOD_GSK3_1	154	161	PF00069	0.495
MOD_GSK3_1	268	275	PF00069	0.762
MOD_GSK3_1	312	319	PF00069	0.557
MOD_GSK3_1	365	372	PF00069	0.609
MOD_GSK3_1	42	49	PF00069	0.546
MOD_GSK3_1	516	523	PF00069	0.656
MOD_GSK3_1	542	549	PF00069	0.413
MOD_GSK3_1	6	13	PF00069	0.525
MOD_GSK3_1	73	80	PF00069	0.630
MOD_N-GLC_1	127	132	PF02516	0.524
MOD_N-GLC_1	294	299	PF02516	0.409
MOD_NEK2_1	1	6	PF00069	0.659
MOD_NEK2_1	104	109	PF00069	0.667
MOD_NEK2_1	250	255	PF00069	0.641
MOD_NEK2_1	293	298	PF00069	0.576
MOD_NEK2_1	323	328	PF00069	0.511
MOD_NEK2_1	367	372	PF00069	0.636
MOD_NEK2_2	18	23	PF00069	0.559
MOD_NEK2_2	34	39	PF00069	0.507
MOD_NEK2_2	51	56	PF00069	0.671
MOD_PIKK_1	240	246	PF00454	0.648
MOD_PIKK_1	316	322	PF00454	0.502
MOD_PIKK_1	401	407	PF00454	0.577
MOD_PIKK_1	419	425	PF00454	0.398
MOD_PIKK_1	585	591	PF00454	0.527
MOD_PIKK_1	647	653	PF00454	0.483
MOD_PIKK_1	707	713	PF00454	0.813
MOD_PKA_1	134	140	PF00069	0.582
MOD_PKA_1	262	268	PF00069	0.480
MOD_PKA_1	647	653	PF00069	0.574
MOD_PKA_2	110	116	PF00069	0.724
MOD_PKA_2	137	143	PF00069	0.645
MOD_PKA_2	146	152	PF00069	0.650
MOD_PKA_2	251	257	PF00069	0.629
MOD_PKA_2	262	268	PF00069	0.649
MOD_PKA_2	293	299	PF00069	0.516
MOD_PKA_2	351	357	PF00069	0.447
MOD_PKA_2	647	653	PF00069	0.555
MOD_PKA_2	77	83	PF00069	0.490
MOD_PKB_1	260	268	PF00069	0.480
MOD_PKB_1	66	74	PF00069	0.537
MOD_Plk_1	18	24	PF00069	0.554
MOD_Plk_1	190	196	PF00069	0.505
MOD_Plk_1	294	300	PF00069	0.406
MOD_Plk_1	435	441	PF00069	0.607
MOD_Plk_1	542	548	PF00069	0.536
MOD_Plk_1	676	682	PF00069	0.636
MOD_Plk_4	18	24	PF00069	0.531
MOD_Plk_4	294	300	PF00069	0.575
MOD_Plk_4	323	329	PF00069	0.466
MOD_Plk_4	34	40	PF00069	0.510
MOD_Plk_4	42	48	PF00069	0.613
MOD_Plk_4	421	427	PF00069	0.618
MOD_Plk_4	51	57	PF00069	0.622
MOD_Plk_4	516	522	PF00069	0.580
MOD_Plk_4	668	674	PF00069	0.722
MOD_ProDKin_1	13	19	PF00069	0.614
MOD_ProDKin_1	174	180	PF00069	0.630
MOD_ProDKin_1	662	668	PF00069	0.552
MOD_ProDKin_1	702	708	PF00069	0.496
TRG_DiLeu_BaLyEn_6	416	421	PF01217	0.542
TRG_DiLeu_BaLyEn_6	552	557	PF01217	0.537
TRG_ENDOCYTIC_2	255	258	PF00928	0.753
TRG_ENDOCYTIC_2	311	314	PF00928	0.476
TRG_ENDOCYTIC_2	379	382	PF00928	0.630
TRG_ER_diArg_1	259	262	PF00400	0.735
TRG_ER_diArg_1	376	378	PF00400	0.411
TRG_ER_diArg_1	534	536	PF00400	0.547
TRG_ER_diArg_1	637	640	PF00400	0.731
TRG_ER_diArg_1	65	68	PF00400	0.550
TRG_ER_diArg_1	95	98	PF00400	0.763

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE66	Leptomonas seymouri	40%	100%
A0A1X0NZK2	Trypanosomatidae	25%	100%
A0A3Q8IEA8	Leishmania donovani	83%	100%
A0A3R7NL89	Trypanosoma rangeli	27%	100%
A4HH77	Leishmania braziliensis	68%	98%
A4I4C3	Leishmania infantum	83%	100%
E9ADS2	Leishmania major	85%	99%
V5BUN1	Trypanosoma cruzi	26%	100%