BBS2_Mid domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

bardet-biedl syndrome 7 protein

Species:

Leishmania mexicana

UniProt:

E9AM07_LEIMU

TriTrypDb:

LmxM.08_29.0710

Length:

855

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0012506	vesicle membrane	4	1
GO:0016020	membrane	2	1
GO:0020018	ciliary pocket membrane	6	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0030665	clathrin-coated vesicle membrane	6	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0032991	protein-containing complex	1	1
GO:0034464	BBSome	2	1
GO:0035869	ciliary transition zone	2	1
GO:0036064	ciliary basal body	3	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0060170	ciliary membrane	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9AM07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM07

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	1
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006826	iron ion transport	8	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030001	metal ion transport	6	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0033036	macromolecule localization	2	1
GO:0033572	transferrin transport	5	1
GO:0044782	cilium organization	5	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0060271	cilium assembly	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070925	organelle assembly	5	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	238	242	PF00656	0.247
CLV_C14_Caspase3-7	299	303	PF00656	0.481
CLV_C14_Caspase3-7	441	445	PF00656	0.226
CLV_NRD_NRD_1	108	110	PF00675	0.370
CLV_NRD_NRD_1	13	15	PF00675	0.439
CLV_NRD_NRD_1	148	150	PF00675	0.498
CLV_NRD_NRD_1	688	690	PF00675	0.559
CLV_PCSK_KEX2_1	13	15	PF00082	0.463
CLV_PCSK_KEX2_1	504	506	PF00082	0.443
CLV_PCSK_KEX2_1	57	59	PF00082	0.558
CLV_PCSK_KEX2_1	644	646	PF00082	0.400
CLV_PCSK_KEX2_1	688	690	PF00082	0.559
CLV_PCSK_KEX2_1	738	740	PF00082	0.526
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.512
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.479
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.558
CLV_PCSK_PC1ET2_1	644	646	PF00082	0.405
CLV_PCSK_PC1ET2_1	738	740	PF00082	0.526
CLV_PCSK_SKI1_1	112	116	PF00082	0.385
CLV_PCSK_SKI1_1	15	19	PF00082	0.440
CLV_PCSK_SKI1_1	223	227	PF00082	0.481
CLV_PCSK_SKI1_1	35	39	PF00082	0.250
CLV_PCSK_SKI1_1	602	606	PF00082	0.467
CLV_PCSK_SKI1_1	629	633	PF00082	0.406
CLV_PCSK_SKI1_1	84	88	PF00082	0.491
DEG_APCC_DBOX_1	579	587	PF00400	0.430
DEG_Nend_UBRbox_2	1	3	PF02207	0.432
DEG_ODPH_VHL_1	156	168	PF01847	0.485
DEG_SPOP_SBC_1	473	477	PF00917	0.722
DEG_SPOP_SBC_1	801	805	PF00917	0.555
DOC_CDC14_PxL_1	590	598	PF14671	0.405
DOC_CDC14_PxL_1	706	714	PF14671	0.482
DOC_CKS1_1	130	135	PF01111	0.360
DOC_CKS1_1	65	70	PF01111	0.467
DOC_CYCLIN_RxL_1	219	229	PF00134	0.496
DOC_MAPK_gen_1	35	43	PF00069	0.381
DOC_MAPK_gen_1	504	512	PF00069	0.388
DOC_MAPK_gen_1	57	65	PF00069	0.492
DOC_MAPK_gen_1	644	650	PF00069	0.435
DOC_MAPK_MEF2A_6	160	168	PF00069	0.446
DOC_MAPK_MEF2A_6	405	414	PF00069	0.588
DOC_MAPK_MEF2A_6	57	65	PF00069	0.530
DOC_PP1_RVXF_1	148	155	PF00149	0.479
DOC_PP1_RVXF_1	221	227	PF00149	0.496
DOC_PP4_FxxP_1	155	158	PF00568	0.503
DOC_PP4_FxxP_1	65	68	PF00568	0.439
DOC_USP7_MATH_1	439	443	PF00917	0.436
DOC_USP7_MATH_1	678	682	PF00917	0.515
DOC_USP7_MATH_1	832	836	PF00917	0.594
DOC_USP7_MATH_1	838	842	PF00917	0.678
DOC_USP7_MATH_1	849	853	PF00917	0.583
DOC_WW_Pin1_4	129	134	PF00397	0.361
DOC_WW_Pin1_4	412	417	PF00397	0.507
DOC_WW_Pin1_4	422	427	PF00397	0.443
DOC_WW_Pin1_4	474	479	PF00397	0.746
DOC_WW_Pin1_4	494	499	PF00397	0.384
DOC_WW_Pin1_4	64	69	PF00397	0.452
DOC_WW_Pin1_4	840	845	PF00397	0.555
DOC_WW_Pin1_4	847	852	PF00397	0.615
LIG_14-3-3_CanoR_1	257	265	PF00244	0.441
LIG_14-3-3_CanoR_1	317	322	PF00244	0.461
LIG_14-3-3_CanoR_1	521	525	PF00244	0.539
LIG_Actin_WH2_2	181	198	PF00022	0.452
LIG_BRCT_BRCA1_1	261	265	PF00533	0.528
LIG_BRCT_BRCA1_1	414	418	PF00533	0.433
LIG_FHA_1	120	126	PF00498	0.397
LIG_FHA_1	130	136	PF00498	0.346
LIG_FHA_1	212	218	PF00498	0.408
LIG_FHA_1	392	398	PF00498	0.474
LIG_FHA_1	464	470	PF00498	0.538
LIG_FHA_1	482	488	PF00498	0.566
LIG_FHA_1	530	536	PF00498	0.428
LIG_FHA_1	552	558	PF00498	0.534
LIG_FHA_1	613	619	PF00498	0.447
LIG_FHA_1	802	808	PF00498	0.664
LIG_FHA_2	143	149	PF00498	0.475
LIG_FHA_2	236	242	PF00498	0.233
LIG_FHA_2	297	303	PF00498	0.507
LIG_FHA_2	377	383	PF00498	0.585
LIG_FHA_2	423	429	PF00498	0.498
LIG_FHA_2	439	445	PF00498	0.260
LIG_FHA_2	702	708	PF00498	0.590
LIG_FHA_2	788	794	PF00498	0.598
LIG_LIR_Gen_1	131	142	PF02991	0.423
LIG_LIR_Gen_1	262	270	PF02991	0.531
LIG_LIR_Gen_1	747	756	PF02991	0.525
LIG_LIR_LC3C_4	434	437	PF02991	0.511
LIG_LIR_Nem_3	131	137	PF02991	0.460
LIG_LIR_Nem_3	262	268	PF02991	0.525
LIG_LIR_Nem_3	47	53	PF02991	0.466
LIG_LIR_Nem_3	747	751	PF02991	0.469
LIG_LYPXL_S_1	676	680	PF13949	0.494
LIG_LYPXL_yS_3	677	680	PF13949	0.500
LIG_PCNA_yPIPBox_3	191	202	PF02747	0.463
LIG_Pex14_2	605	609	PF04695	0.434
LIG_SH2_NCK_1	546	550	PF00017	0.386
LIG_SH2_PTP2	167	170	PF00017	0.453
LIG_SH2_PTP2	537	540	PF00017	0.496
LIG_SH2_PTP2	815	818	PF00017	0.634
LIG_SH2_SRC	280	283	PF00017	0.420
LIG_SH2_STAP1	525	529	PF00017	0.569
LIG_SH2_STAT3	227	230	PF00017	0.450
LIG_SH2_STAT3	525	528	PF00017	0.525
LIG_SH2_STAT5	167	170	PF00017	0.483
LIG_SH2_STAT5	184	187	PF00017	0.362
LIG_SH2_STAT5	537	540	PF00017	0.496
LIG_SH2_STAT5	736	739	PF00017	0.374
LIG_SH2_STAT5	750	753	PF00017	0.394
LIG_SH2_STAT5	815	818	PF00017	0.634
LIG_SH2_STAT5	98	101	PF00017	0.488
LIG_SUMO_SIM_anti_2	566	572	PF11976	0.498
LIG_SUMO_SIM_par_1	410	415	PF11976	0.496
LIG_SUMO_SIM_par_1	6	11	PF11976	0.483
LIG_SUMO_SIM_par_1	612	617	PF11976	0.463
LIG_SUMO_SIM_par_1	636	642	PF11976	0.335
LIG_TRAF2_1	719	722	PF00917	0.511
LIG_TRAF2_1	731	734	PF00917	0.504
LIG_TRAF2_1	790	793	PF00917	0.621
LIG_TRFH_1	154	158	PF08558	0.484
LIG_TYR_ITIM	535	540	PF00017	0.499
LIG_WRC_WIRS_1	337	342	PF05994	0.368
LIG_WRC_WIRS_1	745	750	PF05994	0.499
MOD_CDK_SPxxK_3	412	419	PF00069	0.541
MOD_CDK_SPxxK_3	847	854	PF00069	0.455
MOD_CK1_1	438	444	PF00069	0.226
MOD_CK1_1	477	483	PF00069	0.739
MOD_CK1_1	551	557	PF00069	0.534
MOD_CK1_1	612	618	PF00069	0.457
MOD_CK1_1	636	642	PF00069	0.373
MOD_CK1_1	681	687	PF00069	0.522
MOD_CK1_1	840	846	PF00069	0.605
MOD_CK2_1	142	148	PF00069	0.463
MOD_CK2_1	310	316	PF00069	0.451
MOD_CK2_1	376	382	PF00069	0.573
MOD_CK2_1	422	428	PF00069	0.521
MOD_CK2_1	656	662	PF00069	0.488
MOD_CK2_1	716	722	PF00069	0.469
MOD_CK2_1	74	80	PF00069	0.648
MOD_CK2_1	787	793	PF00069	0.604
MOD_Cter_Amidation	55	58	PF01082	0.523
MOD_GlcNHglycan	170	173	PF01048	0.438
MOD_GlcNHglycan	2	5	PF01048	0.718
MOD_GlcNHglycan	21	24	PF01048	0.309
MOD_GlcNHglycan	219	222	PF01048	0.398
MOD_GlcNHglycan	230	233	PF01048	0.395
MOD_GlcNHglycan	340	343	PF01048	0.361
MOD_GlcNHglycan	437	440	PF01048	0.510
MOD_GlcNHglycan	481	484	PF01048	0.718
MOD_GlcNHglycan	525	528	PF01048	0.523
MOD_GlcNHglycan	557	560	PF01048	0.534
MOD_GlcNHglycan	718	721	PF01048	0.532
MOD_GlcNHglycan	76	79	PF01048	0.664
MOD_GlcNHglycan	833	837	PF01048	0.542
MOD_GlcNHglycan	839	843	PF01048	0.539
MOD_GSK3_1	15	22	PF00069	0.384
MOD_GSK3_1	226	233	PF00069	0.388
MOD_GSK3_1	290	297	PF00069	0.513
MOD_GSK3_1	391	398	PF00069	0.561
MOD_GSK3_1	410	417	PF00069	0.486
MOD_GSK3_1	418	425	PF00069	0.442
MOD_GSK3_1	431	438	PF00069	0.479
MOD_GSK3_1	452	459	PF00069	0.483
MOD_GSK3_1	472	479	PF00069	0.413
MOD_GSK3_1	488	495	PF00069	0.377
MOD_GSK3_1	516	523	PF00069	0.444
MOD_GSK3_1	548	555	PF00069	0.538
MOD_GSK3_1	67	74	PF00069	0.554
MOD_GSK3_1	678	685	PF00069	0.505
MOD_GSK3_1	802	809	PF00069	0.647
MOD_GSK3_1	838	845	PF00069	0.716
MOD_N-GLC_1	119	124	PF02516	0.402
MOD_N-GLC_1	656	661	PF02516	0.504
MOD_NEK2_1	141	146	PF00069	0.359
MOD_NEK2_1	226	231	PF00069	0.486
MOD_NEK2_1	292	297	PF00069	0.538
MOD_NEK2_1	336	341	PF00069	0.368
MOD_NEK2_1	418	423	PF00069	0.414
MOD_NEK2_1	520	525	PF00069	0.417
MOD_NEK2_1	609	614	PF00069	0.396
MOD_NEK2_1	656	661	PF00069	0.446
MOD_NEK2_1	665	670	PF00069	0.405
MOD_NEK2_1	679	684	PF00069	0.426
MOD_NEK2_1	744	749	PF00069	0.351
MOD_NEK2_1	8	13	PF00069	0.361
MOD_NEK2_1	802	807	PF00069	0.562
MOD_NEK2_1	818	823	PF00069	0.531
MOD_NEK2_1	837	842	PF00069	0.496
MOD_PIKK_1	226	232	PF00454	0.429
MOD_PIKK_1	355	361	PF00454	0.610
MOD_PIKK_1	376	382	PF00454	0.573
MOD_PIKK_1	477	483	PF00454	0.675
MOD_PIKK_1	683	689	PF00454	0.533
MOD_PK_1	294	300	PF00069	0.537
MOD_PK_1	317	323	PF00069	0.479
MOD_PK_1	51	57	PF00069	0.481
MOD_PK_1	548	554	PF00069	0.493
MOD_PKA_2	256	262	PF00069	0.561
MOD_PKA_2	520	526	PF00069	0.496
MOD_PKB_1	393	401	PF00069	0.636
MOD_Plk_1	439	445	PF00069	0.439
MOD_Plk_1	552	558	PF00069	0.604
MOD_Plk_1	787	793	PF00069	0.558
MOD_Plk_1	832	838	PF00069	0.444
MOD_Plk_4	212	218	PF00069	0.389
MOD_Plk_4	304	310	PF00069	0.408
MOD_Plk_4	431	437	PF00069	0.472
MOD_Plk_4	452	458	PF00069	0.493
MOD_Plk_4	520	526	PF00069	0.464
MOD_Plk_4	552	558	PF00069	0.617
MOD_Plk_4	609	615	PF00069	0.382
MOD_Plk_4	633	639	PF00069	0.387
MOD_Plk_4	665	671	PF00069	0.405
MOD_Plk_4	802	808	PF00069	0.450
MOD_Plk_4	87	93	PF00069	0.381
MOD_Plk_4	99	105	PF00069	0.351
MOD_ProDKin_1	129	135	PF00069	0.356
MOD_ProDKin_1	412	418	PF00069	0.490
MOD_ProDKin_1	422	428	PF00069	0.450
MOD_ProDKin_1	474	480	PF00069	0.744
MOD_ProDKin_1	494	500	PF00069	0.391
MOD_ProDKin_1	64	70	PF00069	0.463
MOD_ProDKin_1	840	846	PF00069	0.558
MOD_ProDKin_1	847	853	PF00069	0.615
MOD_SUMO_for_1	374	377	PF00179	0.317
MOD_SUMO_rev_2	147	152	PF00179	0.557
MOD_SUMO_rev_2	76	86	PF00179	0.658
TRG_DiLeu_BaEn_2	150	156	PF01217	0.541
TRG_DiLeu_BaEn_3	598	604	PF01217	0.490
TRG_DiLeu_BaLyEn_6	220	225	PF01217	0.483
TRG_DiLeu_BaLyEn_6	564	569	PF01217	0.508
TRG_ENDOCYTIC_2	537	540	PF00928	0.437
TRG_ENDOCYTIC_2	546	549	PF00928	0.341
TRG_ENDOCYTIC_2	677	680	PF00928	0.500
TRG_ENDOCYTIC_2	745	748	PF00928	0.402
TRG_ENDOCYTIC_2	815	818	PF00928	0.634
TRG_ER_diArg_1	688	690	PF00400	0.559
TRG_NLS_MonoExtN_4	32	39	PF00514	0.427
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	387	392	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.624
TRG_Pf-PMV_PEXEL_1	645	649	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	694	698	PF00026	0.271

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7W9	Leptomonas seymouri	62%	100%
A0A1X0NZL6	Trypanosomatidae	35%	100%
A0A3Q8IR58	Leishmania donovani	92%	100%
A0A422NRV6	Trypanosoma rangeli	35%	100%
A4HH78	Leishmania braziliensis	80%	100%
A4I4C4	Leishmania infantum	92%	100%
C9ZL44	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ADS3	Leishmania major	92%	100%
Q8IWZ6	Homo sapiens	24%	100%
Q8K2G4	Mus musculus	24%	100%
V5BKF4	Trypanosoma cruzi	35%	100%