E3 ubiquitin-protein ligase RNF220

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AM05_LEIMU

TriTrypDb:

LmxM.08_29.0730

Length:

225

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AM05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM05

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.705
CLV_C14_Caspase3-7	130	134	PF00656	0.563
CLV_C14_Caspase3-7	167	171	PF00656	0.613
CLV_NRD_NRD_1	16	18	PF00675	0.728
CLV_NRD_NRD_1	3	5	PF00675	0.532
CLV_NRD_NRD_1	36	38	PF00675	0.480
CLV_NRD_NRD_1	48	50	PF00675	0.595
CLV_NRD_NRD_1	99	101	PF00675	0.642
CLV_PCSK_KEX2_1	16	18	PF00082	0.728
CLV_PCSK_KEX2_1	3	5	PF00082	0.532
CLV_PCSK_KEX2_1	36	38	PF00082	0.480
CLV_PCSK_KEX2_1	48	50	PF00082	0.595
CLV_PCSK_KEX2_1	88	90	PF00082	0.626
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.566
CLV_PCSK_PC7_1	12	18	PF00082	0.616
CLV_PCSK_SKI1_1	148	152	PF00082	0.521
CLV_PCSK_SKI1_1	210	214	PF00082	0.571
CLV_PCSK_SKI1_1	41	45	PF00082	0.580
CLV_PCSK_SKI1_1	94	98	PF00082	0.669
DEG_APCC_DBOX_1	209	217	PF00400	0.388
DEG_Nend_Nbox_1	1	3	PF02207	0.756
DEG_SPOP_SBC_1	127	131	PF00917	0.543
DOC_PP2B_LxvP_1	173	176	PF13499	0.581
DOC_USP7_MATH_1	108	112	PF00917	0.586
DOC_USP7_MATH_1	127	131	PF00917	0.755
DOC_USP7_MATH_1	177	181	PF00917	0.623
DOC_USP7_MATH_1	190	194	PF00917	0.434
DOC_USP7_MATH_1	219	223	PF00917	0.436
DOC_WW_Pin1_4	113	118	PF00397	0.748
DOC_WW_Pin1_4	155	160	PF00397	0.713
DOC_WW_Pin1_4	4	9	PF00397	0.700
LIG_14-3-3_CanoR_1	100	104	PF00244	0.512
LIG_14-3-3_CanoR_1	3	8	PF00244	0.694
LIG_14-3-3_CanoR_1	67	71	PF00244	0.599
LIG_APCC_ABBA_1	118	123	PF00400	0.722
LIG_BRCT_BRCA1_1	27	31	PF00533	0.463
LIG_FHA_1	167	173	PF00498	0.733
LIG_FHA_1	38	44	PF00498	0.509
LIG_FHA_2	104	110	PF00498	0.692
LIG_FHA_2	55	61	PF00498	0.592
LIG_LIR_Gen_1	191	202	PF02991	0.592
LIG_LIR_Nem_3	191	197	PF02991	0.587
LIG_LIR_Nem_3	200	206	PF02991	0.590
LIG_SH2_CRK	68	72	PF00017	0.653
LIG_SH2_NCK_1	68	72	PF00017	0.653
LIG_SH2_STAP1	181	185	PF00017	0.576
LIG_SH2_STAT5	68	71	PF00017	0.599
LIG_SH3_3	111	117	PF00018	0.674
LIG_SH3_3	156	162	PF00018	0.638
LIG_SH3_3	199	205	PF00018	0.572
LIG_SUMO_SIM_anti_2	195	201	PF11976	0.410
LIG_SUMO_SIM_par_1	195	201	PF11976	0.410
LIG_TRAF2_1	180	183	PF00917	0.566
LIG_UBA3_1	213	220	PF00899	0.401
MOD_CK1_1	112	118	PF00069	0.658
MOD_CK1_1	128	134	PF00069	0.678
MOD_CK1_1	155	161	PF00069	0.715
MOD_CK1_1	171	177	PF00069	0.593
MOD_CK1_1	82	88	PF00069	0.505
MOD_CK1_1	95	101	PF00069	0.732
MOD_CK2_1	158	164	PF00069	0.812
MOD_CK2_1	177	183	PF00069	0.576
MOD_Cter_Amidation	86	89	PF01082	0.560
MOD_Cter_Amidation	98	101	PF01082	0.489
MOD_DYRK1A_RPxSP_1	4	8	PF00069	0.522
MOD_GlcNHglycan	103	106	PF01048	0.735
MOD_GlcNHglycan	111	114	PF01048	0.663
MOD_GlcNHglycan	185	188	PF01048	0.689
MOD_GlcNHglycan	85	88	PF01048	0.752
MOD_GlcNHglycan	94	97	PF01048	0.696
MOD_GSK3_1	108	115	PF00069	0.751
MOD_GSK3_1	127	134	PF00069	0.691
MOD_GSK3_1	148	155	PF00069	0.630
MOD_GSK3_1	171	178	PF00069	0.718
MOD_GSK3_1	188	195	PF00069	0.545
MOD_GSK3_1	25	32	PF00069	0.653
MOD_GSK3_1	4	11	PF00069	0.541
MOD_GSK3_1	66	73	PF00069	0.653
MOD_GSK3_1	79	86	PF00069	0.704
MOD_GSK3_1	88	95	PF00069	0.706
MOD_GSK3_1	99	106	PF00069	0.632
MOD_LATS_1	81	87	PF00433	0.591
MOD_LATS_1	92	98	PF00433	0.686
MOD_N-GLC_1	152	157	PF02516	0.673
MOD_N-GLC_1	18	23	PF02516	0.714
MOD_NEK2_1	103	108	PF00069	0.643
MOD_NEK2_1	2	7	PF00069	0.742
MOD_NEK2_1	25	30	PF00069	0.762
MOD_NEK2_1	43	48	PF00069	0.507
MOD_NEK2_1	54	59	PF00069	0.532
MOD_PIKK_1	43	49	PF00454	0.579
MOD_PK_1	168	174	PF00069	0.722
MOD_PKA_1	148	154	PF00069	0.642
MOD_PKA_1	3	9	PF00069	0.528
MOD_PKA_1	88	94	PF00069	0.514
MOD_PKA_2	131	137	PF00069	0.686
MOD_PKA_2	2	8	PF00069	0.695
MOD_PKA_2	66	72	PF00069	0.601
MOD_PKA_2	79	85	PF00069	0.691
MOD_PKA_2	88	94	PF00069	0.661
MOD_PKA_2	99	105	PF00069	0.567
MOD_Plk_1	152	158	PF00069	0.662
MOD_Plk_4	168	174	PF00069	0.586
MOD_Plk_4	71	77	PF00069	0.692
MOD_ProDKin_1	113	119	PF00069	0.747
MOD_ProDKin_1	155	161	PF00069	0.714
MOD_ProDKin_1	4	10	PF00069	0.700
TRG_DiLeu_BaEn_1	209	214	PF01217	0.635
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.585
TRG_ENDOCYTIC_2	203	206	PF00928	0.581
TRG_ER_diArg_1	2	4	PF00400	0.537
TRG_ER_diArg_1	36	38	PF00400	0.703
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I154	Leptomonas seymouri	40%	98%
A0A3Q8IF96	Leishmania donovani	79%	100%
A4HH80	Leishmania braziliensis	59%	100%
A4I4C6	Leishmania infantum	77%	100%
E9ADS5	Leishmania major	80%	100%