Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxisomal targeting signal 2 receptor, putative

Species:

Leishmania mexicana

UniProt:

E9AM04_LEIMU

TriTrypDb:

LmxM.08_29.0740

Length:

373

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	11
GO:0005840	ribosome	5	11
GO:0032991	protein-containing complex	1	11
GO:0042579	microbody	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005737	cytoplasm	2	1
GO:0005782	peroxisomal matrix	6	1
GO:0005829	cytosol	2	1
GO:0020015	glycosome	7	1
GO:0031907	microbody lumen	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1

Expansion

Sequence features

E9AM04

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM04

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	11
GO:0006625	protein targeting to peroxisome	5	11
GO:0006810	transport	3	11
GO:0006886	intracellular protein transport	4	11
GO:0006996	organelle organization	4	11
GO:0007031	peroxisome organization	5	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0015919	peroxisomal membrane transport	5	11
GO:0016043	cellular component organization	3	11
GO:0016558	protein import into peroxisome matrix	5	11
GO:0033036	macromolecule localization	2	11
GO:0033365	protein localization to organelle	5	11
GO:0043574	peroxisomal transport	4	11
GO:0044743	protein transmembrane import into intracellular organelle	4	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0055085	transmembrane transport	2	11
GO:0065002	intracellular protein transmembrane transport	4	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0071806	protein transmembrane transport	3	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0072594	establishment of protein localization to organelle	4	11
GO:0072662	protein localization to peroxisome	6	11
GO:0072663	establishment of protein localization to peroxisome	5	11

Molecular functions
Term	Name	Level	Count
GO:0000268	peroxisome targeting sequence binding	5	11
GO:0005048	signal sequence binding	4	11
GO:0005053	peroxisome matrix targeting signal-2 binding	6	11
GO:0005488	binding	1	11
GO:0033218	amide binding	2	11
GO:0042277	peptide binding	3	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.513
CLV_NRD_NRD_1	233	235	PF00675	0.419
CLV_NRD_NRD_1	250	252	PF00675	0.231
CLV_PCSK_KEX2_1	125	127	PF00082	0.513
CLV_PCSK_KEX2_1	233	235	PF00082	0.431
CLV_PCSK_KEX2_1	250	252	PF00082	0.261
CLV_PCSK_SKI1_1	192	196	PF00082	0.471
DEG_APCC_DBOX_1	191	199	PF00400	0.444
DOC_CKS1_1	62	67	PF01111	0.320
DOC_CYCLIN_yClb5_NLxxxL_5	89	98	PF00134	0.434
DOC_MAPK_JIP1_4	21	27	PF00069	0.424
DOC_PP1_RVXF_1	248	255	PF00149	0.474
DOC_USP7_MATH_1	11	15	PF00917	0.408
DOC_USP7_MATH_1	114	118	PF00917	0.471
DOC_USP7_MATH_1	120	124	PF00917	0.488
DOC_USP7_MATH_1	146	150	PF00917	0.409
DOC_USP7_MATH_1	190	194	PF00917	0.546
DOC_USP7_MATH_1	238	242	PF00917	0.507
DOC_USP7_MATH_1	306	310	PF00917	0.396
DOC_USP7_MATH_1	325	329	PF00917	0.407
DOC_USP7_MATH_1	52	56	PF00917	0.255
DOC_WW_Pin1_4	166	171	PF00397	0.499
DOC_WW_Pin1_4	186	191	PF00397	0.500
DOC_WW_Pin1_4	365	370	PF00397	0.735
DOC_WW_Pin1_4	61	66	PF00397	0.408
LIG_14-3-3_CanoR_1	251	261	PF00244	0.531
LIG_BRCT_BRCA1_1	206	210	PF00533	0.513
LIG_BRCT_BRCA1_1	29	33	PF00533	0.452
LIG_BRCT_BRCA1_1	314	318	PF00533	0.455
LIG_BRCT_BRCA1_2	206	212	PF00533	0.513
LIG_deltaCOP1_diTrp_1	179	185	PF00928	0.461
LIG_FHA_1	21	27	PF00498	0.419
LIG_FHA_1	224	230	PF00498	0.473
LIG_FHA_1	324	330	PF00498	0.643
LIG_FHA_1	346	352	PF00498	0.680
LIG_FHA_2	150	156	PF00498	0.407
LIG_IRF3_LxIS_1	22	28	PF10401	0.336
LIG_LIR_Gen_1	70	81	PF02991	0.369
LIG_LIR_Nem_3	155	160	PF02991	0.511
LIG_LIR_Nem_3	30	36	PF02991	0.511
LIG_LIR_Nem_3	315	321	PF02991	0.470
LIG_LIR_Nem_3	70	76	PF02991	0.442
LIG_MLH1_MIPbox_1	314	318	PF16413	0.455
LIG_NRP_CendR_1	370	373	PF00754	0.758
LIG_Pex14_2	69	73	PF04695	0.347
LIG_SH2_CRK	141	145	PF00017	0.510
LIG_SH2_NCK_1	161	165	PF00017	0.540
LIG_SH2_SRC	287	290	PF00017	0.448
LIG_SH2_STAP1	130	134	PF00017	0.427
LIG_SH2_STAP1	267	271	PF00017	0.461
LIG_SH2_STAT5	42	45	PF00017	0.389
LIG_SH3_1	16	22	PF00018	0.414
LIG_SH3_1	349	355	PF00018	0.556
LIG_SH3_3	16	22	PF00018	0.453
LIG_SH3_3	232	238	PF00018	0.451
LIG_SH3_3	276	282	PF00018	0.438
LIG_SH3_3	333	339	PF00018	0.555
LIG_SH3_3	340	346	PF00018	0.630
LIG_SH3_3	349	355	PF00018	0.547
LIG_SH3_3	366	372	PF00018	0.724
LIG_SUMO_SIM_anti_2	147	152	PF11976	0.357
LIG_SUMO_SIM_anti_2	54	60	PF11976	0.457
LIG_SUMO_SIM_par_1	204	209	PF11976	0.461
LIG_TRAF2_1	152	155	PF00917	0.465
LIG_WRC_WIRS_1	1	6	PF05994	0.453
LIG_WW_3	339	343	PF00397	0.542
MOD_CDC14_SPxK_1	189	192	PF00782	0.543
MOD_CDK_SPK_2	365	370	PF00069	0.739
MOD_CDK_SPxK_1	186	192	PF00069	0.544
MOD_CK1_1	133	139	PF00069	0.399
MOD_CK1_1	14	20	PF00069	0.525
MOD_CK1_1	149	155	PF00069	0.396
MOD_CK1_1	169	175	PF00069	0.328
MOD_CK1_1	193	199	PF00069	0.337
MOD_CK1_1	54	60	PF00069	0.457
MOD_CK2_1	149	155	PF00069	0.410
MOD_CMANNOS	182	185	PF00535	0.261
MOD_Cter_Amidation	123	126	PF01082	0.511
MOD_GlcNHglycan	122	125	PF01048	0.560
MOD_GlcNHglycan	130	133	PF01048	0.465
MOD_GlcNHglycan	141	144	PF01048	0.282
MOD_GlcNHglycan	176	179	PF01048	0.261
MOD_GlcNHglycan	219	222	PF01048	0.313
MOD_GlcNHglycan	264	267	PF01048	0.245
MOD_GlcNHglycan	308	311	PF01048	0.358
MOD_GlcNHglycan	313	317	PF01048	0.362
MOD_GlcNHglycan	356	359	PF01048	0.455
MOD_GlcNHglycan	37	40	PF01048	0.364
MOD_GSK3_1	130	137	PF00069	0.377
MOD_GSK3_1	162	169	PF00069	0.515
MOD_GSK3_1	174	181	PF00069	0.413
MOD_GSK3_1	186	193	PF00069	0.446
MOD_GSK3_1	253	260	PF00069	0.542
MOD_GSK3_1	308	315	PF00069	0.392
MOD_GSK3_1	361	368	PF00069	0.721
MOD_N-GLC_1	186	191	PF02516	0.494
MOD_NEK2_1	25	30	PF00069	0.386
MOD_NEK2_1	261	266	PF00069	0.491
MOD_NEK2_1	297	302	PF00069	0.373
MOD_NEK2_1	317	322	PF00069	0.452
MOD_NEK2_1	363	368	PF00069	0.701
MOD_NEK2_1	94	99	PF00069	0.509
MOD_NEK2_2	11	16	PF00069	0.411
MOD_NEK2_2	134	139	PF00069	0.380
MOD_PIKK_1	193	199	PF00454	0.329
MOD_PIKK_1	20	26	PF00454	0.407
MOD_PIKK_1	27	33	PF00454	0.388
MOD_PIKK_1	297	303	PF00454	0.488
MOD_PKA_1	125	131	PF00069	0.473
MOD_PKA_2	125	131	PF00069	0.452
MOD_PKA_2	252	258	PF00069	0.540
MOD_PKB_1	251	259	PF00069	0.564
MOD_Plk_1	114	120	PF00069	0.477
MOD_Plk_1	134	140	PF00069	0.448
MOD_Plk_1	146	152	PF00069	0.463
MOD_Plk_1	223	229	PF00069	0.482
MOD_Plk_4	125	131	PF00069	0.421
MOD_Plk_4	146	152	PF00069	0.446
MOD_Plk_4	169	175	PF00069	0.461
MOD_Plk_4	257	263	PF00069	0.540
MOD_Plk_4	54	60	PF00069	0.457
MOD_ProDKin_1	166	172	PF00069	0.499
MOD_ProDKin_1	186	192	PF00069	0.505
MOD_ProDKin_1	365	371	PF00069	0.712
MOD_ProDKin_1	61	67	PF00069	0.407
MOD_SUMO_for_1	144	147	PF00179	0.533
TRG_ENDOCYTIC_2	141	144	PF00928	0.525
TRG_ER_diArg_1	233	235	PF00400	0.433
TRG_ER_diArg_1	250	253	PF00400	0.474
TRG_ER_diArg_1	344	347	PF00400	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHN2	Leptomonas seymouri	25%	71%
A0A0N1IM97	Leptomonas seymouri	85%	100%
A0A0S4JHX6	Bodo saltans	52%	92%
A0A1X0P138	Trypanosomatidae	64%	100%
A0A3Q8IF18	Leishmania donovani	97%	100%
A0A3Q8IGC4	Leishmania donovani	26%	71%
A4HDT7	Leishmania braziliensis	25%	71%
A4HH81	Leishmania braziliensis	91%	100%
A4I135	Leishmania infantum	26%	71%
A4I4C7	Leishmania infantum	97%	100%
B4JWA1	Drosophila grimshawi	26%	91%
B8M0Q1	Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)	26%	81%
C9ZL39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
D1ZEB4	Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)	24%	81%
E9AX72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	71%
F6ZT52	Xenopus tropicalis	27%	79%
O00628	Homo sapiens	33%	100%
O14021	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	87%
O22212	Arabidopsis thaliana	26%	67%
O59894	Komagataella pastoris	29%	99%
O94244	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	87%
P0CS36	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	22%	86%
P0CS37	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	22%	86%
P39108	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	99%
P49177	Arabidopsis thaliana	24%	99%
P78798	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
P93397	Nicotiana tabacum	24%	99%
P93398	Nicotiana tabacum	24%	99%
P93563	Solanum tuberosum	23%	99%
P97865	Mus musculus	34%	100%
Q17963	Caenorhabditis elegans	24%	99%
Q2UA71	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	23%	86%
Q40507	Nicotiana tabacum	24%	99%
Q4I7L0	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	22%	86%
Q4QAA4	Leishmania major	26%	71%
Q4VQ66	Leishmania major	95%	100%
Q4WEI5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	86%
Q54WA3	Dictyostelium discoideum	35%	100%
Q6BK34	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	22%	90%
Q6C7Q4	Yarrowia lipolytica (strain CLIB 122 / E 150)	24%	83%
Q6NPN9	Arabidopsis thaliana	24%	100%
Q6NX08	Danio rerio	26%	88%
Q6P315	Xenopus tropicalis	30%	88%
Q75C99	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	25%	88%
Q7RY30	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	24%	82%
Q7S7N3	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	22%	84%
Q8JZX3	Mus musculus	26%	92%
Q8R537	Cricetulus griseus	34%	100%
Q9XF57	Arabidopsis thaliana	38%	100%
V5BEB2	Trypanosoma cruzi	24%	69%
V5BQ16	Trypanosoma cruzi	65%	100%