Putative U3 small nucleolar ribonucleoprotein protein MPP10

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U3 small nucleolar ribonucleoprotein protein MPP10, putative

Species:

Leishmania mexicana

UniProt:

E9AM03_LEIMU

TriTrypDb:

LmxM.08_29.0750

Length:

679

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005732	sno(s)RNA-containing ribonucleoprotein complex	3	10
GO:0032991	protein-containing complex	1	10
GO:0034457	Mpp10 complex	3	10
GO:0140513	nuclear protein-containing complex	2	10
GO:1990904	ribonucleoprotein complex	2	10
GO:0005730	nucleolus	5	1
GO:0030684	preribosome	3	1
GO:0032040	small-subunit processome	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AM03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM03

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006364	rRNA processing	8	10
GO:0006396	RNA processing	6	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0016072	rRNA metabolic process	7	10
GO:0034470	ncRNA processing	7	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034660	ncRNA metabolic process	6	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	247	251	PF00656	0.421
CLV_NRD_NRD_1	112	114	PF00675	0.376
CLV_NRD_NRD_1	134	136	PF00675	0.446
CLV_NRD_NRD_1	190	192	PF00675	0.413
CLV_NRD_NRD_1	193	195	PF00675	0.385
CLV_NRD_NRD_1	241	243	PF00675	0.443
CLV_NRD_NRD_1	265	267	PF00675	0.354
CLV_NRD_NRD_1	415	417	PF00675	0.349
CLV_NRD_NRD_1	46	48	PF00675	0.636
CLV_NRD_NRD_1	487	489	PF00675	0.389
CLV_NRD_NRD_1	644	646	PF00675	0.441
CLV_NRD_NRD_1	656	658	PF00675	0.369
CLV_NRD_NRD_1	668	670	PF00675	0.577
CLV_NRD_NRD_1	81	83	PF00675	0.646
CLV_PCSK_FUR_1	236	240	PF00082	0.449
CLV_PCSK_KEX2_1	112	114	PF00082	0.376
CLV_PCSK_KEX2_1	190	192	PF00082	0.412
CLV_PCSK_KEX2_1	238	240	PF00082	0.444
CLV_PCSK_KEX2_1	241	243	PF00082	0.444
CLV_PCSK_KEX2_1	265	267	PF00082	0.354
CLV_PCSK_KEX2_1	421	423	PF00082	0.392
CLV_PCSK_KEX2_1	438	440	PF00082	0.288
CLV_PCSK_KEX2_1	46	48	PF00082	0.677
CLV_PCSK_KEX2_1	487	489	PF00082	0.434
CLV_PCSK_KEX2_1	644	646	PF00082	0.385
CLV_PCSK_KEX2_1	670	672	PF00082	0.620
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.445
CLV_PCSK_PC1ET2_1	421	423	PF00082	0.418
CLV_PCSK_PC1ET2_1	438	440	PF00082	0.288
CLV_PCSK_PC1ET2_1	487	489	PF00082	0.477
CLV_PCSK_PC1ET2_1	670	672	PF00082	0.620
CLV_PCSK_PC7_1	236	242	PF00082	0.485
CLV_PCSK_PC7_1	640	646	PF00082	0.399
CLV_PCSK_SKI1_1	101	105	PF00082	0.287
CLV_PCSK_SKI1_1	161	165	PF00082	0.401
CLV_PCSK_SKI1_1	195	199	PF00082	0.378
CLV_PCSK_SKI1_1	209	213	PF00082	0.326
CLV_PCSK_SKI1_1	28	32	PF00082	0.577
CLV_PCSK_SKI1_1	421	425	PF00082	0.432
CLV_PCSK_SKI1_1	441	445	PF00082	0.155
CLV_PCSK_SKI1_1	522	526	PF00082	0.444
CLV_PCSK_SKI1_1	640	644	PF00082	0.326
CLV_PCSK_SKI1_1	85	89	PF00082	0.351
DEG_APCC_DBOX_1	100	108	PF00400	0.401
DEG_APCC_DBOX_1	440	448	PF00400	0.444
DEG_MDM2_SWIB_1	424	431	PF02201	0.485
DOC_CKS1_1	574	579	PF01111	0.280
DOC_MAPK_gen_1	438	447	PF00069	0.444
DOC_MAPK_gen_1	511	519	PF00069	0.369
DOC_MAPK_MEF2A_6	66	74	PF00069	0.634
DOC_USP7_MATH_1	2	6	PF00917	0.732
DOC_USP7_MATH_1	509	513	PF00917	0.427
DOC_USP7_UBL2_3	186	190	PF12436	0.415
DOC_USP7_UBL2_3	417	421	PF12436	0.457
DOC_USP7_UBL2_3	648	652	PF12436	0.384
DOC_WW_Pin1_4	573	578	PF00397	0.344
DOC_WW_Pin1_4	633	638	PF00397	0.444
DOC_WW_Pin1_4	66	71	PF00397	0.573
DOC_WW_Pin1_4	7	12	PF00397	0.755
LIG_14-3-3_CanoR_1	33	43	PF00244	0.647
LIG_14-3-3_CanoR_1	422	431	PF00244	0.373
LIG_14-3-3_CanoR_1	488	493	PF00244	0.322
LIG_14-3-3_CanoR_1	621	630	PF00244	0.474
LIG_14-3-3_CanoR_1	85	93	PF00244	0.364
LIG_Actin_WH2_2	542	557	PF00022	0.321
LIG_Actin_WH2_2	60	75	PF00022	0.615
LIG_BIR_III_4	376	380	PF00653	0.316
LIG_BRCT_BRCA1_1	623	627	PF00533	0.444
LIG_Clathr_ClatBox_1	444	448	PF01394	0.444
LIG_deltaCOP1_diTrp_1	205	212	PF00928	0.329
LIG_FHA_1	166	172	PF00498	0.369
LIG_FHA_1	465	471	PF00498	0.351
LIG_FHA_1	630	636	PF00498	0.429
LIG_FHA_1	87	93	PF00498	0.401
LIG_FHA_2	492	498	PF00498	0.345
LIG_FHA_2	545	551	PF00498	0.344
LIG_FHA_2	606	612	PF00498	0.369
LIG_FHA_2	634	640	PF00498	0.444
LIG_FHA_2	79	85	PF00498	0.642
LIG_LIR_Apic_2	571	577	PF02991	0.245
LIG_LIR_Gen_1	425	436	PF02991	0.453
LIG_LIR_Gen_1	624	635	PF02991	0.369
LIG_LIR_Nem_3	425	431	PF02991	0.453
LIG_LIR_Nem_3	480	486	PF02991	0.344
LIG_LIR_Nem_3	624	630	PF02991	0.369
LIG_LIR_Nem_3	90	96	PF02991	0.401
LIG_Pex14_1	208	212	PF04695	0.344
LIG_Pex14_2	424	428	PF04695	0.401
LIG_PTB_Apo_2	446	453	PF02174	0.485
LIG_PTB_Apo_2	569	576	PF02174	0.344
LIG_PTB_Phospho_1	569	575	PF10480	0.401
LIG_SH2_NCK_1	61	65	PF00017	0.564
LIG_SH2_SRC	483	486	PF00017	0.401
LIG_SH2_STAP1	503	507	PF00017	0.444
LIG_SH2_STAP1	520	524	PF00017	0.155
LIG_SH2_STAT3	334	337	PF00017	0.408
LIG_SH2_STAT5	341	344	PF00017	0.347
LIG_SH2_STAT5	575	578	PF00017	0.401
LIG_SH3_3	12	18	PF00018	0.725
LIG_SH3_3	535	541	PF00018	0.429
LIG_SH3_4	578	585	PF00018	0.401
LIG_SUMO_SIM_par_1	442	448	PF11976	0.444
LIG_TRAF2_1	217	220	PF00917	0.444
LIG_TRAF2_1	245	248	PF00917	0.408
LIG_UBA3_1	516	522	PF00899	0.344
MOD_CDC14_SPxK_1	10	13	PF00782	0.787
MOD_CDK_SPK_2	573	578	PF00069	0.344
MOD_CDK_SPK_2	633	638	PF00069	0.444
MOD_CDK_SPxK_1	7	13	PF00069	0.793
MOD_CDK_SPxxK_3	633	640	PF00069	0.444
MOD_CDK_SPxxK_3	66	73	PF00069	0.633
MOD_CK1_1	134	140	PF00069	0.194
MOD_CK1_1	165	171	PF00069	0.348
MOD_CK1_1	3	9	PF00069	0.702
MOD_CK1_1	45	51	PF00069	0.573
MOD_CK1_1	512	518	PF00069	0.370
MOD_CK1_1	53	59	PF00069	0.491
MOD_CK1_1	62	68	PF00069	0.420
MOD_CK2_1	123	129	PF00069	0.304
MOD_CK2_1	147	153	PF00069	0.407
MOD_CK2_1	190	196	PF00069	0.291
MOD_CK2_1	397	403	PF00069	0.415
MOD_CK2_1	544	550	PF00069	0.344
MOD_CK2_1	605	611	PF00069	0.369
MOD_CK2_1	633	639	PF00069	0.410
MOD_CK2_1	643	649	PF00069	0.420
MOD_CK2_1	672	678	PF00069	0.527
MOD_CK2_1	78	84	PF00069	0.669
MOD_Cter_Amidation	650	653	PF01082	0.444
MOD_GlcNHglycan	125	128	PF01048	0.442
MOD_GlcNHglycan	140	143	PF01048	0.433
MOD_GlcNHglycan	148	152	PF01048	0.407
MOD_GlcNHglycan	2	5	PF01048	0.746
MOD_GlcNHglycan	47	50	PF01048	0.580
MOD_GlcNHglycan	6	9	PF01048	0.735
MOD_GSK3_1	134	141	PF00069	0.452
MOD_GSK3_1	162	169	PF00069	0.348
MOD_GSK3_1	2	9	PF00069	0.700
MOD_GSK3_1	422	429	PF00069	0.345
MOD_GSK3_1	460	467	PF00069	0.338
MOD_GSK3_1	487	494	PF00069	0.346
MOD_GSK3_1	62	69	PF00069	0.492
MOD_GSK3_1	629	636	PF00069	0.437
MOD_NEK2_1	34	39	PF00069	0.561
MOD_NEK2_1	42	47	PF00069	0.506
MOD_NEK2_1	643	648	PF00069	0.485
MOD_PKA_1	190	196	PF00069	0.291
MOD_PKA_1	487	493	PF00069	0.384
MOD_PKA_2	134	140	PF00069	0.247
MOD_PKA_2	166	172	PF00069	0.444
MOD_PKA_2	190	196	PF00069	0.291
MOD_PKA_2	24	30	PF00069	0.597
MOD_PKA_2	32	38	PF00069	0.580
MOD_PKA_2	45	51	PF00069	0.643
MOD_PKA_2	487	493	PF00069	0.326
MOD_PKA_2	53	59	PF00069	0.586
MOD_PKA_2	620	626	PF00069	0.385
MOD_PKA_2	643	649	PF00069	0.470
MOD_Plk_1	204	210	PF00069	0.424
MOD_Plk_1	426	432	PF00069	0.444
MOD_Plk_2-3	397	403	PF00069	0.485
MOD_Plk_2-3	544	550	PF00069	0.344
MOD_Plk_2-3	629	635	PF00069	0.429
MOD_Plk_4	512	518	PF00069	0.325
MOD_Plk_4	94	100	PF00069	0.230
MOD_ProDKin_1	573	579	PF00069	0.344
MOD_ProDKin_1	633	639	PF00069	0.444
MOD_ProDKin_1	66	72	PF00069	0.580
MOD_ProDKin_1	7	13	PF00069	0.756
MOD_SUMO_for_1	468	471	PF00179	0.369
MOD_SUMO_for_1	541	544	PF00179	0.408
TRG_DiLeu_BaEn_1	179	184	PF01217	0.369
TRG_DiLeu_BaEn_4	317	323	PF01217	0.485
TRG_ENDOCYTIC_2	483	486	PF00928	0.401
TRG_ER_diArg_1	111	113	PF00400	0.428
TRG_ER_diArg_1	236	239	PF00400	0.449
TRG_ER_diArg_1	240	242	PF00400	0.438
TRG_ER_diArg_1	265	268	PF00400	0.324
TRG_ER_diArg_1	527	530	PF00400	0.429
TRG_ER_diArg_1	643	645	PF00400	0.366
TRG_NLS_Bipartite_1	652	673	PF00514	0.665
TRG_NLS_MonoCore_2	668	673	PF00514	0.680
TRG_NLS_MonoExtC_3	189	194	PF00514	0.438
TRG_NLS_MonoExtC_3	668	674	PF00514	0.476
TRG_NLS_MonoExtN_4	190	195	PF00514	0.365
TRG_Pf-PMV_PEXEL_1	292	297	PF00026	0.485
TRG_Pf-PMV_PEXEL_1	416	420	PF00026	0.298

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Q4	Leptomonas seymouri	69%	99%
A0A0S4JKJ8	Bodo saltans	45%	100%
A0A3S7X283	Leishmania donovani	91%	100%
A0A422NRR1	Trypanosoma rangeli	47%	100%
A4HH82	Leishmania braziliensis	83%	100%
A4I4C8	Leishmania infantum	91%	100%
C9ZL36	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ADS7	Leishmania major	90%	100%