Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AM01_LEIMU

TriTrypDb:

LmxM.08_29.0770

Length:

195

Annotations

LeishMANIAdb annotations

Seems to form a single continuous helix according to predictions. Kinetoplastid-only protein.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AM01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM01

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	14	18	PF00656	0.669
CLV_NRD_NRD_1	108	110	PF00675	0.336
CLV_NRD_NRD_1	143	145	PF00675	0.608
CLV_NRD_NRD_1	53	55	PF00675	0.439
CLV_NRD_NRD_1	70	72	PF00675	0.335
CLV_PCSK_FUR_1	141	145	PF00082	0.542
CLV_PCSK_FUR_1	94	98	PF00082	0.459
CLV_PCSK_KEX2_1	143	145	PF00082	0.613
CLV_PCSK_KEX2_1	191	193	PF00082	0.683
CLV_PCSK_KEX2_1	53	55	PF00082	0.407
CLV_PCSK_KEX2_1	96	98	PF00082	0.416
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.683
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.416
DEG_APCC_DBOX_1	101	109	PF00400	0.635
DOC_MAPK_gen_1	109	117	PF00069	0.461
DOC_MAPK_MEF2A_6	109	117	PF00069	0.461
DOC_PP2B_LxvP_1	44	47	PF13499	0.682
DOC_USP7_MATH_1	152	156	PF00917	0.429
DOC_USP7_MATH_1	18	22	PF00917	0.633
DOC_USP7_MATH_1	25	29	PF00917	0.632
DOC_USP7_UBL2_3	72	76	PF12436	0.690
DOC_WW_Pin1_4	168	173	PF00397	0.327
LIG_14-3-3_CanoR_1	102	108	PF00244	0.631
LIG_BIR_II_1	1	5	PF00653	0.660
LIG_BRCT_BRCA1_1	6	10	PF00533	0.678
LIG_BRCT_BRCA1_1	69	73	PF00533	0.723
LIG_FHA_1	127	133	PF00498	0.348
LIG_FHA_1	24	30	PF00498	0.602
LIG_LIR_Apic_2	127	133	PF02991	0.281
LIG_SH2_NCK_1	149	153	PF00017	0.429
LIG_SH2_STAT5	130	133	PF00017	0.462
LIG_SH2_STAT5	135	138	PF00017	0.387
LIG_SH3_3	169	175	PF00018	0.426
MOD_CK1_1	11	17	PF00069	0.724
MOD_CK1_1	3	9	PF00069	0.747
MOD_CK1_1	66	72	PF00069	0.697
MOD_GlcNHglycan	13	16	PF01048	0.501
MOD_GlcNHglycan	20	23	PF01048	0.475
MOD_GlcNHglycan	5	9	PF01048	0.498
MOD_GlcNHglycan	77	80	PF01048	0.400
MOD_GSK3_1	4	11	PF00069	0.727
MOD_GSK3_1	63	70	PF00069	0.696
MOD_N-GLC_1	103	108	PF02516	0.420
MOD_NEK2_1	10	15	PF00069	0.726
MOD_NEK2_1	126	131	PF00069	0.419
MOD_NEK2_1	190	195	PF00069	0.444
MOD_Plk_1	103	109	PF00069	0.618
MOD_Plk_4	103	109	PF00069	0.618
MOD_Plk_4	126	132	PF00069	0.412
MOD_ProDKin_1	168	174	PF00069	0.324
MOD_SUMO_rev_2	68	78	PF00179	0.628
TRG_ENDOCYTIC_2	135	138	PF00928	0.351
TRG_ER_diArg_1	141	144	PF00400	0.357
TRG_ER_diArg_1	53	56	PF00400	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8C6	Leptomonas seymouri	63%	100%
A0A0S4ISL6	Bodo saltans	39%	100%
A0A1X0NZL1	Trypanosomatidae	48%	100%
A0A3S7X2B4	Leishmania donovani	87%	100%
A4HH84	Leishmania braziliensis	76%	100%
A4I4D0	Leishmania infantum	87%	100%
C9ZL34	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9ADS9	Leishmania major	89%	100%