Putative U-box domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U-box domain protein, putative

Species:

Leishmania mexicana

UniProt:

E9AM00_LEIMU

TriTrypDb:

LmxM.08_29.0780

Length:

601

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AM00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM00

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004842	ubiquitin-protein transferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0019787	ubiquitin-like protein transferase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.437
CLV_C14_Caspase3-7	508	512	PF00656	0.682
CLV_C14_Caspase3-7	514	518	PF00656	0.637
CLV_NRD_NRD_1	428	430	PF00675	0.572
CLV_NRD_NRD_1	50	52	PF00675	0.467
CLV_NRD_NRD_1	72	74	PF00675	0.501
CLV_PCSK_FUR_1	484	488	PF00082	0.443
CLV_PCSK_KEX2_1	428	430	PF00082	0.572
CLV_PCSK_KEX2_1	486	488	PF00082	0.546
CLV_PCSK_KEX2_1	50	52	PF00082	0.414
CLV_PCSK_KEX2_1	72	74	PF00082	0.501
CLV_PCSK_PC1ET2_1	486	488	PF00082	0.546
CLV_PCSK_SKI1_1	107	111	PF00082	0.569
CLV_PCSK_SKI1_1	428	432	PF00082	0.602
CLV_PCSK_SKI1_1	562	566	PF00082	0.395
DOC_CDC14_PxL_1	477	485	PF14671	0.620
DOC_CYCLIN_yClb1_LxF_4	368	374	PF00134	0.477
DOC_MAPK_gen_1	107	117	PF00069	0.545
DOC_MAPK_gen_1	484	493	PF00069	0.578
DOC_MAPK_gen_1	50	57	PF00069	0.499
DOC_MAPK_gen_1	72	81	PF00069	0.354
DOC_MAPK_MEF2A_6	123	132	PF00069	0.350
DOC_MAPK_MEF2A_6	209	218	PF00069	0.382
DOC_PP1_RVXF_1	207	213	PF00149	0.401
DOC_PP1_RVXF_1	89	96	PF00149	0.440
DOC_PP4_FxxP_1	185	188	PF00568	0.355
DOC_USP7_MATH_1	116	120	PF00917	0.604
DOC_USP7_MATH_1	233	237	PF00917	0.583
DOC_USP7_MATH_1	357	361	PF00917	0.524
DOC_USP7_MATH_1	43	47	PF00917	0.594
DOC_USP7_MATH_1	437	441	PF00917	0.553
DOC_USP7_MATH_1	89	93	PF00917	0.464
DOC_USP7_UBL2_3	205	209	PF12436	0.466
DOC_USP7_UBL2_3	260	264	PF12436	0.462
DOC_USP7_UBL2_3	486	490	PF12436	0.530
DOC_WW_Pin1_4	532	537	PF00397	0.361
DOC_WW_Pin1_4	567	572	PF00397	0.466
LIG_14-3-3_CanoR_1	123	131	PF00244	0.348
LIG_14-3-3_CanoR_1	336	342	PF00244	0.434
LIG_14-3-3_CanoR_1	428	436	PF00244	0.471
LIG_14-3-3_CanoR_1	475	483	PF00244	0.715
LIG_14-3-3_CanoR_1	562	571	PF00244	0.432
LIG_14-3-3_CanoR_1	585	589	PF00244	0.593
LIG_Actin_WH2_2	125	143	PF00022	0.379
LIG_AP2alpha_1	342	346	PF02296	0.489
LIG_BIR_II_1	1	5	PF00653	0.417
LIG_BRCT_BRCA1_1	314	318	PF00533	0.394
LIG_BRCT_BRCA1_1	439	443	PF00533	0.473
LIG_BRCT_BRCA1_1	91	95	PF00533	0.435
LIG_CaM_IQ_9	577	593	PF13499	0.444
LIG_deltaCOP1_diTrp_1	421	427	PF00928	0.523
LIG_EH1_1	154	162	PF00400	0.361
LIG_EH1_1	385	393	PF00400	0.609
LIG_eIF4E_1	386	392	PF01652	0.537
LIG_EVH1_2	168	172	PF00568	0.477
LIG_FHA_1	205	211	PF00498	0.384
LIG_FHA_1	237	243	PF00498	0.347
LIG_FHA_1	275	281	PF00498	0.349
LIG_FHA_1	457	463	PF00498	0.390
LIG_FHA_1	486	492	PF00498	0.480
LIG_FHA_1	523	529	PF00498	0.337
LIG_FHA_1	588	594	PF00498	0.652
LIG_FHA_2	276	282	PF00498	0.379
LIG_FHA_2	506	512	PF00498	0.512
LIG_GBD_Chelix_1	291	299	PF00786	0.459
LIG_GBD_Chelix_1	306	314	PF00786	0.408
LIG_LIR_Gen_1	23	31	PF02991	0.464
LIG_LIR_Gen_1	340	350	PF02991	0.487
LIG_LIR_Gen_1	440	451	PF02991	0.371
LIG_LIR_Gen_1	75	84	PF02991	0.432
LIG_LIR_Gen_1	92	101	PF02991	0.473
LIG_LIR_Nem_3	317	323	PF02991	0.435
LIG_LIR_Nem_3	340	345	PF02991	0.456
LIG_LIR_Nem_3	421	427	PF02991	0.587
LIG_LIR_Nem_3	440	446	PF02991	0.263
LIG_LIR_Nem_3	75	80	PF02991	0.406
LIG_LIR_Nem_3	85	90	PF02991	0.381
LIG_LIR_Nem_3	92	98	PF02991	0.315
LIG_MYND_1	481	485	PF01753	0.690
LIG_NRBOX	160	166	PF00104	0.349
LIG_PCNA_PIPBox_1	401	410	PF02747	0.278
LIG_PCNA_yPIPBox_3	401	410	PF02747	0.278
LIG_PDZ_Class_2	596	601	PF00595	0.574
LIG_Pex14_1	423	427	PF04695	0.466
LIG_Pex14_2	338	342	PF04695	0.493
LIG_Pex14_2	419	423	PF04695	0.433
LIG_SH2_CRK	87	91	PF00017	0.434
LIG_SH2_GRB2like	367	370	PF00017	0.477
LIG_SH2_GRB2like	60	63	PF00017	0.362
LIG_SH2_PTP2	367	370	PF00017	0.406
LIG_SH2_STAP1	170	174	PF00017	0.420
LIG_SH2_STAP1	541	545	PF00017	0.466
LIG_SH2_STAT5	10	13	PF00017	0.572
LIG_SH2_STAT5	287	290	PF00017	0.362
LIG_SH2_STAT5	367	370	PF00017	0.362
LIG_SH2_STAT5	60	63	PF00017	0.377
LIG_SH3_2	482	487	PF14604	0.588
LIG_SH3_3	381	387	PF00018	0.541
LIG_SH3_3	461	467	PF00018	0.635
LIG_SH3_3	479	485	PF00018	0.707
LIG_SH3_3	530	536	PF00018	0.360
LIG_SUMO_SIM_anti_2	125	132	PF11976	0.344
LIG_SxIP_EBH_1	473	487	PF03271	0.590
LIG_TRAF2_1	331	334	PF00917	0.450
LIG_TYR_ITIM	365	370	PF00017	0.414
LIG_UBA3_1	132	141	PF00899	0.467
LIG_UBA3_1	159	166	PF00899	0.349
LIG_UBA3_1	255	260	PF00899	0.516
LIG_WRC_WIRS_1	338	343	PF05994	0.491
MOD_CK1_1	236	242	PF00069	0.565
MOD_CK1_1	263	269	PF00069	0.437
MOD_CK1_1	29	35	PF00069	0.455
MOD_CK1_1	290	296	PF00069	0.434
MOD_CK1_1	455	461	PF00069	0.625
MOD_CK1_1	570	576	PF00069	0.513
MOD_CK2_1	100	106	PF00069	0.461
MOD_CK2_1	259	265	PF00069	0.599
MOD_GlcNHglycan	12	15	PF01048	0.576
MOD_GlcNHglycan	179	182	PF01048	0.441
MOD_GlcNHglycan	359	362	PF01048	0.482
MOD_GlcNHglycan	396	399	PF01048	0.503
MOD_GSK3_1	259	266	PF00069	0.390
MOD_GSK3_1	310	317	PF00069	0.452
MOD_GSK3_1	452	459	PF00069	0.484
MOD_GSK3_1	485	492	PF00069	0.407
MOD_GSK3_1	570	577	PF00069	0.500
MOD_N-GLC_1	248	253	PF02516	0.498
MOD_N-GLC_1	552	557	PF02516	0.356
MOD_N-GLC_1	82	87	PF02516	0.520
MOD_NEK2_1	105	110	PF00069	0.417
MOD_NEK2_1	183	188	PF00069	0.352
MOD_NEK2_1	259	264	PF00069	0.425
MOD_NEK2_1	274	279	PF00069	0.290
MOD_NEK2_1	280	285	PF00069	0.340
MOD_NEK2_1	295	300	PF00069	0.440
MOD_NEK2_1	310	315	PF00069	0.501
MOD_NEK2_1	346	351	PF00069	0.414
MOD_NEK2_2	445	450	PF00069	0.394
MOD_PIKK_1	150	156	PF00454	0.426
MOD_PIKK_1	183	189	PF00454	0.361
MOD_PIKK_1	241	247	PF00454	0.298
MOD_PIKK_1	264	270	PF00454	0.390
MOD_PIKK_1	329	335	PF00454	0.457
MOD_PIKK_1	452	458	PF00454	0.463
MOD_PIKK_1	587	593	PF00454	0.491
MOD_PKA_1	428	434	PF00069	0.557
MOD_PKA_1	50	56	PF00069	0.438
MOD_PKA_1	72	78	PF00069	0.447
MOD_PKA_2	122	128	PF00069	0.360
MOD_PKA_2	357	363	PF00069	0.561
MOD_PKA_2	428	434	PF00069	0.479
MOD_PKA_2	50	56	PF00069	0.424
MOD_PKA_2	584	590	PF00069	0.557
MOD_PKA_2	72	78	PF00069	0.447
MOD_Plk_1	18	24	PF00069	0.325
MOD_Plk_1	248	254	PF00069	0.496
MOD_Plk_1	264	270	PF00069	0.531
MOD_Plk_1	438	444	PF00069	0.533
MOD_Plk_1	82	88	PF00069	0.497
MOD_Plk_1	99	105	PF00069	0.461
MOD_Plk_2-3	100	106	PF00069	0.565
MOD_Plk_2-3	18	24	PF00069	0.302
MOD_Plk_4	100	106	PF00069	0.553
MOD_Plk_4	251	257	PF00069	0.459
MOD_Plk_4	275	281	PF00069	0.364
MOD_Plk_4	314	320	PF00069	0.498
MOD_Plk_4	337	343	PF00069	0.470
MOD_Plk_4	431	437	PF00069	0.425
MOD_ProDKin_1	532	538	PF00069	0.361
MOD_ProDKin_1	567	573	PF00069	0.466
MOD_SUMO_for_1	109	112	PF00179	0.479
MOD_SUMO_for_1	408	411	PF00179	0.472
TRG_DiLeu_BaEn_2	207	213	PF01217	0.427
TRG_DiLeu_BaLyEn_6	238	243	PF01217	0.351
TRG_DiLeu_BaLyEn_6	472	477	PF01217	0.660
TRG_ENDOCYTIC_2	367	370	PF00928	0.348
TRG_ENDOCYTIC_2	424	427	PF00928	0.548
TRG_ENDOCYTIC_2	87	90	PF00928	0.440
TRG_ER_diArg_1	427	429	PF00400	0.551
TRG_ER_diArg_1	49	51	PF00400	0.511
TRG_ER_diArg_1	71	73	PF00400	0.511
TRG_NLS_MonoExtN_4	70	77	PF00514	0.457
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMG8	Leptomonas seymouri	73%	100%
A0A0S4IVT7	Bodo saltans	49%	98%
A0A1X0NZM7	Trypanosomatidae	45%	96%
A0A3R7MLP4	Trypanosoma rangeli	45%	99%
A0A3S7X270	Leishmania donovani	96%	100%
A4HH85	Leishmania braziliensis	88%	100%
A4I4D1	Leishmania infantum	96%	100%
C9ZL32	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	96%
E9ADT0	Leishmania major	96%	100%
V5DLG6	Trypanosoma cruzi	45%	99%