Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALZ7_LEIMU

TriTrypDb:

LmxM.08_29.0805

Length:

602

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALZ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.700
CLV_C14_Caspase3-7	277	281	PF00656	0.651
CLV_C14_Caspase3-7	316	320	PF00656	0.551
CLV_NRD_NRD_1	15	17	PF00675	0.540
CLV_NRD_NRD_1	272	274	PF00675	0.575
CLV_NRD_NRD_1	290	292	PF00675	0.626
CLV_NRD_NRD_1	347	349	PF00675	0.674
CLV_NRD_NRD_1	430	432	PF00675	0.762
CLV_NRD_NRD_1	495	497	PF00675	0.500
CLV_NRD_NRD_1	577	579	PF00675	0.513
CLV_PCSK_KEX2_1	15	17	PF00082	0.540
CLV_PCSK_KEX2_1	272	274	PF00082	0.575
CLV_PCSK_KEX2_1	430	432	PF00082	0.762
CLV_PCSK_KEX2_1	495	497	PF00082	0.500
CLV_PCSK_KEX2_1	577	579	PF00082	0.513
CLV_PCSK_SKI1_1	102	106	PF00082	0.701
CLV_PCSK_SKI1_1	251	255	PF00082	0.395
CLV_PCSK_SKI1_1	556	560	PF00082	0.421
CLV_PCSK_SKI1_1	591	595	PF00082	0.475
CLV_Separin_Metazoa	384	388	PF03568	0.540
DEG_APCC_DBOX_1	27	35	PF00400	0.443
DEG_Nend_Nbox_1	1	3	PF02207	0.549
DEG_ODPH_VHL_1	526	538	PF01847	0.490
DEG_SCF_FBW7_1	103	110	PF00400	0.629
DEG_SPOP_SBC_1	146	150	PF00917	0.504
DEG_SPOP_SBC_1	164	168	PF00917	0.679
DEG_SPOP_SBC_1	281	285	PF00917	0.575
DEG_SPOP_SBC_1	61	65	PF00917	0.617
DEG_SPOP_SBC_1	83	87	PF00917	0.662
DOC_CKS1_1	104	109	PF01111	0.630
DOC_CKS1_1	124	129	PF01111	0.571
DOC_MAPK_gen_1	435	442	PF00069	0.561
DOC_MAPK_gen_1	477	486	PF00069	0.614
DOC_PP2B_LxvP_1	171	174	PF13499	0.514
DOC_USP7_MATH_1	107	111	PF00917	0.633
DOC_USP7_MATH_1	146	150	PF00917	0.576
DOC_USP7_MATH_1	206	210	PF00917	0.747
DOC_USP7_MATH_1	281	285	PF00917	0.646
DOC_USP7_MATH_1	301	305	PF00917	0.758
DOC_USP7_MATH_1	363	367	PF00917	0.585
DOC_USP7_MATH_1	420	424	PF00917	0.628
DOC_USP7_MATH_1	436	440	PF00917	0.481
DOC_USP7_MATH_1	83	87	PF00917	0.662
DOC_WW_Pin1_4	103	108	PF00397	0.542
DOC_WW_Pin1_4	111	116	PF00397	0.650
DOC_WW_Pin1_4	123	128	PF00397	0.535
DOC_WW_Pin1_4	160	165	PF00397	0.544
DOC_WW_Pin1_4	228	233	PF00397	0.642
DOC_WW_Pin1_4	264	269	PF00397	0.559
DOC_WW_Pin1_4	291	296	PF00397	0.669
DOC_WW_Pin1_4	424	429	PF00397	0.643
DOC_WW_Pin1_4	84	89	PF00397	0.762
LIG_14-3-3_CanoR_1	102	107	PF00244	0.627
LIG_14-3-3_CanoR_1	28	32	PF00244	0.492
LIG_14-3-3_CanoR_1	338	346	PF00244	0.558
LIG_14-3-3_CanoR_1	408	418	PF00244	0.666
LIG_14-3-3_CanoR_1	419	429	PF00244	0.601
LIG_14-3-3_CanoR_1	480	486	PF00244	0.585
LIG_14-3-3_CanoR_1	548	554	PF00244	0.559
LIG_AP2alpha_2	403	405	PF02296	0.475
LIG_BRCT_BRCA1_1	437	441	PF00533	0.580
LIG_BRCT_BRCA1_1	51	55	PF00533	0.646
LIG_FHA_1	103	109	PF00498	0.572
LIG_FHA_1	146	152	PF00498	0.569
LIG_FHA_1	166	172	PF00498	0.637
LIG_FHA_1	284	290	PF00498	0.683
LIG_FHA_1	442	448	PF00498	0.560
LIG_FHA_1	550	556	PF00498	0.583
LIG_FHA_1	557	563	PF00498	0.472
LIG_FHA_1	8	14	PF00498	0.532
LIG_FHA_2	1	7	PF00498	0.600
LIG_FHA_2	229	235	PF00498	0.808
LIG_FHA_2	245	251	PF00498	0.435
LIG_FHA_2	292	298	PF00498	0.619
LIG_FHA_2	372	378	PF00498	0.622
LIG_LIR_Apic_2	48	54	PF02991	0.626
LIG_LIR_Gen_1	260	269	PF02991	0.602
LIG_LIR_Gen_1	293	303	PF02991	0.773
LIG_LIR_Gen_1	589	598	PF02991	0.487
LIG_LIR_Gen_1	97	108	PF02991	0.651
LIG_LIR_Nem_3	260	264	PF02991	0.544
LIG_LIR_Nem_3	293	299	PF02991	0.662
LIG_LIR_Nem_3	589	595	PF02991	0.486
LIG_LIR_Nem_3	6	12	PF02991	0.503
LIG_LIR_Nem_3	97	103	PF02991	0.648
LIG_Pex14_1	257	261	PF04695	0.486
LIG_Pex14_1	588	592	PF04695	0.506
LIG_PTAP_UEV_1	87	92	PF05743	0.694
LIG_SH2_CRK	261	265	PF00017	0.507
LIG_SH2_CRK	51	55	PF00017	0.706
LIG_SH2_CRK	592	596	PF00017	0.489
LIG_SH2_NCK_1	51	55	PF00017	0.646
LIG_SH2_STAP1	147	151	PF00017	0.513
LIG_SH2_STAP1	9	13	PF00017	0.515
LIG_SH2_STAT3	568	571	PF00017	0.566
LIG_SH2_STAT5	147	150	PF00017	0.561
LIG_SH2_STAT5	381	384	PF00017	0.672
LIG_SH2_STAT5	9	12	PF00017	0.501
LIG_SH3_2	268	273	PF14604	0.486
LIG_SH3_3	101	107	PF00018	0.560
LIG_SH3_3	124	130	PF00018	0.638
LIG_SH3_3	159	165	PF00018	0.509
LIG_SH3_3	229	235	PF00018	0.579
LIG_SH3_3	265	271	PF00018	0.454
LIG_SH3_3	398	404	PF00018	0.507
LIG_SH3_3	422	428	PF00018	0.625
LIG_SH3_3	437	443	PF00018	0.488
LIG_SH3_3	69	75	PF00018	0.649
LIG_SH3_3	85	91	PF00018	0.580
LIG_SUMO_SIM_par_1	233	239	PF11976	0.529
LIG_TRAF2_1	239	242	PF00917	0.514
LIG_TRAF2_1	4	7	PF00917	0.505
MOD_CDC14_SPxK_1	427	430	PF00782	0.627
MOD_CDK_SPxK_1	424	430	PF00069	0.623
MOD_CDK_SPxxK_3	424	431	PF00069	0.624
MOD_CK1_1	136	142	PF00069	0.637
MOD_CK1_1	149	155	PF00069	0.631
MOD_CK1_1	163	169	PF00069	0.647
MOD_CK1_1	172	178	PF00069	0.573
MOD_CK1_1	201	207	PF00069	0.639
MOD_CK1_1	225	231	PF00069	0.773
MOD_CK1_1	283	289	PF00069	0.683
MOD_CK1_1	353	359	PF00069	0.592
MOD_CK1_1	366	372	PF00069	0.631
MOD_CK1_1	56	62	PF00069	0.569
MOD_CK1_1	63	69	PF00069	0.541
MOD_CK1_1	76	82	PF00069	0.635
MOD_CK1_1	86	92	PF00069	0.813
MOD_CK2_1	1	7	PF00069	0.524
MOD_CK2_1	201	207	PF00069	0.701
MOD_CK2_1	228	234	PF00069	0.799
MOD_CK2_1	236	242	PF00069	0.684
MOD_CK2_1	244	250	PF00069	0.477
MOD_CK2_1	371	377	PF00069	0.625
MOD_GlcNHglycan	118	121	PF01048	0.601
MOD_GlcNHglycan	171	174	PF01048	0.568
MOD_GlcNHglycan	195	198	PF01048	0.692
MOD_GlcNHglycan	224	227	PF01048	0.661
MOD_GlcNHglycan	238	241	PF01048	0.627
MOD_GlcNHglycan	303	306	PF01048	0.604
MOD_GlcNHglycan	329	333	PF01048	0.611
MOD_GlcNHglycan	368	371	PF01048	0.604
MOD_GlcNHglycan	405	408	PF01048	0.580
MOD_GlcNHglycan	411	414	PF01048	0.706
MOD_GlcNHglycan	422	425	PF01048	0.708
MOD_GlcNHglycan	522	525	PF01048	0.685
MOD_GlcNHglycan	545	548	PF01048	0.609
MOD_GlcNHglycan	579	582	PF01048	0.601
MOD_GlcNHglycan	59	62	PF01048	0.670
MOD_GlcNHglycan	78	81	PF01048	0.712
MOD_GlcNHglycan	88	91	PF01048	0.596
MOD_GSK3_1	103	110	PF00069	0.703
MOD_GSK3_1	116	123	PF00069	0.584
MOD_GSK3_1	145	152	PF00069	0.668
MOD_GSK3_1	160	167	PF00069	0.641
MOD_GSK3_1	201	208	PF00069	0.624
MOD_GSK3_1	222	229	PF00069	0.760
MOD_GSK3_1	279	286	PF00069	0.703
MOD_GSK3_1	353	360	PF00069	0.608
MOD_GSK3_1	362	369	PF00069	0.601
MOD_GSK3_1	420	427	PF00069	0.626
MOD_GSK3_1	45	52	PF00069	0.551
MOD_GSK3_1	53	60	PF00069	0.555
MOD_GSK3_1	61	68	PF00069	0.538
MOD_GSK3_1	79	86	PF00069	0.778
MOD_LATS_1	409	415	PF00433	0.481
MOD_N-GLC_1	311	316	PF02516	0.489
MOD_N-GLC_1	366	371	PF02516	0.676
MOD_NEK2_1	45	50	PF00069	0.564
MOD_NEK2_1	55	60	PF00069	0.580
MOD_NEK2_1	94	99	PF00069	0.669
MOD_NEK2_2	206	211	PF00069	0.517
MOD_NEK2_2	436	441	PF00069	0.608
MOD_PIKK_1	120	126	PF00454	0.665
MOD_PIKK_1	411	417	PF00454	0.480
MOD_PKA_1	577	583	PF00069	0.523
MOD_PKA_1	73	79	PF00069	0.679
MOD_PKA_2	210	216	PF00069	0.605
MOD_PKA_2	27	33	PF00069	0.411
MOD_PKA_2	337	343	PF00069	0.560
MOD_PKA_2	479	485	PF00069	0.587
MOD_PKA_2	576	582	PF00069	0.522
MOD_PKA_2	76	82	PF00069	0.691
MOD_Plk_1	206	212	PF00069	0.695
MOD_Plk_1	350	356	PF00069	0.545
MOD_Plk_1	366	372	PF00069	0.712
MOD_Plk_1	37	43	PF00069	0.472
MOD_Plk_4	128	134	PF00069	0.629
MOD_Plk_4	436	442	PF00069	0.607
MOD_ProDKin_1	103	109	PF00069	0.542
MOD_ProDKin_1	111	117	PF00069	0.651
MOD_ProDKin_1	123	129	PF00069	0.532
MOD_ProDKin_1	160	166	PF00069	0.545
MOD_ProDKin_1	228	234	PF00069	0.646
MOD_ProDKin_1	264	270	PF00069	0.563
MOD_ProDKin_1	291	297	PF00069	0.668
MOD_ProDKin_1	424	430	PF00069	0.645
MOD_ProDKin_1	84	90	PF00069	0.761
MOD_SUMO_rev_2	131	139	PF00179	0.635
TRG_DiLeu_BaEn_1	260	265	PF01217	0.504
TRG_DiLeu_BaEn_4	241	247	PF01217	0.454
TRG_ENDOCYTIC_2	261	264	PF00928	0.545
TRG_ENDOCYTIC_2	592	595	PF00928	0.513
TRG_ER_diArg_1	15	17	PF00400	0.540
TRG_ER_diArg_1	271	273	PF00400	0.572
TRG_ER_diArg_1	275	278	PF00400	0.586
TRG_ER_diArg_1	429	431	PF00400	0.753
TRG_ER_diArg_1	495	497	PF00400	0.454
TRG_Pf-PMV_PEXEL_1	495	499	PF00026	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG51	Leptomonas seymouri	34%	100%
A0A3Q8IIM2	Leishmania donovani	83%	100%
A4HH88	Leishmania braziliensis	67%	99%
A4I4D4	Leishmania infantum	83%	100%
E9ADT3	Leishmania major	83%	100%