Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALZ6_LEIMU

TriTrypDb:

LmxM.08_29.0810

Length:

613

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9ALZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALZ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.669
CLV_C14_Caspase3-7	245	249	PF00656	0.631
CLV_C14_Caspase3-7	306	310	PF00656	0.664
CLV_C14_Caspase3-7	356	360	PF00656	0.712
CLV_NRD_NRD_1	291	293	PF00675	0.391
CLV_NRD_NRD_1	469	471	PF00675	0.443
CLV_NRD_NRD_1	472	474	PF00675	0.446
CLV_NRD_NRD_1	527	529	PF00675	0.483
CLV_NRD_NRD_1	564	566	PF00675	0.419
CLV_NRD_NRD_1	573	575	PF00675	0.443
CLV_PCSK_FUR_1	289	293	PF00082	0.383
CLV_PCSK_FUR_1	470	474	PF00082	0.530
CLV_PCSK_FUR_1	528	532	PF00082	0.465
CLV_PCSK_KEX2_1	291	293	PF00082	0.391
CLV_PCSK_KEX2_1	469	471	PF00082	0.443
CLV_PCSK_KEX2_1	472	474	PF00082	0.446
CLV_PCSK_KEX2_1	527	529	PF00082	0.482
CLV_PCSK_KEX2_1	530	532	PF00082	0.421
CLV_PCSK_KEX2_1	573	575	PF00082	0.412
CLV_PCSK_PC1ET2_1	530	532	PF00082	0.451
CLV_PCSK_PC7_1	465	471	PF00082	0.529
CLV_PCSK_SKI1_1	169	173	PF00082	0.463
CLV_PCSK_SKI1_1	192	196	PF00082	0.338
CLV_PCSK_SKI1_1	535	539	PF00082	0.448
DEG_Nend_Nbox_1	1	3	PF02207	0.676
DOC_ANK_TNKS_1	400	407	PF00023	0.778
DOC_CYCLIN_RxL_1	189	198	PF00134	0.625
DOC_CYCLIN_RxL_1	530	539	PF00134	0.645
DOC_MAPK_gen_1	182	190	PF00069	0.654
DOC_USP7_MATH_1	130	134	PF00917	0.613
DOC_USP7_MATH_1	149	153	PF00917	0.458
DOC_USP7_MATH_1	304	308	PF00917	0.658
DOC_USP7_MATH_1	578	582	PF00917	0.674
DOC_USP7_UBL2_3	105	109	PF12436	0.571
DOC_USP7_UBL2_3	117	121	PF12436	0.479
DOC_WW_Pin1_4	23	28	PF00397	0.661
DOC_WW_Pin1_4	300	305	PF00397	0.646
DOC_WW_Pin1_4	4	9	PF00397	0.665
DOC_WW_Pin1_4	409	414	PF00397	0.620
LIG_14-3-3_CanoR_1	134	140	PF00244	0.272
LIG_14-3-3_CanoR_1	163	172	PF00244	0.606
LIG_14-3-3_CanoR_1	23	27	PF00244	0.725
LIG_14-3-3_CanoR_1	373	379	PF00244	0.760
LIG_14-3-3_CanoR_1	391	399	PF00244	0.584
LIG_APCC_ABBA_1	293	298	PF00400	0.604
LIG_APCC_ABBAyCdc20_2	292	298	PF00400	0.601
LIG_deltaCOP1_diTrp_1	602	610	PF00928	0.784
LIG_FHA_1	135	141	PF00498	0.310
LIG_FHA_1	176	182	PF00498	0.620
LIG_FHA_1	26	32	PF00498	0.728
LIG_FHA_1	36	42	PF00498	0.472
LIG_FHA_2	174	180	PF00498	0.511
LIG_FHA_2	209	215	PF00498	0.676
LIG_FHA_2	224	230	PF00498	0.569
LIG_FHA_2	492	498	PF00498	0.629
LIG_LIR_Gen_1	185	195	PF02991	0.629
LIG_LIR_Gen_1	275	284	PF02991	0.547
LIG_LIR_Gen_1	536	545	PF02991	0.644
LIG_LIR_Gen_1	57	66	PF02991	0.673
LIG_LIR_Gen_1	77	87	PF02991	0.517
LIG_LIR_Nem_3	185	190	PF02991	0.639
LIG_LIR_Nem_3	241	246	PF02991	0.680
LIG_LIR_Nem_3	536	541	PF02991	0.556
LIG_LIR_Nem_3	57	63	PF02991	0.453
LIG_LIR_Nem_3	77	83	PF02991	0.513
LIG_PDZ_Class_3	608	613	PF00595	0.698
LIG_SH2_PTP2	187	190	PF00017	0.630
LIG_SH2_PTP2	60	63	PF00017	0.530
LIG_SH2_STAP1	18	22	PF00017	0.770
LIG_SH2_STAP1	423	427	PF00017	0.675
LIG_SH2_STAT3	452	455	PF00017	0.655
LIG_SH2_STAT5	187	190	PF00017	0.630
LIG_SH2_STAT5	278	281	PF00017	0.545
LIG_SH2_STAT5	452	455	PF00017	0.655
LIG_SH2_STAT5	60	63	PF00017	0.530
LIG_SH3_1	410	416	PF00018	0.741
LIG_SH3_3	324	330	PF00018	0.683
LIG_SH3_3	410	416	PF00018	0.723
LIG_SH3_3	5	11	PF00018	0.733
LIG_SUMO_SIM_anti_2	441	451	PF11976	0.573
LIG_TRAF2_1	464	467	PF00917	0.744
LIG_TYR_ITIM	58	63	PF00017	0.671
MOD_CK1_1	133	139	PF00069	0.297
MOD_CK1_1	209	215	PF00069	0.676
MOD_CK1_1	26	32	PF00069	0.736
MOD_CK1_1	3	9	PF00069	0.677
MOD_CK1_1	68	74	PF00069	0.469
MOD_CK1_1	78	84	PF00069	0.429
MOD_CK2_1	173	179	PF00069	0.518
MOD_CK2_1	223	229	PF00069	0.578
MOD_CK2_1	362	368	PF00069	0.732
MOD_CK2_1	461	467	PF00069	0.661
MOD_CK2_1	491	497	PF00069	0.782
MOD_GlcNHglycan	151	154	PF01048	0.453
MOD_GlcNHglycan	160	163	PF01048	0.464
MOD_GlcNHglycan	2	5	PF01048	0.551
MOD_GlcNHglycan	240	243	PF01048	0.457
MOD_GlcNHglycan	28	31	PF01048	0.555
MOD_GlcNHglycan	364	367	PF01048	0.524
MOD_GlcNHglycan	386	389	PF01048	0.423
MOD_GlcNHglycan	50	53	PF01048	0.467
MOD_GlcNHglycan	580	583	PF01048	0.485
MOD_GlcNHglycan	67	70	PF01048	0.575
MOD_GSK3_1	130	137	PF00069	0.521
MOD_GSK3_1	206	213	PF00069	0.692
MOD_GSK3_1	22	29	PF00069	0.782
MOD_GSK3_1	300	307	PF00069	0.651
MOD_GSK3_1	31	38	PF00069	0.644
MOD_GSK3_1	374	381	PF00069	0.651
MOD_GSK3_1	544	551	PF00069	0.580
MOD_GSK3_1	74	81	PF00069	0.430
MOD_NEK2_1	158	163	PF00069	0.679
MOD_NEK2_1	2	7	PF00069	0.679
MOD_NEK2_1	238	243	PF00069	0.606
MOD_NEK2_1	374	379	PF00069	0.589
MOD_NEK2_1	48	53	PF00069	0.411
MOD_NEK2_1	54	59	PF00069	0.340
MOD_NEK2_1	544	549	PF00069	0.580
MOD_PKA_2	133	139	PF00069	0.205
MOD_PKA_2	22	28	PF00069	0.724
MOD_PKA_2	31	37	PF00069	0.608
MOD_PKA_2	379	385	PF00069	0.738
MOD_PKB_1	86	94	PF00069	0.535
MOD_Plk_1	216	222	PF00069	0.598
MOD_Plk_1	394	400	PF00069	0.687
MOD_Plk_2-3	491	497	PF00069	0.782
MOD_Plk_4	170	176	PF00069	0.655
MOD_Plk_4	374	380	PF00069	0.691
MOD_Plk_4	394	400	PF00069	0.800
MOD_Plk_4	54	60	PF00069	0.366
MOD_Plk_4	75	81	PF00069	0.454
MOD_ProDKin_1	23	29	PF00069	0.662
MOD_ProDKin_1	300	306	PF00069	0.645
MOD_ProDKin_1	4	10	PF00069	0.667
MOD_ProDKin_1	409	415	PF00069	0.619
MOD_SUMO_rev_2	161	171	PF00179	0.683
TRG_DiLeu_BaEn_1	445	450	PF01217	0.742
TRG_ENDOCYTIC_2	187	190	PF00928	0.630
TRG_ENDOCYTIC_2	243	246	PF00928	0.677
TRG_ENDOCYTIC_2	278	281	PF00928	0.559
TRG_ENDOCYTIC_2	423	426	PF00928	0.677
TRG_ENDOCYTIC_2	60	63	PF00928	0.673
TRG_ER_diArg_1	288	291	PF00400	0.577
TRG_ER_diArg_1	468	470	PF00400	0.723
TRG_ER_diArg_1	86	89	PF00400	0.459
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	401	405	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7X5	Leptomonas seymouri	46%	100%
A0A3S7X291	Leishmania donovani	86%	99%
A4HH89	Leishmania braziliensis	70%	100%
A4I4D5	Leishmania infantum	85%	99%
E9ADT4	Leishmania major	86%	100%