Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALZ4_LEIMU

TriTrypDb:

LmxM.08_29.0830

Length:

478

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9ALZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALZ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.513
CLV_C14_Caspase3-7	59	63	PF00656	0.418
CLV_NRD_NRD_1	239	241	PF00675	0.635
CLV_NRD_NRD_1	287	289	PF00675	0.521
CLV_NRD_NRD_1	355	357	PF00675	0.707
CLV_NRD_NRD_1	468	470	PF00675	0.408
CLV_PCSK_KEX2_1	239	241	PF00082	0.635
CLV_PCSK_KEX2_1	355	357	PF00082	0.734
CLV_PCSK_KEX2_1	468	470	PF00082	0.361
CLV_PCSK_SKI1_1	202	206	PF00082	0.546
CLV_PCSK_SKI1_1	222	226	PF00082	0.439
CLV_PCSK_SKI1_1	231	235	PF00082	0.548
CLV_PCSK_SKI1_1	26	30	PF00082	0.704
CLV_PCSK_SKI1_1	288	292	PF00082	0.480
DEG_Nend_UBRbox_2	1	3	PF02207	0.516
DEG_SPOP_SBC_1	13	17	PF00917	0.484
DEG_SPOP_SBC_1	136	140	PF00917	0.439
DOC_CDC14_PxL_1	266	274	PF14671	0.364
DOC_CDC14_PxL_1	336	344	PF14671	0.492
DOC_MAPK_gen_1	209	217	PF00069	0.343
DOC_MAPK_gen_1	378	388	PF00069	0.466
DOC_MAPK_HePTP_8	444	456	PF00069	0.272
DOC_MAPK_MEF2A_6	207	215	PF00069	0.329
DOC_MAPK_MEF2A_6	447	456	PF00069	0.313
DOC_MAPK_RevD_3	453	469	PF00069	0.236
DOC_USP7_MATH_1	132	136	PF00917	0.533
DOC_USP7_MATH_1	229	233	PF00917	0.398
DOC_USP7_MATH_1	253	257	PF00917	0.383
DOC_USP7_MATH_1	350	354	PF00917	0.492
DOC_USP7_MATH_1	391	395	PF00917	0.384
DOC_USP7_MATH_1	405	409	PF00917	0.508
DOC_USP7_MATH_1	9	13	PF00917	0.541
DOC_USP7_UBL2_3	173	177	PF12436	0.422
DOC_WW_Pin1_4	327	332	PF00397	0.352
DOC_WW_Pin1_4	340	345	PF00397	0.511
DOC_WW_Pin1_4	37	42	PF00397	0.516
DOC_WW_Pin1_4	439	444	PF00397	0.528
LIG_14-3-3_CanoR_1	163	168	PF00244	0.388
LIG_14-3-3_CanoR_1	447	452	PF00244	0.313
LIG_Actin_WH2_2	258	275	PF00022	0.314
LIG_BRCT_BRCA1_1	449	453	PF00533	0.247
LIG_deltaCOP1_diTrp_1	292	302	PF00928	0.379
LIG_FHA_2	252	258	PF00498	0.441
LIG_FHA_2	435	441	PF00498	0.389
LIG_FHA_2	82	88	PF00498	0.505
LIG_Integrin_RGD_1	77	79	PF01839	0.619
LIG_LIR_Gen_1	208	217	PF02991	0.303
LIG_LIR_Gen_1	450	461	PF02991	0.277
LIG_LIR_Nem_3	208	213	PF02991	0.308
LIG_LIR_Nem_3	263	269	PF02991	0.353
LIG_LIR_Nem_3	313	319	PF02991	0.345
LIG_LIR_Nem_3	445	449	PF02991	0.316
LIG_LIR_Nem_3	450	456	PF02991	0.335
LIG_MYND_1	340	344	PF01753	0.502
LIG_NRBOX	451	457	PF00104	0.366
LIG_PTB_Apo_2	159	166	PF02174	0.256
LIG_SH2_CRK	446	450	PF00017	0.272
LIG_SH2_NCK_1	125	129	PF00017	0.403
LIG_SH2_SRC	125	128	PF00017	0.401
LIG_SH2_SRC	167	170	PF00017	0.384
LIG_SH2_STAT5	167	170	PF00017	0.363
LIG_SH2_STAT5	276	279	PF00017	0.334
LIG_SH2_STAT5	325	328	PF00017	0.435
LIG_SH3_2	329	334	PF14604	0.448
LIG_SH3_3	214	220	PF00018	0.356
LIG_SH3_3	264	270	PF00018	0.374
LIG_SH3_3	326	332	PF00018	0.413
LIG_SH3_3	341	347	PF00018	0.502
LIG_SH3_3	38	44	PF00018	0.474
LIG_SH3_3	418	424	PF00018	0.495
LIG_SUMO_SIM_par_1	138	148	PF11976	0.427
LIG_SUMO_SIM_par_1	9	17	PF11976	0.524
LIG_TRAF2_1	119	122	PF00917	0.476
LIG_TRAF2_1	52	55	PF00917	0.496
LIG_TRAF2_2	347	352	PF00917	0.526
LIG_TYR_ITIM	444	449	PF00017	0.405
MOD_CDK_SPxK_1	340	346	PF00069	0.506
MOD_CDK_SPxxK_3	327	334	PF00069	0.379
MOD_CK1_1	12	18	PF00069	0.555
MOD_CK1_1	135	141	PF00069	0.496
MOD_CK1_1	40	46	PF00069	0.509
MOD_CK1_1	400	406	PF00069	0.553
MOD_CK1_1	408	414	PF00069	0.570
MOD_CK1_1	63	69	PF00069	0.411
MOD_CK2_1	434	440	PF00069	0.396
MOD_CK2_1	86	92	PF00069	0.445
MOD_GlcNHglycan	133	137	PF01048	0.702
MOD_GlcNHglycan	156	159	PF01048	0.569
MOD_GlcNHglycan	393	396	PF01048	0.642
MOD_GlcNHglycan	414	417	PF01048	0.675
MOD_GSK3_1	132	139	PF00069	0.524
MOD_GSK3_1	294	301	PF00069	0.383
MOD_GSK3_1	305	312	PF00069	0.373
MOD_GSK3_1	323	330	PF00069	0.364
MOD_GSK3_1	33	40	PF00069	0.579
MOD_GSK3_1	405	412	PF00069	0.550
MOD_GSK3_1	428	435	PF00069	0.472
MOD_GSK3_1	468	475	PF00069	0.557
MOD_GSK3_1	56	63	PF00069	0.529
MOD_GSK3_1	9	16	PF00069	0.520
MOD_N-GLC_1	323	328	PF02516	0.630
MOD_NEK2_1	145	150	PF00069	0.385
MOD_NEK2_1	197	202	PF00069	0.347
MOD_NEK2_1	461	466	PF00069	0.313
MOD_NEK2_1	473	478	PF00069	0.572
MOD_NEK2_2	229	234	PF00069	0.374
MOD_PIKK_1	294	300	PF00454	0.377
MOD_PIKK_1	397	403	PF00454	0.513
MOD_PK_1	447	453	PF00069	0.313
MOD_PKA_1	468	474	PF00069	0.545
MOD_PKA_2	377	383	PF00069	0.463
MOD_PKA_2	412	418	PF00069	0.490
MOD_PKA_2	468	474	PF00069	0.612
MOD_Plk_1	56	62	PF00069	0.533
MOD_Plk_2-3	56	62	PF00069	0.510
MOD_Plk_2-3	81	87	PF00069	0.420
MOD_Plk_4	187	193	PF00069	0.404
MOD_Plk_4	447	453	PF00069	0.369
MOD_ProDKin_1	327	333	PF00069	0.361
MOD_ProDKin_1	340	346	PF00069	0.512
MOD_ProDKin_1	37	43	PF00069	0.516
MOD_ProDKin_1	439	445	PF00069	0.520
MOD_SUMO_for_1	290	293	PF00179	0.350
TRG_ENDOCYTIC_2	446	449	PF00928	0.410
TRG_ER_diArg_1	355	358	PF00400	0.509
TRG_ER_diArg_1	367	370	PF00400	0.486
TRG_ER_diArg_1	373	376	PF00400	0.439
TRG_ER_diArg_1	467	469	PF00400	0.550
TRG_Pf-PMV_PEXEL_1	288	292	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Q7	Leptomonas seymouri	58%	95%
A0A3S7X2C7	Leishmania donovani	85%	99%
A4HH91	Leishmania braziliensis	70%	100%
A4I4D7	Leishmania infantum	86%	99%
C9ZL27	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	97%
E9ADT6	Leishmania major	86%	100%