LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9ALZ3_LEIMU
TriTrypDb:
LmxM.08_29.0840
Length:
391

Annotations

LeishMANIAdb annotations

This protein is only found among Kinetoplastds. However, its function is unclear, could be a transporter or channel protein.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9
GO:0005635 nuclear envelope 4 1
GO:0005737 cytoplasm 2 1
GO:0005819 spindle 5 1
GO:0031967 organelle envelope 3 1
GO:0031975 envelope 2 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1

Expansion

Sequence features

E9ALZ3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALZ3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 122 124 PF00675 0.421
CLV_NRD_NRD_1 183 185 PF00675 0.442
CLV_PCSK_KEX2_1 122 124 PF00082 0.421
CLV_PCSK_KEX2_1 183 185 PF00082 0.442
CLV_PCSK_SKI1_1 178 182 PF00082 0.522
CLV_PCSK_SKI1_1 183 187 PF00082 0.387
DEG_SPOP_SBC_1 78 82 PF00917 0.320
DOC_CKS1_1 369 374 PF01111 0.402
DOC_MAPK_gen_1 122 130 PF00069 0.523
DOC_MAPK_MEF2A_6 123 132 PF00069 0.514
DOC_MAPK_MEF2A_6 208 216 PF00069 0.589
DOC_MAPK_RevD_3 170 184 PF00069 0.430
DOC_PP2B_LxvP_1 87 90 PF13499 0.464
DOC_PP2B_PxIxI_1 106 112 PF00149 0.447
DOC_PP4_FxxP_1 104 107 PF00568 0.370
DOC_PP4_FxxP_1 11 14 PF00568 0.681
DOC_PP4_FxxP_1 118 121 PF00568 0.576
DOC_PP4_FxxP_1 338 341 PF00568 0.693
DOC_PP4_FxxP_1 51 54 PF00568 0.373
DOC_USP7_MATH_1 139 143 PF00917 0.349
DOC_USP7_MATH_1 259 263 PF00917 0.436
DOC_USP7_MATH_1 311 315 PF00917 0.429
DOC_WW_Pin1_4 10 15 PF00397 0.684
DOC_WW_Pin1_4 27 32 PF00397 0.556
DOC_WW_Pin1_4 368 373 PF00397 0.330
LIG_14-3-3_CanoR_1 122 128 PF00244 0.662
LIG_14-3-3_CanoR_1 45 51 PF00244 0.515
LIG_Actin_WH2_2 311 328 PF00022 0.188
LIG_APCC_ABBA_1 65 70 PF00400 0.572
LIG_BIR_II_1 1 5 PF00653 0.725
LIG_BRCT_BRCA1_1 268 272 PF00533 0.454
LIG_BRCT_BRCA1_1 29 33 PF00533 0.590
LIG_CaM_NSCaTE_8 347 354 PF13499 0.480
LIG_CSL_BTD_1 209 212 PF09270 0.670
LIG_DLG_GKlike_1 123 130 PF00625 0.586
LIG_EVH1_1 87 91 PF00568 0.364
LIG_FHA_1 159 165 PF00498 0.468
LIG_FHA_1 216 222 PF00498 0.335
LIG_FHA_1 369 375 PF00498 0.441
LIG_FHA_1 47 53 PF00498 0.395
LIG_FHA_1 96 102 PF00498 0.331
LIG_IRF3_LxIS_1 159 166 PF10401 0.285
LIG_LIR_Apic_2 10 14 PF02991 0.682
LIG_LIR_Apic_2 49 54 PF02991 0.378
LIG_LIR_Gen_1 129 140 PF02991 0.369
LIG_LIR_Nem_3 129 135 PF02991 0.413
LIG_LIR_Nem_3 166 170 PF02991 0.429
LIG_LIR_Nem_3 203 209 PF02991 0.679
LIG_LIR_Nem_3 277 282 PF02991 0.377
LIG_LIR_Nem_3 30 36 PF02991 0.584
LIG_LIR_Nem_3 56 61 PF02991 0.397
LIG_PDZ_Class_2 386 391 PF00595 0.447
LIG_Pex14_1 201 205 PF04695 0.643
LIG_Pex14_2 114 118 PF04695 0.578
LIG_Pex14_2 46 50 PF04695 0.484
LIG_Pex14_2 51 55 PF04695 0.462
LIG_PTB_Apo_2 384 391 PF02174 0.402
LIG_SH2_CRK 279 283 PF00017 0.388
LIG_SH2_NCK_1 196 200 PF00017 0.402
LIG_SH2_STAP1 196 200 PF00017 0.434
LIG_SH2_STAT5 19 22 PF00017 0.601
LIG_SH2_STAT5 196 199 PF00017 0.401
LIG_SH2_STAT5 309 312 PF00017 0.392
LIG_SH2_STAT5 36 39 PF00017 0.528
LIG_SH2_STAT5 370 373 PF00017 0.442
LIG_SH2_STAT5 47 50 PF00017 0.335
LIG_SH3_3 107 113 PF00018 0.416
LIG_SH3_3 206 212 PF00018 0.632
LIG_SH3_3 214 220 PF00018 0.358
LIG_SH3_3 338 344 PF00018 0.595
LIG_SH3_3 366 372 PF00018 0.386
LIG_SH3_3 82 88 PF00018 0.478
LIG_SUMO_SIM_anti_2 171 176 PF11976 0.396
LIG_SUMO_SIM_anti_2 98 104 PF11976 0.408
LIG_SUMO_SIM_par_1 173 179 PF11976 0.360
LIG_TYR_ITIM 60 65 PF00017 0.381
LIG_UBA3_1 57 66 PF00899 0.402
LIG_WRC_WIRS_1 140 145 PF05994 0.368
LIG_WW_2 212 215 PF00397 0.659
MOD_CDK_SPxxK_3 27 34 PF00069 0.655
MOD_CK1_1 126 132 PF00069 0.451
MOD_CK1_1 304 310 PF00069 0.328
MOD_CK1_1 79 85 PF00069 0.500
MOD_GlcNHglycan 225 228 PF01048 0.480
MOD_GlcNHglycan 244 247 PF01048 0.545
MOD_GlcNHglycan 257 260 PF01048 0.612
MOD_GSK3_1 242 249 PF00069 0.396
MOD_GSK3_1 255 262 PF00069 0.414
MOD_GSK3_1 266 273 PF00069 0.337
MOD_GSK3_1 300 307 PF00069 0.377
MOD_GSK3_1 347 354 PF00069 0.375
MOD_GSK3_1 76 83 PF00069 0.523
MOD_NEK2_1 153 158 PF00069 0.435
MOD_NEK2_1 163 168 PF00069 0.435
MOD_NEK2_1 200 205 PF00069 0.639
MOD_NEK2_1 240 245 PF00069 0.341
MOD_NEK2_1 255 260 PF00069 0.417
MOD_NEK2_1 270 275 PF00069 0.374
MOD_NEK2_1 351 356 PF00069 0.379
MOD_NEK2_1 46 51 PF00069 0.376
MOD_NEK2_1 76 81 PF00069 0.475
MOD_Plk_4 123 129 PF00069 0.572
MOD_Plk_4 131 137 PF00069 0.366
MOD_Plk_4 246 252 PF00069 0.405
MOD_Plk_4 285 291 PF00069 0.402
MOD_Plk_4 304 310 PF00069 0.290
MOD_Plk_4 32 38 PF00069 0.645
MOD_Plk_4 342 348 PF00069 0.514
MOD_Plk_4 357 363 PF00069 0.292
MOD_Plk_4 46 52 PF00069 0.295
MOD_Plk_4 95 101 PF00069 0.381
MOD_ProDKin_1 10 16 PF00069 0.678
MOD_ProDKin_1 27 33 PF00069 0.556
MOD_ProDKin_1 368 374 PF00069 0.330
TRG_ENDOCYTIC_2 150 153 PF00928 0.464
TRG_ENDOCYTIC_2 279 282 PF00928 0.387
TRG_ENDOCYTIC_2 62 65 PF00928 0.336
TRG_ER_diArg_1 121 123 PF00400 0.619
TRG_ER_diArg_1 182 184 PF00400 0.442
TRG_ER_diArg_1 201 204 PF00400 0.449
TRG_ER_diArg_1 5 8 PF00400 0.520
TRG_Pf-PMV_PEXEL_1 184 189 PF00026 0.355

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PEY8 Leptomonas seymouri 60% 100%
A0A1X0P088 Trypanosomatidae 34% 100%
A0A3Q8IH62 Leishmania donovani 93% 100%
A0A3R7MU19 Trypanosoma rangeli 37% 92%
A4HH92 Leishmania braziliensis 84% 100%
A4I4D8 Leishmania infantum 93% 100%
C9ZL26 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
E9ADT7 Leishmania major 94% 100%
V5BH42 Trypanosoma cruzi 33% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS