High mobility group protein homolog tdp-1,putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

High mobility group protein TDP1

Species:

Leishmania mexicana

UniProt:

E9ALZ2_LEIMU

TriTrypDb:

LmxM.08_29.0850

Length:

300

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005730	nucleolus	5	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

E9ALZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALZ2

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0000182	rDNA binding	7	1
GO:0000217	DNA secondary structure binding	5	1
GO:0000400	four-way junction DNA binding	6	1
GO:0000402	crossed form four-way junction DNA binding	7	1
GO:0003690	double-stranded DNA binding	5	1
GO:0008301	DNA binding, bending	5	1
GO:0043565	sequence-specific DNA binding	5	1
GO:1990837	sequence-specific double-stranded DNA binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	292	296	PF00656	0.730
CLV_NRD_NRD_1	36	38	PF00675	0.344
CLV_NRD_NRD_1	83	85	PF00675	0.624
CLV_PCSK_FUR_1	84	88	PF00082	0.692
CLV_PCSK_KEX2_1	190	192	PF00082	0.579
CLV_PCSK_KEX2_1	209	211	PF00082	0.244
CLV_PCSK_KEX2_1	262	264	PF00082	0.316
CLV_PCSK_KEX2_1	35	37	PF00082	0.344
CLV_PCSK_KEX2_1	83	85	PF00082	0.578
CLV_PCSK_KEX2_1	86	88	PF00082	0.572
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.565
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.244
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.316
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.574
CLV_PCSK_SKI1_1	115	119	PF00082	0.314
CLV_PCSK_SKI1_1	15	19	PF00082	0.362
CLV_PCSK_SKI1_1	153	157	PF00082	0.164
CLV_PCSK_SKI1_1	194	198	PF00082	0.664
CLV_PCSK_SKI1_1	209	213	PF00082	0.349
CLV_PCSK_SKI1_1	59	63	PF00082	0.501
CLV_PCSK_SKI1_1	83	87	PF00082	0.691
DEG_SPOP_SBC_1	289	293	PF00917	0.762
DOC_CKS1_1	61	66	PF01111	0.559
DOC_MAPK_MEF2A_6	115	124	PF00069	0.510
DOC_USP7_MATH_1	266	270	PF00917	0.536
DOC_USP7_MATH_1	280	284	PF00917	0.631
DOC_USP7_MATH_1	288	292	PF00917	0.766
DOC_USP7_MATH_1	5	9	PF00917	0.675
DOC_USP7_UBL2_3	131	135	PF12436	0.532
DOC_USP7_UBL2_3	190	194	PF12436	0.541
DOC_USP7_UBL2_3	197	201	PF12436	0.551
DOC_USP7_UBL2_3	96	100	PF12436	0.714
DOC_WW_Pin1_4	116	121	PF00397	0.528
DOC_WW_Pin1_4	273	278	PF00397	0.466
DOC_WW_Pin1_4	284	289	PF00397	0.499
DOC_WW_Pin1_4	44	49	PF00397	0.508
DOC_WW_Pin1_4	60	65	PF00397	0.560
DOC_WW_Pin1_4	87	92	PF00397	0.648
LIG_14-3-3_CanoR_1	210	218	PF00244	0.444
LIG_BIR_II_1	1	5	PF00653	0.581
LIG_FHA_1	140	146	PF00498	0.455
LIG_FHA_1	48	54	PF00498	0.590
LIG_FHA_1	61	67	PF00498	0.397
LIG_FHA_2	154	160	PF00498	0.364
LIG_FHA_2	60	66	PF00498	0.606
LIG_LIR_Gen_1	119	125	PF02991	0.455
LIG_LIR_Gen_1	161	167	PF02991	0.545
LIG_LIR_Nem_3	119	124	PF02991	0.444
LIG_LIR_Nem_3	161	166	PF02991	0.520
LIG_LIR_Nem_3	213	218	PF02991	0.444
LIG_LIR_Nem_3	45	49	PF02991	0.508
LIG_RPA_C_Fungi	179	191	PF08784	0.592
LIG_SH2_CRK	163	167	PF00017	0.318
LIG_SH2_STAP1	174	178	PF00017	0.454
LIG_SH2_STAP1	253	257	PF00017	0.283
LIG_SH2_STAT5	121	124	PF00017	0.299
LIG_SH2_STAT5	181	184	PF00017	0.548
LIG_SH2_STAT5	215	218	PF00017	0.299
LIG_SH3_1	274	280	PF00018	0.483
LIG_SH3_2	205	210	PF14604	0.606
LIG_SH3_3	202	208	PF00018	0.628
LIG_SH3_3	272	278	PF00018	0.666
LIG_SUMO_SIM_anti_2	16	23	PF11976	0.430
LIG_TRAF2_1	156	159	PF00917	0.316
LIG_TRAF2_1	246	249	PF00917	0.419
LIG_TRAF2_1	252	255	PF00917	0.429
LIG_UBA3_1	144	153	PF00899	0.318
MOD_CDC14_SPxK_1	276	279	PF00782	0.486
MOD_CDK_SPxK_1	273	279	PF00069	0.472
MOD_CK1_1	27	33	PF00069	0.368
MOD_CK1_1	273	279	PF00069	0.687
MOD_CK1_1	283	289	PF00069	0.754
MOD_CK1_1	291	297	PF00069	0.689
MOD_CK2_1	13	19	PF00069	0.428
MOD_CK2_1	153	159	PF00069	0.424
MOD_CK2_1	243	249	PF00069	0.385
MOD_CK2_1	59	65	PF00069	0.591
MOD_Cter_Amidation	192	195	PF01082	0.606
MOD_GlcNHglycan	1	4	PF01048	0.649
MOD_GlcNHglycan	101	104	PF01048	0.775
MOD_GlcNHglycan	245	248	PF01048	0.491
MOD_GlcNHglycan	267	271	PF01048	0.649
MOD_GlcNHglycan	282	285	PF01048	0.824
MOD_GlcNHglycan	78	83	PF01048	0.548
MOD_GlcNHglycan	91	94	PF01048	0.568
MOD_GSK3_1	139	146	PF00069	0.407
MOD_GSK3_1	266	273	PF00069	0.688
MOD_GSK3_1	280	287	PF00069	0.663
MOD_GSK3_1	289	296	PF00069	0.717
MOD_GSK3_1	87	94	PF00069	0.654
MOD_N-GLC_1	5	10	PF02516	0.575
MOD_NEK2_1	13	18	PF00069	0.420
MOD_PKA_1	153	159	PF00069	0.374
MOD_PKA_1	197	203	PF00069	0.442
MOD_PKB_1	87	95	PF00069	0.710
MOD_Plk_1	13	19	PF00069	0.385
MOD_Plk_1	158	164	PF00069	0.374
MOD_Plk_4	13	19	PF00069	0.364
MOD_ProDKin_1	116	122	PF00069	0.402
MOD_ProDKin_1	273	279	PF00069	0.472
MOD_ProDKin_1	284	290	PF00069	0.501
MOD_ProDKin_1	44	50	PF00069	0.374
MOD_ProDKin_1	60	66	PF00069	0.553
MOD_ProDKin_1	87	93	PF00069	0.650
MOD_SUMO_for_1	85	88	PF00179	0.671
MOD_SUMO_rev_2	101	110	PF00179	0.542
MOD_SUMO_rev_2	157	161	PF00179	0.372
MOD_SUMO_rev_2	168	172	PF00179	0.265
MOD_SUMO_rev_2	200	208	PF00179	0.404
MOD_SUMO_rev_2	246	252	PF00179	0.349
TRG_DiLeu_BaEn_1	52	57	PF01217	0.374
TRG_ENDOCYTIC_2	121	124	PF00928	0.299
TRG_ENDOCYTIC_2	163	166	PF00928	0.299
TRG_ENDOCYTIC_2	215	218	PF00928	0.299
TRG_ENDOCYTIC_2	253	256	PF00928	0.299
TRG_ER_diArg_1	34	37	PF00400	0.299
TRG_ER_diArg_1	83	85	PF00400	0.535
TRG_NLS_MonoExtC_3	193	198	PF00514	0.670
TRG_NLS_MonoExtN_4	191	198	PF00514	0.670
TRG_Pf-PMV_PEXEL_1	83	88	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8C9	Leptomonas seymouri	65%	99%
A0A0S4KNH5	Bodo saltans	36%	78%
A0A1X0NZM0	Trypanosomatidae	42%	100%
A0A3Q8IEB8	Leishmania donovani	93%	99%
A0A3R7KR63	Trypanosoma rangeli	45%	100%
A4HH93	Leishmania braziliensis	86%	100%
A4I4D9	Leishmania infantum	93%	99%
C9ZL24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9ADT8	Leishmania major	94%	100%
P26586	Trypanosoma brucei rhodesiense	41%	100%
V5B1M8	Trypanosoma cruzi	45%	100%