Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ALZ1_LEIMU

TriTrypDb:

LmxM.08_29.0860

Length:

468

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALZ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.509
CLV_NRD_NRD_1	200	202	PF00675	0.693
CLV_NRD_NRD_1	216	218	PF00675	0.555
CLV_NRD_NRD_1	344	346	PF00675	0.699
CLV_PCSK_KEX2_1	200	202	PF00082	0.686
CLV_PCSK_KEX2_1	216	218	PF00082	0.560
CLV_PCSK_PC7_1	196	202	PF00082	0.690
CLV_PCSK_SKI1_1	232	236	PF00082	0.728
CLV_PCSK_SKI1_1	362	366	PF00082	0.682
CLV_PCSK_SKI1_1	414	418	PF00082	0.629
DEG_Nend_UBRbox_2	1	3	PF02207	0.553
DEG_SCF_TRCP1_1	105	111	PF00400	0.385
DEG_SPOP_SBC_1	20	24	PF00917	0.811
DOC_CKS1_1	227	232	PF01111	0.539
DOC_CKS1_1	400	405	PF01111	0.809
DOC_CYCLIN_RxL_1	359	369	PF00134	0.682
DOC_MAPK_DCC_7	311	320	PF00069	0.518
DOC_MAPK_MEF2A_6	84	93	PF00069	0.486
DOC_PP1_RVXF_1	360	367	PF00149	0.781
DOC_PP2B_LxvP_1	357	360	PF13499	0.779
DOC_PP2B_LxvP_1	408	411	PF13499	0.667
DOC_PP2B_LxvP_1	460	463	PF13499	0.489
DOC_SPAK_OSR1_1	286	290	PF12202	0.534
DOC_USP7_MATH_1	19	23	PF00917	0.815
DOC_USP7_MATH_1	205	209	PF00917	0.723
DOC_USP7_MATH_1	233	237	PF00917	0.671
DOC_USP7_MATH_1	358	362	PF00917	0.503
DOC_USP7_MATH_1	385	389	PF00917	0.726
DOC_USP7_MATH_1	404	408	PF00917	0.743
DOC_USP7_MATH_1	423	427	PF00917	0.558
DOC_USP7_MATH_1	47	51	PF00917	0.681
DOC_WW_Pin1_4	182	187	PF00397	0.530
DOC_WW_Pin1_4	199	204	PF00397	0.749
DOC_WW_Pin1_4	21	26	PF00397	0.808
DOC_WW_Pin1_4	220	225	PF00397	0.740
DOC_WW_Pin1_4	226	231	PF00397	0.706
DOC_WW_Pin1_4	291	296	PF00397	0.658
DOC_WW_Pin1_4	313	318	PF00397	0.683
DOC_WW_Pin1_4	332	337	PF00397	0.565
DOC_WW_Pin1_4	393	398	PF00397	0.734
DOC_WW_Pin1_4	399	404	PF00397	0.717
DOC_WW_Pin1_4	425	430	PF00397	0.524
DOC_WW_Pin1_4	67	72	PF00397	0.801
LIG_14-3-3_CanoR_1	232	238	PF00244	0.736
LIG_14-3-3_CanoR_1	362	367	PF00244	0.720
LIG_14-3-3_CanoR_1	54	63	PF00244	0.701
LIG_BRCT_BRCA1_1	268	272	PF00533	0.523
LIG_BRCT_BRCA1_1	58	62	PF00533	0.626
LIG_FHA_1	154	160	PF00498	0.627
LIG_FHA_1	220	226	PF00498	0.695
LIG_FHA_1	276	282	PF00498	0.619
LIG_FHA_1	294	300	PF00498	0.518
LIG_FHA_1	32	38	PF00498	0.797
LIG_FHA_1	428	434	PF00498	0.568
LIG_FHA_1	55	61	PF00498	0.708
LIG_FHA_1	8	14	PF00498	0.680
LIG_FHA_1	88	94	PF00498	0.478
LIG_FHA_2	238	244	PF00498	0.499
LIG_FHA_2	363	369	PF00498	0.783
LIG_FHA_2	72	78	PF00498	0.775
LIG_LIR_Gen_1	278	287	PF02991	0.592
LIG_LIR_Nem_3	269	275	PF02991	0.551
LIG_LIR_Nem_3	278	282	PF02991	0.492
LIG_MYND_3	11	15	PF01753	0.532
LIG_PDZ_Class_2	463	468	PF00595	0.486
LIG_RPA_C_Fungi	281	293	PF08784	0.560
LIG_SH2_CRK	227	231	PF00017	0.536
LIG_SH2_CRK	334	338	PF00017	0.506
LIG_SH2_NCK_1	227	231	PF00017	0.536
LIG_SH2_NCK_1	334	338	PF00017	0.506
LIG_SH2_NCK_1	44	48	PF00017	0.667
LIG_SH2_STAP1	252	256	PF00017	0.481
LIG_SH2_STAP1	275	279	PF00017	0.546
LIG_SH2_STAT3	351	354	PF00017	0.513
LIG_SH2_STAT5	334	337	PF00017	0.509
LIG_SH3_3	294	300	PF00018	0.702
LIG_SH3_3	309	315	PF00018	0.710
LIG_SH3_3	394	400	PF00018	0.725
LIG_SUMO_SIM_par_1	432	438	PF11976	0.438
LIG_TRAF2_1	111	114	PF00917	0.636
LIG_WW_3	229	233	PF00397	0.536
MOD_CDK_SPxK_1	226	232	PF00069	0.535
MOD_CK1_1	155	161	PF00069	0.598
MOD_CK1_1	208	214	PF00069	0.709
MOD_CK1_1	291	297	PF00069	0.666
MOD_CK1_1	302	308	PF00069	0.723
MOD_CK1_1	32	38	PF00069	0.821
MOD_CK1_1	52	58	PF00069	0.462
MOD_CK2_1	108	114	PF00069	0.629
MOD_CK2_1	237	243	PF00069	0.604
MOD_CK2_1	362	368	PF00069	0.782
MOD_CK2_1	69	75	PF00069	0.738
MOD_DYRK1A_RPxSP_1	293	297	PF00069	0.689
MOD_GlcNHglycan	105	108	PF01048	0.420
MOD_GlcNHglycan	212	216	PF01048	0.752
MOD_GlcNHglycan	235	238	PF01048	0.804
MOD_GlcNHglycan	251	255	PF01048	0.391
MOD_GlcNHglycan	290	293	PF01048	0.631
MOD_GlcNHglycan	444	447	PF01048	0.718
MOD_GSK3_1	191	198	PF00069	0.593
MOD_GSK3_1	233	240	PF00069	0.538
MOD_GSK3_1	29	36	PF00069	0.822
MOD_GSK3_1	291	298	PF00069	0.759
MOD_GSK3_1	358	365	PF00069	0.697
MOD_GSK3_1	376	383	PF00069	0.647
MOD_GSK3_1	423	430	PF00069	0.579
MOD_GSK3_1	49	56	PF00069	0.485
MOD_GSK3_1	65	72	PF00069	0.794
MOD_GSK3_1	99	106	PF00069	0.522
MOD_N-GLC_2	242	244	PF02516	0.650
MOD_NEK2_1	108	113	PF00069	0.442
MOD_NEK2_1	288	293	PF00069	0.582
MOD_NEK2_1	53	58	PF00069	0.604
MOD_NEK2_1	93	98	PF00069	0.468
MOD_PIKK_1	109	115	PF00454	0.515
MOD_PIKK_1	266	272	PF00454	0.517
MOD_PIKK_1	302	308	PF00454	0.746
MOD_PIKK_1	340	346	PF00454	0.654
MOD_PIKK_1	54	60	PF00454	0.716
MOD_PIKK_1	99	105	PF00454	0.584
MOD_PKA_2	195	201	PF00069	0.697
MOD_PKA_2	53	59	PF00069	0.669
MOD_PKB_1	148	156	PF00069	0.480
MOD_Plk_1	1	7	PF00069	0.737
MOD_Plk_1	163	169	PF00069	0.505
MOD_Plk_1	32	38	PF00069	0.776
MOD_Plk_1	47	53	PF00069	0.536
MOD_Plk_1	87	93	PF00069	0.468
MOD_Plk_2-3	75	81	PF00069	0.735
MOD_Plk_4	163	169	PF00069	0.602
MOD_Plk_4	362	368	PF00069	0.782
MOD_Plk_4	404	410	PF00069	0.571
MOD_Plk_4	93	99	PF00069	0.596
MOD_ProDKin_1	182	188	PF00069	0.531
MOD_ProDKin_1	199	205	PF00069	0.742
MOD_ProDKin_1	21	27	PF00069	0.811
MOD_ProDKin_1	220	226	PF00069	0.738
MOD_ProDKin_1	291	297	PF00069	0.666
MOD_ProDKin_1	313	319	PF00069	0.683
MOD_ProDKin_1	332	338	PF00069	0.563
MOD_ProDKin_1	393	399	PF00069	0.732
MOD_ProDKin_1	425	431	PF00069	0.525
MOD_ProDKin_1	67	73	PF00069	0.799
TRG_DiLeu_BaLyEn_6	221	226	PF01217	0.722
TRG_DiLeu_BaLyEn_6	9	14	PF01217	0.531
TRG_ER_diArg_1	37	40	PF00400	0.731
TRG_Pf-PMV_PEXEL_1	126	131	PF00026	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I162	Leptomonas seymouri	43%	74%
A0A3Q8IR74	Leishmania donovani	86%	100%
E9ADT9	Leishmania major	86%	100%
E9AHI3	Leishmania infantum	86%	100%
E9AIT6	Leishmania braziliensis	72%	100%