LeishMANIAdb
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Cytochrome b5 heme-binding domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cytochrome b5 heme-binding domain-containing protein
Gene product:
cytochrome b5-like Heme/Steroid binding domain containing protein, putative
Species:
Leishmania mexicana
UniProt:
E9ALY8_LEIMU
TriTrypDb:
LmxM.08_29.0868
Length:
168

Annotations

LeishMANIAdb annotations

This cluster contains a high variety of cytochrome b5 homologs. Although all membrane-anchored, some use the N-terminal [type-III] while others the C-terminal TM helix [type-IV]. The heme domain is assumed to be cytoplasmic.. Localization: ER (by homology) / Mitochondrial outer membrane (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0016020 membrane 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9ALY8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALY8

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0020037 heme binding 4 1
GO:0046906 tetrapyrrole binding 3 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 11 13 PF00675 0.654
CLV_NRD_NRD_1 156 158 PF00675 0.665
CLV_NRD_NRD_1 29 31 PF00675 0.390
CLV_NRD_NRD_1 59 61 PF00675 0.390
CLV_NRD_NRD_1 84 86 PF00675 0.585
CLV_PCSK_KEX2_1 13 15 PF00082 0.682
CLV_PCSK_KEX2_1 156 158 PF00082 0.665
CLV_PCSK_KEX2_1 29 31 PF00082 0.337
CLV_PCSK_KEX2_1 59 61 PF00082 0.412
CLV_PCSK_PC1ET2_1 13 15 PF00082 0.614
CLV_PCSK_SKI1_1 111 115 PF00082 0.743
DEG_APCC_DBOX_1 28 36 PF00400 0.390
DEG_Nend_Nbox_1 1 3 PF02207 0.603
DOC_PP2B_LxvP_1 98 101 PF13499 0.716
DOC_WW_Pin1_4 117 122 PF00397 0.662
DOC_WW_Pin1_4 147 152 PF00397 0.671
DOC_WW_Pin1_4 158 163 PF00397 0.682
DOC_WW_Pin1_4 88 93 PF00397 0.537
LIG_14-3-3_CanoR_1 156 164 PF00244 0.679
LIG_14-3-3_CanoR_1 29 33 PF00244 0.339
LIG_FHA_1 108 114 PF00498 0.672
LIG_FHA_1 136 142 PF00498 0.661
LIG_FHA_1 42 48 PF00498 0.412
LIG_FHA_1 89 95 PF00498 0.600
LIG_NRBOX 1 7 PF00104 0.623
LIG_NRP_CendR_1 166 168 PF00754 0.656
LIG_Pex14_2 7 11 PF04695 0.586
LIG_SH2_STAT3 77 80 PF00017 0.404
LIG_SH2_STAT5 71 74 PF00017 0.602
LIG_TRAF2_1 105 108 PF00917 0.649
LIG_TRAF2_1 132 135 PF00917 0.736
LIG_TRAF2_1 78 81 PF00917 0.396
LIG_UBA3_1 5 13 PF00899 0.620
LIG_WW_3 99 103 PF00397 0.723
MOD_CK1_1 36 42 PF00069 0.390
MOD_CK2_1 129 135 PF00069 0.830
MOD_GlcNHglycan 131 134 PF01048 0.799
MOD_GlcNHglycan 35 38 PF01048 0.371
MOD_GlcNHglycan 8 11 PF01048 0.581
MOD_GSK3_1 107 114 PF00069 0.524
MOD_GSK3_1 129 136 PF00069 0.755
MOD_GSK3_1 140 147 PF00069 0.561
MOD_NEK2_1 25 30 PF00069 0.185
MOD_NEK2_1 6 11 PF00069 0.535
MOD_NEK2_2 69 74 PF00069 0.604
MOD_PIKK_1 123 129 PF00454 0.509
MOD_PKA_2 155 161 PF00069 0.683
MOD_PKA_2 28 34 PF00069 0.390
MOD_Plk_1 69 75 PF00069 0.599
MOD_Plk_4 36 42 PF00069 0.412
MOD_ProDKin_1 117 123 PF00069 0.664
MOD_ProDKin_1 147 153 PF00069 0.675
MOD_ProDKin_1 158 164 PF00069 0.680
MOD_ProDKin_1 88 94 PF00069 0.545
TRG_ER_diArg_1 11 14 PF00400 0.603
TRG_ER_diArg_1 155 157 PF00400 0.697
TRG_ER_diArg_1 58 60 PF00400 0.390
TRG_NLS_MonoExtC_3 11 16 PF00514 0.616
TRG_Pf-PMV_PEXEL_1 85 89 PF00026 0.366

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMH0 Leptomonas seymouri 63% 98%
A0A3S7X2B2 Leishmania donovani 93% 100%
A0A3S7X2E8 Leishmania donovani 43% 97%
A4HH96 Leishmania braziliensis 81% 100%
A4I4E2 Leishmania infantum 93% 100%
E9ADU2 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS