Signal recognition particle subunit SRP68

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALY7_LEIMU

TriTrypDb:

LmxM.08_29.0870

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALY7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	213	215	PF00675	0.542
CLV_NRD_NRD_1	30	32	PF00675	0.406
CLV_NRD_NRD_1	38	40	PF00675	0.500
CLV_PCSK_KEX2_1	213	215	PF00082	0.451
CLV_PCSK_KEX2_1	30	32	PF00082	0.381
CLV_PCSK_KEX2_1	398	400	PF00082	0.519
CLV_PCSK_KEX2_1	97	99	PF00082	0.355
CLV_PCSK_PC1ET2_1	398	400	PF00082	0.395
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.355
CLV_PCSK_SKI1_1	16	20	PF00082	0.462
CLV_PCSK_SKI1_1	249	253	PF00082	0.514
CLV_PCSK_SKI1_1	409	413	PF00082	0.369
CLV_PCSK_SKI1_1	450	454	PF00082	0.316
CLV_PCSK_SKI1_1	457	461	PF00082	0.349
CLV_PCSK_SKI1_1	470	474	PF00082	0.248
CLV_PCSK_SKI1_1	98	102	PF00082	0.239
DEG_APCC_DBOX_1	66	74	PF00400	0.396
DEG_APCC_DBOX_1	8	16	PF00400	0.573
DEG_Nend_Nbox_1	1	3	PF02207	0.551
DEG_SCF_FBW7_1	363	369	PF00400	0.531
DEG_SPOP_SBC_1	366	370	PF00917	0.615
DOC_CKS1_1	363	368	PF01111	0.572
DOC_CYCLIN_RxL_1	405	415	PF00134	0.375
DOC_CYCLIN_RxL_1	447	456	PF00134	0.346
DOC_CYCLIN_RxL_1	457	466	PF00134	0.370
DOC_MAPK_gen_1	455	464	PF00069	0.425
DOC_MAPK_gen_1	97	105	PF00069	0.328
DOC_PP2B_LxvP_1	8	11	PF13499	0.500
DOC_USP7_MATH_1	128	132	PF00917	0.442
DOC_USP7_MATH_1	295	299	PF00917	0.568
DOC_USP7_MATH_1	361	365	PF00917	0.586
DOC_USP7_MATH_1	366	370	PF00917	0.531
DOC_USP7_MATH_1	377	381	PF00917	0.400
DOC_USP7_MATH_1	384	388	PF00917	0.371
DOC_USP7_MATH_1	45	49	PF00917	0.386
DOC_USP7_UBL2_3	343	347	PF12436	0.566
DOC_USP7_UBL2_3	401	405	PF12436	0.484
DOC_WW_Pin1_4	145	150	PF00397	0.395
DOC_WW_Pin1_4	185	190	PF00397	0.419
DOC_WW_Pin1_4	305	310	PF00397	0.536
DOC_WW_Pin1_4	362	367	PF00397	0.617
DOC_WW_Pin1_4	434	439	PF00397	0.479
DOC_WW_Pin1_4	483	488	PF00397	0.624
LIG_14-3-3_CanoR_1	104	112	PF00244	0.483
LIG_14-3-3_CanoR_1	321	327	PF00244	0.567
LIG_14-3-3_CanoR_1	477	483	PF00244	0.513
LIG_Actin_WH2_2	1	18	PF00022	0.524
LIG_AP2alpha_1	277	281	PF02296	0.413
LIG_BRCT_BRCA1_1	327	331	PF00533	0.587
LIG_BRCT_BRCA1_1	455	459	PF00533	0.202
LIG_CaM_IQ_9	242	257	PF13499	0.420
LIG_CaM_NSCaTE_8	152	159	PF13499	0.445
LIG_eIF4E_1	447	453	PF01652	0.388
LIG_FHA_1	23	29	PF00498	0.407
LIG_FHA_1	435	441	PF00498	0.473
LIG_FHA_1	59	65	PF00498	0.448
LIG_FHA_1	76	82	PF00498	0.508
LIG_FHA_2	124	130	PF00498	0.393
LIG_FHA_2	174	180	PF00498	0.362
LIG_FHA_2	225	231	PF00498	0.497
LIG_FHA_2	255	261	PF00498	0.410
LIG_FHA_2	265	271	PF00498	0.340
LIG_FHA_2	281	287	PF00498	0.602
LIG_FHA_2	464	470	PF00498	0.497
LIG_FHA_2	484	490	PF00498	0.412
LIG_FHA_2	51	57	PF00498	0.533
LIG_GBD_Chelix_1	403	411	PF00786	0.467
LIG_LIR_Gen_1	169	178	PF02991	0.382
LIG_LIR_Gen_1	202	212	PF02991	0.440
LIG_LIR_Gen_1	444	453	PF02991	0.311
LIG_LIR_Nem_3	140	144	PF02991	0.355
LIG_LIR_Nem_3	160	164	PF02991	0.196
LIG_LIR_Nem_3	169	175	PF02991	0.348
LIG_LIR_Nem_3	202	208	PF02991	0.433
LIG_LIR_Nem_3	456	462	PF02991	0.395
LIG_LRP6_Inhibitor_1	24	30	PF00058	0.481
LIG_NRBOX	337	343	PF00104	0.493
LIG_PCNA_yPIPBox_3	26	40	PF02747	0.525
LIG_Pex14_2	277	281	PF04695	0.413
LIG_SH2_STAT3	413	416	PF00017	0.389
LIG_SH2_STAT5	164	167	PF00017	0.461
LIG_SH2_STAT5	185	188	PF00017	0.417
LIG_SH2_STAT5	445	448	PF00017	0.335
LIG_SH2_STAT5	71	74	PF00017	0.385
LIG_SH3_3	360	366	PF00018	0.569
LIG_TRAF2_1	167	170	PF00917	0.480
LIG_TRAF2_1	257	260	PF00917	0.412
LIG_TRAF2_1	267	270	PF00917	0.339
LIG_UBA3_1	111	115	PF00899	0.393
MOD_CDK_SPxxK_3	483	490	PF00069	0.635
MOD_CK1_1	162	168	PF00069	0.461
MOD_CK1_1	22	28	PF00069	0.341
MOD_CK1_1	325	331	PF00069	0.586
MOD_CK1_1	387	393	PF00069	0.414
MOD_CK2_1	104	110	PF00069	0.466
MOD_CK2_1	123	129	PF00069	0.299
MOD_CK2_1	173	179	PF00069	0.479
MOD_CK2_1	224	230	PF00069	0.435
MOD_CK2_1	254	260	PF00069	0.400
MOD_CK2_1	264	270	PF00069	0.342
MOD_CK2_1	351	357	PF00069	0.554
MOD_CK2_1	45	51	PF00069	0.460
MOD_CK2_1	478	484	PF00069	0.597
MOD_GlcNHglycan	121	124	PF01048	0.508
MOD_GlcNHglycan	129	133	PF01048	0.388
MOD_GlcNHglycan	224	227	PF01048	0.528
MOD_GlcNHglycan	297	300	PF01048	0.542
MOD_GlcNHglycan	343	346	PF01048	0.524
MOD_GlcNHglycan	43	46	PF01048	0.475
MOD_GSK3_1	119	126	PF00069	0.526
MOD_GSK3_1	128	135	PF00069	0.425
MOD_GSK3_1	195	202	PF00069	0.477
MOD_GSK3_1	347	354	PF00069	0.509
MOD_GSK3_1	361	368	PF00069	0.446
MOD_GSK3_1	387	394	PF00069	0.502
MOD_GSK3_1	41	48	PF00069	0.483
MOD_GSK3_1	71	78	PF00069	0.476
MOD_N-GLC_1	41	46	PF02516	0.510
MOD_NEK2_1	119	124	PF00069	0.489
MOD_NEK2_1	144	149	PF00069	0.470
MOD_NEK2_1	19	24	PF00069	0.356
MOD_NEK2_1	264	269	PF00069	0.533
MOD_NEK2_1	341	346	PF00069	0.457
MOD_NEK2_1	412	417	PF00069	0.311
MOD_NEK2_1	453	458	PF00069	0.449
MOD_NEK2_1	478	483	PF00069	0.537
MOD_NEK2_1	58	63	PF00069	0.407
MOD_NEK2_2	11	16	PF00069	0.554
MOD_NEK2_2	159	164	PF00069	0.434
MOD_NEK2_2	377	382	PF00069	0.627
MOD_PIKK_1	22	28	PF00454	0.475
MOD_PIKK_1	412	418	PF00454	0.366
MOD_PK_1	347	353	PF00069	0.519
MOD_PKA_2	322	328	PF00069	0.568
MOD_PKA_2	355	361	PF00069	0.471
MOD_Plk_1	128	134	PF00069	0.301
MOD_Plk_1	159	165	PF00069	0.461
MOD_Plk_1	203	209	PF00069	0.437
MOD_Plk_1	347	353	PF00069	0.568
MOD_Plk_1	41	47	PF00069	0.511
MOD_Plk_4	159	165	PF00069	0.465
MOD_Plk_4	347	353	PF00069	0.623
MOD_ProDKin_1	145	151	PF00069	0.390
MOD_ProDKin_1	185	191	PF00069	0.425
MOD_ProDKin_1	305	311	PF00069	0.537
MOD_ProDKin_1	362	368	PF00069	0.610
MOD_ProDKin_1	434	440	PF00069	0.475
MOD_ProDKin_1	483	489	PF00069	0.630
MOD_SUMO_for_1	219	222	PF00179	0.513
MOD_SUMO_for_1	314	317	PF00179	0.606
MOD_SUMO_rev_2	107	117	PF00179	0.406
MOD_SUMO_rev_2	135	144	PF00179	0.416
MOD_SUMO_rev_2	177	182	PF00179	0.427
MOD_SUMO_rev_2	333	338	PF00179	0.518
MOD_SUMO_rev_2	469	475	PF00179	0.432
TRG_DiLeu_BaEn_4	259	265	PF01217	0.503
TRG_ENDOCYTIC_2	141	144	PF00928	0.342
TRG_ENDOCYTIC_2	172	175	PF00928	0.337
TRG_ENDOCYTIC_2	445	448	PF00928	0.335
TRG_ER_diArg_1	103	106	PF00400	0.343
TRG_ER_diArg_1	212	214	PF00400	0.547
TRG_ER_diArg_1	29	31	PF00400	0.391
TRG_Pf-PMV_PEXEL_1	470	474	PF00026	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9E1	Leptomonas seymouri	80%	100%
A0A0S4IX38	Bodo saltans	29%	95%
A0A1X0P156	Trypanosomatidae	45%	100%
A0A3S7X2A6	Leishmania donovani	96%	100%
A0A422NRS1	Trypanosoma rangeli	44%	100%
A4HH97	Leishmania braziliensis	87%	100%
A4I4E3	Leishmania infantum	96%	100%
C9ZL20	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9ADU3	Leishmania major	95%	100%
V5BR79	Trypanosoma cruzi	45%	100%