Putative ADP ribosylation factor 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ADP-ribosylation factor-like protein 3A, putative

Species:

Leishmania mexicana

UniProt:

E9ALY6_LEIMU

TriTrypDb:

LmxM.08_29.0880

Length:

179

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	2
GO:0005815	microtubule organizing center	2	1
GO:0005856	cytoskeleton	5	2
GO:0005930	axoneme	2	1
GO:0015630	microtubule cytoskeleton	6	2
GO:0036064	ciliary basal body	3	1
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	2

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Expansion

Sequence features

E9ALY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALY6

Function

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Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0030030	cell projection organization	4	2
GO:0030031	cell projection assembly	5	2
GO:0044782	cilium organization	5	2
GO:0060271	cilium assembly	6	2
GO:0070925	organelle assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	15
GO:0003824	catalytic activity	1	15
GO:0003924	GTPase activity	7	15
GO:0005488	binding	1	15
GO:0005525	GTP binding	5	15
GO:0016462	pyrophosphatase activity	5	15
GO:0016787	hydrolase activity	2	15
GO:0016817	hydrolase activity, acting on acid anhydrides	3	15
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	15
GO:0017076	purine nucleotide binding	4	15

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	33	35	PF00675	0.313
CLV_NRD_NRD_1	7	9	PF00675	0.300
CLV_NRD_NRD_1	97	99	PF00675	0.341
CLV_PCSK_KEX2_1	96	98	PF00082	0.341
CLV_PCSK_SKI1_1	174	178	PF00082	0.455
CLV_PCSK_SKI1_1	8	12	PF00082	0.309
DOC_CDC14_PxL_1	115	123	PF14671	0.288
DOC_MAPK_gen_1	114	123	PF00069	0.288
DOC_MAPK_MEF2A_6	114	123	PF00069	0.341
DOC_PP1_SILK_1	30	35	PF00149	0.341

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Q3	Leptomonas seymouri	38%	94%
A0A0N0P4P7	Leptomonas seymouri	31%	99%
A0A0N0P633	Leptomonas seymouri	42%	98%
A0A0N0P8D4	Leptomonas seymouri	93%	100%
A0A0N0P8Z3	Leptomonas seymouri	52%	100%
A0A0N1HS40	Leptomonas seymouri	39%	100%
A0A0N1HTN6	Leptomonas seymouri	43%	95%
A0A0N1I3A9	Leptomonas seymouri	49%	100%
A0A0N1I556	Leptomonas seymouri	46%	100%
A0A0N1I6N0	Leptomonas seymouri	43%	100%

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