Phytanoyl-CoA dioxygenase (PhyH)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phytanoyl-CoA dioxygenase (PhyH), putative

Species:

Leishmania mexicana

UniProt:

E9ALY5_LEIMU

TriTrypDb:

LmxM.08_29.0885

Length:

349

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ALY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALY5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0003824	catalytic activity	1	1
GO:0016491	oxidoreductase activity	2	1
GO:0051213	dioxygenase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	312	314	PF00675	0.581
CLV_PCSK_KEX2_1	312	314	PF00082	0.590
CLV_PCSK_KEX2_1	316	318	PF00082	0.490
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.549
CLV_PCSK_PC7_1	312	318	PF00082	0.542
CLV_PCSK_SKI1_1	284	288	PF00082	0.470
CLV_PCSK_SKI1_1	331	335	PF00082	0.668
CLV_PCSK_SKI1_1	79	83	PF00082	0.476
DEG_Nend_UBRbox_1	1	4	PF02207	0.496
DOC_MAPK_gen_1	312	320	PF00069	0.450
DOC_MAPK_MEF2A_6	260	268	PF00069	0.295
DOC_PP2B_PxIxI_1	233	239	PF00149	0.399
DOC_SPAK_OSR1_1	153	157	PF12202	0.430
DOC_USP7_MATH_1	135	139	PF00917	0.351
DOC_USP7_MATH_1	333	337	PF00917	0.572
DOC_USP7_UBL2_3	82	86	PF12436	0.510
DOC_WW_Pin1_4	260	265	PF00397	0.385
LIG_14-3-3_CanoR_1	12	18	PF00244	0.518
LIG_14-3-3_CanoR_1	284	290	PF00244	0.393
LIG_Actin_WH2_2	271	286	PF00022	0.430
LIG_BRCT_BRCA1_1	150	154	PF00533	0.209
LIG_BRCT_BRCA1_1	196	200	PF00533	0.430
LIG_Clathr_ClatBox_1	235	239	PF01394	0.327
LIG_FHA_1	103	109	PF00498	0.351
LIG_FHA_1	160	166	PF00498	0.433
LIG_FHA_1	343	349	PF00498	0.479
LIG_FHA_2	14	20	PF00498	0.291
LIG_FHA_2	95	101	PF00498	0.476
LIG_LIR_Apic_2	258	264	PF02991	0.176
LIG_LIR_Gen_1	151	161	PF02991	0.287
LIG_LIR_Gen_1	197	204	PF02991	0.430
LIG_LIR_Gen_1	87	95	PF02991	0.285
LIG_LIR_Nem_3	140	146	PF02991	0.308
LIG_LIR_Nem_3	151	157	PF02991	0.291
LIG_LIR_Nem_3	197	203	PF02991	0.352
LIG_LIR_Nem_3	275	279	PF02991	0.308
LIG_LIR_Nem_3	87	92	PF02991	0.285
LIG_MYND_3	136	140	PF01753	0.352
LIG_NRBOX	178	184	PF00104	0.308
LIG_SH2_CRK	276	280	PF00017	0.308
LIG_SH2_GRB2like	143	146	PF00017	0.385
LIG_SH2_PTP2	261	264	PF00017	0.176
LIG_SH2_STAP1	126	130	PF00017	0.275
LIG_SH2_STAP1	227	231	PF00017	0.308
LIG_SH2_STAP1	298	302	PF00017	0.227
LIG_SH2_STAT3	126	129	PF00017	0.397
LIG_SH2_STAT5	118	121	PF00017	0.322
LIG_SH2_STAT5	261	264	PF00017	0.176
LIG_SH2_STAT5	295	298	PF00017	0.416
LIG_SH3_3	228	234	PF00018	0.317
LIG_SH3_3	259	265	PF00018	0.314
LIG_SUMO_SIM_par_1	234	240	PF11976	0.385
LIG_TRAF2_1	47	50	PF00917	0.346
MOD_CK1_1	138	144	PF00069	0.314
MOD_CK1_1	237	243	PF00069	0.441
MOD_CK1_1	343	349	PF00069	0.654
MOD_CK2_1	13	19	PF00069	0.390
MOD_CK2_1	324	330	PF00069	0.591
MOD_CK2_1	94	100	PF00069	0.351
MOD_Cter_Amidation	190	193	PF01082	0.437
MOD_GlcNHglycan	140	143	PF01048	0.317
MOD_GlcNHglycan	150	153	PF01048	0.292
MOD_GlcNHglycan	196	199	PF01048	0.366
MOD_GlcNHglycan	62	65	PF01048	0.304
MOD_GSK3_1	102	109	PF00069	0.455
MOD_GSK3_1	171	178	PF00069	0.452
MOD_GSK3_1	199	206	PF00069	0.287
MOD_GSK3_1	237	244	PF00069	0.422
MOD_GSK3_1	256	263	PF00069	0.339
MOD_GSK3_1	294	301	PF00069	0.345
MOD_GSK3_1	303	310	PF00069	0.424
MOD_GSK3_1	67	74	PF00069	0.614
MOD_N-GLC_1	241	246	PF02516	0.294
MOD_N-GLC_1	307	312	PF02516	0.462
MOD_N-GLC_2	56	58	PF02516	0.258
MOD_NEK2_1	160	165	PF00069	0.461
MOD_NEK2_1	41	46	PF00069	0.414
MOD_NEK2_1	94	99	PF00069	0.418
MOD_NEK2_2	13	18	PF00069	0.512
MOD_NEK2_2	35	40	PF00069	0.377
MOD_PIKK_1	205	211	PF00454	0.397
MOD_PIKK_1	343	349	PF00454	0.654
MOD_PKA_1	71	77	PF00069	0.515
MOD_PKA_2	148	154	PF00069	0.199
MOD_PKA_2	256	262	PF00069	0.353
MOD_Plk_1	106	112	PF00069	0.399
MOD_Plk_2-3	96	102	PF00069	0.351
MOD_Plk_4	199	205	PF00069	0.419
MOD_Plk_4	298	304	PF00069	0.298
MOD_ProDKin_1	260	266	PF00069	0.385
MOD_SUMO_rev_2	255	262	PF00179	0.205
MOD_SUMO_rev_2	43	53	PF00179	0.517
MOD_SUMO_rev_2	63	70	PF00179	0.322
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.244
TRG_DiLeu_BaLyEn_6	231	236	PF01217	0.399
TRG_ENDOCYTIC_2	143	146	PF00928	0.355
TRG_ENDOCYTIC_2	276	279	PF00928	0.308
TRG_ER_diArg_1	146	149	PF00400	0.385
TRG_ER_diArg_1	312	314	PF00400	0.643
TRG_NLS_Bipartite_1	316	338	PF00514	0.589
TRG_NLS_MonoExtC_3	333	339	PF00514	0.538
TRG_NLS_MonoExtN_4	331	338	PF00514	0.608
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8R0	Leptomonas seymouri	60%	100%
A0A0S4IX88	Bodo saltans	33%	70%
A0A1X0NZP8	Trypanosomatidae	44%	100%
A0A3S7X2B0	Leishmania donovani	88%	100%
A0A422NRL2	Trypanosoma rangeli	45%	100%
A4HH99	Leishmania braziliensis	78%	100%
A4I4E5	Leishmania infantum	88%	100%
C9ZL18	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9ADU5	Leishmania major	87%	100%
V5BH47	Trypanosoma cruzi	45%	100%