Solute carrier family 35 member F2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic protein of unknown function (DUF914), putative

Species:

Leishmania mexicana

UniProt:

E9ALY4_LEIMU

TriTrypDb:

LmxM.08_29.0890

Length:

452

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9ALY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALY4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0022857	transmembrane transporter activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	427	431	PF00656	0.389
CLV_PCSK_KEX2_1	17	19	PF00082	0.270
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.272
CLV_PCSK_PC7_1	13	19	PF00082	0.220
CLV_PCSK_SKI1_1	13	17	PF00082	0.223
CLV_PCSK_SKI1_1	18	22	PF00082	0.259
CLV_PCSK_SKI1_1	203	207	PF00082	0.662
CLV_PCSK_SKI1_1	285	289	PF00082	0.309
CLV_PCSK_SKI1_1	353	357	PF00082	0.397
DEG_APCC_DBOX_1	12	20	PF00400	0.466
DEG_APCC_KENBOX_2	391	395	PF00400	0.444
DEG_MDM2_SWIB_1	84	92	PF02201	0.405
DEG_SPOP_SBC_1	418	422	PF00917	0.412
DOC_CYCLIN_yClb1_LxF_4	351	356	PF00134	0.509
DOC_MAPK_gen_1	200	208	PF00069	0.326
DOC_MAPK_gen_1	86	95	PF00069	0.456
DOC_MAPK_MEF2A_6	200	208	PF00069	0.273
DOC_MAPK_MEF2A_6	220	229	PF00069	0.441
DOC_MAPK_MEF2A_6	253	260	PF00069	0.382
DOC_PP1_RVXF_1	351	357	PF00149	0.509
DOC_PP4_FxxP_1	122	125	PF00568	0.255
DOC_PP4_FxxP_1	198	201	PF00568	0.230
DOC_PP4_FxxP_1	61	64	PF00568	0.311
DOC_USP7_MATH_1	265	269	PF00917	0.385
DOC_USP7_MATH_1	289	293	PF00917	0.483
DOC_USP7_MATH_1	418	422	PF00917	0.371
DOC_WW_Pin1_4	221	226	PF00397	0.479
LIG_14-3-3_CanoR_1	291	295	PF00244	0.514
LIG_BIR_II_1	1	5	PF00653	0.571
LIG_BIR_III_4	161	165	PF00653	0.205
LIG_BRCT_BRCA1_1	323	327	PF00533	0.205
LIG_BRCT_BRCA1_1	5	9	PF00533	0.575
LIG_Clathr_ClatBox_1	157	161	PF01394	0.240
LIG_deltaCOP1_diTrp_1	283	287	PF00928	0.416
LIG_deltaCOP1_diTrp_1	298	305	PF00928	0.416
LIG_EH1_1	304	312	PF00400	0.305
LIG_eIF4E_1	62	68	PF01652	0.276
LIG_FHA_1	109	115	PF00498	0.250
LIG_FHA_1	140	146	PF00498	0.288
LIG_FHA_1	188	194	PF00498	0.248
LIG_FHA_1	222	228	PF00498	0.480
LIG_FHA_1	306	312	PF00498	0.305
LIG_FHA_1	332	338	PF00498	0.334
LIG_FHA_1	34	40	PF00498	0.276
LIG_FHA_1	361	367	PF00498	0.341
LIG_FHA_1	370	376	PF00498	0.510
LIG_FHA_1	436	442	PF00498	0.545
LIG_FHA_2	217	223	PF00498	0.356
LIG_FHA_2	293	299	PF00498	0.431
LIG_FHA_2	396	402	PF00498	0.434
LIG_LIR_Apic_2	195	201	PF02991	0.231
LIG_LIR_Gen_1	268	277	PF02991	0.334
LIG_LIR_Gen_1	298	309	PF02991	0.447
LIG_LIR_Gen_1	324	335	PF02991	0.216
LIG_LIR_Gen_1	358	367	PF02991	0.280
LIG_LIR_Gen_1	53	63	PF02991	0.246
LIG_LIR_Gen_1	99	110	PF02991	0.274
LIG_LIR_Nem_3	131	135	PF02991	0.299
LIG_LIR_Nem_3	268	273	PF02991	0.320
LIG_LIR_Nem_3	283	287	PF02991	0.434
LIG_LIR_Nem_3	298	304	PF02991	0.433
LIG_LIR_Nem_3	324	330	PF02991	0.229
LIG_LIR_Nem_3	345	350	PF02991	0.281
LIG_LIR_Nem_3	358	362	PF02991	0.252
LIG_LIR_Nem_3	45	49	PF02991	0.211
LIG_LIR_Nem_3	53	58	PF02991	0.242
LIG_LIR_Nem_3	6	12	PF02991	0.558
LIG_LIR_Nem_3	79	84	PF02991	0.427
LIG_LIR_Nem_3	85	90	PF02991	0.415
LIG_LIR_Nem_3	99	105	PF02991	0.247
LIG_LYPXL_yS_3	46	49	PF13949	0.230
LIG_Pex14_2	270	274	PF04695	0.342
LIG_Pex14_2	280	284	PF04695	0.240
LIG_Pex14_2	301	305	PF04695	0.334
LIG_Pex14_2	379	383	PF04695	0.426
LIG_Pex14_2	57	61	PF04695	0.332
LIG_Pex14_2	83	87	PF04695	0.463
LIG_PTB_Apo_2	77	84	PF02174	0.448
LIG_REV1ctd_RIR_1	130	140	PF16727	0.299
LIG_REV1ctd_RIR_1	81	90	PF16727	0.446
LIG_SH2_CRK	359	363	PF00017	0.304
LIG_SH2_CRK	55	59	PF00017	0.308
LIG_SH2_CRK	90	94	PF00017	0.274
LIG_SH2_GRB2like	110	113	PF00017	0.309
LIG_SH2_PTP2	102	105	PF00017	0.334
LIG_SH2_SRC	338	341	PF00017	0.250
LIG_SH2_SRC	62	65	PF00017	0.367
LIG_SH2_STAP1	110	114	PF00017	0.201
LIG_SH2_STAP1	338	342	PF00017	0.251
LIG_SH2_STAP1	55	59	PF00017	0.274
LIG_SH2_STAP1	90	94	PF00017	0.377
LIG_SH2_STAT5	102	105	PF00017	0.272
LIG_SH2_STAT5	110	113	PF00017	0.186
LIG_SH2_STAT5	313	316	PF00017	0.240
LIG_SH2_STAT5	62	65	PF00017	0.276
LIG_SH3_3	198	204	PF00018	0.321
LIG_SH3_3	249	255	PF00018	0.372
LIG_SH3_3	372	378	PF00018	0.374
LIG_SUMO_SIM_par_1	156	161	PF11976	0.243
LIG_SUMO_SIM_par_1	308	314	PF11976	0.334
LIG_SUMO_SIM_par_1	91	97	PF11976	0.334
LIG_TYR_ITIM	357	362	PF00017	0.299
LIG_TYR_ITSM	51	58	PF00017	0.240
LIG_UBA3_1	134	138	PF00899	0.458
LIG_UBA3_1	340	348	PF00899	0.417
LIG_UBA3_1	67	72	PF00899	0.385
LIG_WRC_WIRS_1	129	134	PF05994	0.274
LIG_WRC_WIRS_1	267	272	PF05994	0.395
MOD_CK1_1	216	222	PF00069	0.442
MOD_CK1_1	292	298	PF00069	0.464
MOD_CK1_1	331	337	PF00069	0.279
MOD_CK1_1	42	48	PF00069	0.259
MOD_CK1_1	422	428	PF00069	0.557
MOD_CK2_1	163	169	PF00069	0.308
MOD_CK2_1	216	222	PF00069	0.351
MOD_CK2_1	397	403	PF00069	0.545
MOD_GlcNHglycan	215	218	PF01048	0.677
MOD_GlcNHglycan	323	326	PF01048	0.418
MOD_GlcNHglycan	424	427	PF01048	0.786
MOD_GSK3_1	108	115	PF00069	0.205
MOD_GSK3_1	165	172	PF00069	0.268
MOD_GSK3_1	183	190	PF00069	0.259
MOD_GSK3_1	216	223	PF00069	0.413
MOD_GSK3_1	29	36	PF00069	0.285
MOD_GSK3_1	418	425	PF00069	0.468
MOD_GSK3_1	431	438	PF00069	0.441
MOD_N-GLC_1	213	218	PF02516	0.611
MOD_N-GLC_1	289	294	PF02516	0.292
MOD_N-GLC_1	328	333	PF02516	0.240
MOD_N-GLC_1	342	347	PF02516	0.240
MOD_N-GLC_1	369	374	PF02516	0.532
MOD_N-GLC_1	395	400	PF02516	0.590
MOD_N-GLC_1	42	47	PF02516	0.418
MOD_N-GLC_1	422	427	PF02516	0.724
MOD_N-GLC_2	209	211	PF02516	0.592
MOD_NEK2_1	128	133	PF00069	0.246
MOD_NEK2_1	139	144	PF00069	0.416
MOD_NEK2_1	182	187	PF00069	0.250
MOD_NEK2_1	227	232	PF00069	0.501
MOD_NEK2_1	266	271	PF00069	0.340
MOD_NEK2_1	27	32	PF00069	0.282
MOD_NEK2_1	272	277	PF00069	0.286
MOD_NEK2_1	305	310	PF00069	0.254
MOD_NEK2_1	311	316	PF00069	0.240
MOD_NEK2_1	320	325	PF00069	0.194
MOD_NEK2_1	355	360	PF00069	0.260
MOD_NEK2_1	39	44	PF00069	0.205
MOD_NEK2_1	48	53	PF00069	0.187
MOD_NEK2_2	342	347	PF00069	0.255
MOD_PIKK_1	169	175	PF00454	0.332
MOD_PIKK_1	440	446	PF00454	0.470
MOD_PKA_2	169	175	PF00069	0.304
MOD_PKA_2	290	296	PF00069	0.486
MOD_PKA_2	76	82	PF00069	0.420
MOD_Plk_1	289	295	PF00069	0.479
MOD_Plk_1	328	334	PF00069	0.240
MOD_Plk_1	342	348	PF00069	0.410
MOD_Plk_1	42	48	PF00069	0.205
MOD_Plk_2-3	397	403	PF00069	0.439
MOD_Plk_4	128	134	PF00069	0.240
MOD_Plk_4	183	189	PF00069	0.290
MOD_Plk_4	305	311	PF00069	0.278
MOD_ProDKin_1	221	227	PF00069	0.480
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.140
TRG_ENDOCYTIC_2	102	105	PF00928	0.240
TRG_ENDOCYTIC_2	110	113	PF00928	0.186
TRG_ENDOCYTIC_2	313	316	PF00928	0.240
TRG_ENDOCYTIC_2	338	341	PF00928	0.240
TRG_ENDOCYTIC_2	359	362	PF00928	0.240
TRG_ENDOCYTIC_2	46	49	PF00928	0.228
TRG_ENDOCYTIC_2	55	58	PF00928	0.298
TRG_ENDOCYTIC_2	90	93	PF00928	0.272

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8D2	Leptomonas seymouri	64%	100%
A0A0S4ISV7	Bodo saltans	42%	100%
A0A1X0PAA4	Trypanosomatidae	53%	100%
A0A3S7X2D4	Leishmania donovani	89%	100%
A0A422NJ67	Trypanosoma rangeli	50%	100%
A4HHA0	Leishmania braziliensis	78%	100%
A4I4E6	Leishmania infantum	89%	100%
C9ZLM2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9ADU6	Leishmania major	89%	100%
O59785	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	90%
Q0V9U2	Xenopus tropicalis	28%	100%
Q5T1Q4	Homo sapiens	29%	100%
Q8BGK5	Mus musculus	29%	100%
V5BCU4	Trypanosoma cruzi	45%	100%