Putative signal peptide peptidase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

signal peptide peptidase, putative

Species:

Leishmania mexicana

UniProt:

E9ALY2_LEIMU

TriTrypDb:

LmxM.08_29.0910

Length:

309

Annotations

LeishMANIAdb annotations

Orthologous to animal ER-localized signal peptide peptidases, including minor histocompatibility antigen H13.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9ALY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALY2

Function

Biological processes
Term	Name	Level	Count
GO:0006465	signal peptide processing	5	1
GO:0006508	proteolysis	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0019538	protein metabolic process	3	1
GO:0033619	membrane protein proteolysis	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043603	amide metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	11
GO:0004190	aspartic-type endopeptidase activity	5	11
GO:0008233	peptidase activity	3	11
GO:0016787	hydrolase activity	2	11
GO:0070001	aspartic-type peptidase activity	4	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.242
CLV_PCSK_KEX2_1	188	190	PF00082	0.242
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.216
CLV_PCSK_SKI1_1	147	151	PF00082	0.411
CLV_PCSK_SKI1_1	161	165	PF00082	0.246
DEG_APCC_DBOX_1	188	196	PF00400	0.455
DEG_SPOP_SBC_1	254	258	PF00917	0.516
DOC_CDC14_PxL_1	223	231	PF14671	0.246
DOC_CYCLIN_yClb1_LxF_4	145	150	PF00134	0.267
DOC_MAPK_gen_1	160	166	PF00069	0.306
DOC_MAPK_gen_1	188	194	PF00069	0.467
DOC_MAPK_gen_1	3	10	PF00069	0.589
DOC_MAPK_MEF2A_6	38	47	PF00069	0.313
DOC_PP1_RVXF_1	145	151	PF00149	0.242
DOC_PP2B_LxvP_1	16	19	PF13499	0.324
DOC_PP4_FxxP_1	224	227	PF00568	0.264
DOC_USP7_UBL2_3	184	188	PF12436	0.483
DOC_USP7_UBL2_3	62	66	PF12436	0.506
LIG_AP2alpha_1	123	127	PF02296	0.264
LIG_BRCT_BRCA1_1	190	194	PF00533	0.492
LIG_BRCT_BRCA1_1	31	35	PF00533	0.442
LIG_deltaCOP1_diTrp_1	125	130	PF00928	0.246
LIG_EH1_1	192	200	PF00400	0.483
LIG_FHA_1	111	117	PF00498	0.467
LIG_FHA_1	194	200	PF00498	0.444
LIG_FHA_1	206	212	PF00498	0.201
LIG_FHA_1	69	75	PF00498	0.406
LIG_FHA_2	138	144	PF00498	0.257
LIG_FHA_2	255	261	PF00498	0.605
LIG_FHA_2	297	303	PF00498	0.541
LIG_FHA_2	99	105	PF00498	0.379
LIG_LIR_Gen_1	112	123	PF02991	0.426
LIG_LIR_Gen_1	232	239	PF02991	0.379
LIG_LIR_Gen_1	28	37	PF02991	0.277
LIG_LIR_Gen_1	39	49	PF02991	0.236
LIG_LIR_Nem_3	112	118	PF02991	0.425
LIG_LIR_Nem_3	125	130	PF02991	0.220
LIG_LIR_Nem_3	232	236	PF02991	0.379
LIG_LIR_Nem_3	28	33	PF02991	0.277
LIG_LIR_Nem_3	39	44	PF02991	0.236
LIG_LIR_Nem_3	46	51	PF02991	0.323
LIG_MLH1_MIPbox_1	190	194	PF16413	0.492
LIG_PCNA_yPIPBox_3	244	255	PF02747	0.372
LIG_Pex14_2	111	115	PF04695	0.425
LIG_Pex14_2	123	127	PF04695	0.264
LIG_Pex14_2	224	228	PF04695	0.264
LIG_Pex14_2	84	88	PF04695	0.346
LIG_SH2_GRB2like	40	43	PF00017	0.225
LIG_SH2_PTP2	30	33	PF00017	0.246
LIG_SH2_PTP2	64	67	PF00017	0.506
LIG_SH2_STAP1	124	128	PF00017	0.246
LIG_SH2_STAP1	201	205	PF00017	0.289
LIG_SH2_STAT5	186	189	PF00017	0.416
LIG_SH2_STAT5	193	196	PF00017	0.406
LIG_SH2_STAT5	201	204	PF00017	0.227
LIG_SH2_STAT5	30	33	PF00017	0.246
LIG_SH2_STAT5	40	43	PF00017	0.246
LIG_SH2_STAT5	48	51	PF00017	0.267
LIG_SH2_STAT5	64	67	PF00017	0.446
LIG_SH3_1	261	267	PF00018	0.550
LIG_SH3_3	261	267	PF00018	0.665
LIG_SUMO_SIM_anti_2	112	120	PF11976	0.426
LIG_SUMO_SIM_anti_2	132	138	PF11976	0.125
LIG_SUMO_SIM_anti_2	202	208	PF11976	0.302
LIG_SUMO_SIM_par_1	132	140	PF11976	0.225
LIG_SUMO_SIM_par_1	250	260	PF11976	0.516
LIG_TRAF2_1	269	272	PF00917	0.652
LIG_TRAF2_1	299	302	PF00917	0.517
LIG_WRC_WIRS_1	230	235	PF05994	0.290
LIG_WRC_WIRS_1	275	280	PF05994	0.486
LIG_WRC_WIRS_1	44	49	PF05994	0.310
MOD_CK1_1	159	165	PF00069	0.258
MOD_CK1_1	253	259	PF00069	0.624
MOD_CK1_1	274	280	PF00069	0.538
MOD_CK1_1	50	56	PF00069	0.331
MOD_CK2_1	254	260	PF00069	0.593
MOD_CK2_1	296	302	PF00069	0.566
MOD_CK2_1	98	104	PF00069	0.379
MOD_GlcNHglycan	233	236	PF01048	0.311
MOD_GSK3_1	176	183	PF00069	0.264
MOD_GSK3_1	201	208	PF00069	0.246
MOD_GSK3_1	25	32	PF00069	0.311
MOD_GSK3_1	250	257	PF00069	0.531
MOD_GSK3_1	43	50	PF00069	0.125
MOD_GSK3_1	75	82	PF00069	0.365
MOD_GSK3_1	94	101	PF00069	0.314
MOD_N-GLC_1	20	25	PF02516	0.338
MOD_NEK2_1	111	116	PF00069	0.383
MOD_NEK2_1	194	199	PF00069	0.454
MOD_NEK2_1	20	25	PF00069	0.292
MOD_NEK2_1	205	210	PF00069	0.199
MOD_NEK2_1	229	234	PF00069	0.250
MOD_NEK2_1	29	34	PF00069	0.329
MOD_NEK2_1	47	52	PF00069	0.180
MOD_NEK2_1	94	99	PF00069	0.351
MOD_NEK2_2	79	84	PF00069	0.311
MOD_PKA_1	188	194	PF00069	0.426
MOD_PKA_2	188	194	PF00069	0.451
MOD_Plk_1	271	277	PF00069	0.643
MOD_Plk_4	111	117	PF00069	0.432
MOD_Plk_4	150	156	PF00069	0.238
MOD_Plk_4	159	165	PF00069	0.186
MOD_Plk_4	176	182	PF00069	0.246
MOD_Plk_4	188	194	PF00069	0.404
MOD_Plk_4	20	26	PF00069	0.290
MOD_Plk_4	201	207	PF00069	0.283
MOD_Plk_4	250	256	PF00069	0.494
MOD_Plk_4	274	280	PF00069	0.607
MOD_Plk_4	47	53	PF00069	0.265
MOD_Plk_4	79	85	PF00069	0.464
MOD_SUMO_rev_2	292	300	PF00179	0.611
MOD_SUMO_rev_2	301	309	PF00179	0.600
TRG_ENDOCYTIC_2	124	127	PF00928	0.246
TRG_ENDOCYTIC_2	30	33	PF00928	0.294
TRG_ENDOCYTIC_2	40	43	PF00928	0.246
TRG_ENDOCYTIC_2	48	51	PF00928	0.125
TRG_ER_diLys_1	304	309	PF00400	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Y2	Leptomonas seymouri	67%	91%
A0A0S4JJ36	Bodo saltans	47%	82%
A0A1X0P170	Trypanosomatidae	59%	87%
A0A3Q8IDL5	Leishmania donovani	93%	100%
A0A3R7NBZ0	Trypanosoma rangeli	58%	100%
A4HHA2	Leishmania braziliensis	87%	100%
A4I4E8	Leishmania infantum	93%	100%
B9FJ61	Oryza sativa subsp. japonica	39%	90%
C9ZLJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	88%
E9ADU8	Leishmania major	93%	100%
O81062	Arabidopsis thaliana	36%	90%
P49049	Caenorhabditis elegans	41%	66%
Q6ZGL9	Oryza sativa subsp. japonica	36%	90%
Q8TCT6	Homo sapiens	30%	80%
Q8TCT9	Homo sapiens	31%	82%
Q93Z32	Arabidopsis thaliana	25%	83%
Q9CUS9	Mus musculus	30%	80%
Q9D8V0	Mus musculus	32%	82%
Q9UTA3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%