Letm1 RBD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LETM1 and EF-hand domain-containing protein 1, putative

Species:

Leishmania mexicana

UniProt:

E9ALY1_LEIMU

TriTrypDb:

LmxM.08_29.0920

Length:

503

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	12
GO:0016020	membrane	2	12
GO:0019866	organelle inner membrane	4	12
GO:0031090	organelle membrane	3	12
GO:0031966	mitochondrial membrane	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

E9ALY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALY1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	2
GO:0006812	monoatomic cation transport	5	2
GO:0006816	calcium ion transport	7	2
GO:0006851	mitochondrial calcium ion transmembrane transport	4	2
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006875	obsolete intracellular metal ion homeostasis	6	1
GO:0009987	cellular process	1	2
GO:0019725	cellular homeostasis	2	1
GO:0030001	metal ion transport	6	2
GO:0030003	intracellular monoatomic cation homeostasis	5	1
GO:0034220	monoatomic ion transmembrane transport	3	2
GO:0042592	homeostatic process	3	1
GO:0048878	chemical homeostasis	4	1
GO:0050801	monoatomic ion homeostasis	5	1
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055065	obsolete metal ion homeostasis	7	1
GO:0055080	monoatomic cation homeostasis	6	1
GO:0055082	intracellular chemical homeostasis	3	1
GO:0055085	transmembrane transport	2	2
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0070588	calcium ion transmembrane transport	6	2
GO:0098655	monoatomic cation transmembrane transport	4	2
GO:0098660	inorganic ion transmembrane transport	4	2
GO:0098662	inorganic cation transmembrane transport	5	2
GO:0098771	inorganic ion homeostasis	6	1
GO:1990542	mitochondrial transmembrane transport	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0043021	ribonucleoprotein complex binding	3	12
GO:0043022	ribosome binding	4	12
GO:0044877	protein-containing complex binding	2	12
GO:0005215	transporter activity	1	2
GO:0005432	calcium:sodium antiporter activity	7	2
GO:0005509	calcium ion binding	5	2
GO:0008324	monoatomic cation transmembrane transporter activity	4	2
GO:0015075	monoatomic ion transmembrane transporter activity	3	2
GO:0015081	sodium ion transmembrane transporter activity	6	2
GO:0015085	calcium ion transmembrane transporter activity	6	2
GO:0015291	secondary active transmembrane transporter activity	4	2
GO:0015297	antiporter activity	5	2
GO:0015298	obsolete solute:monoatomic cation antiporter activity	5	2
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	2
GO:0015368	calcium:monoatomic cation antiporter activity	7	2
GO:0022804	active transmembrane transporter activity	3	2
GO:0022853	active monoatomic ion transmembrane transporter activity	4	2
GO:0022857	transmembrane transporter activity	2	2
GO:0022890	inorganic cation transmembrane transporter activity	4	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046873	metal ion transmembrane transporter activity	5	2
GO:0140828	metal cation:monoatomic cation antiporter activity	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	255	259	PF00656	0.282
CLV_C14_Caspase3-7	378	382	PF00656	0.564
CLV_NRD_NRD_1	172	174	PF00675	0.500
CLV_NRD_NRD_1	235	237	PF00675	0.449
CLV_NRD_NRD_1	240	242	PF00675	0.455
CLV_NRD_NRD_1	314	316	PF00675	0.607
CLV_NRD_NRD_1	326	328	PF00675	0.579
CLV_NRD_NRD_1	467	469	PF00675	0.665
CLV_NRD_NRD_1	8	10	PF00675	0.478
CLV_NRD_NRD_1	80	82	PF00675	0.250
CLV_PCSK_KEX2_1	172	174	PF00082	0.500
CLV_PCSK_KEX2_1	235	237	PF00082	0.449
CLV_PCSK_KEX2_1	240	242	PF00082	0.452
CLV_PCSK_KEX2_1	326	328	PF00082	0.622
CLV_PCSK_KEX2_1	8	10	PF00082	0.481
CLV_PCSK_KEX2_1	80	82	PF00082	0.254
CLV_PCSK_PC7_1	236	242	PF00082	0.536
CLV_PCSK_SKI1_1	327	331	PF00082	0.600
CLV_PCSK_SKI1_1	403	407	PF00082	0.544
CLV_PCSK_SKI1_1	453	457	PF00082	0.559
CLV_PCSK_SKI1_1	458	462	PF00082	0.544
CLV_PCSK_SKI1_1	56	60	PF00082	0.358
CLV_PCSK_SKI1_1	70	74	PF00082	0.328
CLV_PCSK_SKI1_1	83	87	PF00082	0.254
CLV_PCSK_SKI1_1	91	95	PF00082	0.281
DEG_APCC_DBOX_1	325	333	PF00400	0.394
DEG_APCC_DBOX_1	339	347	PF00400	0.431
DEG_Nend_Nbox_1	1	3	PF02207	0.605
DEG_SPOP_SBC_1	484	488	PF00917	0.517
DOC_AGCK_PIF_2	443	448	PF00069	0.440
DOC_CYCLIN_RxL_1	80	90	PF00134	0.444
DOC_CYCLIN_yCln2_LP_2	110	116	PF00134	0.284
DOC_MAPK_gen_1	315	323	PF00069	0.418
DOC_MAPK_gen_1	326	332	PF00069	0.356
DOC_MAPK_gen_1	36	43	PF00069	0.565
DOC_MAPK_gen_1	70	78	PF00069	0.522
DOC_MAPK_gen_1	80	86	PF00069	0.444
DOC_MAPK_MEF2A_6	202	211	PF00069	0.316
DOC_PP1_RVXF_1	54	60	PF00149	0.537
DOC_PP1_RVXF_1	61	67	PF00149	0.540
DOC_PP2B_LxvP_1	110	113	PF13499	0.284
DOC_PP2B_LxvP_1	187	190	PF13499	0.276
DOC_PP4_FxxP_1	201	204	PF00568	0.282
DOC_USP7_MATH_1	19	23	PF00917	0.732
DOC_USP7_MATH_1	377	381	PF00917	0.510
DOC_USP7_MATH_1	415	419	PF00917	0.389
DOC_USP7_UBL2_3	16	20	PF12436	0.682
DOC_USP7_UBL2_3	32	36	PF12436	0.686
DOC_USP7_UBL2_3	365	369	PF12436	0.475
DOC_USP7_UBL2_3	404	408	PF12436	0.401
DOC_WW_Pin1_4	228	233	PF00397	0.296
LIG_14-3-3_CanoR_1	275	283	PF00244	0.244
LIG_14-3-3_CanoR_1	3	7	PF00244	0.643
LIG_14-3-3_CanoR_1	315	319	PF00244	0.379
LIG_14-3-3_CanoR_1	340	344	PF00244	0.484
LIG_Actin_WH2_2	34	51	PF00022	0.571
LIG_Actin_WH2_2	57	75	PF00022	0.520
LIG_APCC_ABBA_1	104	109	PF00400	0.284
LIG_APCC_ABBAyCdc20_2	134	140	PF00400	0.336
LIG_BRCT_BRCA1_1	439	443	PF00533	0.311
LIG_Clathr_ClatBox_1	251	255	PF01394	0.258
LIG_eIF4E_1	52	58	PF01652	0.508
LIG_FHA_1	16	22	PF00498	0.675
LIG_FHA_1	225	231	PF00498	0.340
LIG_FHA_1	24	30	PF00498	0.625
LIG_FHA_1	278	284	PF00498	0.249
LIG_FHA_1	88	94	PF00498	0.477
LIG_FHA_2	343	349	PF00498	0.421
LIG_FHA_2	439	445	PF00498	0.331
LIG_FHA_2	487	493	PF00498	0.551
LIG_FHA_2	77	83	PF00498	0.444
LIG_LIR_Apic_2	199	204	PF02991	0.300
LIG_LIR_Apic_2	303	309	PF02991	0.233
LIG_LIR_Gen_1	100	110	PF02991	0.305
LIG_LIR_Gen_1	195	204	PF02991	0.324
LIG_LIR_Gen_1	288	294	PF02991	0.244
LIG_LIR_Gen_1	298	309	PF02991	0.244
LIG_LIR_Gen_1	440	450	PF02991	0.336
LIG_LIR_Nem_3	100	105	PF02991	0.305
LIG_LIR_Nem_3	195	201	PF02991	0.259
LIG_LIR_Nem_3	288	293	PF02991	0.244
LIG_LIR_Nem_3	298	304	PF02991	0.244
LIG_LIR_Nem_3	383	389	PF02991	0.447
LIG_LIR_Nem_3	440	446	PF02991	0.323
LIG_MYND_1	120	124	PF01753	0.233
LIG_NRP_CendR_1	502	503	PF00754	0.711
LIG_PCNA_PIPBox_1	390	399	PF02747	0.344
LIG_PCNA_yPIPBox_3	390	404	PF02747	0.346
LIG_Pex14_2	55	59	PF04695	0.524
LIG_SH2_CRK	221	225	PF00017	0.277
LIG_SH2_CRK	40	44	PF00017	0.583
LIG_SH2_STAP1	68	72	PF00017	0.500
LIG_SH2_STAT3	68	71	PF00017	0.494
LIG_SH2_STAT5	154	157	PF00017	0.258
LIG_SH2_STAT5	191	194	PF00017	0.336
LIG_SH2_STAT5	396	399	PF00017	0.328
LIG_SH3_3	226	232	PF00018	0.336
LIG_SH3_3	468	474	PF00018	0.460
LIG_SH3_4	32	39	PF00018	0.563
LIG_SH3_CIN85_PxpxPR_1	473	478	PF14604	0.381
LIG_Sin3_3	108	115	PF02671	0.303
LIG_TRAF2_1	479	482	PF00917	0.520
LIG_TRAF2_1	489	492	PF00917	0.561
LIG_TYR_ITIM	299	304	PF00017	0.233
LIG_TYR_ITIM	43	48	PF00017	0.621
LIG_UBA3_1	405	413	PF00899	0.345
LIG_WRC_WIRS_1	160	165	PF05994	0.277
MOD_CDK_SPxxK_3	228	235	PF00069	0.282
MOD_CK1_1	22	28	PF00069	0.673
MOD_CK1_1	342	348	PF00069	0.497
MOD_CK1_1	354	360	PF00069	0.531
MOD_CK1_1	486	492	PF00069	0.522
MOD_CK2_1	122	128	PF00069	0.233
MOD_CK2_1	342	348	PF00069	0.453
MOD_CK2_1	372	378	PF00069	0.463
MOD_CK2_1	485	491	PF00069	0.564
MOD_CK2_1	76	82	PF00069	0.444
MOD_Cter_Amidation	500	503	PF01082	0.702
MOD_DYRK1A_RPxSP_1	228	232	PF00069	0.282
MOD_GlcNHglycan	155	158	PF01048	0.517
MOD_GlcNHglycan	22	25	PF01048	0.533
MOD_GlcNHglycan	361	364	PF01048	0.698
MOD_GlcNHglycan	375	378	PF01048	0.597
MOD_GSK3_1	122	129	PF00069	0.233
MOD_GSK3_1	15	22	PF00069	0.724
MOD_GSK3_1	155	162	PF00069	0.302
MOD_GSK3_1	220	227	PF00069	0.292
MOD_GSK3_1	310	317	PF00069	0.343
MOD_GSK3_1	335	342	PF00069	0.453
MOD_GSK3_1	373	380	PF00069	0.460
MOD_GSK3_1	415	422	PF00069	0.366
MOD_GSK3_1	429	436	PF00069	0.371
MOD_GSK3_1	449	456	PF00069	0.396
MOD_N-GLC_1	268	273	PF02516	0.540
MOD_N-GLC_1	433	438	PF02516	0.609
MOD_NEK2_1	155	160	PF00069	0.253
MOD_NEK2_1	176	181	PF00069	0.300
MOD_NEK2_1	2	7	PF00069	0.590
MOD_NEK2_1	211	216	PF00069	0.244
MOD_NEK2_1	234	239	PF00069	0.321
MOD_NEK2_1	59	64	PF00069	0.518
MOD_NEK2_1	85	90	PF00069	0.447
MOD_NEK2_2	141	146	PF00069	0.258
MOD_NEK2_2	279	284	PF00069	0.336
MOD_PIKK_1	128	134	PF00454	0.244
MOD_PIKK_1	23	29	PF00454	0.730
MOD_PKA_2	2	8	PF00069	0.592
MOD_PKA_2	234	240	PF00069	0.282
MOD_PKA_2	274	280	PF00069	0.244
MOD_PKA_2	310	316	PF00069	0.342
MOD_PKA_2	339	345	PF00069	0.450
MOD_Plk_1	295	301	PF00069	0.250
MOD_Plk_1	415	421	PF00069	0.368
MOD_Plk_1	433	439	PF00069	0.302
MOD_Plk_1	491	497	PF00069	0.482
MOD_Plk_2-3	491	497	PF00069	0.512
MOD_Plk_4	2	8	PF00069	0.644
MOD_Plk_4	220	226	PF00069	0.316
MOD_Plk_4	300	306	PF00069	0.233
MOD_Plk_4	415	421	PF00069	0.448
MOD_Plk_4	438	444	PF00069	0.330
MOD_ProDKin_1	228	234	PF00069	0.296
MOD_SUMO_rev_2	486	495	PF00179	0.566
TRG_DiLeu_BaEn_1	247	252	PF01217	0.258
TRG_DiLeu_BaLyEn_6	80	85	PF01217	0.458
TRG_DiLeu_LyEn_5	247	252	PF01217	0.258
TRG_ENDOCYTIC_2	221	224	PF00928	0.242
TRG_ENDOCYTIC_2	301	304	PF00928	0.233
TRG_ENDOCYTIC_2	40	43	PF00928	0.577
TRG_ENDOCYTIC_2	45	48	PF00928	0.567
TRG_ENDOCYTIC_2	52	55	PF00928	0.514
TRG_ER_diArg_1	134	137	PF00400	0.283
TRG_ER_diArg_1	145	148	PF00400	0.199
TRG_ER_diArg_1	171	173	PF00400	0.300
TRG_ER_diArg_1	234	236	PF00400	0.249
TRG_ER_diArg_1	239	241	PF00400	0.254
TRG_ER_diArg_1	7	9	PF00400	0.681
TRG_NLS_MonoExtC_3	410	415	PF00514	0.425
TRG_NLS_MonoExtN_4	408	415	PF00514	0.408
TRG_Pf-PMV_PEXEL_1	412	416	PF00026	0.635
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.244

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD73	Leptomonas seymouri	87%	99%
A0A0S4JFV9	Bodo saltans	52%	100%
A0A1X0NZY3	Trypanosomatidae	62%	100%
A0A3S5IR30	Trypanosoma rangeli	65%	100%
A0A3S7X2D5	Leishmania donovani	99%	100%
A4HHA3	Leishmania braziliensis	94%	100%
A4I4E9	Leishmania infantum	99%	100%
C9ZLK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9ADU9	Leishmania major	98%	100%
V5DI32	Trypanosoma cruzi	61%	100%