Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ALX6_LEIMU

TriTrypDb:

LmxM.08_29.0960

Length:

440

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALX6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.658
CLV_C14_Caspase3-7	273	277	PF00656	0.671
CLV_C14_Caspase3-7	413	417	PF00656	0.642
CLV_NRD_NRD_1	67	69	PF00675	0.595
CLV_PCSK_KEX2_1	123	125	PF00082	0.596
CLV_PCSK_KEX2_1	67	69	PF00082	0.595
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.596
CLV_PCSK_SKI1_1	124	128	PF00082	0.601
CLV_PCSK_SKI1_1	151	155	PF00082	0.624
CLV_PCSK_SKI1_1	336	340	PF00082	0.651
CLV_PCSK_SKI1_1	341	345	PF00082	0.597
CLV_PCSK_SKI1_1	409	413	PF00082	0.696
CLV_PCSK_SKI1_1	49	53	PF00082	0.668
CLV_PCSK_SKI1_1	61	65	PF00082	0.531
DOC_CKS1_1	317	322	PF01111	0.654
DOC_CKS1_1	418	423	PF01111	0.650
DOC_MAPK_gen_1	38	45	PF00069	0.541
DOC_PP1_RVXF_1	39	46	PF00149	0.539
DOC_PP2B_LxvP_1	176	179	PF13499	0.634
DOC_PP2B_LxvP_1	355	358	PF13499	0.650
DOC_USP7_MATH_1	155	159	PF00917	0.736
DOC_USP7_MATH_1	179	183	PF00917	0.603
DOC_USP7_MATH_1	20	24	PF00917	0.695
DOC_USP7_MATH_1	259	263	PF00917	0.494
DOC_USP7_MATH_1	274	278	PF00917	0.562
DOC_USP7_MATH_1	284	288	PF00917	0.806
DOC_USP7_MATH_1	320	324	PF00917	0.655
DOC_WW_Pin1_4	114	119	PF00397	0.738
DOC_WW_Pin1_4	163	168	PF00397	0.623
DOC_WW_Pin1_4	182	187	PF00397	0.638
DOC_WW_Pin1_4	200	205	PF00397	0.670
DOC_WW_Pin1_4	214	219	PF00397	0.572
DOC_WW_Pin1_4	267	272	PF00397	0.719
DOC_WW_Pin1_4	280	285	PF00397	0.580
DOC_WW_Pin1_4	316	321	PF00397	0.772
DOC_WW_Pin1_4	323	328	PF00397	0.606
DOC_WW_Pin1_4	336	341	PF00397	0.684
DOC_WW_Pin1_4	417	422	PF00397	0.646
LIG_14-3-3_CanoR_1	124	133	PF00244	0.668
LIG_14-3-3_CanoR_1	156	164	PF00244	0.651
LIG_14-3-3_CanoR_1	200	204	PF00244	0.626
LIG_14-3-3_CanoR_1	228	236	PF00244	0.695
LIG_14-3-3_CanoR_1	409	418	PF00244	0.739
LIG_14-3-3_CanoR_1	424	432	PF00244	0.619
LIG_14-3-3_CanoR_1	74	82	PF00244	0.583
LIG_BIR_II_1	1	5	PF00653	0.618
LIG_BRCT_BRCA1_1	184	188	PF00533	0.627
LIG_BRCT_BRCA1_1	361	365	PF00533	0.675
LIG_deltaCOP1_diTrp_1	77	82	PF00928	0.631
LIG_FHA_1	117	123	PF00498	0.623
LIG_FHA_1	157	163	PF00498	0.599
LIG_FHA_1	171	177	PF00498	0.682
LIG_FHA_1	350	356	PF00498	0.700
LIG_FHA_1	418	424	PF00498	0.716
LIG_FHA_1	54	60	PF00498	0.670
LIG_FHA_2	424	430	PF00498	0.620
LIG_FHA_2	52	58	PF00498	0.739
LIG_GBD_Chelix_1	43	51	PF00786	0.634
LIG_LIR_Gen_1	100	109	PF02991	0.546
LIG_LIR_Nem_3	100	105	PF02991	0.543
LIG_LIR_Nem_3	396	400	PF02991	0.650
LIG_MYND_1	214	218	PF01753	0.601
LIG_REV1ctd_RIR_1	43	53	PF16727	0.458
LIG_SH2_CRK	254	258	PF00017	0.662
LIG_SH2_NCK_1	111	115	PF00017	0.494
LIG_SH2_STAP1	111	115	PF00017	0.522
LIG_SH2_STAT5	254	257	PF00017	0.601
LIG_SH2_STAT5	5	8	PF00017	0.471
LIG_SH3_3	133	139	PF00018	0.625
LIG_SH3_3	183	189	PF00018	0.563
LIG_SH3_3	212	218	PF00018	0.623
LIG_SH3_3	238	244	PF00018	0.672
LIG_SH3_3	301	307	PF00018	0.656
LIG_TRAF2_1	75	78	PF00917	0.634
LIG_TRAF2_2	358	363	PF00917	0.627
LIG_TYR_ITIM	109	114	PF00017	0.489
MOD_CDC14_SPxK_1	283	286	PF00782	0.663
MOD_CDC14_SPxK_1	326	329	PF00782	0.771
MOD_CDK_SPK_2	336	341	PF00069	0.673
MOD_CDK_SPxK_1	280	286	PF00069	0.667
MOD_CDK_SPxK_1	323	329	PF00069	0.807
MOD_CDK_SPxxK_3	417	424	PF00069	0.691
MOD_CK1_1	165	171	PF00069	0.618
MOD_CK1_1	182	188	PF00069	0.574
MOD_CK1_1	196	202	PF00069	0.565
MOD_CK1_1	203	209	PF00069	0.612
MOD_CK1_1	287	293	PF00069	0.735
MOD_CK1_1	323	329	PF00069	0.700
MOD_CK1_1	331	337	PF00069	0.727
MOD_CK1_1	376	382	PF00069	0.634
MOD_CK1_1	403	409	PF00069	0.590
MOD_CK1_1	9	15	PF00069	0.736
MOD_CK2_1	165	171	PF00069	0.750
MOD_CK2_1	22	28	PF00069	0.677
MOD_CK2_1	423	429	PF00069	0.622
MOD_CK2_1	51	57	PF00069	0.729
MOD_CK2_1	72	78	PF00069	0.553
MOD_Cter_Amidation	36	39	PF01082	0.468
MOD_Cter_Amidation	65	68	PF01082	0.641
MOD_DYRK1A_RPxSP_1	200	204	PF00069	0.580
MOD_GlcNHglycan	1	4	PF01048	0.682
MOD_GlcNHglycan	106	109	PF01048	0.491
MOD_GlcNHglycan	15	18	PF01048	0.550
MOD_GlcNHglycan	167	170	PF01048	0.606
MOD_GlcNHglycan	181	184	PF01048	0.720
MOD_GlcNHglycan	24	27	PF01048	0.608
MOD_GlcNHglycan	257	260	PF01048	0.546
MOD_GlcNHglycan	272	275	PF01048	0.593
MOD_GlcNHglycan	311	314	PF01048	0.620
MOD_GlcNHglycan	387	390	PF01048	0.711
MOD_GlcNHglycan	82	85	PF01048	0.627
MOD_GSK3_1	151	158	PF00069	0.720
MOD_GSK3_1	165	172	PF00069	0.584
MOD_GSK3_1	195	202	PF00069	0.623
MOD_GSK3_1	20	27	PF00069	0.558
MOD_GSK3_1	228	235	PF00069	0.649
MOD_GSK3_1	255	262	PF00069	0.580
MOD_GSK3_1	266	273	PF00069	0.697
MOD_GSK3_1	280	287	PF00069	0.574
MOD_GSK3_1	316	323	PF00069	0.609
MOD_GSK3_1	339	346	PF00069	0.694
MOD_GSK3_1	372	379	PF00069	0.661
MOD_GSK3_1	9	16	PF00069	0.678
MOD_N-GLC_1	383	388	PF02516	0.639
MOD_NEK2_1	266	271	PF00069	0.657
MOD_NEK2_1	367	372	PF00069	0.753
MOD_NEK2_1	410	415	PF00069	0.701
MOD_NEK2_1	6	11	PF00069	0.602
MOD_PIKK_1	400	406	PF00454	0.616
MOD_PKA_2	155	161	PF00069	0.649
MOD_PKA_2	199	205	PF00069	0.626
MOD_PKA_2	244	250	PF00069	0.680
MOD_PKA_2	285	291	PF00069	0.667
MOD_PKA_2	367	373	PF00069	0.673
MOD_PKA_2	423	429	PF00069	0.662
MOD_PKA_2	73	79	PF00069	0.714
MOD_Plk_1	170	176	PF00069	0.756
MOD_Plk_1	232	238	PF00069	0.630
MOD_Plk_1	383	389	PF00069	0.638
MOD_Plk_4	351	357	PF00069	0.822
MOD_Plk_4	367	373	PF00069	0.485
MOD_ProDKin_1	114	120	PF00069	0.742
MOD_ProDKin_1	163	169	PF00069	0.622
MOD_ProDKin_1	182	188	PF00069	0.640
MOD_ProDKin_1	200	206	PF00069	0.668
MOD_ProDKin_1	214	220	PF00069	0.571
MOD_ProDKin_1	267	273	PF00069	0.721
MOD_ProDKin_1	280	286	PF00069	0.583
MOD_ProDKin_1	316	322	PF00069	0.773
MOD_ProDKin_1	323	329	PF00069	0.610
MOD_ProDKin_1	336	342	PF00069	0.682
MOD_ProDKin_1	417	423	PF00069	0.648
MOD_SUMO_rev_2	48	54	PF00179	0.663
TRG_DiLeu_BaLyEn_6	215	220	PF01217	0.603
TRG_DiLeu_BaLyEn_6	434	439	PF01217	0.634
TRG_ENDOCYTIC_2	111	114	PF00928	0.485
TRG_ER_diArg_1	432	435	PF00400	0.506
TRG_ER_diArg_1	91	94	PF00400	0.476
TRG_NLS_MonoCore_2	37	42	PF00514	0.456
TRG_Pf-PMV_PEXEL_1	237	242	PF00026	0.639
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.668

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8D7	Leptomonas seymouri	39%	100%
A0A3Q8IFA6	Leishmania donovani	89%	100%
A4HHA8	Leishmania braziliensis	69%	99%
A4I4F4	Leishmania infantum	88%	100%
E9ADV4	Leishmania major	88%	100%