PDZ domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALX2_LEIMU

TriTrypDb:

LmxM.08_29.1000

Length:

628

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALX2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	139	145	PF00089	0.463
CLV_MEL_PAP_1	339	345	PF00089	0.552
CLV_NRD_NRD_1	172	174	PF00675	0.508
CLV_NRD_NRD_1	341	343	PF00675	0.676
CLV_NRD_NRD_1	459	461	PF00675	0.644
CLV_NRD_NRD_1	473	475	PF00675	0.616
CLV_NRD_NRD_1	505	507	PF00675	0.523
CLV_PCSK_KEX2_1	119	121	PF00082	0.571
CLV_PCSK_KEX2_1	172	174	PF00082	0.508
CLV_PCSK_KEX2_1	291	293	PF00082	0.582
CLV_PCSK_KEX2_1	341	343	PF00082	0.676
CLV_PCSK_KEX2_1	459	461	PF00082	0.700
CLV_PCSK_KEX2_1	472	474	PF00082	0.625
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.373
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.582
CLV_PCSK_SKI1_1	188	192	PF00082	0.601
CLV_PCSK_SKI1_1	207	211	PF00082	0.436
CLV_PCSK_SKI1_1	357	361	PF00082	0.473
CLV_PCSK_SKI1_1	517	521	PF00082	0.512
CLV_PCSK_SKI1_1	597	601	PF00082	0.559
CLV_PCSK_SKI1_1	69	73	PF00082	0.457
CLV_Separin_Metazoa	204	208	PF03568	0.497
CLV_Separin_Metazoa	456	460	PF03568	0.642
DEG_APCC_DBOX_1	47	55	PF00400	0.559
DEG_APCC_DBOX_1	505	513	PF00400	0.469
DEG_COP1_1	5	14	PF00400	0.575
DEG_SPOP_SBC_1	418	422	PF00917	0.523
DEG_SPOP_SBC_1	601	605	PF00917	0.606
DOC_CYCLIN_yCln2_LP_2	595	601	PF00134	0.628
DOC_MAPK_gen_1	186	193	PF00069	0.555
DOC_MAPK_gen_1	472	479	PF00069	0.690
DOC_MAPK_MEF2A_6	25	34	PF00069	0.403
DOC_MAPK_MEF2A_6	472	479	PF00069	0.670
DOC_PP2B_LxvP_1	191	194	PF13499	0.445
DOC_PP2B_PxIxI_1	1	7	PF00149	0.629
DOC_PP4_FxxP_1	585	588	PF00568	0.688
DOC_USP7_MATH_1	146	150	PF00917	0.289
DOC_USP7_MATH_1	214	218	PF00917	0.530
DOC_USP7_MATH_1	220	224	PF00917	0.533
DOC_USP7_MATH_1	226	230	PF00917	0.488
DOC_USP7_MATH_1	275	279	PF00917	0.586
DOC_USP7_MATH_1	383	387	PF00917	0.578
DOC_USP7_MATH_1	419	423	PF00917	0.682
DOC_USP7_MATH_1	435	439	PF00917	0.461
DOC_USP7_MATH_1	515	519	PF00917	0.495
DOC_USP7_MATH_1	548	552	PF00917	0.725
DOC_USP7_UBL2_3	503	507	PF12436	0.480
DOC_WW_Pin1_4	420	425	PF00397	0.679
DOC_WW_Pin1_4	618	623	PF00397	0.700
LIG_14-3-3_CanoR_1	120	128	PF00244	0.446
LIG_14-3-3_CanoR_1	142	150	PF00244	0.403
LIG_14-3-3_CanoR_1	172	179	PF00244	0.618
LIG_14-3-3_CanoR_1	188	194	PF00244	0.323
LIG_14-3-3_CanoR_1	227	235	PF00244	0.498
LIG_14-3-3_CanoR_1	25	33	PF00244	0.497
LIG_14-3-3_CanoR_1	313	318	PF00244	0.481
LIG_14-3-3_CanoR_1	341	346	PF00244	0.469
LIG_14-3-3_CanoR_1	437	442	PF00244	0.687
LIG_14-3-3_CanoR_1	472	478	PF00244	0.673
LIG_14-3-3_CanoR_1	562	570	PF00244	0.681
LIG_14-3-3_CanoR_1	587	595	PF00244	0.700
LIG_CSL_BTD_1	431	434	PF09270	0.468
LIG_DLG_GKlike_1	230	238	PF00625	0.536
LIG_eIF4E_1	553	559	PF01652	0.653
LIG_FHA_1	185	191	PF00498	0.505
LIG_FHA_1	25	31	PF00498	0.476
LIG_FHA_1	452	458	PF00498	0.714
LIG_FHA_1	590	596	PF00498	0.698
LIG_FHA_1	77	83	PF00498	0.553
LIG_FHA_1	98	104	PF00498	0.516
LIG_FHA_2	294	300	PF00498	0.608
LIG_FHA_2	444	450	PF00498	0.476
LIG_FHA_2	78	84	PF00498	0.449
LIG_Integrin_RGD_1	581	583	PF01839	0.611
LIG_LIR_Apic_2	429	435	PF02991	0.478
LIG_LIR_Apic_2	551	556	PF02991	0.652
LIG_LIR_Apic_2	583	588	PF02991	0.647
LIG_LIR_Gen_1	195	203	PF02991	0.416
LIG_LIR_Gen_1	20	30	PF02991	0.396
LIG_LIR_Nem_3	195	199	PF02991	0.485
LIG_LIR_Nem_3	20	26	PF02991	0.395
LIG_MYND_1	556	560	PF01753	0.697
LIG_MYND_3	273	277	PF01753	0.606
LIG_NRBOX	205	211	PF00104	0.523
LIG_NRBOX	313	319	PF00104	0.571
LIG_Pex14_2	156	160	PF04695	0.430
LIG_RPA_C_Fungi	225	237	PF08784	0.521
LIG_SH2_CRK	23	27	PF00017	0.390
LIG_SH2_CRK	553	557	PF00017	0.657
LIG_SH2_NCK_1	553	557	PF00017	0.657
LIG_SH2_STAP1	113	117	PF00017	0.577
LIG_SH2_STAT5	189	192	PF00017	0.382
LIG_SH2_STAT5	234	237	PF00017	0.686
LIG_SH2_STAT5	608	611	PF00017	0.593
LIG_SH3_2	557	562	PF14604	0.601
LIG_SH3_3	554	560	PF00018	0.656
LIG_SUMO_SIM_anti_2	454	459	PF11976	0.636
LIG_SUMO_SIM_par_1	189	195	PF11976	0.441
LIG_TRAF2_1	74	77	PF00917	0.590
LIG_TYR_ITIM	21	26	PF00017	0.392
LIG_UBA3_1	498	503	PF00899	0.399
LIG_WRC_WIRS_1	193	198	PF05994	0.439
MOD_CK1_1	192	198	PF00069	0.442
MOD_CK1_1	24	30	PF00069	0.452
MOD_CK1_1	363	369	PF00069	0.688
MOD_CK1_1	393	399	PF00069	0.578
MOD_CK1_1	420	426	PF00069	0.703
MOD_CK1_1	444	450	PF00069	0.613
MOD_CK1_1	586	592	PF00069	0.694
MOD_CK1_1	603	609	PF00069	0.485
MOD_CK2_1	141	147	PF00069	0.553
MOD_CK2_1	291	297	PF00069	0.634
MOD_CK2_1	341	347	PF00069	0.495
MOD_CK2_1	443	449	PF00069	0.508
MOD_CK2_1	515	521	PF00069	0.473
MOD_CK2_1	77	83	PF00069	0.602
MOD_Cter_Amidation	170	173	PF01082	0.556
MOD_GlcNHglycan	143	146	PF01048	0.407
MOD_GlcNHglycan	246	250	PF01048	0.651
MOD_GlcNHglycan	254	257	PF01048	0.529
MOD_GlcNHglycan	277	280	PF01048	0.588
MOD_GlcNHglycan	293	296	PF01048	0.608
MOD_GlcNHglycan	365	368	PF01048	0.584
MOD_GlcNHglycan	395	398	PF01048	0.669
MOD_GlcNHglycan	407	410	PF01048	0.660
MOD_GlcNHglycan	517	520	PF01048	0.470
MOD_GlcNHglycan	550	553	PF01048	0.648
MOD_GlcNHglycan	564	567	PF01048	0.670
MOD_GlcNHglycan	589	592	PF01048	0.678
MOD_GSK3_1	17	24	PF00069	0.405
MOD_GSK3_1	226	233	PF00069	0.499
MOD_GSK3_1	435	442	PF00069	0.531
MOD_GSK3_1	515	522	PF00069	0.599
MOD_GSK3_1	583	590	PF00069	0.678
MOD_GSK3_1	616	623	PF00069	0.579
MOD_N-GLC_1	616	621	PF02516	0.590
MOD_NEK2_1	128	133	PF00069	0.592
MOD_NEK2_1	179	184	PF00069	0.438
MOD_NEK2_1	19	24	PF00069	0.399
MOD_NEK2_1	318	323	PF00069	0.606
MOD_NEK2_1	520	525	PF00069	0.540
MOD_NEK2_1	600	605	PF00069	0.580
MOD_NEK2_1	85	90	PF00069	0.614
MOD_PIKK_1	461	467	PF00454	0.673
MOD_PIKK_1	52	58	PF00454	0.428
MOD_PK_1	437	443	PF00069	0.487
MOD_PK_1	473	479	PF00069	0.634
MOD_PKA_1	119	125	PF00069	0.373
MOD_PKA_1	291	297	PF00069	0.553
MOD_PKA_1	341	347	PF00069	0.524
MOD_PKA_1	473	479	PF00069	0.634
MOD_PKA_2	119	125	PF00069	0.440
MOD_PKA_2	141	147	PF00069	0.432
MOD_PKA_2	171	177	PF00069	0.560
MOD_PKA_2	226	232	PF00069	0.449
MOD_PKA_2	24	30	PF00069	0.452
MOD_PKA_2	291	297	PF00069	0.553
MOD_PKA_2	341	347	PF00069	0.576
MOD_PKA_2	390	396	PF00069	0.724
MOD_PKA_2	436	442	PF00069	0.632
MOD_PKA_2	473	479	PF00069	0.685
MOD_PKA_2	586	592	PF00069	0.672
MOD_Plk_1	146	152	PF00069	0.508
MOD_Plk_1	179	185	PF00069	0.531
MOD_Plk_1	616	622	PF00069	0.670
MOD_Plk_4	179	185	PF00069	0.558
MOD_Plk_4	230	236	PF00069	0.587
MOD_Plk_4	313	319	PF00069	0.571
MOD_Plk_4	341	347	PF00069	0.524
MOD_Plk_4	603	609	PF00069	0.654
MOD_ProDKin_1	420	426	PF00069	0.682
MOD_ProDKin_1	618	624	PF00069	0.701
MOD_SUMO_rev_2	500	509	PF00179	0.399
MOD_SUMO_rev_2	83	88	PF00179	0.503
TRG_DiLeu_BaEn_3	493	499	PF01217	0.493
TRG_DiLeu_BaEn_4	201	207	PF01217	0.457
TRG_ENDOCYTIC_2	23	26	PF00928	0.389
TRG_ER_diArg_1	186	189	PF00400	0.503
TRG_ER_diArg_1	341	343	PF00400	0.568
TRG_ER_diArg_1	458	460	PF00400	0.700
TRG_ER_diArg_1	472	474	PF00400	0.582
TRG_ER_diArg_1	485	488	PF00400	0.393
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	507	511	PF00026	0.672

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IB58	Leptomonas seymouri	52%	100%
A0A1X0P0W9	Trypanosomatidae	32%	100%
A0A3S7X2E5	Leishmania donovani	90%	100%
A4HHB2	Leishmania braziliensis	78%	99%
A4I4F8	Leishmania infantum	88%	98%
C9ZLK7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ADV8	Leishmania major	88%	100%
V5BH56	Trypanosoma cruzi	29%	100%