PKS_ER domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

putative NAD(P)H quinone oxidoreductase, PIG3 family, putative

Species:

Leishmania mexicana

UniProt:

E9ALX1_LEIMU

TriTrypDb:

LmxM.08_29.1010

Length:

350

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALX1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	18
GO:0016491	oxidoreductase activity	2	18
GO:0000166	nucleotide binding	3	2
GO:0005488	binding	1	2
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	8
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0050661	NADP binding	4	2
GO:0070402	NADPH binding	4	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2
GO:0003960	NADPH:quinone reductase activity	5	7
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	44	48	PF00656	0.236
CLV_NRD_NRD_1	141	143	PF00675	0.376
CLV_NRD_NRD_1	50	52	PF00675	0.317
CLV_PCSK_SKI1_1	208	212	PF00082	0.359
CLV_PCSK_SKI1_1	32	36	PF00082	0.296
CLV_PCSK_SKI1_1	328	332	PF00082	0.283
CLV_PCSK_SKI1_1	5	9	PF00082	0.321
CLV_PCSK_SKI1_1	81	85	PF00082	0.253
DEG_APCC_DBOX_1	31	39	PF00400	0.296
DEG_MDM2_SWIB_1	128	135	PF02201	0.302
DEG_Nend_UBRbox_3	1	3	PF02207	0.506
DEG_SCF_FBW7_1	192	199	PF00400	0.458
DEG_SPOP_SBC_1	172	176	PF00917	0.383
DOC_CDC14_PxL_1	255	263	PF14671	0.386
DOC_CKS1_1	345	350	PF01111	0.483
DOC_CYCLIN_RxL_1	205	213	PF00134	0.386
DOC_MAPK_gen_1	142	149	PF00069	0.403
DOC_MAPK_gen_1	238	247	PF00069	0.386
DOC_MAPK_gen_1	262	269	PF00069	0.293
DOC_MAPK_gen_1	30	38	PF00069	0.386
DOC_MAPK_HePTP_8	235	247	PF00069	0.386
DOC_MAPK_MEF2A_6	238	247	PF00069	0.386
DOC_MAPK_MEF2A_6	30	38	PF00069	0.311
DOC_MAPK_MEF2A_6	324	333	PF00069	0.271
DOC_USP7_MATH_1	151	155	PF00917	0.350
DOC_USP7_MATH_1	302	306	PF00917	0.364
DOC_USP7_MATH_1	41	45	PF00917	0.379
DOC_USP7_MATH_1	58	62	PF00917	0.278
DOC_USP7_UBL2_3	324	328	PF12436	0.273
DOC_USP7_UBL2_3	84	88	PF12436	0.296
DOC_WW_Pin1_4	192	197	PF00397	0.386
DOC_WW_Pin1_4	201	206	PF00397	0.358
DOC_WW_Pin1_4	344	349	PF00397	0.606
LIG_14-3-3_CanoR_1	142	148	PF00244	0.254
LIG_14-3-3_CanoR_1	5	10	PF00244	0.331
LIG_APCC_ABBA_1	80	85	PF00400	0.151
LIG_FHA_1	13	19	PF00498	0.413
LIG_FHA_1	144	150	PF00498	0.335
LIG_FHA_1	250	256	PF00498	0.392
LIG_FHA_1	305	311	PF00498	0.337
LIG_FHA_1	340	346	PF00498	0.577
LIG_FHA_2	121	127	PF00498	0.376
LIG_FHA_2	173	179	PF00498	0.393
LIG_FHA_2	193	199	PF00498	0.451
LIG_LIR_Gen_1	130	137	PF02991	0.359
LIG_LIR_Nem_3	130	135	PF02991	0.313
LIG_LIR_Nem_3	323	329	PF02991	0.404
LIG_Pex14_2	128	132	PF04695	0.301
LIG_SH2_GRB2like	294	297	PF00017	0.386
LIG_SH2_STAP1	98	102	PF00017	0.319
LIG_SH2_STAT5	167	170	PF00017	0.320
LIG_SH2_STAT5	228	231	PF00017	0.283
LIG_SH3_3	296	302	PF00018	0.345
LIG_TRAF2_1	309	312	PF00917	0.334
LIG_UBA3_1	17	25	PF00899	0.354
LIG_WRC_WIRS_1	284	289	PF05994	0.331
LIG_WRC_WIRS_1	330	335	PF05994	0.457
MOD_CDK_SPK_2	201	206	PF00069	0.329
MOD_CDK_SPK_2	344	349	PF00069	0.471
MOD_CDK_SPxxK_3	201	208	PF00069	0.325
MOD_CK1_1	176	182	PF00069	0.502
MOD_CK1_1	227	233	PF00069	0.331
MOD_CK1_1	335	341	PF00069	0.594
MOD_CK2_1	114	120	PF00069	0.350
MOD_CK2_1	172	178	PF00069	0.433
MOD_CK2_1	192	198	PF00069	0.394
MOD_GlcNHglycan	153	156	PF01048	0.334
MOD_GlcNHglycan	337	340	PF01048	0.607
MOD_GlcNHglycan	38	41	PF01048	0.351
MOD_GlcNHglycan	68	72	PF01048	0.248
MOD_GSK3_1	151	158	PF00069	0.346
MOD_GSK3_1	168	175	PF00069	0.323
MOD_GSK3_1	186	193	PF00069	0.420
MOD_GSK3_1	335	342	PF00069	0.422
MOD_N-GLC_1	190	195	PF02516	0.350
MOD_NEK2_1	168	173	PF00069	0.380
MOD_NEK2_1	18	23	PF00069	0.416
MOD_NEK2_1	224	229	PF00069	0.372
MOD_NEK2_1	320	325	PF00069	0.322
MOD_NEK2_1	337	342	PF00069	0.514
MOD_NEK2_1	67	72	PF00069	0.253
MOD_NEK2_2	249	254	PF00069	0.255
MOD_Plk_2-3	120	126	PF00069	0.174
MOD_Plk_4	105	111	PF00069	0.283
MOD_Plk_4	114	120	PF00069	0.317
MOD_Plk_4	143	149	PF00069	0.358
MOD_Plk_4	206	212	PF00069	0.244
MOD_Plk_4	219	225	PF00069	0.315
MOD_ProDKin_1	192	198	PF00069	0.395
MOD_ProDKin_1	201	207	PF00069	0.353
MOD_ProDKin_1	344	350	PF00069	0.616
MOD_SUMO_rev_2	176	181	PF00179	0.426
MOD_SUMO_rev_2	321	325	PF00179	0.232
MOD_SUMO_rev_2	74	83	PF00179	0.314
TRG_DiLeu_BaLyEn_6	256	261	PF01217	0.386
TRG_ENDOCYTIC_2	116	119	PF00928	0.362
TRG_ER_diArg_1	261	264	PF00400	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Q4	Leptomonas seymouri	59%	100%
A0A0N1I913	Leptomonas seymouri	30%	100%
A0A0N1I9E8	Leptomonas seymouri	73%	100%
A0A0N1PB21	Leptomonas seymouri	27%	100%
A0A0N1PDX1	Leptomonas seymouri	79%	100%
A0A0S4ILS9	Bodo saltans	28%	100%
A0A0S4IT20	Bodo saltans	27%	100%
A0A0S4IUY2	Bodo saltans	25%	100%
A0A0S4JJT8	Bodo saltans	29%	90%
A0A0S4JMB1	Bodo saltans	29%	100%
A0A0S4KHW9	Bodo saltans	25%	100%
A0A1X0NRR2	Trypanosomatidae	26%	72%
A0A1X0NZZ5	Trypanosomatidae	61%	100%
A0A1X0P8R2	Trypanosomatidae	22%	100%
A0A3Q8ICJ5	Leishmania donovani	59%	100%
A0A3Q8IEG7	Leishmania donovani	24%	100%
A0A3S7X2E3	Leishmania donovani	94%	100%
A0A422NF38	Trypanosoma rangeli	58%	100%
A0A451EJQ8	Leishmania donovani	26%	100%
A4H3L9	Leishmania braziliensis	26%	100%
A4HCV8	Leishmania braziliensis	57%	100%
A4HHB3	Leishmania braziliensis	88%	100%
A4I076	Leishmania infantum	24%	100%
A4I0D8	Leishmania infantum	59%	100%
A4I4G0	Leishmania infantum	94%	100%
A4YGN2	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	26%	100%
A6QQF5	Bos taurus	30%	100%
A7RK30	Nematostella vectensis	27%	96%
B0BNC9	Rattus norvegicus	27%	100%
C9ZLK8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
D7UPN2	Alternaria alternata	26%	100%
E9ACK2	Leishmania major	27%	100%
E9ADV9	Leishmania major	93%	100%
E9AG46	Leishmania infantum	26%	100%
E9AJU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AW40	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AWA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
K4BW79	Solanum lycopersicum	31%	90%
O23939	Fragaria vesca	29%	100%
O35017	Bacillus subtilis (strain 168)	24%	100%
O42909	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
O74489	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
O94564	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
O97764	Bos taurus	28%	100%
P0DN30	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	23%	100%
P11415	Cavia porcellus	27%	100%
P19333	Tetronarce californica	27%	92%
P28304	Escherichia coli (strain K12)	27%	100%
P34055	Hypocrea atroviridis	24%	100%
P38230	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P39462	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	24%	100%
P40783	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	25%	100%
P43903	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	28%	100%
P47199	Mus musculus	27%	100%
P50381	Sulfolobus sp. (strain RC3)	23%	100%
Q08257	Homo sapiens	29%	100%
Q0MVN8	Sus scrofa	28%	100%
Q0VC50	Bos taurus	26%	88%
Q28452	Lama guanicoe	30%	100%
Q3MIE4	Rattus norvegicus	28%	87%
Q3UNZ8	Mus musculus	28%	100%
Q4J781	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	24%	100%
Q4QB77	Leishmania major	59%	100%
Q4QBD8	Leishmania major	23%	100%
Q4W4Z2	Caenorhabditis elegans	28%	96%
Q53FA7	Homo sapiens	38%	100%
Q54II4	Dictyostelium discoideum	22%	99%
Q59I44	Burkholderia sp.	24%	100%
Q5HM44	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	24%	100%
Q5R4S7	Pongo abelii	28%	100%
Q62465	Mus musculus	28%	86%
Q6AYT0	Rattus norvegicus	26%	100%
Q7T3C7	Danio rerio	31%	90%
Q80TB8	Mus musculus	31%	84%
Q84V25	Fragaria ananassa	28%	100%
Q8BGC4	Mus musculus	27%	93%
Q8CRJ7	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	24%	100%
Q8JFV8	Danio rerio	27%	72%
Q8WWV3	Homo sapiens	26%	88%
Q924D0	Mus musculus	27%	88%
Q941I0	Fragaria ananassa	30%	100%
Q96XE0	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	23%	100%
Q975C8	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	27%	100%
Q99536	Homo sapiens	27%	89%
Q9HCJ6	Homo sapiens	31%	84%
Q9V6U9	Drosophila melanogaster	25%	98%
V5B1P3	Trypanosoma cruzi	62%	100%
V5BXF0	Trypanosoma cruzi	24%	100%