DNA-directed DNA polymerase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALX0_LEIMU

TriTrypDb:

LmxM.08_29.1020

Length:

721

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALX0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.621
CLV_C14_Caspase3-7	524	528	PF00656	0.497
CLV_C14_Caspase3-7	63	67	PF00656	0.459
CLV_C14_Caspase3-7	655	659	PF00656	0.590
CLV_C14_Caspase3-7	99	103	PF00656	0.481
CLV_NRD_NRD_1	127	129	PF00675	0.706
CLV_NRD_NRD_1	25	27	PF00675	0.509
CLV_NRD_NRD_1	335	337	PF00675	0.719
CLV_NRD_NRD_1	351	353	PF00675	0.555
CLV_NRD_NRD_1	369	371	PF00675	0.782
CLV_NRD_NRD_1	45	47	PF00675	0.359
CLV_NRD_NRD_1	477	479	PF00675	0.443
CLV_NRD_NRD_1	541	543	PF00675	0.662
CLV_NRD_NRD_1	680	682	PF00675	0.546
CLV_PCSK_FUR_1	634	638	PF00082	0.506
CLV_PCSK_KEX2_1	127	129	PF00082	0.723
CLV_PCSK_KEX2_1	24	26	PF00082	0.520
CLV_PCSK_KEX2_1	337	339	PF00082	0.683
CLV_PCSK_KEX2_1	351	353	PF00082	0.547
CLV_PCSK_KEX2_1	369	371	PF00082	0.720
CLV_PCSK_KEX2_1	44	46	PF00082	0.354
CLV_PCSK_KEX2_1	541	543	PF00082	0.662
CLV_PCSK_KEX2_1	636	638	PF00082	0.591
CLV_PCSK_KEX2_1	680	682	PF00082	0.546
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.652
CLV_PCSK_PC1ET2_1	636	638	PF00082	0.591
CLV_PCSK_PC7_1	347	353	PF00082	0.621
CLV_PCSK_PC7_1	365	371	PF00082	0.590
CLV_PCSK_SKI1_1	417	421	PF00082	0.573
CLV_PCSK_SKI1_1	470	474	PF00082	0.485
CLV_PCSK_SKI1_1	599	603	PF00082	0.378
DEG_APCC_DBOX_1	103	111	PF00400	0.574
DEG_APCC_DBOX_1	23	31	PF00400	0.489
DEG_APCC_DBOX_1	43	51	PF00400	0.351
DEG_Nend_Nbox_1	1	3	PF02207	0.536
DOC_ANK_TNKS_1	236	243	PF00023	0.527
DOC_CKS1_1	285	290	PF01111	0.626
DOC_CKS1_1	418	423	PF01111	0.512
DOC_MAPK_gen_1	101	109	PF00069	0.482
DOC_MIT_MIM_1	20	31	PF04212	0.455
DOC_PP2B_LxvP_1	269	272	PF13499	0.617
DOC_PP4_FxxP_1	121	124	PF00568	0.595
DOC_PP4_FxxP_1	428	431	PF00568	0.607
DOC_PP4_FxxP_1	697	700	PF00568	0.632
DOC_USP7_MATH_1	176	180	PF00917	0.590
DOC_USP7_MATH_1	228	232	PF00917	0.696
DOC_USP7_MATH_1	254	258	PF00917	0.537
DOC_USP7_MATH_1	353	357	PF00917	0.567
DOC_USP7_MATH_1	377	381	PF00917	0.669
DOC_USP7_MATH_1	438	442	PF00917	0.548
DOC_USP7_MATH_1	60	64	PF00917	0.637
DOC_USP7_MATH_1	660	664	PF00917	0.585
DOC_USP7_MATH_1	669	673	PF00917	0.475
DOC_USP7_MATH_1	692	696	PF00917	0.492
DOC_USP7_UBL2_3	221	225	PF12436	0.550
DOC_WW_Pin1_4	120	125	PF00397	0.528
DOC_WW_Pin1_4	272	277	PF00397	0.731
DOC_WW_Pin1_4	284	289	PF00397	0.668
DOC_WW_Pin1_4	322	327	PF00397	0.556
DOC_WW_Pin1_4	409	414	PF00397	0.562
DOC_WW_Pin1_4	417	422	PF00397	0.497
DOC_WW_Pin1_4	459	464	PF00397	0.529
DOC_WW_Pin1_4	547	552	PF00397	0.625
LIG_14-3-3_CanoR_1	112	121	PF00244	0.523
LIG_14-3-3_CanoR_1	19	24	PF00244	0.431
LIG_14-3-3_CanoR_1	312	318	PF00244	0.500
LIG_14-3-3_CanoR_1	351	361	PF00244	0.739
LIG_14-3-3_CanoR_1	378	382	PF00244	0.533
LIG_14-3-3_CanoR_1	470	477	PF00244	0.551
LIG_14-3-3_CanoR_1	542	551	PF00244	0.714
LIG_14-3-3_CanoR_1	570	576	PF00244	0.654
LIG_BIR_III_4	227	231	PF00653	0.515
LIG_BRCT_BRCA1_1	498	502	PF00533	0.476
LIG_CaM_IQ_9	38	54	PF13499	0.503
LIG_eIF4E_1	575	581	PF01652	0.399
LIG_FHA_1	3	9	PF00498	0.587
LIG_FHA_1	312	318	PF00498	0.615
LIG_FHA_1	471	477	PF00498	0.474
LIG_FHA_1	559	565	PF00498	0.583
LIG_FHA_1	572	578	PF00498	0.519
LIG_FHA_1	684	690	PF00498	0.555
LIG_FHA_1	710	716	PF00498	0.571
LIG_FHA_2	103	109	PF00498	0.482
LIG_FHA_2	149	155	PF00498	0.615
LIG_FHA_2	268	274	PF00498	0.730
LIG_FHA_2	285	291	PF00498	0.790
LIG_FHA_2	393	399	PF00498	0.532
LIG_FHA_2	582	588	PF00498	0.538
LIG_Integrin_isoDGR_2	539	541	PF01839	0.583
LIG_IRF3_LxIS_1	93	98	PF10401	0.577
LIG_LIR_Apic_2	120	124	PF02991	0.592
LIG_LIR_Apic_2	694	700	PF02991	0.562
LIG_LIR_Gen_1	142	150	PF02991	0.517
LIG_LIR_Gen_1	152	163	PF02991	0.498
LIG_LIR_Gen_1	297	308	PF02991	0.555
LIG_LIR_Gen_1	497	504	PF02991	0.396
LIG_LIR_Gen_1	574	581	PF02991	0.434
LIG_LIR_Gen_1	587	596	PF02991	0.412
LIG_LIR_Nem_3	142	147	PF02991	0.537
LIG_LIR_Nem_3	152	158	PF02991	0.497
LIG_LIR_Nem_3	497	501	PF02991	0.389
LIG_LIR_Nem_3	574	578	PF02991	0.456
LIG_LIR_Nem_3	587	593	PF02991	0.501
LIG_LIR_Nem_3	694	699	PF02991	0.630
LIG_LYPXL_SIV_4	486	494	PF13949	0.423
LIG_MLH1_MIPbox_1	498	502	PF16413	0.476
LIG_MYND_1	427	431	PF01753	0.515
LIG_NRBOX	46	52	PF00104	0.567
LIG_Pex14_2	159	163	PF04695	0.459
LIG_Pex14_2	428	432	PF04695	0.526
LIG_Pex14_2	498	502	PF04695	0.386
LIG_RPA_C_Fungi	14	26	PF08784	0.390
LIG_SH2_PTP2	144	147	PF00017	0.475
LIG_SH2_STAP1	575	579	PF00017	0.399
LIG_SH2_STAT5	144	147	PF00017	0.475
LIG_SH2_STAT5	155	158	PF00017	0.451
LIG_SH2_STAT5	436	439	PF00017	0.527
LIG_SH2_STAT5	487	490	PF00017	0.504
LIG_SH2_STAT5	696	699	PF00017	0.608
LIG_SH2_STAT5	704	707	PF00017	0.525
LIG_SH3_3	164	170	PF00018	0.483
LIG_SH3_3	454	460	PF00018	0.465
LIG_SH3_3	514	520	PF00018	0.447
LIG_SH3_3	686	692	PF00018	0.490
LIG_SUMO_SIM_anti_2	105	111	PF11976	0.570
LIG_SUMO_SIM_anti_2	452	458	PF11976	0.470
LIG_SUMO_SIM_anti_2	576	585	PF11976	0.411
LIG_SUMO_SIM_par_1	576	585	PF11976	0.411
LIG_TRAF2_1	382	385	PF00917	0.718
LIG_TRAF2_1	396	399	PF00917	0.485
LIG_TYR_ITIM	153	158	PF00017	0.475
LIG_TYR_ITIM	573	578	PF00017	0.453
LIG_WRC_WIRS_1	118	123	PF05994	0.586
MOD_CDC14_SPxK_1	325	328	PF00782	0.484
MOD_CDK_SPxK_1	322	328	PF00069	0.493
MOD_CDK_SPxxK_3	120	127	PF00069	0.620
MOD_CDK_SPxxK_3	322	329	PF00069	0.494
MOD_CK1_1	120	126	PF00069	0.537
MOD_CK1_1	177	183	PF00069	0.589
MOD_CK1_1	275	281	PF00069	0.685
MOD_CK1_1	315	321	PF00069	0.669
MOD_CK1_1	392	398	PF00069	0.636
MOD_CK1_1	511	517	PF00069	0.494
MOD_CK1_1	543	549	PF00069	0.700
MOD_CK2_1	102	108	PF00069	0.500
MOD_CK2_1	148	154	PF00069	0.493
MOD_CK2_1	379	385	PF00069	0.650
MOD_CK2_1	392	398	PF00069	0.473
MOD_CK2_1	459	465	PF00069	0.494
MOD_CK2_1	547	553	PF00069	0.625
MOD_CK2_1	581	587	PF00069	0.531
MOD_CK2_1	629	635	PF00069	0.616
MOD_Cter_Amidation	349	352	PF01082	0.516
MOD_Cter_Amidation	367	370	PF01082	0.670
MOD_Cter_Amidation	539	542	PF01082	0.653
MOD_GlcNHglycan	169	173	PF01048	0.506
MOD_GlcNHglycan	176	179	PF01048	0.479
MOD_GlcNHglycan	183	186	PF01048	0.561
MOD_GlcNHglycan	229	233	PF01048	0.640
MOD_GlcNHglycan	256	259	PF01048	0.711
MOD_GlcNHglycan	391	394	PF01048	0.616
MOD_GlcNHglycan	497	501	PF01048	0.536
MOD_GlcNHglycan	510	513	PF01048	0.429
MOD_GlcNHglycan	56	59	PF01048	0.637
MOD_GlcNHglycan	63	66	PF01048	0.716
MOD_GlcNHglycan	67	70	PF01048	0.739
MOD_GlcNHglycan	671	674	PF01048	0.561
MOD_GSK3_1	113	120	PF00069	0.598
MOD_GSK3_1	174	181	PF00069	0.571
MOD_GSK3_1	195	202	PF00069	0.694
MOD_GSK3_1	311	318	PF00069	0.648
MOD_GSK3_1	404	411	PF00069	0.617
MOD_GSK3_1	466	473	PF00069	0.546
MOD_GSK3_1	54	61	PF00069	0.548
MOD_GSK3_1	540	547	PF00069	0.680
MOD_GSK3_1	582	589	PF00069	0.532
MOD_GSK3_1	698	705	PF00069	0.547
MOD_N-GLC_1	114	119	PF02516	0.598
MOD_N-GLC_1	409	414	PF02516	0.559
MOD_N-GLC_1	445	450	PF02516	0.477
MOD_N-GLC_1	61	66	PF02516	0.509
MOD_NEK2_1	1	6	PF00069	0.589
MOD_NEK2_1	113	118	PF00069	0.548
MOD_NEK2_1	174	179	PF00069	0.591
MOD_NEK2_1	299	304	PF00069	0.539
MOD_NEK2_1	30	35	PF00069	0.566
MOD_NEK2_1	466	471	PF00069	0.506
MOD_NEK2_1	580	585	PF00069	0.469
MOD_NEK2_1	586	591	PF00069	0.465
MOD_PIKK_1	230	236	PF00454	0.625
MOD_PIKK_1	530	536	PF00454	0.573
MOD_PK_1	597	603	PF00069	0.418
MOD_PKA_1	336	342	PF00069	0.744
MOD_PKA_1	544	550	PF00069	0.482
MOD_PKA_2	30	36	PF00069	0.458
MOD_PKA_2	311	317	PF00069	0.731
MOD_PKA_2	377	383	PF00069	0.555
MOD_PKA_2	540	546	PF00069	0.738
MOD_PKB_1	334	342	PF00069	0.590
MOD_PKB_1	542	550	PF00069	0.484
MOD_Plk_1	114	120	PF00069	0.600
MOD_Plk_1	438	444	PF00069	0.491
MOD_Plk_1	445	451	PF00069	0.458
MOD_Plk_1	496	502	PF00069	0.458
MOD_Plk_1	558	564	PF00069	0.588
MOD_Plk_1	586	592	PF00069	0.595
MOD_Plk_1	647	653	PF00069	0.727
MOD_Plk_2-3	102	108	PF00069	0.486
MOD_Plk_2-3	629	635	PF00069	0.542
MOD_Plk_4	114	120	PF00069	0.506
MOD_Plk_4	195	201	PF00069	0.532
MOD_Plk_4	299	305	PF00069	0.614
MOD_Plk_4	3	9	PF00069	0.549
MOD_Plk_4	439	445	PF00069	0.472
MOD_Plk_4	692	698	PF00069	0.562
MOD_ProDKin_1	120	126	PF00069	0.529
MOD_ProDKin_1	272	278	PF00069	0.731
MOD_ProDKin_1	284	290	PF00069	0.665
MOD_ProDKin_1	322	328	PF00069	0.556
MOD_ProDKin_1	409	415	PF00069	0.563
MOD_ProDKin_1	417	423	PF00069	0.499
MOD_ProDKin_1	459	465	PF00069	0.528
MOD_ProDKin_1	547	553	PF00069	0.625
MOD_SUMO_for_1	488	491	PF00179	0.524
MOD_SUMO_rev_2	130	136	PF00179	0.522
MOD_SUMO_rev_2	241	247	PF00179	0.654
MOD_SUMO_rev_2	398	403	PF00179	0.563
MOD_SUMO_rev_2	713	717	PF00179	0.667
TRG_DiLeu_BaEn_1	559	564	PF01217	0.640
TRG_DiLeu_BaEn_1	576	581	PF01217	0.300
TRG_DiLeu_LyEn_5	559	564	PF01217	0.557
TRG_ENDOCYTIC_2	144	147	PF00928	0.498
TRG_ENDOCYTIC_2	155	158	PF00928	0.532
TRG_ENDOCYTIC_2	487	490	PF00928	0.433
TRG_ENDOCYTIC_2	575	578	PF00928	0.435
TRG_ENDOCYTIC_2	696	699	PF00928	0.633
TRG_ER_diArg_1	127	129	PF00400	0.719
TRG_ER_diArg_1	23	26	PF00400	0.476
TRG_ER_diArg_1	321	324	PF00400	0.753
TRG_ER_diArg_1	331	334	PF00400	0.744
TRG_ER_diArg_1	44	46	PF00400	0.500
TRG_ER_diArg_1	541	544	PF00400	0.795
TRG_ER_diArg_1	560	563	PF00400	0.546
TRG_ER_diArg_1	679	681	PF00400	0.531
TRG_NLS_MonoExtN_4	334	340	PF00514	0.717
TRG_Pf-PMV_PEXEL_1	475	480	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	562	566	PF00026	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Y8	Leptomonas seymouri	54%	99%
A0A1X0NZR8	Trypanosomatidae	39%	100%
A0A3S7X2C1	Leishmania donovani	88%	100%
A4HHB4	Leishmania braziliensis	75%	100%
A4I4G1	Leishmania infantum	88%	100%
E9ADW0	Leishmania major	88%	100%
V5DI40	Trypanosoma cruzi	41%	100%