Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALW9_LEIMU

TriTrypDb:

LmxM.08_29.1030

Length:

197

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALW9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALW9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.629
CLV_NRD_NRD_1	115	117	PF00675	0.499
CLV_NRD_NRD_1	122	124	PF00675	0.476
CLV_NRD_NRD_1	85	87	PF00675	0.583
CLV_PCSK_KEX2_1	109	111	PF00082	0.576
CLV_PCSK_KEX2_1	117	119	PF00082	0.497
CLV_PCSK_KEX2_1	122	124	PF00082	0.495
CLV_PCSK_KEX2_1	158	160	PF00082	0.490
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.547
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.490
CLV_PCSK_PC7_1	118	124	PF00082	0.525
CLV_PCSK_SKI1_1	142	146	PF00082	0.579
CLV_PCSK_SKI1_1	64	68	PF00082	0.388
CLV_PCSK_SKI1_1	8	12	PF00082	0.527
DOC_USP7_UBL2_3	137	141	PF12436	0.521
DOC_USP7_UBL2_3	55	59	PF12436	0.617
DOC_USP7_UBL2_3	94	98	PF12436	0.685
DOC_WW_Pin1_4	13	18	PF00397	0.570
LIG_14-3-3_CanoR_1	150	156	PF00244	0.536
LIG_14-3-3_CanoR_1	43	47	PF00244	0.569
LIG_FHA_1	173	179	PF00498	0.535
LIG_LIR_Nem_3	124	130	PF02991	0.553
LIG_LIR_Nem_3	161	167	PF02991	0.590
LIG_Rb_pABgroove_1	64	72	PF01858	0.590
LIG_SH2_PTP2	167	170	PF00017	0.575
LIG_SH2_SRC	167	170	PF00017	0.565
LIG_SH2_STAP1	127	131	PF00017	0.616
LIG_SH2_STAP1	70	74	PF00017	0.467
LIG_SH2_STAT3	28	31	PF00017	0.496
LIG_SH2_STAT3	70	73	PF00017	0.481
LIG_SH2_STAT5	167	170	PF00017	0.591
LIG_SH3_1	167	173	PF00018	0.627
LIG_SH3_3	167	173	PF00018	0.511
LIG_TRAF2_1	16	19	PF00917	0.523
MOD_CK2_1	13	19	PF00069	0.554
MOD_CK2_1	55	61	PF00069	0.550
MOD_CK2_1	77	83	PF00069	0.525
MOD_Cter_Amidation	139	142	PF01082	0.636
MOD_GSK3_1	172	179	PF00069	0.536
MOD_GSK3_1	189	196	PF00069	0.563
MOD_GSK3_1	42	49	PF00069	0.565
MOD_NEK2_1	190	195	PF00069	0.677
MOD_NEK2_1	46	51	PF00069	0.569
MOD_NEK2_1	77	82	PF00069	0.590
MOD_PIKK_1	116	122	PF00454	0.577
MOD_PKA_1	116	122	PF00069	0.518
MOD_PKA_2	149	155	PF00069	0.535
MOD_PKA_2	188	194	PF00069	0.558
MOD_PKA_2	42	48	PF00069	0.647
MOD_ProDKin_1	13	19	PF00069	0.565
MOD_SUMO_rev_2	113	119	PF00179	0.602
MOD_SUMO_rev_2	80	88	PF00179	0.600
MOD_SUMO_rev_2	90	99	PF00179	0.411
TRG_DiLeu_BaEn_1	19	24	PF01217	0.515
TRG_DiLeu_BaEn_1	5	10	PF01217	0.615
TRG_DiLeu_BaEn_1	61	66	PF01217	0.531
TRG_ENDOCYTIC_2	29	32	PF00928	0.530
TRG_ENDOCYTIC_2	7	10	PF00928	0.683
TRG_ER_diArg_1	108	110	PF00400	0.629
TRG_Pf-PMV_PEXEL_1	109	113	PF00026	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HS21	Leptomonas seymouri	28%	100%
A0A0N1PE73	Leptomonas seymouri	63%	99%
A0A0S4KEQ5	Bodo saltans	36%	100%
A0A1X0P0C6	Trypanosomatidae	58%	100%
A0A3Q8IR92	Leishmania donovani	91%	100%
A0A3R7K1K7	Trypanosoma rangeli	31%	100%
A0A422NF15	Trypanosoma rangeli	55%	100%
A0A422NMA5	Trypanosoma rangeli	26%	100%
A4HHB5	Leishmania braziliensis	82%	100%
A4I4G2	Leishmania infantum	91%	100%
C9ZLL0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9ADW1	Leishmania major	93%	100%
V5B1S3	Trypanosoma cruzi	55%	100%