Putative KU70 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

KU70 protein, putative

Species:

Leishmania mexicana

UniProt:

E9ALW7_LEIMU

TriTrypDb:

LmxM.08_29.1050

Length:

948

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Show entries

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	10
GO:0043564	Ku70:Ku80 complex	3	10
GO:0140513	nuclear protein-containing complex	2	10

Previous1Next

Expansion

Sequence features

E9ALW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALW7

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0000723	telomere maintenance	5	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006259	DNA metabolic process	4	10
GO:0006281	DNA repair	5	10
GO:0006302	double-strand break repair	6	10
GO:0006303	double-strand break repair via nonhomologous end joining	7	10
GO:0006310	DNA recombination	5	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0006950	response to stress	2	10

Previous1 2 3 4 5Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0003678	DNA helicase activity	3	1
GO:0003684	damaged DNA binding	5	10
GO:0003824	catalytic activity	1	10
GO:0004386	helicase activity	2	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0008094	ATP-dependent activity, acting on DNA	2	1

Previous1 2 3Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	270	274	PF00656	0.505
CLV_C14_Caspase3-7	514	518	PF00656	0.515
CLV_C14_Caspase3-7	625	629	PF00656	0.502
CLV_NRD_NRD_1	258	260	PF00675	0.379
CLV_NRD_NRD_1	324	326	PF00675	0.511
CLV_NRD_NRD_1	36	38	PF00675	0.375
CLV_NRD_NRD_1	459	461	PF00675	0.437
CLV_NRD_NRD_1	525	527	PF00675	0.286
CLV_NRD_NRD_1	602	604	PF00675	0.287
CLV_NRD_NRD_1	637	639	PF00675	0.315

Previous1 2 3 4 5…30Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8R7	Leptomonas seymouri	43%	100%
A0A0S4JJL6	Bodo saltans	27%	100%
A0A3R7KD14	Trypanosoma rangeli	32%	100%
A4HHB7	Leishmania braziliensis	72%	100%
A4I4G4	Leishmania infantum	86%	98%
E5KZN0	Leishmania donovani	86%	98%
E9ADW3	Leishmania major	82%	96%
V5BH85	Trypanosoma cruzi	30%	100%

Previous1Next