Putative KU70 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

KU70 protein, putative

Species:

Leishmania mexicana

UniProt:

E9ALW7_LEIMU

TriTrypDb:

LmxM.08_29.1050

Length:

948

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	10
GO:0043564	Ku70:Ku80 complex	3	10
GO:0140513	nuclear protein-containing complex	2	10

Expansion

Sequence features

E9ALW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALW7

Function

Biological processes
Term	Name	Level	Count
GO:0000723	telomere maintenance	5	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006259	DNA metabolic process	4	10
GO:0006281	DNA repair	5	10
GO:0006302	double-strand break repair	6	10
GO:0006303	double-strand break repair via nonhomologous end joining	7	10
GO:0006310	DNA recombination	5	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0006950	response to stress	2	10
GO:0006974	DNA damage response	4	10
GO:0006996	organelle organization	4	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0032200	telomere organization	6	10
GO:0033554	cellular response to stress	3	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0046483	heterocycle metabolic process	3	10
GO:0050896	response to stimulus	1	10
GO:0051276	chromosome organization	5	10
GO:0051716	cellular response to stimulus	2	10
GO:0071704	organic substance metabolic process	2	10
GO:0071840	cellular component organization or biogenesis	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:0009314	response to radiation	3	1
GO:0009628	response to abiotic stimulus	2	1
GO:0010165	response to X-ray	5	1
GO:0010212	response to ionizing radiation	4	1
GO:0010332	response to gamma radiation	5	1
GO:0071214	cellular response to abiotic stimulus	3	1
GO:0071478	cellular response to radiation	4	1
GO:0071479	cellular response to ionizing radiation	5	1
GO:0071480	cellular response to gamma radiation	6	1
GO:0071481	cellular response to X-ray	6	1
GO:0104004	cellular response to environmental stimulus	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0003684	damaged DNA binding	5	10
GO:0003824	catalytic activity	1	10
GO:0004386	helicase activity	2	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0016787	hydrolase activity	2	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0042162	telomeric DNA binding	6	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0043565	sequence-specific DNA binding	5	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140640	catalytic activity, acting on a nucleic acid	2	10
GO:0140657	ATP-dependent activity	1	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003678	DNA helicase activity	3	1
GO:0008094	ATP-dependent activity, acting on DNA	2	1
GO:0140097	catalytic activity, acting on DNA	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	270	274	PF00656	0.505
CLV_C14_Caspase3-7	514	518	PF00656	0.515
CLV_C14_Caspase3-7	625	629	PF00656	0.502
CLV_NRD_NRD_1	258	260	PF00675	0.379
CLV_NRD_NRD_1	324	326	PF00675	0.511
CLV_NRD_NRD_1	36	38	PF00675	0.375
CLV_NRD_NRD_1	459	461	PF00675	0.437
CLV_NRD_NRD_1	525	527	PF00675	0.286
CLV_NRD_NRD_1	602	604	PF00675	0.287
CLV_NRD_NRD_1	637	639	PF00675	0.315
CLV_NRD_NRD_1	662	664	PF00675	0.341
CLV_NRD_NRD_1	780	782	PF00675	0.548
CLV_NRD_NRD_1	872	874	PF00675	0.713
CLV_NRD_NRD_1	900	902	PF00675	0.374
CLV_NRD_NRD_1	931	933	PF00675	0.499
CLV_PCSK_FUR_1	256	260	PF00082	0.447
CLV_PCSK_KEX2_1	258	260	PF00082	0.379
CLV_PCSK_KEX2_1	324	326	PF00082	0.511
CLV_PCSK_KEX2_1	36	38	PF00082	0.375
CLV_PCSK_KEX2_1	459	461	PF00082	0.440
CLV_PCSK_KEX2_1	525	527	PF00082	0.292
CLV_PCSK_KEX2_1	604	606	PF00082	0.291
CLV_PCSK_KEX2_1	631	633	PF00082	0.363
CLV_PCSK_KEX2_1	637	639	PF00082	0.341
CLV_PCSK_KEX2_1	662	664	PF00082	0.341
CLV_PCSK_KEX2_1	872	874	PF00082	0.644
CLV_PCSK_KEX2_1	900	902	PF00082	0.381
CLV_PCSK_KEX2_1	931	933	PF00082	0.492
CLV_PCSK_PC1ET2_1	604	606	PF00082	0.302
CLV_PCSK_PC1ET2_1	631	633	PF00082	0.371
CLV_PCSK_SKI1_1	220	224	PF00082	0.594
CLV_PCSK_SKI1_1	244	248	PF00082	0.429
CLV_PCSK_SKI1_1	258	262	PF00082	0.286
CLV_PCSK_SKI1_1	351	355	PF00082	0.525
CLV_PCSK_SKI1_1	638	642	PF00082	0.172
CLV_PCSK_SKI1_1	736	740	PF00082	0.578
CLV_PCSK_SKI1_1	788	792	PF00082	0.558
CLV_PCSK_SKI1_1	84	88	PF00082	0.466
CLV_PCSK_SKI1_1	848	852	PF00082	0.536
DEG_COP1_1	720	728	PF00400	0.506
DEG_Nend_UBRbox_2	1	3	PF02207	0.713
DEG_SCF_TRCP1_1	552	557	PF00400	0.467
DOC_ANK_TNKS_1	413	420	PF00023	0.484
DOC_CDC14_PxL_1	722	730	PF14671	0.600
DOC_CYCLIN_RxL_1	241	251	PF00134	0.409
DOC_CYCLIN_RxL_1	255	264	PF00134	0.330
DOC_CYCLIN_RxL_1	782	795	PF00134	0.425
DOC_MAPK_gen_1	36	46	PF00069	0.384
DOC_MAPK_gen_1	522	530	PF00069	0.500
DOC_MAPK_gen_1	603	609	PF00069	0.502
DOC_MAPK_gen_1	662	672	PF00069	0.575
DOC_MAPK_gen_1	931	939	PF00069	0.473
DOC_MAPK_MEF2A_6	135	142	PF00069	0.447
DOC_MAPK_MEF2A_6	289	296	PF00069	0.468
DOC_MAPK_MEF2A_6	496	505	PF00069	0.251
DOC_MAPK_RevD_3	245	259	PF00069	0.450
DOC_PP1_RVXF_1	349	355	PF00149	0.473
DOC_PP1_RVXF_1	593	599	PF00149	0.493
DOC_PP2B_LxvP_1	501	504	PF13499	0.467
DOC_PP2B_LxvP_1	85	88	PF13499	0.467
DOC_PP2B_LxvP_1	911	914	PF13499	0.442
DOC_PP4_FxxP_1	398	401	PF00568	0.440
DOC_PP4_FxxP_1	944	947	PF00568	0.535
DOC_USP7_MATH_1	107	111	PF00917	0.572
DOC_USP7_MATH_1	16	20	PF00917	0.694
DOC_USP7_MATH_1	180	184	PF00917	0.449
DOC_USP7_MATH_1	208	212	PF00917	0.562
DOC_USP7_MATH_1	432	436	PF00917	0.593
DOC_USP7_MATH_1	59	63	PF00917	0.711
DOC_USP7_MATH_1	743	747	PF00917	0.707
DOC_USP7_MATH_1	882	886	PF00917	0.790
DOC_USP7_MATH_1	95	99	PF00917	0.656
DOC_WW_Pin1_4	108	113	PF00397	0.500
DOC_WW_Pin1_4	201	206	PF00397	0.792
DOC_WW_Pin1_4	227	232	PF00397	0.528
DOC_WW_Pin1_4	329	334	PF00397	0.607
DOC_WW_Pin1_4	382	387	PF00397	0.706
DOC_WW_Pin1_4	552	557	PF00397	0.534
DOC_WW_Pin1_4	688	693	PF00397	0.519
DOC_WW_Pin1_4	736	741	PF00397	0.581
LIG_14-3-3_CanoR_1	146	150	PF00244	0.467
LIG_14-3-3_CanoR_1	244	250	PF00244	0.529
LIG_14-3-3_CanoR_1	309	316	PF00244	0.494
LIG_14-3-3_CanoR_1	360	365	PF00244	0.628
LIG_14-3-3_CanoR_1	496	502	PF00244	0.417
LIG_14-3-3_CanoR_1	637	641	PF00244	0.530
LIG_Actin_WH2_2	707	725	PF00022	0.490
LIG_APCC_ABBA_1	620	625	PF00400	0.515
LIG_BRCT_BRCA1_1	110	114	PF00533	0.519
LIG_BRCT_BRCA1_1	150	154	PF00533	0.502
LIG_BRCT_BRCA1_1	229	233	PF00533	0.560
LIG_BRCT_BRCA1_1	429	433	PF00533	0.430
LIG_CaM_IQ_9	840	855	PF13499	0.424
LIG_FHA_1	20	26	PF00498	0.541
LIG_FHA_1	311	317	PF00498	0.554
LIG_FHA_1	389	395	PF00498	0.591
LIG_FHA_1	555	561	PF00498	0.472
LIG_FHA_1	617	623	PF00498	0.532
LIG_FHA_1	728	734	PF00498	0.474
LIG_FHA_1	737	743	PF00498	0.562
LIG_FHA_1	77	83	PF00498	0.660
LIG_FHA_1	9	15	PF00498	0.641
LIG_FHA_1	920	926	PF00498	0.494
LIG_FHA_2	18	24	PF00498	0.612
LIG_FHA_2	262	268	PF00498	0.406
LIG_FHA_2	371	377	PF00498	0.497
LIG_FHA_2	597	603	PF00498	0.490
LIG_FHA_2	610	616	PF00498	0.490
LIG_FHA_2	730	736	PF00498	0.388
LIG_FHA_2	748	754	PF00498	0.384
LIG_FHA_2	827	833	PF00498	0.469
LIG_FHA_2	88	94	PF00498	0.712
LIG_GBD_Chelix_1	754	762	PF00786	0.461
LIG_LIR_Apic_2	396	401	PF02991	0.516
LIG_LIR_Gen_1	185	195	PF02991	0.465
LIG_LIR_Gen_1	615	626	PF02991	0.551
LIG_LIR_Gen_1	838	846	PF02991	0.389
LIG_LIR_Gen_1	854	862	PF02991	0.523
LIG_LIR_Gen_1	905	916	PF02991	0.344
LIG_LIR_Nem_3	151	157	PF02991	0.536
LIG_LIR_Nem_3	185	191	PF02991	0.465
LIG_LIR_Nem_3	396	402	PF02991	0.468
LIG_LIR_Nem_3	500	505	PF02991	0.465
LIG_LIR_Nem_3	51	57	PF02991	0.522
LIG_LIR_Nem_3	615	621	PF02991	0.530
LIG_LIR_Nem_3	838	842	PF02991	0.397
LIG_LIR_Nem_3	854	858	PF02991	0.508
LIG_LIR_Nem_3	905	911	PF02991	0.522
LIG_NBox_RRM_1	235	245	PF00076	0.413
LIG_NRBOX	449	455	PF00104	0.525
LIG_PCNA_yPIPBox_3	50	64	PF02747	0.498
LIG_PCNA_yPIPBox_3	519	528	PF02747	0.500
LIG_Pex14_2	393	397	PF04695	0.562
LIG_Pex14_2	839	843	PF04695	0.460
LIG_RPA_C_Fungi	658	670	PF08784	0.400
LIG_SH2_CRK	588	592	PF00017	0.322
LIG_SH2_CRK	780	784	PF00017	0.417
LIG_SH2_NCK_1	588	592	PF00017	0.391
LIG_SH2_PTP2	502	505	PF00017	0.251
LIG_SH2_PTP2	712	715	PF00017	0.308
LIG_SH2_STAP1	718	722	PF00017	0.308
LIG_SH2_STAT3	158	161	PF00017	0.358
LIG_SH2_STAT3	860	863	PF00017	0.477
LIG_SH2_STAT5	158	161	PF00017	0.284
LIG_SH2_STAT5	21	24	PF00017	0.513
LIG_SH2_STAT5	502	505	PF00017	0.356
LIG_SH2_STAT5	597	600	PF00017	0.428
LIG_SH2_STAT5	675	678	PF00017	0.344
LIG_SH2_STAT5	712	715	PF00017	0.308
LIG_SH2_STAT5	860	863	PF00017	0.549
LIG_SH2_STAT5	919	922	PF00017	0.389
LIG_SH3_1	460	466	PF00018	0.407
LIG_SH3_3	460	466	PF00018	0.444
LIG_SH3_3	686	692	PF00018	0.320
LIG_SH3_3	711	717	PF00018	0.333
LIG_SH3_3	768	774	PF00018	0.458
LIG_SH3_3	794	800	PF00018	0.576
LIG_SUMO_SIM_anti_2	136	142	PF11976	0.327
LIG_SUMO_SIM_anti_2	935	941	PF11976	0.479
LIG_SUMO_SIM_par_1	245	251	PF11976	0.413
LIG_TRAF2_1	187	190	PF00917	0.400
LIG_TRAF2_1	599	602	PF00917	0.270
LIG_TRAF2_1	809	812	PF00917	0.649
LIG_TRAF2_1	822	825	PF00917	0.467
LIG_TRAF2_1	885	888	PF00917	0.669
LIG_TRAF2_1	90	93	PF00917	0.536
LIG_TRAF2_2	822	827	PF00917	0.435
LIG_UBA3_1	122	129	PF00899	0.360
LIG_UBA3_1	622	631	PF00899	0.312
LIG_UBA3_1	912	917	PF00899	0.456
LIG_UBA3_1	936	941	PF00899	0.498
LIG_WRC_WIRS_1	836	841	PF05994	0.448
LIG_WRC_WIRS_1	843	848	PF05994	0.412
MOD_CDC14_SPxK_1	555	558	PF00782	0.312
MOD_CDK_SPxK_1	552	558	PF00069	0.312
MOD_CDK_SPxxK_3	227	234	PF00069	0.523
MOD_CK1_1	110	116	PF00069	0.451
MOD_CK1_1	148	154	PF00069	0.462
MOD_CK1_1	19	25	PF00069	0.522
MOD_CK1_1	199	205	PF00069	0.285
MOD_CK1_1	211	217	PF00069	0.678
MOD_CK1_1	248	254	PF00069	0.453
MOD_CK1_1	311	317	PF00069	0.702
MOD_CK1_1	331	337	PF00069	0.754
MOD_CK1_1	345	351	PF00069	0.639
MOD_CK1_1	478	484	PF00069	0.733
MOD_CK1_1	531	537	PF00069	0.202
MOD_CK1_1	62	68	PF00069	0.664
MOD_CK1_1	678	684	PF00069	0.390
MOD_CK1_1	98	104	PF00069	0.587
MOD_CK2_1	17	23	PF00069	0.635
MOD_CK2_1	432	438	PF00069	0.541
MOD_CK2_1	596	602	PF00069	0.284
MOD_CK2_1	609	615	PF00069	0.284
MOD_CK2_1	747	753	PF00069	0.602
MOD_CK2_1	87	93	PF00069	0.710
MOD_CK2_1	882	888	PF00069	0.773
MOD_GlcNHglycan	147	150	PF01048	0.312
MOD_GlcNHglycan	182	185	PF01048	0.345
MOD_GlcNHglycan	210	213	PF01048	0.693
MOD_GlcNHglycan	267	272	PF01048	0.568
MOD_GlcNHglycan	303	306	PF01048	0.659
MOD_GlcNHglycan	344	347	PF01048	0.750
MOD_GlcNHglycan	348	351	PF01048	0.780
MOD_GlcNHglycan	415	418	PF01048	0.617
MOD_GlcNHglycan	434	437	PF01048	0.455
MOD_GlcNHglycan	446	449	PF01048	0.522
MOD_GlcNHglycan	477	480	PF01048	0.705
MOD_GlcNHglycan	530	533	PF01048	0.343
MOD_GlcNHglycan	552	555	PF01048	0.317
MOD_GlcNHglycan	61	64	PF01048	0.617
MOD_GlcNHglycan	73	76	PF01048	0.657
MOD_GlcNHglycan	868	871	PF01048	0.651
MOD_GlcNHglycan	884	887	PF01048	0.746
MOD_GlcNHglycan	926	929	PF01048	0.554
MOD_GlcNHglycan	97	100	PF01048	0.739
MOD_GSK3_1	144	151	PF00069	0.376
MOD_GSK3_1	161	168	PF00069	0.423
MOD_GSK3_1	196	203	PF00069	0.312
MOD_GSK3_1	307	314	PF00069	0.681
MOD_GSK3_1	328	335	PF00069	0.726
MOD_GSK3_1	338	345	PF00069	0.719
MOD_GSK3_1	367	374	PF00069	0.662
MOD_GSK3_1	380	387	PF00069	0.719
MOD_GSK3_1	528	535	PF00069	0.259
MOD_GSK3_1	550	557	PF00069	0.415
MOD_GSK3_1	59	66	PF00069	0.709
MOD_GSK3_1	674	681	PF00069	0.360
MOD_GSK3_1	688	695	PF00069	0.360
MOD_GSK3_1	743	750	PF00069	0.667
MOD_GSK3_1	878	885	PF00069	0.660
MOD_GSK3_1	94	101	PF00069	0.685
MOD_N-GLC_1	371	376	PF02516	0.575
MOD_N-GLC_1	567	572	PF02516	0.312
MOD_N-GLC_2	278	280	PF02516	0.425
MOD_NEK2_1	115	120	PF00069	0.408
MOD_NEK2_1	142	147	PF00069	0.309
MOD_NEK2_1	261	266	PF00069	0.517
MOD_NEK2_1	279	284	PF00069	0.251
MOD_NEK2_1	308	313	PF00069	0.574
MOD_NEK2_1	354	359	PF00069	0.703
MOD_NEK2_1	453	458	PF00069	0.520
MOD_NEK2_1	497	502	PF00069	0.308
MOD_NEK2_1	609	614	PF00069	0.354
MOD_NEK2_1	641	646	PF00069	0.404
MOD_NEK2_1	742	747	PF00069	0.574
MOD_NEK2_1	762	767	PF00069	0.521
MOD_NEK2_1	826	831	PF00069	0.510
MOD_NEK2_1	842	847	PF00069	0.454
MOD_PIKK_1	63	69	PF00454	0.620
MOD_PKA_2	145	151	PF00069	0.312
MOD_PKA_2	308	314	PF00069	0.764
MOD_PKA_2	413	419	PF00069	0.628
MOD_PKA_2	532	538	PF00069	0.472
MOD_PKA_2	636	642	PF00069	0.399
MOD_Plk_1	161	167	PF00069	0.379
MOD_Plk_1	17	23	PF00069	0.717
MOD_Plk_1	371	377	PF00069	0.630
MOD_Plk_1	743	749	PF00069	0.555
MOD_Plk_1	826	832	PF00069	0.389
MOD_Plk_4	110	116	PF00069	0.450
MOD_Plk_4	453	459	PF00069	0.542
MOD_Plk_4	497	503	PF00069	0.311
MOD_Plk_4	570	576	PF00069	0.312
MOD_Plk_4	729	735	PF00069	0.380
MOD_ProDKin_1	108	114	PF00069	0.482
MOD_ProDKin_1	201	207	PF00069	0.769
MOD_ProDKin_1	227	233	PF00069	0.508
MOD_ProDKin_1	329	335	PF00069	0.606
MOD_ProDKin_1	382	388	PF00069	0.702
MOD_ProDKin_1	552	558	PF00069	0.405
MOD_ProDKin_1	688	694	PF00069	0.385
MOD_ProDKin_1	736	742	PF00069	0.582
MOD_SUMO_for_1	630	633	PF00179	0.360
MOD_SUMO_for_1	807	810	PF00179	0.516
MOD_SUMO_rev_2	214	222	PF00179	0.560
MOD_SUMO_rev_2	600	606	PF00179	0.384
TRG_DiLeu_BaEn_3	601	607	PF01217	0.312
TRG_DiLeu_BaLyEn_6	348	353	PF01217	0.527
TRG_DiLeu_BaLyEn_6	398	403	PF01217	0.502
TRG_ENDOCYTIC_2	188	191	PF00928	0.308
TRG_ENDOCYTIC_2	502	505	PF00928	0.284
TRG_ENDOCYTIC_2	588	591	PF00928	0.324
TRG_ENDOCYTIC_2	780	783	PF00928	0.463
TRG_ENDOCYTIC_2	833	836	PF00928	0.497
TRG_ENDOCYTIC_2	855	858	PF00928	0.505
TRG_ER_diArg_1	255	258	PF00400	0.412
TRG_ER_diArg_1	35	37	PF00400	0.341
TRG_ER_diArg_1	458	460	PF00400	0.492
TRG_ER_diArg_1	524	526	PF00400	0.341
TRG_ER_diArg_1	603	606	PF00400	0.340
TRG_ER_diArg_1	636	638	PF00400	0.379
TRG_ER_diArg_1	661	663	PF00400	0.427
TRG_ER_diArg_1	872	875	PF00400	0.720
TRG_ER_diArg_1	899	901	PF00400	0.377
TRG_NES_CRM1_1	753	767	PF08389	0.506
TRG_Pf-PMV_PEXEL_1	781	785	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	821	825	PF00026	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8R7	Leptomonas seymouri	43%	100%
A0A0S4JJL6	Bodo saltans	27%	100%
A0A3R7KD14	Trypanosoma rangeli	32%	100%
A4HHB7	Leishmania braziliensis	72%	100%
A4I4G4	Leishmania infantum	86%	98%
E5KZN0	Leishmania donovani	86%	98%
E9ADW3	Leishmania major	82%	96%
V5BH85	Trypanosoma cruzi	30%	100%