Putative ribosomal protein L1a

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosomal protein L1a, putative

Species:

Leishmania mexicana

UniProt:

E9ALW4_LEIMU

TriTrypDb:

LmxM.08_29.1090

Length:

434

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 21

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	14
GO:0032991	protein-containing complex	1	15
GO:0043226	organelle	2	15
GO:0043228	non-membrane-bounded organelle	3	15
GO:0043229	intracellular organelle	3	15
GO:0043232	intracellular non-membrane-bounded organelle	4	15
GO:0110165	cellular anatomical entity	1	15
GO:1990904	ribonucleoprotein complex	2	15
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0015934	large ribosomal subunit	4	1
GO:0022625	cytosolic large ribosomal subunit	5	1
GO:0044391	ribosomal subunit	3	1

Expansion

Sequence features

E9ALW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALW4

PDB structure(s): 6az3_C

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	15
GO:0006518	peptide metabolic process	4	15
GO:0006807	nitrogen compound metabolic process	2	15
GO:0008152	metabolic process	1	15
GO:0009058	biosynthetic process	2	15
GO:0009059	macromolecule biosynthetic process	4	15
GO:0009987	cellular process	1	15
GO:0019538	protein metabolic process	3	15
GO:0034641	cellular nitrogen compound metabolic process	3	15
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	15
GO:0043043	peptide biosynthetic process	5	15
GO:0043170	macromolecule metabolic process	3	15
GO:0043603	amide metabolic process	3	15
GO:0043604	amide biosynthetic process	4	15
GO:0044237	cellular metabolic process	2	15
GO:0044238	primary metabolic process	2	15
GO:0044249	cellular biosynthetic process	3	15
GO:0044260	obsolete cellular macromolecule metabolic process	3	15
GO:0044271	cellular nitrogen compound biosynthetic process	4	15
GO:0071704	organic substance metabolic process	2	15
GO:1901564	organonitrogen compound metabolic process	3	15
GO:1901566	organonitrogen compound biosynthetic process	4	15
GO:1901576	organic substance biosynthetic process	3	15

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	15
GO:0005198	structural molecule activity	1	15
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	317	321	PF00656	0.229
CLV_NRD_NRD_1	169	171	PF00675	0.328
CLV_NRD_NRD_1	172	174	PF00675	0.328
CLV_NRD_NRD_1	259	261	PF00675	0.319
CLV_NRD_NRD_1	264	266	PF00675	0.314
CLV_NRD_NRD_1	358	360	PF00675	0.328
CLV_NRD_NRD_1	384	386	PF00675	0.342
CLV_NRD_NRD_1	413	415	PF00675	0.529
CLV_PCSK_FUR_1	257	261	PF00082	0.328
CLV_PCSK_KEX2_1	169	171	PF00082	0.328
CLV_PCSK_KEX2_1	180	182	PF00082	0.328
CLV_PCSK_KEX2_1	259	261	PF00082	0.328
CLV_PCSK_KEX2_1	264	266	PF00082	0.328
CLV_PCSK_KEX2_1	358	360	PF00082	0.328
CLV_PCSK_KEX2_1	384	386	PF00082	0.339
CLV_PCSK_KEX2_1	395	397	PF00082	0.149
CLV_PCSK_KEX2_1	413	415	PF00082	0.399
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.328
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.455
CLV_PCSK_PC7_1	260	266	PF00082	0.328
CLV_PCSK_SKI1_1	281	285	PF00082	0.328
CLV_PCSK_SKI1_1	313	317	PF00082	0.300
CLV_PCSK_SKI1_1	334	338	PF00082	0.424
CLV_PCSK_SKI1_1	358	362	PF00082	0.328
CLV_PCSK_SKI1_1	414	418	PF00082	0.546
CLV_PCSK_SKI1_1	426	430	PF00082	0.525
CLV_PCSK_SKI1_1	51	55	PF00082	0.430
DEG_Nend_UBRbox_4	1	3	PF02207	0.405
DEG_ODPH_VHL_1	299	310	PF01847	0.328
DOC_MAPK_DCC_7	203	212	PF00069	0.444
DOC_MAPK_gen_1	169	177	PF00069	0.328
DOC_MAPK_gen_1	223	230	PF00069	0.328
DOC_MAPK_gen_1	264	270	PF00069	0.328
DOC_MAPK_gen_1	278	288	PF00069	0.328
DOC_MAPK_gen_1	382	390	PF00069	0.328
DOC_MAPK_MEF2A_6	203	212	PF00069	0.444
DOC_MAPK_MEF2A_6	264	271	PF00069	0.328
DOC_MAPK_MEF2A_6	382	390	PF00069	0.342
DOC_PP1_RVXF_1	305	312	PF00149	0.328
DOC_PP2B_LxvP_1	269	272	PF13499	0.342
DOC_PP2B_LxvP_1	338	341	PF13499	0.328
DOC_PP4_FxxP_1	336	339	PF00568	0.342
DOC_PP4_FxxP_1	88	91	PF00568	0.342
DOC_SPAK_OSR1_1	181	185	PF12202	0.328
DOC_SPAK_OSR1_1	307	311	PF12202	0.328
DOC_USP7_MATH_1	105	109	PF00917	0.305
DOC_USP7_MATH_1	183	187	PF00917	0.341
DOC_USP7_MATH_1	189	193	PF00917	0.328
DOC_USP7_MATH_1	289	293	PF00917	0.457
DOC_USP7_MATH_1	424	428	PF00917	0.610
DOC_USP7_MATH_1	64	68	PF00917	0.498
DOC_USP7_MATH_1	9	13	PF00917	0.402
DOC_USP7_UBL2_3	365	369	PF12436	0.336
DOC_USP7_UBL2_3	426	430	PF12436	0.578
DOC_WW_Pin1_4	52	57	PF00397	0.434
LIG_14-3-3_CanoR_1	350	360	PF00244	0.328
LIG_14-3-3_CanoR_1	36	42	PF00244	0.632
LIG_14-3-3_CanoR_1	51	56	PF00244	0.575
LIG_14-3-3_CanoR_1	65	71	PF00244	0.452
LIG_BRCT_BRCA1_1	42	46	PF00533	0.431
LIG_FHA_1	376	382	PF00498	0.384
LIG_FHA_1	79	85	PF00498	0.420
LIG_FHA_1	87	93	PF00498	0.332
LIG_FHA_2	323	329	PF00498	0.428
LIG_FHA_2	342	348	PF00498	0.195
LIG_IBAR_NPY_1	391	393	PF08397	0.470
LIG_LIR_Apic_2	12	16	PF02991	0.405
LIG_LIR_Apic_2	372	377	PF02991	0.358
LIG_LIR_Gen_1	314	323	PF02991	0.397
LIG_LIR_Gen_1	39	47	PF02991	0.430
LIG_LIR_LC3C_4	209	214	PF02991	0.328
LIG_LIR_Nem_3	12	18	PF02991	0.524
LIG_LIR_Nem_3	277	283	PF02991	0.328
LIG_LIR_Nem_3	314	319	PF02991	0.345
LIG_LIR_Nem_3	320	326	PF02991	0.371
LIG_LIR_Nem_3	39	44	PF02991	0.545
LIG_Pex14_2	280	284	PF04695	0.328
LIG_PTB_Apo_2	255	262	PF02174	0.342
LIG_PTB_Phospho_1	255	261	PF10480	0.342
LIG_SH2_CRK	374	378	PF00017	0.349
LIG_SH2_STAT5	261	264	PF00017	0.328
LIG_SH2_STAT5	393	396	PF00017	0.470
LIG_SH3_3	17	23	PF00018	0.699
LIG_SH3_3	205	211	PF00018	0.457
LIG_SH3_3	357	363	PF00018	0.342
LIG_SUMO_SIM_par_1	16	21	PF11976	0.404
LIG_SUMO_SIM_par_1	209	217	PF11976	0.328
LIG_UBA3_1	268	275	PF00899	0.321
LIG_WRC_WIRS_1	323	328	PF05994	0.407
MOD_CK1_1	123	129	PF00069	0.342
MOD_CK1_1	192	198	PF00069	0.387
MOD_CK1_1	40	46	PF00069	0.595
MOD_CK1_1	60	66	PF00069	0.535
MOD_CK1_1	69	75	PF00069	0.426
MOD_CK2_1	311	317	PF00069	0.377
MOD_CK2_1	322	328	PF00069	0.396
MOD_GlcNHglycan	117	120	PF01048	0.331
MOD_GlcNHglycan	122	125	PF01048	0.324
MOD_GlcNHglycan	139	142	PF01048	0.300
MOD_GlcNHglycan	146	149	PF01048	0.296
MOD_GlcNHglycan	185	188	PF01048	0.328
MOD_GlcNHglycan	291	294	PF01048	0.457
MOD_GlcNHglycan	313	316	PF01048	0.372
MOD_GlcNHglycan	328	332	PF01048	0.432
MOD_GlcNHglycan	426	429	PF01048	0.616
MOD_GlcNHglycan	430	433	PF01048	0.672
MOD_GlcNHglycan	62	65	PF01048	0.602
MOD_GlcNHglycan	71	74	PF01048	0.391
MOD_GSK3_1	137	144	PF00069	0.457
MOD_GSK3_1	188	195	PF00069	0.397
MOD_GSK3_1	318	325	PF00069	0.278
MOD_GSK3_1	32	39	PF00069	0.421
MOD_GSK3_1	424	431	PF00069	0.458
MOD_GSK3_1	60	67	PF00069	0.562
MOD_GSK3_1	74	81	PF00069	0.562
MOD_N-GLC_1	120	125	PF02516	0.395
MOD_N-GLC_1	243	248	PF02516	0.328
MOD_N-GLC_1	289	294	PF02516	0.457
MOD_N-GLC_2	154	156	PF02516	0.342
MOD_NEK2_1	120	125	PF00069	0.457
MOD_NEK2_1	18	23	PF00069	0.402
MOD_NEK2_1	188	193	PF00069	0.328
MOD_NEK2_1	196	201	PF00069	0.328
MOD_NEK2_1	37	42	PF00069	0.427
MOD_NEK2_1	99	104	PF00069	0.342
MOD_NEK2_2	66	71	PF00069	0.445
MOD_PKA_1	369	375	PF00069	0.342
MOD_PKA_1	395	401	PF00069	0.357
MOD_PKA_2	115	121	PF00069	0.342
MOD_PKA_2	137	143	PF00069	0.457
MOD_PKA_2	395	401	PF00069	0.429
MOD_PKA_2	419	425	PF00069	0.629
MOD_PKA_2	64	70	PF00069	0.462
MOD_Plk_1	214	220	PF00069	0.376
MOD_Plk_1	289	295	PF00069	0.457
MOD_Plk_1	327	333	PF00069	0.492
MOD_Plk_1	346	352	PF00069	0.178
MOD_Plk_4	192	198	PF00069	0.387
MOD_Plk_4	318	324	PF00069	0.280
MOD_Plk_4	66	72	PF00069	0.440
MOD_Plk_4	74	80	PF00069	0.460
MOD_ProDKin_1	52	58	PF00069	0.435
MOD_SUMO_for_1	394	397	PF00179	0.470
TRG_DiLeu_BaEn_2	225	231	PF01217	0.339
TRG_DiLeu_BaLyEn_6	13	18	PF01217	0.408
TRG_ER_diArg_1	168	170	PF00400	0.329
TRG_ER_diArg_1	256	259	PF00400	0.329
TRG_ER_diArg_1	357	359	PF00400	0.328
TRG_ER_diArg_1	384	387	PF00400	0.350
TRG_NLS_MonoExtN_4	413	418	PF00514	0.576
TRG_PTS1	431	434	PF00515	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBP3	Leptomonas seymouri	96%	100%
A0A0S4JFT4	Bodo saltans	84%	100%
A0A1D8PFV1	Candida albicans (strain SC5314 / ATCC MYA-2876)	50%	100%
A0A1X0NDR6	Trypanosomatidae	90%	100%
A0A3S5H7L0	Leishmania donovani	98%	100%
A0A422MZW3	Trypanosoma rangeli	88%	100%
A4HHB9	Leishmania braziliensis	97%	100%
A4I4G7	Leishmania infantum	98%	100%
C9ZLL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	100%
C9ZLL5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	88%	100%
E9ADW5	Leishmania major	97%	100%
E9AHI5	Leishmania infantum	98%	100%
E9ALW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
O02056	Caenorhabditis elegans	51%	100%
P02385	Xenopus laevis	53%	100%
P08429	Xenopus laevis	53%	100%
P09180	Drosophila melanogaster	52%	100%
P0DJ55	Tetrahymena thermophila (strain SB210)	52%	100%
P10664	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	53%	100%
P35679	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	55%	100%
P36578	Homo sapiens	58%	100%
P49165	Urechis caupo	56%	100%
P49626	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	53%	100%
P49669	Trypanosoma brucei brucei	83%	100%
P49691	Arabidopsis thaliana	54%	100%
P50878	Rattus norvegicus	57%	100%
Q28346	Canis lupus familiaris	56%	100%
Q4R5P9	Macaca fascicularis	58%	100%
Q54Z69	Dictyostelium discoideum	56%	100%
Q58DW0	Bos taurus	58%	100%
Q5RCR3	Pongo abelii	58%	100%
Q9D8E6	Mus musculus	58%	100%
Q9P784	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	55%	100%
Q9SF40	Arabidopsis thaliana	54%	100%
Q9XF97	Prunus armeniaca	57%	100%
V5BH60	Trypanosoma cruzi	87%	100%