ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies), putative

Species:

Leishmania mexicana

UniProt:

E9ALW3_LEIMU

TriTrypDb:

LmxM.08_29.1100

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ALW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALW3

PDB structure(s): 3ljn_A

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	44	50	PF00089	0.293
CLV_NRD_NRD_1	24	26	PF00675	0.250
CLV_NRD_NRD_1	325	327	PF00675	0.652
CLV_NRD_NRD_1	33	35	PF00675	0.292
CLV_PCSK_KEX2_1	325	327	PF00082	0.648
CLV_PCSK_KEX2_1	33	35	PF00082	0.290
CLV_PCSK_KEX2_1	335	337	PF00082	0.543
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.650
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.575
CLV_PCSK_SKI1_1	182	186	PF00082	0.353
CLV_PCSK_SKI1_1	335	339	PF00082	0.579
CLV_Separin_Metazoa	311	315	PF03568	0.314
DEG_APCC_DBOX_1	181	189	PF00400	0.248
DOC_MAPK_gen_1	180	189	PF00069	0.377
DOC_MAPK_JIP1_4	82	88	PF00069	0.249
DOC_MAPK_MEF2A_6	180	189	PF00069	0.218
DOC_MAPK_MEF2A_6	225	233	PF00069	0.498
DOC_MAPK_MEF2A_6	92	99	PF00069	0.410
DOC_MAPK_NFAT4_5	182	190	PF00069	0.218
DOC_PP1_RVXF_1	281	287	PF00149	0.318
DOC_USP7_MATH_1	251	255	PF00917	0.291
DOC_USP7_MATH_1	294	298	PF00917	0.309
DOC_USP7_MATH_1	353	357	PF00917	0.663
DOC_USP7_UBL2_3	325	329	PF12436	0.562
DOC_WW_Pin1_4	158	163	PF00397	0.223
DOC_WW_Pin1_4	168	173	PF00397	0.199
DOC_WW_Pin1_4	38	43	PF00397	0.308
LIG_14-3-3_CanoR_1	25	35	PF00244	0.237
LIG_14-3-3_CanoR_1	47	55	PF00244	0.312
LIG_14-3-3_CanoR_1	9	17	PF00244	0.522
LIG_FHA_1	144	150	PF00498	0.164
LIG_FHA_1	239	245	PF00498	0.445
LIG_FHA_1	254	260	PF00498	0.284
LIG_FHA_1	27	33	PF00498	0.269
LIG_FHA_1	275	281	PF00498	0.412
LIG_FHA_2	161	167	PF00498	0.368
LIG_LIR_Gen_1	146	156	PF02991	0.359
LIG_LIR_LC3C_4	94	97	PF02991	0.244
LIG_LIR_Nem_3	2	7	PF02991	0.507
LIG_PCNA_yPIPBox_3	306	314	PF02747	0.297
LIG_PTAP_UEV_1	340	345	PF05743	0.506
LIG_SH2_GRB2like	273	276	PF00017	0.405
LIG_SH2_STAT5	148	151	PF00017	0.249
LIG_SH2_STAT5	245	248	PF00017	0.314
LIG_SH2_STAT5	67	70	PF00017	0.318
LIG_SH3_1	338	344	PF00018	0.541
LIG_SH3_2	341	346	PF14604	0.514
LIG_SH3_3	338	344	PF00018	0.523
LIG_SUMO_SIM_anti_2	183	191	PF11976	0.218
LIG_SUMO_SIM_par_1	251	256	PF11976	0.418
LIG_SUMO_SIM_par_1	94	101	PF11976	0.398
LIG_TRAF2_1	297	300	PF00917	0.463
MOD_CDK_SPxxK_3	158	165	PF00069	0.235
MOD_CDK_SPxxK_3	168	175	PF00069	0.235
MOD_CK1_1	194	200	PF00069	0.332
MOD_CK1_1	315	321	PF00069	0.425
MOD_CK2_1	294	300	PF00069	0.469
MOD_CK2_1	67	73	PF00069	0.436
MOD_CK2_1	9	15	PF00069	0.541
MOD_GlcNHglycan	341	344	PF01048	0.548
MOD_GlcNHglycan	355	358	PF01048	0.722
MOD_GSK3_1	344	351	PF00069	0.612
MOD_LATS_1	131	137	PF00433	0.381
MOD_N-GLC_1	274	279	PF02516	0.319
MOD_N-GLC_2	115	117	PF02516	0.249
MOD_NEK2_1	188	193	PF00069	0.297
MOD_NEK2_1	244	249	PF00069	0.379
MOD_NEK2_1	35	40	PF00069	0.371
MOD_NEK2_1	48	53	PF00069	0.197
MOD_NEK2_2	134	139	PF00069	0.134
MOD_PKA_2	353	359	PF00069	0.532
MOD_PKB_1	346	354	PF00069	0.676
MOD_Plk_1	238	244	PF00069	0.329
MOD_Plk_4	109	115	PF00069	0.381
MOD_Plk_4	275	281	PF00069	0.307
MOD_ProDKin_1	158	164	PF00069	0.223
MOD_ProDKin_1	168	174	PF00069	0.199
MOD_ProDKin_1	38	44	PF00069	0.308
TRG_DiLeu_BaEn_1	150	155	PF01217	0.309
TRG_DiLeu_BaEn_1	183	188	PF01217	0.218
TRG_DiLeu_BaEn_1	300	305	PF01217	0.323
TRG_DiLeu_BaEn_1	31	36	PF01217	0.269
TRG_DiLeu_LyEn_5	31	36	PF01217	0.330
TRG_ENDOCYTIC_2	148	151	PF00928	0.249
TRG_ENDOCYTIC_2	245	248	PF00928	0.445
TRG_ER_diArg_1	179	182	PF00400	0.272
TRG_ER_diArg_1	32	34	PF00400	0.328
TRG_ER_diArg_1	345	348	PF00400	0.524
TRG_NES_CRM1_1	220	232	PF08389	0.399
TRG_NLS_Bipartite_1	325	339	PF00514	0.697
TRG_NLS_MonoCore_2	324	329	PF00514	0.621
TRG_NLS_MonoExtC_3	324	329	PF00514	0.591
TRG_NLS_MonoExtN_4	325	331	PF00514	0.538
TRG_NLS_MonoExtN_4	332	339	PF00514	0.516
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.268

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9S9	Leptomonas seymouri	72%	99%
A0A1X0NIN0	Trypanosomatidae	25%	91%
A0A1X0NZR2	Trypanosomatidae	56%	100%
A0A3Q8IDM3	Leishmania donovani	96%	100%
A0A3R7N419	Trypanosoma rangeli	26%	91%
A0A422MZY2	Trypanosoma rangeli	55%	100%
A4HHC0	Leishmania braziliensis	88%	100%
A4HIR5	Leishmania braziliensis	26%	87%
A4I4G8	Leishmania infantum	97%	100%
B6DTG8	Bodo saltans	52%	100%
C7B178	Petunia hybrida	24%	67%
C9ZLL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
D0A6Y4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	92%
E9ADW8	Leishmania major	96%	100%
E9B1A1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	88%
Q495B1	Homo sapiens	23%	69%
Q91ZT7	Mus musculus	25%	77%
Q9GKW8	Macaca fascicularis	24%	76%
Q9J516	Fowlpox virus (strain NVSL)	23%	83%
V5B1P9	Trypanosoma cruzi	49%	100%