Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALW2_LEIMU

TriTrypDb:

LmxM.08_29.1110

Length:

625

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALW2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	254	258	PF00656	0.588
CLV_C14_Caspase3-7	314	318	PF00656	0.494
CLV_C14_Caspase3-7	96	100	PF00656	0.596
CLV_NRD_NRD_1	129	131	PF00675	0.574
CLV_NRD_NRD_1	136	138	PF00675	0.533
CLV_NRD_NRD_1	301	303	PF00675	0.502
CLV_NRD_NRD_1	370	372	PF00675	0.438
CLV_PCSK_KEX2_1	129	131	PF00082	0.599
CLV_PCSK_KEX2_1	135	137	PF00082	0.554
CLV_PCSK_KEX2_1	298	300	PF00082	0.528
CLV_PCSK_KEX2_1	370	372	PF00082	0.481
CLV_PCSK_KEX2_1	599	601	PF00082	0.664
CLV_PCSK_KEX2_1	82	84	PF00082	0.605
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.649
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.538
CLV_PCSK_PC1ET2_1	599	601	PF00082	0.656
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.605
CLV_PCSK_PC7_1	125	131	PF00082	0.623
CLV_PCSK_SKI1_1	125	129	PF00082	0.624
CLV_PCSK_SKI1_1	130	134	PF00082	0.585
CLV_PCSK_SKI1_1	346	350	PF00082	0.541
CLV_PCSK_SKI1_1	53	57	PF00082	0.631
CLV_Separin_Metazoa	237	241	PF03568	0.460
DEG_Nend_UBRbox_2	1	3	PF02207	0.726
DEG_SPOP_SBC_1	147	151	PF00917	0.712
DOC_CDC14_PxL_1	188	196	PF14671	0.689
DOC_CKS1_1	70	75	PF01111	0.451
DOC_MAPK_DCC_7	406	416	PF00069	0.555
DOC_MAPK_gen_1	283	293	PF00069	0.526
DOC_MAPK_gen_1	370	376	PF00069	0.437
DOC_PP2B_LxvP_1	336	339	PF13499	0.376
DOC_USP7_MATH_1	147	151	PF00917	0.626
DOC_USP7_MATH_1	156	160	PF00917	0.733
DOC_USP7_MATH_1	23	27	PF00917	0.697
DOC_USP7_MATH_1	319	323	PF00917	0.446
DOC_USP7_MATH_1	466	470	PF00917	0.664
DOC_USP7_MATH_1	531	535	PF00917	0.613
DOC_USP7_MATH_1	589	593	PF00917	0.773
DOC_USP7_MATH_1	611	615	PF00917	0.754
DOC_WW_Pin1_4	69	74	PF00397	0.540
LIG_14-3-3_CanoR_1	199	209	PF00244	0.560
LIG_14-3-3_CanoR_1	217	223	PF00244	0.603
LIG_14-3-3_CanoR_1	276	284	PF00244	0.522
LIG_14-3-3_CanoR_1	286	292	PF00244	0.361
LIG_14-3-3_CanoR_1	401	407	PF00244	0.674
LIG_14-3-3_CanoR_1	498	502	PF00244	0.652
LIG_14-3-3_CanoR_1	590	598	PF00244	0.486
LIG_Actin_WH2_2	114	131	PF00022	0.386
LIG_Actin_WH2_2	392	410	PF00022	0.637
LIG_Actin_WH2_2	484	500	PF00022	0.668
LIG_APCC_ABBA_1	570	575	PF00400	0.628
LIG_BIR_III_4	34	38	PF00653	0.661
LIG_BRCT_BRCA1_1	289	293	PF00533	0.431
LIG_BRCT_BRCA1_1	311	315	PF00533	0.484
LIG_eIF4E_1	202	208	PF01652	0.559
LIG_FHA_1	101	107	PF00498	0.638
LIG_FHA_1	283	289	PF00498	0.439
LIG_FHA_1	331	337	PF00498	0.547
LIG_FHA_1	351	357	PF00498	0.203
LIG_FHA_1	384	390	PF00498	0.596
LIG_FHA_1	70	76	PF00498	0.726
LIG_FHA_1	86	92	PF00498	0.677
LIG_FHA_2	232	238	PF00498	0.689
LIG_FHA_2	312	318	PF00498	0.523
LIG_FHA_2	389	395	PF00498	0.561
LIG_FHA_2	400	406	PF00498	0.723
LIG_Integrin_RGD_1	32	34	PF01839	0.682
LIG_LIR_Apic_2	496	502	PF02991	0.453
LIG_LIR_Apic_2	60	65	PF02991	0.585
LIG_LIR_Gen_1	257	268	PF02991	0.418
LIG_LIR_Gen_1	485	493	PF02991	0.654
LIG_LIR_Gen_1	504	515	PF02991	0.688
LIG_LIR_Gen_1	567	577	PF02991	0.559
LIG_LIR_Nem_3	2	6	PF02991	0.687
LIG_LIR_Nem_3	257	263	PF02991	0.466
LIG_LIR_Nem_3	343	348	PF02991	0.409
LIG_LIR_Nem_3	44	48	PF02991	0.650
LIG_LIR_Nem_3	485	491	PF02991	0.662
LIG_LIR_Nem_3	504	510	PF02991	0.620
LIG_LIR_Nem_3	540	546	PF02991	0.668
LIG_LIR_Nem_3	63	69	PF02991	0.623
LIG_LYPXL_yS_3	114	117	PF13949	0.402
LIG_LYPXL_yS_3	66	69	PF13949	0.698
LIG_NRBOX	287	293	PF00104	0.466
LIG_Pex14_1	289	293	PF04695	0.409
LIG_Pex14_1	62	66	PF04695	0.590
LIG_Pex14_2	311	315	PF04695	0.484
LIG_PTB_Apo_2	406	413	PF02174	0.664
LIG_PTB_Phospho_1	406	412	PF10480	0.663
LIG_SH2_CRK	499	503	PF00017	0.724
LIG_SH2_CRK	507	511	PF00017	0.752
LIG_SH2_CRK	546	550	PF00017	0.560
LIG_SH2_GRB2like	390	393	PF00017	0.567
LIG_SH2_NCK_1	202	206	PF00017	0.640
LIG_SH2_NCK_1	390	394	PF00017	0.568
LIG_SH2_NCK_1	424	428	PF00017	0.466
LIG_SH2_NCK_1	499	503	PF00017	0.455
LIG_SH2_NCK_1	546	550	PF00017	0.652
LIG_SH2_STAP1	352	356	PF00017	0.367
LIG_SH2_STAP1	359	363	PF00017	0.339
LIG_SH2_STAP1	424	428	PF00017	0.409
LIG_SH2_STAT5	202	205	PF00017	0.547
LIG_SH2_STAT5	306	309	PF00017	0.337
LIG_SH2_STAT5	341	344	PF00017	0.463
LIG_SH2_STAT5	352	355	PF00017	0.363
LIG_SH2_STAT5	385	388	PF00017	0.565
LIG_SH2_STAT5	390	393	PF00017	0.528
LIG_SH2_STAT5	520	523	PF00017	0.598
LIG_SH2_STAT5	543	546	PF00017	0.656
LIG_SH2_STAT5	569	572	PF00017	0.556
LIG_SH3_3	112	118	PF00018	0.621
LIG_SH3_3	194	200	PF00018	0.683
LIG_SH3_3	415	421	PF00018	0.545
LIG_SH3_3	453	459	PF00018	0.584
LIG_SH3_3	602	608	PF00018	0.547
LIG_SH3_3	61	67	PF00018	0.558
LIG_SUMO_SIM_par_1	346	351	PF11976	0.502
LIG_SUMO_SIM_par_1	4	10	PF11976	0.716
LIG_TRAF2_1	209	212	PF00917	0.657
LIG_TRAF2_1	234	237	PF00917	0.724
LIG_TRAF2_1	7	10	PF00917	0.719
LIG_TRFH_1	114	118	PF08558	0.581
LIG_TYR_ITIM	111	116	PF00017	0.570
LIG_TYR_ITIM	544	549	PF00017	0.645
LIG_TYR_ITIM	64	69	PF00017	0.670
MOD_CK1_1	149	155	PF00069	0.734
MOD_CK1_1	313	319	PF00069	0.582
MOD_CK1_1	614	620	PF00069	0.487
MOD_CK2_1	231	237	PF00069	0.683
MOD_CK2_1	388	394	PF00069	0.566
MOD_CK2_1	4	10	PF00069	0.716
MOD_CK2_1	419	425	PF00069	0.384
MOD_GlcNHglycan	153	156	PF01048	0.757
MOD_GlcNHglycan	25	28	PF01048	0.686
MOD_GlcNHglycan	277	280	PF01048	0.488
MOD_GlcNHglycan	402	405	PF01048	0.682
MOD_GlcNHglycan	421	424	PF01048	0.619
MOD_GSK3_1	146	153	PF00069	0.658
MOD_GSK3_1	251	258	PF00069	0.590
MOD_GSK3_1	309	316	PF00069	0.424
MOD_GSK3_1	37	44	PF00069	0.664
MOD_GSK3_1	493	500	PF00069	0.609
MOD_GSK3_1	526	533	PF00069	0.461
MOD_GSK3_1	580	587	PF00069	0.620
MOD_N-GLC_1	156	161	PF02516	0.735
MOD_N-GLC_1	558	563	PF02516	0.690
MOD_NEK2_1	105	110	PF00069	0.599
MOD_NEK2_1	282	287	PF00069	0.413
MOD_NEK2_1	293	298	PF00069	0.477
MOD_NEK2_1	311	316	PF00069	0.357
MOD_NEK2_1	399	404	PF00069	0.613
MOD_NEK2_1	407	412	PF00069	0.677
MOD_NEK2_1	493	498	PF00069	0.593
MOD_NEK2_1	84	89	PF00069	0.648
MOD_PIKK_1	11	17	PF00454	0.713
MOD_PIKK_1	218	224	PF00454	0.642
MOD_PIKK_1	251	257	PF00454	0.651
MOD_PIKK_1	37	43	PF00454	0.645
MOD_PKA_2	275	281	PF00069	0.571
MOD_PKA_2	282	288	PF00069	0.514
MOD_PKA_2	330	336	PF00069	0.532
MOD_PKA_2	400	406	PF00069	0.640
MOD_PKA_2	497	503	PF00069	0.710
MOD_PKA_2	589	595	PF00069	0.480
MOD_Plk_1	174	180	PF00069	0.634
MOD_Plk_1	449	455	PF00069	0.613
MOD_Plk_1	503	509	PF00069	0.621
MOD_Plk_1	85	91	PF00069	0.654
MOD_Plk_4	246	252	PF00069	0.508
MOD_Plk_4	407	413	PF00069	0.668
MOD_Plk_4	516	522	PF00069	0.606
MOD_ProDKin_1	69	75	PF00069	0.538
MOD_SUMO_for_1	598	601	PF00179	0.737
MOD_SUMO_rev_2	394	400	PF00179	0.627
MOD_SUMO_rev_2	79	84	PF00179	0.658
TRG_DiLeu_BaEn_2	440	446	PF01217	0.624
TRG_DiLeu_BaEn_4	441	447	PF01217	0.627
TRG_DiLeu_BaLyEn_6	344	349	PF01217	0.496
TRG_ENDOCYTIC_2	113	116	PF00928	0.585
TRG_ENDOCYTIC_2	202	205	PF00928	0.547
TRG_ENDOCYTIC_2	390	393	PF00928	0.567
TRG_ENDOCYTIC_2	507	510	PF00928	0.743
TRG_ENDOCYTIC_2	546	549	PF00928	0.558
TRG_ENDOCYTIC_2	569	572	PF00928	0.561
TRG_ENDOCYTIC_2	66	69	PF00928	0.605
TRG_ENDOCYTIC_2	81	84	PF00928	0.568
TRG_ER_diArg_1	128	130	PF00400	0.663
TRG_ER_diArg_1	161	164	PF00400	0.776
TRG_Pf-PMV_PEXEL_1	199	204	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	346	351	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	379	383	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHI1	Leptomonas seymouri	66%	100%
A0A0S4JMH1	Bodo saltans	28%	100%
A0A1X0P058	Trypanosomatidae	34%	96%
A0A3R7M9T5	Trypanosoma rangeli	33%	98%
A0A3S7X2F4	Leishmania donovani	94%	100%
A4HHC1	Leishmania braziliensis	87%	100%
C9ZLL7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	97%
E9ADW9	Leishmania major	94%	100%
E9AHI6	Leishmania infantum	94%	100%
V5DI43	Trypanosoma cruzi	35%	99%