Tryparedoxin-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tryparedoxin-like protein

Species:

Leishmania mexicana

UniProt:

E9ALW0_LEIMU

TriTrypDb:

LmxM.08_29.1130

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9ALW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALW0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.515
CLV_NRD_NRD_1	107	109	PF00675	0.645
CLV_NRD_NRD_1	147	149	PF00675	0.766
CLV_NRD_NRD_1	166	168	PF00675	0.590
CLV_NRD_NRD_1	193	195	PF00675	0.638
CLV_NRD_NRD_1	287	289	PF00675	0.759
CLV_NRD_NRD_1	360	362	PF00675	0.444
CLV_NRD_NRD_1	94	96	PF00675	0.643
CLV_NRD_NRD_1	99	101	PF00675	0.630
CLV_PCSK_FUR_1	227	231	PF00082	0.580
CLV_PCSK_KEX2_1	107	109	PF00082	0.645
CLV_PCSK_KEX2_1	166	168	PF00082	0.766
CLV_PCSK_KEX2_1	19	21	PF00082	0.625
CLV_PCSK_KEX2_1	193	195	PF00082	0.629
CLV_PCSK_KEX2_1	229	231	PF00082	0.600
CLV_PCSK_KEX2_1	287	289	PF00082	0.759
CLV_PCSK_KEX2_1	359	361	PF00082	0.491
CLV_PCSK_KEX2_1	94	96	PF00082	0.635
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.625
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.600
CLV_PCSK_PC1ET2_1	359	361	PF00082	0.491
CLV_PCSK_SKI1_1	216	220	PF00082	0.690
CLV_PCSK_SKI1_1	253	257	PF00082	0.692
CLV_PCSK_SKI1_1	80	84	PF00082	0.556
CLV_Separin_Metazoa	11	15	PF03568	0.389
DEG_Nend_UBRbox_3	1	3	PF02207	0.389
DOC_CKS1_1	289	294	PF01111	0.519
DOC_CYCLIN_yCln2_LP_2	239	242	PF00134	0.456
DOC_MAPK_FxFP_2	218	221	PF00069	0.429
DOC_MAPK_gen_1	166	173	PF00069	0.487
DOC_MAPK_gen_1	329	338	PF00069	0.346
DOC_MAPK_MEF2A_6	216	225	PF00069	0.408
DOC_PP2B_LxvP_1	239	242	PF13499	0.456
DOC_PP2B_LxvP_1	275	278	PF13499	0.380
DOC_PP4_FxxP_1	218	221	PF00568	0.429
DOC_SPAK_OSR1_1	309	313	PF12202	0.405
DOC_USP7_MATH_1	176	180	PF00917	0.516
DOC_USP7_MATH_1	181	185	PF00917	0.593
DOC_USP7_MATH_1	187	191	PF00917	0.521
DOC_USP7_MATH_1	251	255	PF00917	0.609
DOC_WW_Pin1_4	152	157	PF00397	0.516
DOC_WW_Pin1_4	233	238	PF00397	0.400
DOC_WW_Pin1_4	254	259	PF00397	0.508
DOC_WW_Pin1_4	288	293	PF00397	0.489
DOC_WW_Pin1_4	38	43	PF00397	0.342
LIG_14-3-3_CanoR_1	148	153	PF00244	0.584
LIG_14-3-3_CanoR_1	216	221	PF00244	0.395
LIG_14-3-3_CanoR_1	230	237	PF00244	0.448
LIG_14-3-3_CanoR_1	360	365	PF00244	0.618
LIG_EVH1_1	240	244	PF00568	0.463
LIG_FHA_1	234	240	PF00498	0.370
LIG_FHA_1	289	295	PF00498	0.485
LIG_FHA_1	343	349	PF00498	0.430
LIG_FHA_2	264	270	PF00498	0.414
LIG_HP1_1	30	34	PF01393	0.342
LIG_IRF3_LxIS_1	349	356	PF10401	0.549
LIG_LIR_Gen_1	28	38	PF02991	0.292
LIG_LIR_Gen_1	320	328	PF02991	0.458
LIG_LIR_Gen_1	330	340	PF02991	0.261
LIG_LIR_Gen_1	45	55	PF02991	0.292
LIG_LIR_Nem_3	219	223	PF02991	0.376
LIG_LIR_Nem_3	28	34	PF02991	0.292
LIG_LIR_Nem_3	298	303	PF02991	0.421
LIG_LIR_Nem_3	45	50	PF02991	0.292
LIG_LYPXL_yS_3	220	223	PF13949	0.390
LIG_LYPXL_yS_3	300	303	PF13949	0.415
LIG_MYND_1	237	241	PF01753	0.454
LIG_PCNA_PIPBox_1	48	57	PF02747	0.324
LIG_Pex14_1	197	201	PF04695	0.379
LIG_Pex14_2	36	40	PF04695	0.317
LIG_SH2_NCK_1	201	205	PF00017	0.376
LIG_SH2_NCK_1	73	77	PF00017	0.356
LIG_SH2_PTP2	31	34	PF00017	0.292
LIG_SH2_SRC	201	204	PF00017	0.386
LIG_SH2_STAT3	3	6	PF00017	0.381
LIG_SH2_STAT5	126	129	PF00017	0.397
LIG_SH2_STAT5	3	6	PF00017	0.381
LIG_SH2_STAT5	31	34	PF00017	0.292
LIG_SH2_STAT5	68	71	PF00017	0.340
LIG_SH3_3	204	210	PF00018	0.423
LIG_SH3_3	238	244	PF00018	0.507
LIG_SH3_3	291	297	PF00018	0.543
LIG_SH3_3	348	354	PF00018	0.258
LIG_SUMO_SIM_anti_2	345	350	PF11976	0.501
LIG_SUMO_SIM_anti_2	8	14	PF11976	0.448
LIG_SUMO_SIM_par_1	339	345	PF11976	0.433
LIG_TYR_ITIM	199	204	PF00017	0.384
LIG_TYR_ITIM	29	34	PF00017	0.356
LIG_WW_2	241	244	PF00397	0.478
MOD_CDK_SPxxK_3	254	261	PF00069	0.415
MOD_CK1_1	157	163	PF00069	0.550
MOD_CK1_1	254	260	PF00069	0.409
MOD_CK2_1	140	146	PF00069	0.562
MOD_CK2_1	263	269	PF00069	0.537
MOD_CK2_1	5	11	PF00069	0.450
MOD_CK2_1	71	77	PF00069	0.295
MOD_Cter_Amidation	191	194	PF01082	0.624
MOD_GlcNHglycan	109	112	PF01048	0.731
MOD_GlcNHglycan	183	186	PF01048	0.717
MOD_GlcNHglycan	231	234	PF01048	0.715
MOD_GlcNHglycan	315	319	PF01048	0.620
MOD_GlcNHglycan	88	91	PF01048	0.684
MOD_GSK3_1	138	145	PF00069	0.574
MOD_GSK3_1	148	155	PF00069	0.567
MOD_GSK3_1	172	179	PF00069	0.453
MOD_GSK3_1	229	236	PF00069	0.380
MOD_GSK3_1	359	366	PF00069	0.535
MOD_GSK3_1	67	74	PF00069	0.317
MOD_GSK3_1	82	89	PF00069	0.390
MOD_LATS_1	214	220	PF00433	0.432
MOD_NEK2_1	36	41	PF00069	0.323
MOD_PIKK_1	268	274	PF00454	0.547
MOD_PIKK_1	353	359	PF00454	0.618
MOD_PIKK_1	363	369	PF00454	0.624
MOD_PK_1	119	125	PF00069	0.426
MOD_PKA_1	107	113	PF00069	0.509
MOD_PKA_1	119	125	PF00069	0.448
MOD_PKA_1	148	154	PF00069	0.563
MOD_PKA_1	229	235	PF00069	0.393
MOD_PKA_1	359	365	PF00069	0.689
MOD_PKA_2	107	113	PF00069	0.509
MOD_PKA_2	229	235	PF00069	0.435
MOD_PKA_2	359	365	PF00069	0.652
MOD_PKA_2	86	92	PF00069	0.440
MOD_Plk_1	169	175	PF00069	0.540
MOD_Plk_1	251	257	PF00069	0.558
MOD_Plk_4	342	348	PF00069	0.490
MOD_ProDKin_1	152	158	PF00069	0.517
MOD_ProDKin_1	233	239	PF00069	0.401
MOD_ProDKin_1	254	260	PF00069	0.508
MOD_ProDKin_1	288	294	PF00069	0.485
MOD_ProDKin_1	38	44	PF00069	0.342
MOD_SUMO_rev_2	112	122	PF00179	0.601
MOD_SUMO_rev_2	56	64	PF00179	0.356
TRG_DiLeu_BaEn_2	42	48	PF01217	0.407
TRG_ENDOCYTIC_2	201	204	PF00928	0.372
TRG_ENDOCYTIC_2	220	223	PF00928	0.243
TRG_ENDOCYTIC_2	300	303	PF00928	0.415
TRG_ENDOCYTIC_2	31	34	PF00928	0.292
TRG_ER_diArg_1	107	109	PF00400	0.497
TRG_ER_diArg_1	165	167	PF00400	0.408
TRG_Pf-PMV_PEXEL_1	107	112	PF00026	0.709

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6T6	Leptomonas seymouri	50%	100%
A0A0N1HYA5	Leptomonas seymouri	26%	98%
A0A3Q8IE94	Leishmania donovani	88%	100%
A4HHC4	Leishmania braziliensis	76%	100%
A4I4H0	Leishmania infantum	88%	100%
E9ADX1	Leishmania major	86%	99%