Tryparedoxin-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tryparedoxin-like protein

Species:

Leishmania mexicana

UniProt:

E9ALV9_LEIMU

TriTrypDb:

LmxM.08_29.1140

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9ALV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALV9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	98	100	PF00675	0.505
CLV_PCSK_KEX2_1	98	100	PF00082	0.505
CLV_PCSK_SKI1_1	37	41	PF00082	0.333
DEG_SPOP_SBC_1	103	107	PF00917	0.823
DOC_MAPK_gen_1	34	43	PF00069	0.546
DOC_MAPK_gen_1	66	75	PF00069	0.507
DOC_MAPK_MEF2A_6	255	264	PF00069	0.514
DOC_MAPK_MEF2A_6	34	43	PF00069	0.504
DOC_PP2B_LxvP_1	185	188	PF13499	0.660
DOC_USP7_MATH_1	102	106	PF00917	0.791
DOC_USP7_MATH_1	110	114	PF00917	0.660
DOC_USP7_MATH_1	176	180	PF00917	0.681
DOC_WW_Pin1_4	104	109	PF00397	0.799
DOC_WW_Pin1_4	169	174	PF00397	0.781
DOC_WW_Pin1_4	52	57	PF00397	0.504
LIG_14-3-3_CanoR_1	200	205	PF00244	0.613
LIG_BIR_II_1	1	5	PF00653	0.587
LIG_BRCT_BRCA1_1	29	33	PF00533	0.609
LIG_deltaCOP1_diTrp_1	252	258	PF00928	0.600
LIG_eIF4E_1	69	75	PF01652	0.619
LIG_FHA_1	126	132	PF00498	0.739
LIG_FHA_1	53	59	PF00498	0.504
LIG_LIR_Apic_2	44	50	PF02991	0.504
LIG_LIR_Gen_1	199	210	PF02991	0.559
LIG_LIR_Gen_1	256	265	PF02991	0.367
LIG_LIR_Nem_3	12	17	PF02991	0.611
LIG_LIR_Nem_3	199	205	PF02991	0.571
LIG_LIR_Nem_3	256	261	PF02991	0.367
LIG_Pex14_1	254	258	PF04695	0.494
LIG_Pex14_2	10	14	PF04695	0.641
LIG_Pex14_2	238	242	PF04695	0.615
LIG_Pex14_2	43	47	PF04695	0.504
LIG_Pex14_2	71	75	PF04695	0.504
LIG_REV1ctd_RIR_1	86	96	PF16727	0.546
LIG_SH2_CRK	202	206	PF00017	0.610
LIG_SH2_NCK_1	202	206	PF00017	0.610
LIG_SH2_PTP2	38	41	PF00017	0.546
LIG_SH2_STAT5	271	274	PF00017	0.498
LIG_SH2_STAT5	38	41	PF00017	0.511
LIG_SH2_STAT5	42	45	PF00017	0.497
LIG_SH2_STAT5	96	99	PF00017	0.661
LIG_SH3_3	148	154	PF00018	0.796
LIG_SH3_3	170	176	PF00018	0.797
LIG_SH3_3	202	208	PF00018	0.599
LIG_SH3_3	233	239	PF00018	0.633
LIG_SH3_3	94	100	PF00018	0.690
LIG_SUMO_SIM_anti_2	256	263	PF11976	0.513
LIG_SUMO_SIM_par_1	211	217	PF11976	0.595
MOD_CDK_SPK_2	169	174	PF00069	0.765
MOD_CK1_1	156	162	PF00069	0.750
MOD_CK1_1	203	209	PF00069	0.599
MOD_CK2_1	75	81	PF00069	0.531
MOD_Cter_Amidation	34	37	PF01082	0.496
MOD_GlcNHglycan	155	158	PF01048	0.500
MOD_GlcNHglycan	178	181	PF01048	0.473
MOD_GlcNHglycan	43	46	PF01048	0.304
MOD_GSK3_1	104	111	PF00069	0.648
MOD_GSK3_1	117	124	PF00069	0.802
MOD_GSK3_1	132	139	PF00069	0.681
MOD_GSK3_1	162	169	PF00069	0.718
MOD_GSK3_1	196	203	PF00069	0.602
MOD_GSK3_1	23	30	PF00069	0.629
MOD_N-GLC_1	132	137	PF02516	0.558
MOD_N-GLC_1	248	253	PF02516	0.553
MOD_N-GLC_1	90	95	PF02516	0.458
MOD_NEK2_1	117	122	PF00069	0.802
MOD_PIKK_1	9	15	PF00454	0.649
MOD_PK_1	200	206	PF00069	0.614
MOD_PKA_2	254	260	PF00069	0.563
MOD_PKA_2	91	97	PF00069	0.670
MOD_Plk_1	125	131	PF00069	0.793
MOD_Plk_4	200	206	PF00069	0.582
MOD_Plk_4	224	230	PF00069	0.684
MOD_Plk_4	254	260	PF00069	0.555
MOD_ProDKin_1	104	110	PF00069	0.800
MOD_ProDKin_1	169	175	PF00069	0.778
MOD_ProDKin_1	52	58	PF00069	0.504
MOD_SUMO_rev_2	12	20	PF00179	0.630
TRG_DiLeu_BaEn_1	256	261	PF01217	0.513
TRG_DiLeu_BaEn_2	192	198	PF01217	0.666
TRG_DiLeu_BaLyEn_6	53	58	PF01217	0.504
TRG_ENDOCYTIC_2	202	205	PF00928	0.608
TRG_ENDOCYTIC_2	269	272	PF00928	0.424
TRG_ENDOCYTIC_2	38	41	PF00928	0.546
TRG_ER_diArg_1	247	250	PF00400	0.768
TRG_ER_diArg_1	97	99	PF00400	0.691

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6E5	Leptomonas seymouri	63%	97%
A0A3Q8IH82	Leishmania donovani	93%	100%
A4HHC5	Leishmania braziliensis	82%	99%
A4I4H1	Leishmania infantum	93%	100%
E9ADX2	Leishmania major	92%	100%