EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALV6_LEIMU

TriTrypDb:

LmxM.08_29.1170

Length:

363

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALV6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0005509	calcium ion binding	5	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.665
CLV_C14_Caspase3-7	24	28	PF00656	0.508
CLV_MEL_PAP_1	140	146	PF00089	0.628
CLV_NRD_NRD_1	160	162	PF00675	0.631
CLV_PCSK_FUR_1	158	162	PF00082	0.543
CLV_PCSK_KEX2_1	160	162	PF00082	0.665
CLV_PCSK_SKI1_1	131	135	PF00082	0.747
CLV_PCSK_SKI1_1	280	284	PF00082	0.536
CLV_PCSK_SKI1_1	307	311	PF00082	0.454
DEG_Nend_Nbox_1	1	3	PF02207	0.619
DEG_SPOP_SBC_1	169	173	PF00917	0.589
DOC_AGCK_PIF_1	350	355	PF00069	0.365
DOC_CKS1_1	272	277	PF01111	0.574
DOC_MAPK_gen_1	31	38	PF00069	0.406
DOC_PP4_FxxP_1	134	137	PF00568	0.638
DOC_USP7_MATH_1	164	168	PF00917	0.649
DOC_USP7_MATH_1	209	213	PF00917	0.759
DOC_USP7_MATH_1	229	233	PF00917	0.454
DOC_USP7_MATH_1	242	246	PF00917	0.569
DOC_USP7_MATH_2	46	52	PF00917	0.468
DOC_WW_Pin1_4	14	19	PF00397	0.449
DOC_WW_Pin1_4	205	210	PF00397	0.613
DOC_WW_Pin1_4	254	259	PF00397	0.634
DOC_WW_Pin1_4	261	266	PF00397	0.670
DOC_WW_Pin1_4	271	276	PF00397	0.671
LIG_14-3-3_CanoR_1	158	168	PF00244	0.658
LIG_14-3-3_CanoR_1	188	194	PF00244	0.707
LIG_14-3-3_CanoR_1	307	313	PF00244	0.461
LIG_14-3-3_CanoR_1	317	323	PF00244	0.491
LIG_14-3-3_CanoR_1	33	37	PF00244	0.413
LIG_14-3-3_CanoR_1	98	107	PF00244	0.445
LIG_BRCT_BRCA1_1	189	193	PF00533	0.637
LIG_CaM_IQ_9	50	66	PF13499	0.503
LIG_Clathr_ClatBox_1	44	48	PF01394	0.467
LIG_deltaCOP1_diTrp_1	345	353	PF00928	0.374
LIG_FHA_1	1	7	PF00498	0.605
LIG_FHA_1	171	177	PF00498	0.625
LIG_FHA_1	232	238	PF00498	0.599
LIG_FHA_1	285	291	PF00498	0.344
LIG_FHA_1	33	39	PF00498	0.487
LIG_FHA_1	63	69	PF00498	0.606
LIG_FHA_2	272	278	PF00498	0.618
LIG_FHA_2	289	295	PF00498	0.304
LIG_LIR_Apic_2	78	83	PF02991	0.549
LIG_LIR_Gen_1	148	157	PF02991	0.583
LIG_LIR_Gen_1	245	255	PF02991	0.445
LIG_LIR_Gen_1	297	304	PF02991	0.396
LIG_LIR_Gen_1	329	340	PF02991	0.480
LIG_LIR_Gen_1	345	355	PF02991	0.392
LIG_LIR_Gen_1	39	47	PF02991	0.479
LIG_LIR_Nem_3	148	153	PF02991	0.621
LIG_LIR_Nem_3	190	196	PF02991	0.585
LIG_LIR_Nem_3	245	251	PF02991	0.444
LIG_LIR_Nem_3	297	302	PF02991	0.414
LIG_LIR_Nem_3	313	318	PF02991	0.491
LIG_LIR_Nem_3	329	335	PF02991	0.495
LIG_LIR_Nem_3	345	350	PF02991	0.398
LIG_LIR_Nem_3	351	356	PF02991	0.342
LIG_LIR_Nem_3	39	44	PF02991	0.586
LIG_LIR_Nem_3	75	80	PF02991	0.724
LIG_NRBOX	123	129	PF00104	0.444
LIG_PALB2_WD40_1	294	302	PF16756	0.420
LIG_PTAP_UEV_1	238	243	PF05743	0.582
LIG_SH2_CRK	248	252	PF00017	0.503
LIG_SH2_CRK	41	45	PF00017	0.539
LIG_SH2_CRK	80	84	PF00017	0.606
LIG_SH2_GRB2like	226	229	PF00017	0.448
LIG_SH2_GRB2like	80	83	PF00017	0.541
LIG_SH2_NCK_1	226	230	PF00017	0.451
LIG_SH2_SRC	226	229	PF00017	0.448
LIG_SH2_STAP1	226	230	PF00017	0.451
LIG_SH2_STAT5	260	263	PF00017	0.640
LIG_SH2_STAT5	80	83	PF00017	0.582
LIG_SH2_STAT5	95	98	PF00017	0.484
LIG_SH3_2	239	244	PF14604	0.622
LIG_SH3_3	236	242	PF00018	0.668
LIG_SH3_3	40	46	PF00018	0.471
LIG_SUMO_SIM_par_1	308	314	PF11976	0.510
LIG_SUMO_SIM_par_1	333	338	PF11976	0.412
LIG_SxIP_EBH_1	170	182	PF03271	0.468
LIG_TRAF2_1	114	117	PF00917	0.602
LIG_TRAF2_1	291	294	PF00917	0.497
LIG_TRAF2_1	311	314	PF00917	0.240
LIG_TRAF2_1	87	90	PF00917	0.345
LIG_UBA3_1	22	31	PF00899	0.404
MOD_CDK_SPK_2	205	210	PF00069	0.620
MOD_CDK_SPxxK_3	14	21	PF00069	0.438
MOD_CK1_1	106	112	PF00069	0.759
MOD_CK1_1	175	181	PF00069	0.718
MOD_CK1_1	208	214	PF00069	0.649
MOD_CK1_1	232	238	PF00069	0.602
MOD_CK2_1	145	151	PF00069	0.587
MOD_CK2_1	265	271	PF00069	0.696
MOD_CK2_1	288	294	PF00069	0.474
MOD_CK2_1	308	314	PF00069	0.440
MOD_GlcNHglycan	183	186	PF01048	0.614
MOD_GlcNHglycan	211	214	PF01048	0.706
MOD_GlcNHglycan	216	219	PF01048	0.673
MOD_GlcNHglycan	239	242	PF01048	0.667
MOD_GlcNHglycan	328	331	PF01048	0.324
MOD_GlcNHglycan	65	68	PF01048	0.553
MOD_GlcNHglycan	9	12	PF01048	0.661
MOD_GSK3_1	116	123	PF00069	0.662
MOD_GSK3_1	160	167	PF00069	0.624
MOD_GSK3_1	168	175	PF00069	0.596
MOD_GSK3_1	205	212	PF00069	0.697
MOD_GSK3_1	229	236	PF00069	0.598
MOD_GSK3_1	254	261	PF00069	0.626
MOD_GSK3_1	284	291	PF00069	0.395
MOD_GSK3_1	32	39	PF00069	0.510
MOD_GSK3_1	96	103	PF00069	0.561
MOD_N-GLC_1	205	210	PF02516	0.768
MOD_N-GLC_1	283	288	PF02516	0.479
MOD_NEK2_1	127	132	PF00069	0.741
MOD_NEK2_1	168	173	PF00069	0.608
MOD_NEK2_1	283	288	PF00069	0.458
MOD_NEK2_1	36	41	PF00069	0.468
MOD_NEK2_2	145	150	PF00069	0.594
MOD_PKA_1	160	166	PF00069	0.647
MOD_PKA_2	159	165	PF00069	0.615
MOD_PKA_2	187	193	PF00069	0.648
MOD_PKA_2	32	38	PF00069	0.451
MOD_PKB_1	158	166	PF00069	0.566
MOD_Plk_1	283	289	PF00069	0.498
MOD_Plk_4	145	151	PF00069	0.547
MOD_Plk_4	164	170	PF00069	0.666
MOD_Plk_4	278	284	PF00069	0.465
MOD_Plk_4	32	38	PF00069	0.447
MOD_Plk_4	48	54	PF00069	0.311
MOD_ProDKin_1	14	20	PF00069	0.442
MOD_ProDKin_1	205	211	PF00069	0.616
MOD_ProDKin_1	254	260	PF00069	0.637
MOD_ProDKin_1	261	267	PF00069	0.671
MOD_ProDKin_1	271	277	PF00069	0.668
MOD_SUMO_rev_2	192	201	PF00179	0.506
TRG_DiLeu_BaEn_2	350	356	PF01217	0.228
TRG_DiLeu_BaEn_2	47	53	PF01217	0.487
TRG_ENDOCYTIC_2	150	153	PF00928	0.617
TRG_ENDOCYTIC_2	248	251	PF00928	0.505
TRG_ENDOCYTIC_2	332	335	PF00928	0.481
TRG_ENDOCYTIC_2	41	44	PF00928	0.592
TRG_ER_diArg_1	157	160	PF00400	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7W0	Leptomonas seymouri	47%	100%
A0A1X0NZT2	Trypanosomatidae	31%	100%
A0A3Q8IRA6	Leishmania donovani	86%	98%
A0A3R7NQI4	Trypanosoma rangeli	30%	100%
A4HHC9	Leishmania braziliensis	70%	100%
A4I4H4	Leishmania infantum	86%	98%
E9ADX5	Leishmania major	85%	100%