EXS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Etoposide-induced protein 2.4 (EI24), putative

Species:

Leishmania mexicana

UniProt:

E9ALV4_LEIMU

TriTrypDb:

LmxM.08_29.1190

Length:

597

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9ALV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALV4

Function

Biological processes
Term	Name	Level	Count
GO:0006914	autophagy	3	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0016236	macroautophagy	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0061919	process utilizing autophagic mechanism	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.457
CLV_NRD_NRD_1	239	241	PF00675	0.509
CLV_NRD_NRD_1	38	40	PF00675	0.629
CLV_PCSK_KEX2_1	37	39	PF00082	0.555
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.555
CLV_PCSK_SKI1_1	106	110	PF00082	0.519
CLV_PCSK_SKI1_1	128	132	PF00082	0.419
CLV_PCSK_SKI1_1	166	170	PF00082	0.397
CLV_PCSK_SKI1_1	187	191	PF00082	0.309
CLV_PCSK_SKI1_1	352	356	PF00082	0.551
CLV_PCSK_SKI1_1	90	94	PF00082	0.493
DEG_APCC_DBOX_1	202	210	PF00400	0.411
DEG_SCF_FBW7_1	80	85	PF00400	0.652
DEG_SPOP_SBC_1	323	327	PF00917	0.645
DEG_SPOP_SBC_1	57	61	PF00917	0.783
DOC_AGCK_PIF_2	465	470	PF00069	0.518
DOC_ANK_TNKS_1	68	75	PF00023	0.713
DOC_CKS1_1	450	455	PF01111	0.411
DOC_CYCLIN_yClb5_NLxxxL_5	125	134	PF00134	0.619
DOC_MAPK_gen_1	118	126	PF00069	0.671
DOC_MAPK_MEF2A_6	574	582	PF00069	0.513
DOC_MAPK_RevD_3	25	39	PF00069	0.786
DOC_PP2B_LxvP_1	53	56	PF13499	0.685
DOC_PP2B_LxvP_1	582	585	PF13499	0.411
DOC_PP4_FxxP_1	108	111	PF00568	0.786
DOC_PP4_FxxP_1	542	545	PF00568	0.654
DOC_USP7_MATH_1	177	181	PF00917	0.790
DOC_USP7_MATH_1	255	259	PF00917	0.773
DOC_USP7_MATH_1	307	311	PF00917	0.748
DOC_USP7_MATH_1	323	327	PF00917	0.698
DOC_USP7_MATH_1	380	384	PF00917	0.770
DOC_USP7_MATH_1	393	397	PF00917	0.677
DOC_USP7_MATH_1	401	405	PF00917	0.756
DOC_USP7_MATH_1	433	437	PF00917	0.411
DOC_USP7_MATH_1	545	549	PF00917	0.667
DOC_USP7_MATH_1	57	61	PF00917	0.736
DOC_WW_Pin1_4	151	156	PF00397	0.506
DOC_WW_Pin1_4	281	286	PF00397	0.827
DOC_WW_Pin1_4	296	301	PF00397	0.551
DOC_WW_Pin1_4	314	319	PF00397	0.690
DOC_WW_Pin1_4	397	402	PF00397	0.813
DOC_WW_Pin1_4	407	412	PF00397	0.708
DOC_WW_Pin1_4	449	454	PF00397	0.411
DOC_WW_Pin1_4	51	56	PF00397	0.774
DOC_WW_Pin1_4	78	83	PF00397	0.668
LIG_14-3-3_CanoR_1	103	109	PF00244	0.796
LIG_14-3-3_CanoR_1	148	158	PF00244	0.463
LIG_14-3-3_CanoR_1	166	173	PF00244	0.355
LIG_14-3-3_CanoR_1	187	197	PF00244	0.619
LIG_14-3-3_CanoR_1	322	331	PF00244	0.703
LIG_14-3-3_CanoR_1	344	351	PF00244	0.733
LIG_14-3-3_CanoR_1	352	359	PF00244	0.567
LIG_Actin_WH2_2	195	212	PF00022	0.513
LIG_Actin_WH2_2	321	339	PF00022	0.740
LIG_AP2alpha_2	412	414	PF02296	0.788
LIG_APCC_ABBA_1	417	422	PF00400	0.554
LIG_BRCT_BRCA1_1	191	195	PF00533	0.436
LIG_BRCT_BRCA1_1	555	559	PF00533	0.635
LIG_CtBP_PxDLS_1	2	6	PF00389	0.741
LIG_deltaCOP1_diTrp_1	235	243	PF00928	0.673
LIG_eIF4E_1	233	239	PF01652	0.684
LIG_FHA_1	168	174	PF00498	0.403
LIG_FHA_1	184	190	PF00498	0.776
LIG_FHA_1	234	240	PF00498	0.662
LIG_FHA_1	344	350	PF00498	0.652
LIG_FHA_1	358	364	PF00498	0.696
LIG_FHA_1	414	420	PF00498	0.705
LIG_FHA_1	487	493	PF00498	0.648
LIG_FHA_1	5	11	PF00498	0.734
LIG_FHA_1	515	521	PF00498	0.513
LIG_FHA_1	83	89	PF00498	0.793
LIG_FHA_2	315	321	PF00498	0.759
LIG_FHA_2	407	413	PF00498	0.732
LIG_GBD_Chelix_1	576	584	PF00786	0.436
LIG_LIR_Apic_2	107	111	PF02991	0.782
LIG_LIR_Apic_2	540	545	PF02991	0.647
LIG_LIR_Gen_1	112	120	PF02991	0.657
LIG_LIR_Gen_1	192	202	PF02991	0.513
LIG_LIR_Gen_1	412	421	PF02991	0.701
LIG_LIR_Gen_1	434	444	PF02991	0.411
LIG_LIR_Gen_1	534	543	PF02991	0.537
LIG_LIR_Nem_3	112	116	PF02991	0.650
LIG_LIR_Nem_3	140	146	PF02991	0.411
LIG_LIR_Nem_3	192	198	PF02991	0.513
LIG_LIR_Nem_3	23	28	PF02991	0.668
LIG_LIR_Nem_3	412	417	PF02991	0.707
LIG_LIR_Nem_3	426	432	PF02991	0.546
LIG_LIR_Nem_3	434	440	PF02991	0.411
LIG_LIR_Nem_3	499	505	PF02991	0.619
LIG_LIR_Nem_3	534	538	PF02991	0.411
LIG_LIR_Nem_3	556	562	PF02991	0.648
LIG_MYND_1	296	300	PF01753	0.592
LIG_NRBOX	121	127	PF00104	0.732
LIG_NRBOX	192	198	PF00104	0.513
LIG_PALB2_WD40_1	224	232	PF16756	0.513
LIG_PDZ_Class_1	592	597	PF00595	0.718
LIG_Pex14_1	207	211	PF04695	0.488
LIG_Pex14_2	555	559	PF04695	0.635
LIG_SH2_CRK	143	147	PF00017	0.411
LIG_SH2_CRK	218	222	PF00017	0.411
LIG_SH2_STAP1	319	323	PF00017	0.592
LIG_SH2_STAP1	533	537	PF00017	0.411
LIG_SH2_STAP1	560	564	PF00017	0.648
LIG_SH2_STAP1	569	573	PF00017	0.694
LIG_SH2_STAT3	211	214	PF00017	0.492
LIG_SH2_STAT3	472	475	PF00017	0.663
LIG_SH2_STAT3	533	536	PF00017	0.411
LIG_SH2_STAT5	211	214	PF00017	0.492
LIG_SH2_STAT5	218	221	PF00017	0.411
LIG_SH2_STAT5	342	345	PF00017	0.713
LIG_SH2_STAT5	463	466	PF00017	0.424
LIG_SH2_STAT5	583	586	PF00017	0.411
LIG_SH3_3	279	285	PF00018	0.812
LIG_SH3_3	290	296	PF00018	0.625
LIG_SH3_3	541	547	PF00018	0.661
LIG_SH3_3	74	80	PF00018	0.779
LIG_SH3_3	83	89	PF00018	0.750
LIG_SH3_3	96	102	PF00018	0.696
LIG_SUMO_SIM_anti_2	325	332	PF11976	0.719
LIG_SUMO_SIM_par_1	1	8	PF11976	0.747
LIG_SUMO_SIM_par_1	195	201	PF11976	0.436
LIG_SUMO_SIM_par_1	26	33	PF11976	0.765
LIG_TYR_ITIM	141	146	PF00017	0.411
LIG_TYR_ITIM	581	586	PF00017	0.403
LIG_WRC_WIRS_1	22	27	PF05994	0.661
MOD_CK1_1	153	159	PF00069	0.523
MOD_CK1_1	167	173	PF00069	0.443
MOD_CK1_1	180	186	PF00069	0.640
MOD_CK1_1	188	194	PF00069	0.429
MOD_CK1_1	258	264	PF00069	0.734
MOD_CK1_1	271	277	PF00069	0.703
MOD_CK1_1	383	389	PF00069	0.778
MOD_CK1_1	4	10	PF00069	0.739
MOD_CK1_1	486	492	PF00069	0.649
MOD_CK1_1	59	65	PF00069	0.669
MOD_CK2_1	111	117	PF00069	0.626
MOD_CK2_1	302	308	PF00069	0.747
MOD_CK2_1	314	320	PF00069	0.636
MOD_CK2_1	420	426	PF00069	0.585
MOD_CK2_1	439	445	PF00069	0.402
MOD_GlcNHglycan	159	162	PF01048	0.538
MOD_GlcNHglycan	166	169	PF01048	0.426
MOD_GlcNHglycan	173	176	PF01048	0.378
MOD_GlcNHglycan	257	260	PF01048	0.524
MOD_GlcNHglycan	272	276	PF01048	0.503
MOD_GlcNHglycan	304	307	PF01048	0.513
MOD_GlcNHglycan	308	312	PF01048	0.482
MOD_GlcNHglycan	32	35	PF01048	0.523
MOD_GlcNHglycan	382	385	PF01048	0.543
MOD_GlcNHglycan	386	389	PF01048	0.566
MOD_GlcNHglycan	395	398	PF01048	0.497
MOD_GlcNHglycan	441	444	PF01048	0.513
MOD_GlcNHglycan	485	488	PF01048	0.473
MOD_GlcNHglycan	508	511	PF01048	0.411
MOD_GlcNHglycan	539	542	PF01048	0.446
MOD_GlcNHglycan	94	97	PF01048	0.550
MOD_GSK3_1	1	8	PF00069	0.803
MOD_GSK3_1	149	156	PF00069	0.516
MOD_GSK3_1	167	174	PF00069	0.238
MOD_GSK3_1	176	183	PF00069	0.770
MOD_GSK3_1	185	192	PF00069	0.576
MOD_GSK3_1	281	288	PF00069	0.769
MOD_GSK3_1	302	309	PF00069	0.724
MOD_GSK3_1	380	387	PF00069	0.738
MOD_GSK3_1	393	400	PF00069	0.771
MOD_GSK3_1	401	408	PF00069	0.804
MOD_GSK3_1	506	513	PF00069	0.411
MOD_GSK3_1	527	534	PF00069	0.411
MOD_GSK3_1	78	85	PF00069	0.741
MOD_GSK3_1	88	95	PF00069	0.762
MOD_N-GLC_1	180	185	PF02516	0.564
MOD_NEK2_1	104	109	PF00069	0.599
MOD_NEK2_1	144	149	PF00069	0.404
MOD_NEK2_1	150	155	PF00069	0.544
MOD_NEK2_1	189	194	PF00069	0.513
MOD_NEK2_1	198	203	PF00069	0.476
MOD_NEK2_1	324	329	PF00069	0.702
MOD_NEK2_1	335	340	PF00069	0.642
MOD_NEK2_1	439	444	PF00069	0.383
MOD_NEK2_1	5	10	PF00069	0.792
MOD_NEK2_1	514	519	PF00069	0.411
MOD_NEK2_1	58	63	PF00069	0.680
MOD_NEK2_1	592	597	PF00069	0.718
MOD_NEK2_1	94	99	PF00069	0.811
MOD_PIKK_1	227	233	PF00454	0.389
MOD_PIKK_1	401	407	PF00454	0.838
MOD_PIKK_1	5	11	PF00454	0.790
MOD_PKA_2	177	183	PF00069	0.731
MOD_PKA_2	233	239	PF00069	0.684
MOD_PKA_2	245	251	PF00069	0.723
MOD_PKA_2	343	349	PF00069	0.752
MOD_PKA_2	483	489	PF00069	0.685
MOD_Plk_4	1	7	PF00069	0.806
MOD_Plk_4	137	143	PF00069	0.507
MOD_Plk_4	189	195	PF00069	0.513
MOD_Plk_4	216	222	PF00069	0.355
MOD_Plk_4	233	239	PF00069	0.593
MOD_Plk_4	324	330	PF00069	0.644
MOD_Plk_4	413	419	PF00069	0.710
MOD_Plk_4	496	502	PF00069	0.673
MOD_Plk_4	510	516	PF00069	0.309
MOD_Plk_4	519	525	PF00069	0.411
MOD_Plk_4	527	533	PF00069	0.411
MOD_ProDKin_1	151	157	PF00069	0.508
MOD_ProDKin_1	281	287	PF00069	0.826
MOD_ProDKin_1	296	302	PF00069	0.550
MOD_ProDKin_1	314	320	PF00069	0.688
MOD_ProDKin_1	397	403	PF00069	0.813
MOD_ProDKin_1	407	413	PF00069	0.703
MOD_ProDKin_1	449	455	PF00069	0.411
MOD_ProDKin_1	51	57	PF00069	0.773
MOD_ProDKin_1	78	84	PF00069	0.724
MOD_SUMO_rev_2	114	122	PF00179	0.635
TRG_DiLeu_LyEn_5	445	450	PF01217	0.419
TRG_ENDOCYTIC_2	143	146	PF00928	0.411
TRG_ENDOCYTIC_2	218	221	PF00928	0.411
TRG_ENDOCYTIC_2	569	572	PF00928	0.682
TRG_ENDOCYTIC_2	583	586	PF00928	0.411
TRG_ER_diArg_1	38	41	PF00400	0.832

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDR7	Leptomonas seymouri	51%	100%
A0A3S7X2B9	Leishmania donovani	92%	100%
A4HHD1	Leishmania braziliensis	83%	100%
A4I4H6	Leishmania infantum	92%	100%
E9ADX7	Leishmania major	92%	100%