Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALV3_LEIMU

TriTrypDb:

LmxM.08_29.1200

Length:

598

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 5, no: 1
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9ALV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALV3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.580
CLV_C14_Caspase3-7	235	239	PF00656	0.579
CLV_NRD_NRD_1	123	125	PF00675	0.751
CLV_NRD_NRD_1	191	193	PF00675	0.754
CLV_NRD_NRD_1	210	212	PF00675	0.612
CLV_NRD_NRD_1	287	289	PF00675	0.794
CLV_NRD_NRD_1	309	311	PF00675	0.704
CLV_NRD_NRD_1	475	477	PF00675	0.486
CLV_NRD_NRD_1	49	51	PF00675	0.650
CLV_PCSK_FUR_1	47	51	PF00082	0.633
CLV_PCSK_FUR_1	473	477	PF00082	0.434
CLV_PCSK_KEX2_1	123	125	PF00082	0.751
CLV_PCSK_KEX2_1	193	195	PF00082	0.692
CLV_PCSK_KEX2_1	210	212	PF00082	0.735
CLV_PCSK_KEX2_1	287	289	PF00082	0.794
CLV_PCSK_KEX2_1	475	477	PF00082	0.486
CLV_PCSK_KEX2_1	49	51	PF00082	0.650
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.751
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.692
CLV_PCSK_SKI1_1	476	480	PF00082	0.540
CLV_PCSK_SKI1_1	501	505	PF00082	0.403
CLV_PCSK_SKI1_1	55	59	PF00082	0.636
CLV_PCSK_SKI1_1	564	568	PF00082	0.502
CLV_PCSK_SKI1_1	585	589	PF00082	0.516
DEG_APCC_DBOX_1	191	199	PF00400	0.565
DEG_APCC_DBOX_1	500	508	PF00400	0.478
DEG_SCF_FBW7_1	419	425	PF00400	0.616
DEG_SPOP_SBC_1	412	416	PF00917	0.624
DEG_SPOP_SBC_1	434	438	PF00917	0.680
DOC_CKS1_1	150	155	PF01111	0.406
DOC_CKS1_1	419	424	PF01111	0.671
DOC_CKS1_1	78	83	PF01111	0.325
DOC_CYCLIN_yClb5_NLxxxL_5	194	202	PF00134	0.574
DOC_CYCLIN_yCln2_LP_2	179	185	PF00134	0.589
DOC_CYCLIN_yCln2_LP_2	550	556	PF00134	0.513
DOC_MAPK_gen_1	192	201	PF00069	0.489
DOC_MAPK_gen_1	499	508	PF00069	0.353
DOC_MAPK_MEF2A_6	499	508	PF00069	0.357
DOC_MAPK_NFAT4_5	499	507	PF00069	0.411
DOC_PP2B_LxvP_1	179	182	PF13499	0.517
DOC_PP2B_LxvP_1	550	553	PF13499	0.448
DOC_PP4_FxxP_1	536	539	PF00568	0.419
DOC_USP7_MATH_1	167	171	PF00917	0.521
DOC_USP7_MATH_1	346	350	PF00917	0.513
DOC_USP7_MATH_1	394	398	PF00917	0.788
DOC_USP7_MATH_1	422	426	PF00917	0.697
DOC_USP7_MATH_1	433	437	PF00917	0.774
DOC_USP7_MATH_1	439	443	PF00917	0.738
DOC_WW_Pin1_4	149	154	PF00397	0.549
DOC_WW_Pin1_4	35	40	PF00397	0.437
DOC_WW_Pin1_4	398	403	PF00397	0.779
DOC_WW_Pin1_4	415	420	PF00397	0.675
DOC_WW_Pin1_4	435	440	PF00397	0.566
DOC_WW_Pin1_4	448	453	PF00397	0.673
DOC_WW_Pin1_4	489	494	PF00397	0.675
DOC_WW_Pin1_4	77	82	PF00397	0.330
LIG_14-3-3_CanoR_1	244	251	PF00244	0.542
LIG_14-3-3_CanoR_1	410	419	PF00244	0.730
LIG_14-3-3_CanoR_1	483	493	PF00244	0.661
LIG_14-3-3_CanoR_1	8	15	PF00244	0.741
LIG_Actin_WH2_2	549	566	PF00022	0.420
LIG_BIR_II_1	1	5	PF00653	0.705
LIG_BIR_III_4	382	386	PF00653	0.753
LIG_BRCT_BRCA1_1	339	343	PF00533	0.299
LIG_deltaCOP1_diTrp_1	262	269	PF00928	0.392
LIG_deltaCOP1_diTrp_1	363	372	PF00928	0.687
LIG_EH1_1	350	358	PF00400	0.436
LIG_FAT_LD_1	195	203	PF03623	0.519
LIG_FHA_1	240	246	PF00498	0.432
LIG_FHA_1	293	299	PF00498	0.543
LIG_FHA_1	320	326	PF00498	0.549
LIG_FHA_1	419	425	PF00498	0.633
LIG_FHA_1	435	441	PF00498	0.655
LIG_FHA_1	507	513	PF00498	0.246
LIG_FHA_1	54	60	PF00498	0.307
LIG_FHA_2	403	409	PF00498	0.836
LIG_LIR_Gen_1	322	331	PF02991	0.547
LIG_LIR_Gen_1	494	504	PF02991	0.532
LIG_LIR_Gen_1	547	557	PF02991	0.388
LIG_LIR_Gen_1	91	101	PF02991	0.426
LIG_LIR_LC3C_4	547	552	PF02991	0.513
LIG_LIR_Nem_3	322	327	PF02991	0.546
LIG_LIR_Nem_3	494	500	PF02991	0.532
LIG_LIR_Nem_3	515	520	PF02991	0.645
LIG_LIR_Nem_3	547	552	PF02991	0.388
LIG_LIR_Nem_3	91	96	PF02991	0.425
LIG_NBox_RRM_1	343	353	PF00076	0.436
LIG_NRBOX	194	200	PF00104	0.565
LIG_NRBOX	499	505	PF00104	0.513
LIG_Pex14_1	269	273	PF04695	0.490
LIG_Pex14_1	339	343	PF04695	0.436
LIG_REV1ctd_RIR_1	4	12	PF16727	0.700
LIG_REV1ctd_RIR_1	494	503	PF16727	0.549
LIG_SH2_CRK	223	227	PF00017	0.591
LIG_SH2_STAT5	324	327	PF00017	0.551
LIG_SH2_STAT5	549	552	PF00017	0.499
LIG_SH2_STAT5	93	96	PF00017	0.489
LIG_SH3_3	147	153	PF00018	0.559
LIG_SH3_3	29	35	PF00018	0.436
LIG_SH3_3	303	309	PF00018	0.547
LIG_SH3_3	416	422	PF00018	0.673
LIG_SH3_3	67	73	PF00018	0.462
LIG_SUMO_SIM_anti_2	170	176	PF11976	0.379
LIG_SUMO_SIM_anti_2	23	28	PF11976	0.222
LIG_SUMO_SIM_anti_2	303	309	PF11976	0.375
LIG_TRAF2_1	569	572	PF00917	0.675
LIG_UBA3_1	495	499	PF00899	0.513
LIG_UBA3_1	556	564	PF00899	0.568
LIG_WRC_WIRS_1	573	578	PF05994	0.703
MOD_CDC14_SPxK_1	451	454	PF00782	0.595
MOD_CDK_SPxK_1	448	454	PF00069	0.598
MOD_CDK_SPxK_1	77	83	PF00069	0.328
MOD_CDK_SPxxK_3	77	84	PF00069	0.330
MOD_CK1_1	141	147	PF00069	0.415
MOD_CK1_1	170	176	PF00069	0.469
MOD_CK1_1	253	259	PF00069	0.490
MOD_CK1_1	377	383	PF00069	0.735
MOD_CK1_1	38	44	PF00069	0.469
MOD_CK1_1	397	403	PF00069	0.656
MOD_CK1_1	413	419	PF00069	0.642
MOD_CK1_1	420	426	PF00069	0.746
MOD_CK2_1	402	408	PF00069	0.814
MOD_CK2_1	565	571	PF00069	0.628
MOD_CMANNOS	514	517	PF00535	0.513
MOD_GlcNHglycan	140	143	PF01048	0.627
MOD_GlcNHglycan	226	229	PF01048	0.765
MOD_GlcNHglycan	246	249	PF01048	0.529
MOD_GlcNHglycan	252	255	PF01048	0.692
MOD_GlcNHglycan	292	295	PF01048	0.630
MOD_GlcNHglycan	348	351	PF01048	0.472
MOD_GlcNHglycan	376	379	PF01048	0.492
MOD_GlcNHglycan	393	397	PF01048	0.480
MOD_GlcNHglycan	40	43	PF01048	0.687
MOD_GlcNHglycan	402	405	PF01048	0.536
MOD_GlcNHglycan	425	428	PF01048	0.523
MOD_GlcNHglycan	486	489	PF01048	0.482
MOD_GlcNHglycan	546	549	PF01048	0.251
MOD_GlcNHglycan	567	570	PF01048	0.428
MOD_GSK3_1	124	131	PF00069	0.520
MOD_GSK3_1	288	295	PF00069	0.585
MOD_GSK3_1	33	40	PF00069	0.629
MOD_GSK3_1	377	384	PF00069	0.607
MOD_GSK3_1	394	401	PF00069	0.809
MOD_GSK3_1	411	418	PF00069	0.642
MOD_GSK3_1	435	442	PF00069	0.799
MOD_GSK3_1	520	527	PF00069	0.453
MOD_N-GLC_1	128	133	PF02516	0.633
MOD_N-GLC_1	374	379	PF02516	0.580
MOD_NEK2_1	100	105	PF00069	0.427
MOD_NEK2_1	138	143	PF00069	0.414
MOD_NEK2_1	183	188	PF00069	0.507
MOD_NEK2_1	20	25	PF00069	0.442
MOD_NEK2_1	292	297	PF00069	0.545
MOD_NEK2_1	374	379	PF00069	0.625
MOD_NEK2_1	484	489	PF00069	0.706
MOD_NEK2_1	506	511	PF00069	0.415
MOD_NEK2_1	512	517	PF00069	0.409
MOD_NEK2_1	7	12	PF00069	0.732
MOD_PKA_1	124	130	PF00069	0.486
MOD_PKA_2	204	210	PF00069	0.528
MOD_PKA_2	7	13	PF00069	0.691
MOD_Plk_1	288	294	PF00069	0.541
MOD_Plk_1	374	380	PF00069	0.781
MOD_Plk_4	141	147	PF00069	0.537
MOD_Plk_4	167	173	PF00069	0.444
MOD_Plk_4	301	307	PF00069	0.525
MOD_Plk_4	319	325	PF00069	0.510
MOD_Plk_4	439	445	PF00069	0.600
MOD_Plk_4	491	497	PF00069	0.646
MOD_Plk_4	537	543	PF00069	0.417
MOD_Plk_4	89	95	PF00069	0.442
MOD_ProDKin_1	149	155	PF00069	0.550
MOD_ProDKin_1	35	41	PF00069	0.433
MOD_ProDKin_1	398	404	PF00069	0.780
MOD_ProDKin_1	415	421	PF00069	0.675
MOD_ProDKin_1	435	441	PF00069	0.567
MOD_ProDKin_1	448	454	PF00069	0.676
MOD_ProDKin_1	489	495	PF00069	0.672
MOD_ProDKin_1	77	83	PF00069	0.328
MOD_SUMO_for_1	104	107	PF00179	0.416
TRG_DiLeu_BaEn_1	229	234	PF01217	0.595
TRG_DiLeu_BaEn_1	583	588	PF01217	0.643
TRG_DiLeu_BaLyEn_6	498	503	PF01217	0.433
TRG_DiLeu_BaLyEn_6	529	534	PF01217	0.355
TRG_ENDOCYTIC_2	3	6	PF00928	0.715
TRG_ENDOCYTIC_2	324	327	PF00928	0.478
TRG_ENDOCYTIC_2	549	552	PF00928	0.513
TRG_ENDOCYTIC_2	93	96	PF00928	0.416
TRG_ER_diArg_1	192	195	PF00400	0.516
TRG_ER_diArg_1	209	211	PF00400	0.453
TRG_ER_diArg_1	49	51	PF00400	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL17	Leptomonas seymouri	32%	100%
A0A3Q8IBG2	Leishmania donovani	86%	99%
A4HHD2	Leishmania braziliensis	66%	100%
A4I4H7	Leishmania infantum	86%	99%
E9ADX8	Leishmania major	84%	100%