Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALV2_LEIMU

TriTrypDb:

LmxM.08_29.1210

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ALV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALV2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.529
CLV_C14_Caspase3-7	339	343	PF00656	0.660
CLV_NRD_NRD_1	142	144	PF00675	0.495
CLV_NRD_NRD_1	215	217	PF00675	0.595
CLV_NRD_NRD_1	277	279	PF00675	0.633
CLV_NRD_NRD_1	345	347	PF00675	0.733
CLV_PCSK_KEX2_1	142	144	PF00082	0.533
CLV_PCSK_KEX2_1	183	185	PF00082	0.511
CLV_PCSK_KEX2_1	215	217	PF00082	0.558
CLV_PCSK_KEX2_1	276	278	PF00082	0.622
CLV_PCSK_KEX2_1	345	347	PF00082	0.573
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.511
CLV_PCSK_SKI1_1	189	193	PF00082	0.479
CLV_PCSK_SKI1_1	295	299	PF00082	0.544
CLV_Separin_Metazoa	273	277	PF03568	0.652
DEG_MDM2_SWIB_1	118	126	PF02201	0.557
DEG_MDM2_SWIB_1	357	364	PF02201	0.552
DEG_SPOP_SBC_1	155	159	PF00917	0.577
DEG_SPOP_SBC_1	244	248	PF00917	0.423
DEG_SPOP_SBC_1	57	61	PF00917	0.302
DOC_CYCLIN_RxL_1	256	269	PF00134	0.460
DOC_CYCLIN_yCln2_LP_2	249	252	PF00134	0.738
DOC_MAPK_FxFP_2	191	194	PF00069	0.440
DOC_MAPK_gen_1	142	150	PF00069	0.475
DOC_MAPK_gen_1	180	190	PF00069	0.378
DOC_MAPK_gen_1	9	19	PF00069	0.496
DOC_MAPK_HePTP_8	140	152	PF00069	0.583
DOC_MAPK_MEF2A_6	142	150	PF00069	0.420
DOC_MAPK_MEF2A_6	9	17	PF00069	0.494
DOC_PP2B_LxvP_1	249	252	PF13499	0.699
DOC_PP2B_LxvP_1	362	365	PF13499	0.503
DOC_PP4_FxxP_1	191	194	PF00568	0.440
DOC_PP4_FxxP_1	330	333	PF00568	0.506
DOC_USP7_MATH_1	153	157	PF00917	0.694
DOC_USP7_MATH_1	223	227	PF00917	0.692
DOC_USP7_MATH_1	244	248	PF00917	0.509
DOC_USP7_MATH_1	69	73	PF00917	0.742
DOC_WW_Pin1_4	158	163	PF00397	0.677
DOC_WW_Pin1_4	331	336	PF00397	0.428
DOC_WW_Pin1_4	71	76	PF00397	0.747
LIG_14-3-3_CanoR_1	12	16	PF00244	0.501
LIG_14-3-3_CanoR_1	160	170	PF00244	0.602
LIG_14-3-3_CanoR_1	189	194	PF00244	0.465
LIG_14-3-3_CanoR_1	215	222	PF00244	0.746
LIG_14-3-3_CanoR_1	242	252	PF00244	0.420
LIG_14-3-3_CanoR_1	70	74	PF00244	0.747
LIG_APCC_ABBA_1	13	18	PF00400	0.395
LIG_APCC_ABBAyCdc20_2	12	18	PF00400	0.501
LIG_BIR_II_1	1	5	PF00653	0.639
LIG_Clathr_ClatBox_1	54	58	PF01394	0.573
LIG_CtBP_PxDLS_1	194	198	PF00389	0.518
LIG_deltaCOP1_diTrp_1	324	330	PF00928	0.604
LIG_eIF4E_1	292	298	PF01652	0.561
LIG_EVH1_1	250	254	PF00568	0.673
LIG_EVH1_2	253	257	PF00568	0.652
LIG_FHA_1	107	113	PF00498	0.530
LIG_FHA_1	12	18	PF00498	0.471
LIG_FHA_1	135	141	PF00498	0.559
LIG_FHA_1	244	250	PF00498	0.538
LIG_FHA_1	49	55	PF00498	0.470
LIG_FHA_1	91	97	PF00498	0.529
LIG_FHA_2	177	183	PF00498	0.551
LIG_FHA_2	334	340	PF00498	0.718
LIG_FHA_2	358	364	PF00498	0.662
LIG_Integrin_RGD_1	30	32	PF01839	0.578
LIG_LIR_Gen_1	168	178	PF02991	0.625
LIG_LIR_Gen_1	358	367	PF02991	0.580
LIG_LIR_Gen_1	8	17	PF02991	0.500
LIG_LIR_LC3C_4	51	56	PF02991	0.501
LIG_LIR_Nem_3	14	19	PF02991	0.447
LIG_LIR_Nem_3	168	174	PF02991	0.548
LIG_LIR_Nem_3	255	260	PF02991	0.478
LIG_LIR_Nem_3	287	292	PF02991	0.506
LIG_LIR_Nem_3	358	364	PF02991	0.537
LIG_LIR_Nem_3	8	13	PF02991	0.506
LIG_Pex14_1	326	330	PF04695	0.602
LIG_Pex14_2	118	122	PF04695	0.536
LIG_Pex14_2	357	361	PF04695	0.546
LIG_RPA_C_Fungi	340	352	PF08784	0.452
LIG_SH2_CRK	171	175	PF00017	0.576
LIG_SH2_NCK_1	171	175	PF00017	0.617
LIG_SH2_PTP2	16	19	PF00017	0.492
LIG_SH2_SRC	16	19	PF00017	0.443
LIG_SH2_STAP1	108	112	PF00017	0.631
LIG_SH2_STAT5	108	111	PF00017	0.587
LIG_SH2_STAT5	16	19	PF00017	0.464
LIG_SH2_STAT5	171	174	PF00017	0.472
LIG_SH2_STAT5	200	203	PF00017	0.576
LIG_SH3_1	277	283	PF00018	0.657
LIG_SH3_2	251	256	PF14604	0.708
LIG_SH3_3	198	204	PF00018	0.604
LIG_SH3_3	238	244	PF00018	0.601
LIG_SH3_3	248	254	PF00018	0.391
LIG_SH3_3	277	283	PF00018	0.657
LIG_SUMO_SIM_par_1	53	61	PF11976	0.587
LIG_TRAF2_1	165	168	PF00917	0.614
LIG_TRAF2_1	25	28	PF00917	0.701
LIG_TRAF2_1	64	67	PF00917	0.601
LIG_TYR_ITIM	169	174	PF00017	0.598
LIG_TYR_ITSM	12	19	PF00017	0.490
MOD_CDK_SPK_2	158	163	PF00069	0.594
MOD_CK1_1	128	134	PF00069	0.522
MOD_CK1_1	156	162	PF00069	0.606
MOD_CK1_1	176	182	PF00069	0.568
MOD_CK1_1	224	230	PF00069	0.712
MOD_CK1_1	61	67	PF00069	0.574
MOD_CK1_1	71	77	PF00069	0.737
MOD_CK1_1	87	93	PF00069	0.585
MOD_CK2_1	161	167	PF00069	0.621
MOD_CK2_1	61	67	PF00069	0.633
MOD_GlcNHglycan	1	4	PF01048	0.573
MOD_GlcNHglycan	163	166	PF01048	0.630
MOD_GlcNHglycan	175	178	PF01048	0.659
MOD_GlcNHglycan	206	209	PF01048	0.644
MOD_GlcNHglycan	223	226	PF01048	0.551
MOD_GlcNHglycan	268	271	PF01048	0.697
MOD_GlcNHglycan	299	302	PF01048	0.551
MOD_GlcNHglycan	321	324	PF01048	0.652
MOD_GlcNHglycan	45	48	PF01048	0.481
MOD_GlcNHglycan	63	66	PF01048	0.419
MOD_GlcNHglycan	82	85	PF01048	0.450
MOD_GSK3_1	124	131	PF00069	0.477
MOD_GSK3_1	154	161	PF00069	0.566
MOD_GSK3_1	169	176	PF00069	0.589
MOD_GSK3_1	57	64	PF00069	0.518
MOD_GSK3_1	76	83	PF00069	0.684
MOD_GSK3_1	84	91	PF00069	0.609
MOD_N-GLC_1	112	117	PF02516	0.608
MOD_NEK2_1	125	130	PF00069	0.474
MOD_NEK2_1	169	174	PF00069	0.517
MOD_NEK2_1	266	271	PF00069	0.583
MOD_NEK2_1	297	302	PF00069	0.521
MOD_NEK2_1	357	362	PF00069	0.660
MOD_NEK2_1	88	93	PF00069	0.538
MOD_NEK2_2	350	355	PF00069	0.706
MOD_PKA_1	215	221	PF00069	0.499
MOD_PKA_2	11	17	PF00069	0.505
MOD_PKA_2	215	221	PF00069	0.713
MOD_PKA_2	69	75	PF00069	0.752
MOD_Plk_1	112	118	PF00069	0.597
MOD_Plk_1	357	363	PF00069	0.614
MOD_Plk_1	57	63	PF00069	0.350
MOD_Plk_4	11	17	PF00069	0.505
MOD_Plk_4	245	251	PF00069	0.726
MOD_Plk_4	357	363	PF00069	0.649
MOD_ProDKin_1	158	164	PF00069	0.664
MOD_ProDKin_1	331	337	PF00069	0.434
MOD_ProDKin_1	71	77	PF00069	0.747
MOD_SUMO_rev_2	207	214	PF00179	0.730
TRG_DiLeu_BaEn_1	35	40	PF01217	0.581
TRG_DiLeu_BaLyEn_6	277	282	PF01217	0.713
TRG_ENDOCYTIC_2	16	19	PF00928	0.408
TRG_ENDOCYTIC_2	171	174	PF00928	0.562
TRG_ER_diArg_1	214	216	PF00400	0.596
TRG_ER_diArg_1	275	278	PF00400	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6E7	Leptomonas seymouri	42%	100%
A0A1X0NZS1	Trypanosomatidae	28%	90%
A0A3Q8IFC4	Leishmania donovani	86%	99%
A0A3R7LZ67	Trypanosoma rangeli	31%	92%
A4HHD3	Leishmania braziliensis	75%	100%
A4I4H8	Leishmania infantum	86%	98%
E9ADX9	Leishmania major	85%	100%
V5BR99	Trypanosoma cruzi	28%	92%