Splicing factor YJU2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Family of unknown function (DUF572), putative

Species:

Leishmania mexicana

UniProt:

E9ALV1_LEIMU

TriTrypDb:

LmxM.08_29.1220

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005681	spliceosomal complex	3	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0071006	U2-type catalytic step 1 spliceosome	4	1
GO:0071012	catalytic step 1 spliceosome	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9ALV1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALV1

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	7
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	7
GO:0000398	mRNA splicing, via spliceosome	8	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006397	mRNA processing	7	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0008380	RNA splicing	7	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0016071	mRNA metabolic process	6	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	210	214	PF00656	0.327
CLV_C14_Caspase3-7	261	265	PF00656	0.222
CLV_C14_Caspase3-7	348	352	PF00656	0.527
CLV_C14_Caspase3-7	396	400	PF00656	0.816
CLV_NRD_NRD_1	20	22	PF00675	0.411
CLV_NRD_NRD_1	203	205	PF00675	0.389
CLV_NRD_NRD_1	288	290	PF00675	0.404
CLV_NRD_NRD_1	323	325	PF00675	0.426
CLV_NRD_NRD_1	333	335	PF00675	0.596
CLV_NRD_NRD_1	34	36	PF00675	0.414
CLV_NRD_NRD_1	374	376	PF00675	0.521
CLV_NRD_NRD_1	66	68	PF00675	0.357
CLV_NRD_NRD_1	78	80	PF00675	0.355
CLV_PCSK_FUR_1	201	205	PF00082	0.389
CLV_PCSK_FUR_1	32	36	PF00082	0.411
CLV_PCSK_KEX2_1	127	129	PF00082	0.411
CLV_PCSK_KEX2_1	203	205	PF00082	0.389
CLV_PCSK_KEX2_1	288	290	PF00082	0.381
CLV_PCSK_KEX2_1	323	325	PF00082	0.503
CLV_PCSK_KEX2_1	333	335	PF00082	0.635
CLV_PCSK_KEX2_1	34	36	PF00082	0.411
CLV_PCSK_KEX2_1	49	51	PF00082	0.183
CLV_PCSK_KEX2_1	66	68	PF00082	0.411
CLV_PCSK_KEX2_1	78	80	PF00082	0.411
CLV_PCSK_KEX2_1	83	85	PF00082	0.411
CLV_PCSK_PC1ET2_1	127	129	PF00082	0.389
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.411
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.183
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.513
CLV_PCSK_PC7_1	199	205	PF00082	0.389
CLV_PCSK_PC7_1	79	85	PF00082	0.513
CLV_PCSK_SKI1_1	253	257	PF00082	0.416
CLV_PCSK_SKI1_1	323	327	PF00082	0.513
CLV_PCSK_SKI1_1	333	337	PF00082	0.630
CLV_PCSK_SKI1_1	415	419	PF00082	0.730
DEG_SCF_FBW7_1	111	117	PF00400	0.411
DEG_SCF_FBW7_1	370	377	PF00400	0.644
DEG_SPOP_SBC_1	229	233	PF00917	0.513
DEG_SPOP_SBC_1	241	245	PF00917	0.298
DEG_SPOP_SBC_1	339	343	PF00917	0.648
DEG_SPOP_SBC_1	364	368	PF00917	0.730
DOC_CKS1_1	111	116	PF01111	0.411
DOC_CYCLIN_yClb3_PxF_3	412	418	PF00134	0.625
DOC_MAPK_gen_1	223	230	PF00069	0.222
DOC_MAPK_gen_1	49	57	PF00069	0.411
DOC_MAPK_gen_1	83	91	PF00069	0.513
DOC_PP4_FxxP_1	249	252	PF00568	0.513
DOC_PP4_FxxP_1	444	447	PF00568	0.816
DOC_PP4_FxxP_1	53	56	PF00568	0.411
DOC_USP7_MATH_1	229	233	PF00917	0.382
DOC_USP7_MATH_1	242	246	PF00917	0.432
DOC_USP7_MATH_1	374	378	PF00917	0.723
DOC_USP7_MATH_1	400	404	PF00917	0.721
DOC_USP7_MATH_1	417	421	PF00917	0.635
DOC_USP7_MATH_1	445	449	PF00917	0.749
DOC_USP7_MATH_1	69	73	PF00917	0.411
DOC_USP7_UBL2_3	376	380	PF12436	0.711
DOC_WW_Pin1_4	110	115	PF00397	0.411
DOC_WW_Pin1_4	237	242	PF00397	0.471
DOC_WW_Pin1_4	370	375	PF00397	0.599
LIG_14-3-3_CanoR_1	333	340	PF00244	0.708
LIG_14-3-3_CanoR_1	423	429	PF00244	0.722
LIG_14-3-3_CanoR_1	50	54	PF00244	0.411
LIG_BIR_II_1	1	5	PF00653	0.629
LIG_BRCT_BRCA1_1	245	249	PF00533	0.513
LIG_FHA_1	252	258	PF00498	0.272
LIG_FHA_1	425	431	PF00498	0.748
LIG_FHA_1	50	56	PF00498	0.411
LIG_FHA_2	107	113	PF00498	0.411
LIG_FHA_2	185	191	PF00498	0.222
LIG_FHA_2	231	237	PF00498	0.513
LIG_FHA_2	307	313	PF00498	0.319
LIG_FHA_2	339	345	PF00498	0.536
LIG_LIR_Apic_2	10	16	PF02991	0.411
LIG_LIR_Apic_2	246	252	PF02991	0.513
LIG_LIR_Apic_2	358	364	PF02991	0.524
LIG_LIR_Apic_2	442	447	PF02991	0.821
LIG_LIR_Apic_2	52	56	PF02991	0.411
LIG_LIR_Nem_3	130	136	PF02991	0.478
LIG_LIR_Nem_3	17	23	PF02991	0.411
LIG_LIR_Nem_3	276	282	PF02991	0.411
LIG_LIR_Nem_3	287	293	PF02991	0.411
LIG_NRBOX	463	469	PF00104	0.521
LIG_Pex14_2	53	57	PF04695	0.411
LIG_SH2_GRB2like	387	390	PF00017	0.492
LIG_SH2_GRB2like	75	78	PF00017	0.411
LIG_SH2_PTP2	13	16	PF00017	0.411
LIG_SH2_STAT5	106	109	PF00017	0.416
LIG_SH2_STAT5	120	123	PF00017	0.425
LIG_SH2_STAT5	13	16	PF00017	0.411
LIG_SH2_STAT5	85	88	PF00017	0.411
LIG_SH3_1	108	114	PF00018	0.411
LIG_SH3_3	108	114	PF00018	0.411
LIG_SH3_3	410	416	PF00018	0.759
LIG_SUMO_SIM_anti_2	93	98	PF11976	0.411
LIG_SUMO_SIM_par_1	426	432	PF11976	0.514
LIG_TRAF2_1	143	146	PF00917	0.407
LIG_TRAF2_1	182	185	PF00917	0.513
LIG_TRAF2_1	342	345	PF00917	0.540
MOD_CDK_SPK_2	110	115	PF00069	0.411
MOD_CDK_SPK_2	370	375	PF00069	0.520
MOD_CDK_SPxK_1	370	376	PF00069	0.520
MOD_CK1_1	231	237	PF00069	0.491
MOD_CK1_1	240	246	PF00069	0.278
MOD_CK1_1	403	409	PF00069	0.662
MOD_CK1_1	426	432	PF00069	0.759
MOD_CK1_1	448	454	PF00069	0.545
MOD_CK2_1	106	112	PF00069	0.411
MOD_CK2_1	230	236	PF00069	0.513
MOD_CK2_1	263	269	PF00069	0.449
MOD_CK2_1	306	312	PF00069	0.397
MOD_CK2_1	338	344	PF00069	0.568
MOD_Cter_Amidation	32	35	PF01082	0.411
MOD_GlcNHglycan	233	236	PF01048	0.376
MOD_GlcNHglycan	264	268	PF01048	0.489
MOD_GlcNHglycan	357	360	PF01048	0.727
MOD_GlcNHglycan	367	370	PF01048	0.681
MOD_GlcNHglycan	431	434	PF01048	0.718
MOD_GlcNHglycan	436	439	PF01048	0.633
MOD_GlcNHglycan	447	450	PF01048	0.528
MOD_GlcNHglycan	9	12	PF01048	0.506
MOD_GSK3_1	106	113	PF00069	0.393
MOD_GSK3_1	193	200	PF00069	0.411
MOD_GSK3_1	236	243	PF00069	0.416
MOD_GSK3_1	306	313	PF00069	0.397
MOD_GSK3_1	370	377	PF00069	0.604
MOD_GSK3_1	424	431	PF00069	0.773
MOD_N-GLC_1	4	9	PF02516	0.586
MOD_NEK2_1	197	202	PF00069	0.411
MOD_NEK2_1	228	233	PF00069	0.299
MOD_NEK2_1	310	315	PF00069	0.222
MOD_NEK2_1	365	370	PF00069	0.810
MOD_NEK2_1	418	423	PF00069	0.543
MOD_PIKK_1	448	454	PF00454	0.836
MOD_PK_1	375	381	PF00069	0.714
MOD_PKA_1	333	339	PF00069	0.629
MOD_PKA_1	375	381	PF00069	0.714
MOD_PKA_1	49	55	PF00069	0.411
MOD_PKA_2	202	208	PF00069	0.436
MOD_PKA_2	333	339	PF00069	0.629
MOD_PKA_2	374	380	PF00069	0.503
MOD_PKA_2	49	55	PF00069	0.411
MOD_PKA_2	69	75	PF00069	0.411
MOD_Plk_1	311	317	PF00069	0.393
MOD_Plk_1	4	10	PF00069	0.586
MOD_Plk_1	400	406	PF00069	0.741
MOD_Plk_4	193	199	PF00069	0.362
MOD_Plk_4	400	406	PF00069	0.764
MOD_Plk_4	460	466	PF00069	0.811
MOD_ProDKin_1	110	116	PF00069	0.411
MOD_ProDKin_1	237	243	PF00069	0.471
MOD_ProDKin_1	370	376	PF00069	0.599
MOD_SUMO_for_1	150	153	PF00179	0.411
TRG_DiLeu_BaLyEn_6	463	468	PF01217	0.523
TRG_ER_diArg_1	198	201	PF00400	0.400
TRG_ER_diArg_1	202	204	PF00400	0.411
TRG_ER_diArg_1	288	290	PF00400	0.411
TRG_ER_diArg_1	322	324	PF00400	0.425
TRG_ER_diArg_1	333	335	PF00400	0.584
TRG_ER_diArg_1	66	68	PF00400	0.411
TRG_ER_diArg_1	88	91	PF00400	0.222
TRG_NLS_Bipartite_1	21	38	PF00514	0.411
TRG_NLS_MonoExtN_4	32	38	PF00514	0.411
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	291	296	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	466	470	PF00026	0.709

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY11	Leptomonas seymouri	56%	100%
A0A3Q8IF48	Leishmania donovani	86%	100%
A4HHD4	Leishmania braziliensis	74%	99%
A4I4H9	Leishmania infantum	86%	100%
E9ADY0	Leishmania major	85%	100%