Putative ATP-dependent Clp protease subunit, heat shock protein 100 (HSP100)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine peptidase, putative

Species:

Leishmania mexicana

UniProt:

E9ALU6_LEIMU

TriTrypDb:

LmxM.08_29.1270

Length:

865

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9ALU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALU6

PDB structure(s): 7tfm_A

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	1
GO:0008152	metabolic process	1	7
GO:0009266	response to temperature stimulus	3	1
GO:0009408	response to heat	3	1
GO:0009628	response to abiotic stimulus	2	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	7
GO:0033554	cellular response to stress	3	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0008233	peptidase activity	3	7
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0016887	ATP hydrolysis activity	7	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	59	63	PF00656	0.497
CLV_NRD_NRD_1	142	144	PF00675	0.275
CLV_NRD_NRD_1	195	197	PF00675	0.453
CLV_NRD_NRD_1	23	25	PF00675	0.271
CLV_NRD_NRD_1	330	332	PF00675	0.426
CLV_NRD_NRD_1	415	417	PF00675	0.316
CLV_NRD_NRD_1	52	54	PF00675	0.331
CLV_NRD_NRD_1	668	670	PF00675	0.274
CLV_NRD_NRD_1	746	748	PF00675	0.329
CLV_NRD_NRD_1	819	821	PF00675	0.314

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9X7	Leptomonas seymouri	51%	100%
A0A0N1PC62	Leptomonas seymouri	87%	100%
A0A0S4KJV7	Bodo saltans	49%	100%
A0A1X0NJK9	Trypanosomatidae	50%	100%
A0A1X0NRE7	Trypanosomatidae	75%	100%
A0A381MP32	Leishmania infantum	51%	100%
A0A3R7LKM0	Trypanosoma rangeli	74%	100%
A0A3S5H516	Leishmania donovani	51%	100%
A0A3S7X129	Leishmania donovani	53%	100%
A0A3S7X2C6	Leishmania donovani	98%	100%

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